| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | An azaspiro compound that is 8-azaspiro[4.5]decane-7,9-dione substituted at the nitrogen atom by a 4-(piperazin-1-yl)butyl group which in turn is substituted by a pyrimidin-2-yl group at the nitrogen atom. (Chemical Entities of Biological Interest Ontology, CHEBI_3223) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/2477 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Buspirone relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MDM1 | Mdm1 nuclear protein homolog (mouse) | 1.91 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 1.19 |
| POLR1D | polymerase (RNA) I polypeptide D, 16kDa | 1.16 |
| SLC6A17 | solute carrier family 6 (neutral amino acid transporter), member 17 | 0.92 |
| ARMC7 | armadillo repeat containing 7 | 0.81 |
| RPL36AL | ribosomal protein L36a-like | 0.8 |
| SP100 | SP100 nuclear antigen | 0.72 |
| BID | BH3 interacting domain death agonist | 0.69 |
| COMMD8 | COMM domain containing 8 | 0.68 |
| FAU | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | 0.66 |
| EEF1A1P5 | eukaryotic translation elongation factor 1 alpha 1 pseudogene 5 | 0.65 |
| NBPF20 | neuroblastoma breakpoint family, member 20 | 0.64 |
| RPL3L | ribosomal protein L3-like | 0.63 |
| DES | desmin | 0.61 |
| CD320 | CD320 molecule | 0.61 |
| PCBP3 | poly(rC) binding protein 3 | 0.58 |
| CNTNAP4 | contactin associated protein-like 4 | 0.58 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.57 |
| EIF5A | eukaryotic translation initiation factor 5A | 0.57 |
| PRR14L | proline rich 14-like | 0.57 |
| RPS25 | ribosomal protein S25 | 0.55 |
| GID8 | GID complex subunit 8 | 0.55 |
| TMSB10 | thymosin beta 10 | 0.55 |
| GABRQ | gamma-aminobutyric acid (GABA) A receptor, theta | 0.55 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.54 |
| RPL17 | ribosomal protein L17 | 0.54 |
| H1-2 | H1.2 linker histone, cluster member | 0.54 |
| BORCS5 | BLOC-1 related complex subunit 5 | 0.52 |
| IER2 | immediate early response 2 | 0.52 |
| RPL7A | ribosomal protein L7a | 0.52 |
| PRR3 | proline rich 3 | 0.51 |
| RAB28 | RAB28, member RAS oncogene family | 0.5 |
| GREB1L | growth regulation by estrogen in breast cancer-like | 0.5 |
| LLPH | LLP homolog, long-term synaptic facilitation (Aplysia) | 0.49 |
| PEX5 | peroxisomal biogenesis factor 5 | 0.49 |
| RPS20 | ribosomal protein S20 | 0.48 |
| IPMK | inositol polyphosphate multikinase | 0.48 |
| RPS14 | ribosomal protein S14 | 0.47 |
| MT1X | metallothionein 1X | 0.47 |
| RPL6 | ribosomal protein L6 | 0.46 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.46 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.46 |
| MYH6 | myosin, heavy chain 6, cardiac muscle, alpha | 0.46 |
| JAGN1 | jagunal homolog 1 (Drosophila) | 0.45 |
| RPL36A | ribosomal protein L36a | 0.45 |
| MED31 | mediator complex subunit 31 | 0.45 |
| RPL13 | ribosomal protein L13 | 0.45 |
| HIST2H2BF | histone cluster 2, H2bf | 0.45 |
| RPS7 | ribosomal protein S7 | 0.44 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.43 |
| HMGA1 | high mobility group AT-hook 1 | 0.43 |
| H1-3 | H1.3 linker histone, cluster member | 0.42 |
| RPL23A | ribosomal protein L23a | 0.42 |
| FBXO5 | F-box protein 5 | 0.42 |
| RPL10 | ribosomal protein L10 | 0.42 |
| RPS16 | ribosomal protein S16 | 0.42 |
| FAM193A | family with sequence similarity 193, member A | 0.41 |
| MT1E | metallothionein 1E | 0.41 |
| PFN1 | profilin 1 | 0.41 |
| KSR2 | kinase suppressor of ras 2 | 0.41 |
| CCDC170 | coiled-coil domain containing 170 | 0.41 |
| MED7 | mediator complex subunit 7 | 0.4 |
| RPS27A | ribosomal protein S27a | 0.4 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.4 |
| RPS10 | ribosomal protein S10 | 0.4 |
| TUBB3 | tubulin, beta 3 class III | 0.4 |
| MPC2 | mitochondrial pyruvate carrier 2 | 0.39 |
| ZNF721 | zinc finger protein 721 | 0.39 |
| TMEM179B | transmembrane protein 179B | 0.39 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.39 |
| ZNF805 | zinc finger protein 805 | 0.39 |
| LRRC58 | leucine rich repeat containing 58 | 0.39 |
| PKM | pyruvate kinase, muscle | 0.38 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.38 |
| RPL29 | ribosomal protein L29 | 0.38 |
| H1-5 | H1.5 linker histone, cluster member | 0.38 |
| KLF10 | Kruppel-like factor 10 | 0.38 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.38 |
| HPCAL4 | hippocalcin like 4 | 0.38 |
| RPS26 | ribosomal protein S26 | 0.38 |
| HIST2H2BC | histone cluster 2, H2bc (pseudogene) | 0.37 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.37 |
| TFAP2A | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) | 0.37 |
| RPL14 | ribosomal protein L14 | 0.37 |
| CLIC1 | chloride intracellular channel 1 | 0.37 |
| RPL26 | ribosomal protein L26 | 0.36 |
| SYTL3 | synaptotagmin-like 3 | 0.36 |
| ODC1 | ornithine decarboxylase 1 | 0.36 |
| CENPH | centromere protein H | 0.36 |
| DYNLL1 | dynein, light chain, LC8-type 1 | 0.36 |
| PDAP1 | PDGFA associated protein 1 | 0.35 |
| JMJD4 | jumonji domain containing 4 | 0.35 |
| HMGB1 | high mobility group box 1 | 0.35 |
| COPS4 | COP9 signalosome subunit 4 | 0.35 |
| MCOLN1 | mucolipin 1 | 0.35 |
| NAA50 | N(alpha)-acetyltransferase 50, NatE catalytic subunit | 0.35 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.35 |
| CCDC15 | coiled-coil domain containing 15 | 0.35 |
| CAMK1 | calcium/calmodulin-dependent protein kinase I | 0.35 |
| ATP23 | ATP23 metallopeptidase and ATP synthase assembly factor homolog | 0.35 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CCDC32 | coiled-coil domain containing 32 | -0.78 |
| TWSG1 | twisted gastrulation BMP signaling modulator 1 | -0.75 |
| BOK | BCL2-related ovarian killer | -0.74 |
| ENO1 | enolase 1, (alpha) | -0.73 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.64 |
| DOP1A | DOP1 leucine zipper like protein A | -0.63 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.6 |
| PSMC1 | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | -0.58 |
| GM2A | GM2 ganglioside activator | -0.57 |
| BTBD11 | BTB (POZ) domain containing 11 | -0.57 |
| DNM1 | dynamin 1 | -0.56 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | -0.55 |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | -0.55 |
| NF1 | neurofibromin 1 | -0.54 |
| RPL34 | ribosomal protein L34 | -0.53 |
| MED8 | mediator complex subunit 8 | -0.52 |
| ARSG | arylsulfatase G | -0.51 |
| HBA1 | hemoglobin, alpha 1 | -0.51 |
| MRPL57 | mitochondrial ribosomal protein L57 | -0.51 |
| RGN | regucalcin | -0.51 |
| ADPRHL1 | ADP-ribosylhydrolase like 1 | -0.51 |
| MIEF2 | mitochondrial elongation factor 2 | -0.5 |
| CCDC158 | coiled-coil domain containing 158 | -0.49 |
| SYPL1 | synaptophysin-like 1 | -0.49 |
| COL11A1 | collagen, type XI, alpha 1 | -0.49 |
| MRPL51 | mitochondrial ribosomal protein L51 | -0.48 |
| SLC6A9 | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | -0.48 |
| KCNAB2 | potassium channel, voltage gated subfamily A regulatory beta subunit 2 | -0.47 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | -0.46 |
| TANK | TRAF family member-associated NFKB activator | -0.46 |
| CCDC91 | coiled-coil domain containing 91 | -0.45 |
| GLRX | glutaredoxin (thioltransferase) | -0.45 |
| MYH16 | myosin, heavy chain 16 pseudogene | -0.44 |
| SLC12A4 | solute carrier family 12 (potassium/chloride transporter), member 4 | -0.44 |
| RWDD2B | RWD domain containing 2B | -0.44 |
| TIMM8B | translocase of inner mitochondrial membrane 8 homolog B (yeast) | -0.44 |
| TP53 | tumor protein p53 | -0.43 |
| FBXO17 | F-box protein 17 | -0.43 |
| IAH1 | isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae) | -0.43 |
| LRRK1 | leucine-rich repeat kinase 1 | -0.43 |
| ZNF428 | zinc finger protein 428 | -0.42 |
| GDF15 | growth differentiation factor 15 | -0.42 |
| ZNF823 | zinc finger protein 823 | -0.42 |
| NDFIP2 | Nedd4 family interacting protein 2 | -0.41 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.41 |
| EIF2B4 | eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa | -0.41 |
| ELL3 | elongation factor RNA polymerase II-like 3 | -0.41 |
| MPDU1 | mannose-P-dolichol utilization defect 1 | -0.4 |
| DNAH6 | dynein, axonemal, heavy chain 6 | -0.4 |
| CCDC57 | coiled-coil domain containing 57 | -0.39 |
| PPP1R2B | PPP1R2 family member B | -0.39 |
| SYCP1 | synaptonemal complex protein 1 | -0.39 |
| ZNF771 | zinc finger protein 771 | -0.39 |
| ARHGEF19 | Rho guanine nucleotide exchange factor (GEF) 19 | -0.38 |
| PEX7 | peroxisomal biogenesis factor 7 | -0.38 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.38 |
| PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | -0.37 |
| TMUB1 | transmembrane and ubiquitin-like domain containing 1 | -0.37 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.37 |
| ELF4 | E74-like factor 4 (ets domain transcription factor) | -0.36 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.36 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.36 |
| COA6 | cytochrome c oxidase assembly factor 6 | -0.36 |
| GGACT | gamma-glutamylamine cyclotransferase | -0.35 |
| PHLPP2 | PH domain and leucine rich repeat protein phosphatase 2 | -0.35 |
| PRPF40B | PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) | -0.35 |
| TICRR | TOPBP1-interacting checkpoint and replication regulator | -0.35 |
| HSP90AB4P | heat shock protein 90kDa alpha (cytosolic), class B member 4, pseudogene | -0.35 |
| LRRC57 | leucine rich repeat containing 57 | -0.35 |
| TNNC2 | troponin C type 2 (fast) | -0.34 |
| FURIN | furin (paired basic amino acid cleaving enzyme) | -0.34 |
| B2M | beta-2-microglobulin | -0.34 |
| EIF5A2 | eukaryotic translation initiation factor 5A2 | -0.34 |
| FHIT | fragile histidine triad | -0.34 |
| FAM124A | family with sequence similarity 124A | -0.34 |
| FLNB | filamin B, beta | -0.34 |
| SFXN5 | sideroflexin 5 | -0.34 |
| LGALSL | lectin, galactoside-binding-like | -0.34 |
| ZNF236 | zinc finger protein 236 | -0.34 |
| TIMM8A | translocase of inner mitochondrial membrane 8 homolog A (yeast) | -0.34 |
| DNAL4 | dynein, axonemal, light chain 4 | -0.33 |
| TPM4 | tropomyosin 4 | -0.33 |
| TMEM231 | transmembrane protein 231 | -0.33 |
| SLC16A6 | solute carrier family 16, member 6 | -0.33 |
| TMOD2 | tropomodulin 2 (neuronal) | -0.33 |
| BTBD7 | BTB (POZ) domain containing 7 | -0.33 |
| PLK2 | polo-like kinase 2 | -0.33 |
| SLC25A40 | solute carrier family 25, member 40 | -0.33 |
| NMU | neuromedin U | -0.33 |
| FRMD6 | FERM domain containing 6 | -0.33 |
| ZNF362 | zinc finger protein 362 | -0.33 |
| GPR107 | G protein-coupled receptor 107 | -0.33 |
| C1ORF43 | chromosome 1 open reading frame 43 | -0.32 |
| RNASET2 | ribonuclease T2 | -0.32 |
| PLCB4 | phospholipase C, beta 4 | -0.32 |
| STYK1 | serine/threonine/tyrosine kinase 1 | -0.32 |
| MISP3 | MISP family member 3 | -0.32 |
| BCL6 | B-cell CLL/lymphoma 6 | -0.32 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.32 |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | -0.32 |
