Busulfan_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Busulfan perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Busulfan_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
BIRC3 baculoviral IAP repeat containing 3 0.0696803
ECT2 epithelial cell transforming 2 0.0310525
TXNRD1 thioredoxin reductase 1 0.030412
PCBP2 poly(rC) binding protein 2 0.0302351
KIF5B kinesin family member 5B 0.0296494
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0295448
XPO1 exportin 1 0.0291148
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0244467
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0240534
ZBTB20 zinc finger and BTB domain containing 20 0.0237498
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.0229124
PRR16 proline rich 16 0.0226704
CCNL1 cyclin L1 0.0226487
TFG TRK-fused gene 0.0225965
ZNF638 zinc finger protein 638 0.0222226
CHD1 chromodomain helicase DNA binding protein 1 0.0220579
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0215834
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0209379
ZSWIM6 zinc finger, SWIM-type containing 6 0.0209299
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0208583
AKAP9 A kinase (PRKA) anchor protein 9 0.0204419
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0201178
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0199927
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0196692
MBNL1 muscleblind-like splicing regulator 1 0.0193909
TBK1 TANK-binding kinase 1 0.019385
WDR43 WD repeat domain 43 0.0193235
GPBP1 GC-rich promoter binding protein 1 0.0189781
IL6ST interleukin 6 signal transducer 0.0189708
PCM1 pericentriolar material 1 0.0189114
NEK7 NIMA-related kinase 7 0.0185342
NIPBL Nipped-B homolog (Drosophila) 0.0181125
TPR translocated promoter region, nuclear basket protein 0.0179268
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0178888
FXR1 fragile X mental retardation, autosomal homolog 1 0.0178467
DST dystonin 0.0176041
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.0176016
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 0.017545
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0175264
CPOX coproporphyrinogen oxidase 0.0174483
PUM2 pumilio RNA-binding family member 2 0.0171239
TSC22D2 TSC22 domain family, member 2 0.0169893
EEF2 eukaryotic translation elongation factor 2 0.0169617
PLK2 polo-like kinase 2 0.0167837
THOC1 THO complex 1 0.016776
KLHL24 kelch-like family member 24 0.0167348
SNX13 sorting nexin 13 0.0165429
MED13L mediator complex subunit 13-like 0.016386
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0163424
CEP95 centrosomal protein 95kDa 0.0162693
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0161618
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0160715
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0160095
COG5 component of oligomeric golgi complex 5 0.0158125
KMT2E lysine (K)-specific methyltransferase 2E 0.015799
RLF rearranged L-myc fusion 0.015755
BRWD1 bromodomain and WD repeat domain containing 1 0.015671
USP24 ubiquitin specific peptidase 24 0.0156192
QKI QKI, KH domain containing, RNA binding 0.0156043
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0154041
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.0152747
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0151847
NCKAP1 NCK-associated protein 1 0.0150429
MATR3 matrin 3 0.0149972
PRKN parkin RBR E3 ubiquitin protein ligase 0.0149193
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0148452
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0147619
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.0147056
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0144912
ZNF292 zinc finger protein 292 0.0144566
BLTP1 bridge-like lipid transfer protein family member 1 0.0141244
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0139628
HELB helicase (DNA) B 0.0138785
TRA2A transformer 2 alpha homolog (Drosophila) 0.0138185
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0138051
UBA6 ubiquitin-like modifier activating enzyme 6 0.0137802
ZNF148 zinc finger protein 148 0.0137393
GMDS GDP-mannose 4,6-dehydratase 0.0136784
CENPF centromere protein F, 350/400kDa 0.0135756
KTN1 kinectin 1 (kinesin receptor) 0.0134755
RNMT RNA (guanine-7-) methyltransferase 0.0134753
ARRDC3 arrestin domain containing 3 0.0134567
CD2AP CD2-associated protein 0.0134313
ATP11B ATPase, class VI, type 11B 0.0133993
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.013389
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0133732
VRK2 vaccinia related kinase 2 0.0133095
PDZD8 PDZ domain containing 8 0.0133059
NOP58 NOP58 ribonucleoprotein 0.0132833
HBP1 HMG-box transcription factor 1 0.0132344
OSBPL8 oxysterol binding protein-like 8 0.0131706
YTHDC1 YTH domain containing 1 0.0131618
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0130867
ERRFI1 ERBB receptor feedback inhibitor 1 0.0130621
PTK2 protein tyrosine kinase 2 0.0128433
USP33 ubiquitin specific peptidase 33 0.0127981
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0126671
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 0.0126585
MARCHF4 membrane associated ring-CH-type finger 4 0.0126569
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0126331

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.20359
VIM vimentin -0.196073
PTMA prothymosin, alpha -0.092716
EHBP1 EH domain binding protein 1 -0.0728286
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0707927
MYL12B myosin, light chain 12B, regulatory -0.0611222
RPS12 ribosomal protein S12 -0.0580115
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.057261
ACTG1 actin gamma 1 -0.0560441
AREG amphiregulin -0.0493761
RPL35A ribosomal protein L35a -0.0480215
TPT1 tumor protein, translationally-controlled 1 -0.0478766
HMGA2 high mobility group AT-hook 2 -0.0446993
TPI1 triosephosphate isomerase 1 -0.0445575
RPS19 ribosomal protein S19 -0.0444788
PDE4D phosphodiesterase 4D, cAMP-specific -0.0442136
EGR1 early growth response 1 -0.042777
RPS3 ribosomal protein S3 -0.0422569
JMJD1C jumonji domain containing 1C -0.0420209
YBX3 Y box binding protein 3 -0.0398515
FTL ferritin, light polypeptide -0.0394623
CMIP c-Maf inducing protein -0.0392199
RPS21 ribosomal protein S21 -0.0389125
RPL23 ribosomal protein L23 -0.0385865
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0384046
RPS6 ribosomal protein S6 -0.0378079
RPS27A ribosomal protein S27a -0.0372171
RPL19 ribosomal protein L19 -0.0367458
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0366686
RPL37 ribosomal protein L37 -0.0359918
RPLP2 ribosomal protein, large, P2 -0.0357573
RPL12 ribosomal protein L12 -0.0357057
AHNAK AHNAK nucleoprotein -0.0356361
RPL37A ribosomal protein L37a -0.0349209
RPS8 ribosomal protein S8 -0.0335582
RPS13 ribosomal protein S13 -0.0332483
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0330933
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0327757
ASPH aspartate beta-hydroxylase -0.0324779
ANKRD12 ankyrin repeat domain 12 -0.031676
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.031412
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.031001
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0297659
CALR calreticulin -0.0295986
AKAP12 A kinase (PRKA) anchor protein 12 -0.0295312
BCHE butyrylcholinesterase -0.0293002
RPL36 ribosomal protein L36 -0.028858
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.028838
CNRIP1 cannabinoid receptor interacting protein 1 -0.028672
RPL34 ribosomal protein L34 -0.0285285
NHSL1 NHS-like 1 -0.0279213
MTAP methylthioadenosine phosphorylase -0.0276711
BABAM2 BRISC and BRCA1 A complex member 2 -0.0275766
RPS14 ribosomal protein S14 -0.0272821
RPL26 ribosomal protein L26 -0.0272114
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0270864
EDARADD EDAR-associated death domain -0.0270501
RPLP1 ribosomal protein, large, P1 -0.0265602
ANKRD11 ankyrin repeat domain 11 -0.0263055
PGK1 phosphoglycerate kinase 1 -0.0257976
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.02558
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0255085
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0254326
RPS23 ribosomal protein S23 -0.0252191
PFN1 profilin 1 -0.0252119
H1-0 H1.0 linker histone -0.0250092
RPL36A ribosomal protein L36a -0.0242995
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0242582
KLF6 Kruppel-like factor 6 -0.0237525
RPL31 ribosomal protein L31 -0.023677
MAP1B microtubule-associated protein 1B -0.0231379
RPS24 ribosomal protein S24 -0.0229342
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0225309
RPL11 ribosomal protein L11 -0.022416
RPS29 ribosomal protein S29 -0.0218361
NABP1 nucleic acid binding protein 1 -0.0216768
MTCL1 microtubule crosslinking factor 1 -0.021531
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0212486
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.021166
ZNF804A zinc finger protein 804A -0.0211149
RPS4X ribosomal protein S4, X-linked -0.0209037
NAP1L1 nucleosome assembly protein 1-like 1 -0.0208666
GNAS GNAS complex locus -0.0208055
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.02064
ANXA1 annexin A1 -0.02051
RPS27 ribosomal protein S27 -0.0201569
LPP LIM domain containing preferred translocation partner in lipoma -0.0201447
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.01997
RPL38 ribosomal protein L38 -0.0198518
CUX1 cut-like homeobox 1 -0.0198415
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0191207
RPL9 ribosomal protein L9 -0.0189283
LRRC23 leucine rich repeat containing 23 -0.0189243
RPL18 ribosomal protein L18 -0.0189059
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0186531
TRIO trio Rho guanine nucleotide exchange factor -0.0186521
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0186302
MYPN myopalladin -0.0185259
S100A9 S100 calcium binding protein A9 -0.0184233
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0180993