Busulfan_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Busulfan perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Busulfan_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.108238
INTS6 integrator complex subunit 6 0.104641
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.05832
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.055026
PLSCR2 phospholipid scramblase 2 0.0506434
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0389373
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0354047
GCLC glutamate-cysteine ligase, catalytic subunit 0.0351158
ZSWIM6 zinc finger, SWIM-type containing 6 0.032143
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0303147
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0295115
GMDS GDP-mannose 4,6-dehydratase 0.0243131
KYNU kynureninase 0.0223963
TOX3 TOX high mobility group box family member 3 0.0223641
DST dystonin 0.0219023
SMAD3 SMAD family member 3 0.0210308
CATSPERB catsper channel auxiliary subunit beta 0.0208715
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0201637
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0196273
POF1B premature ovarian failure, 1B 0.0195784
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0194274
AEBP2 AE binding protein 2 0.0178974
MBNL2 muscleblind-like splicing regulator 2 0.0178957
PDLIM5 PDZ and LIM domain 5 0.0166562
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.016417
HOMER1 homer scaffolding protein 1 0.0160971
EXT1 exostosin glycosyltransferase 1 0.0159955
PSPC1 paraspeckle component 1 0.0154344
MCU mitochondrial calcium uniporter 0.0149836
ECT2 epithelial cell transforming 2 0.0148746
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0147258
LARP4B La ribonucleoprotein domain family, member 4B 0.0146
FNIP2 folliculin interacting protein 2 0.0145664
DTX3L deltex 3 like, E3 ubiquitin ligase 0.0143626
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0139041
EFNA5 ephrin-A5 0.0137721
SOD2 superoxide dismutase 2, mitochondrial 0.0135738
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0135284
DUSP16 dual specificity phosphatase 16 0.0132629
EFNB2 ephrin-B2 0.0131888
CAPN8 calpain 8 0.0131706
GK glycerol kinase 0.0130638
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0130615
SMYD3 SET and MYND domain containing 3 0.0130586
CFAP44 cilia and flagella associated protein 44 0.013048
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0129843
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.012818
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0125596
BIRC3 baculoviral IAP repeat containing 3 0.0124772
UGDH UDP-glucose 6-dehydrogenase 0.0124553
DPP4 dipeptidyl-peptidase 4 0.0124227
SAMD4A sterile alpha motif domain containing 4A 0.0123758
HKDC1 hexokinase domain containing 1 0.01235
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0119692
PTPRK protein tyrosine phosphatase, receptor type, K 0.0118047
TPP2 tripeptidyl peptidase II 0.0117642
ATF6 activating transcription factor 6 0.011542
NABP1 nucleic acid binding protein 1 0.0114284
TDRD7 tudor domain containing 7 0.0114107
ADIPOR2 adiponectin receptor 2 0.0110959
ANKRD10 ankyrin repeat domain 10 0.0109863
ADORA2B adenosine A2b receptor 0.0109229
APP amyloid beta (A4) precursor protein 0.0109182
RGS6 regulator of G-protein signaling 6 0.0108235
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.010797
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0105747
TTC19 tetratricopeptide repeat domain 19 0.0104649
RUNX1 runt-related transcription factor 1 0.0104637
GOLGA3 golgin A3 0.0103091
SCFD2 sec1 family domain containing 2 0.0101706
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae) 0.0101469
SERINC5 serine incorporator 5 0.0100875
RDH10 retinol dehydrogenase 10 (all-trans) 0.0100435
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.00997806
SLC38A2 solute carrier family 38, member 2 0.00996978
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.00995911
KANSL1L KAT8 regulatory NSL complex subunit 1-like 0.00980322
UTRN utrophin 0.0096839
CANX calnexin 0.0096498
SDCBP syndecan binding protein (syntenin) 0.00960079
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.00960077
XRN2 5'-3' exoribonuclease 2 0.00957776
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.00952182
TMEM65 transmembrane protein 65 0.00945076
ZNF800 zinc finger protein 800 0.0094369
ZBTB20 zinc finger and BTB domain containing 20 0.00940949
CACHD1 cache domain containing 1 0.00933798
MECOM MDS1 and EVI1 complex locus 0.00928246
TFRC transferrin receptor 0.00923371
TOP1 topoisomerase (DNA) I 0.0091987
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.00919291
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.00911521
LARP1B La ribonucleoprotein domain family, member 1B 0.00907357
IGF1R insulin-like growth factor 1 receptor 0.0090023
ATP13A3 ATPase type 13A3 0.0089985
COG3 component of oligomeric golgi complex 3 0.0089955
HSPH1 heat shock 105kDa/110kDa protein 1 0.00894416
EFHC1 EF-hand domain (C-terminal) containing 1 0.00879276
ATXN1 ataxin 1 0.00875294
BLTP2 bridge-like lipid transfer protein family member 2 0.00872004

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.259942
TPT1 tumor protein, translationally-controlled 1 -0.177304
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.149892
ZMYND8 zinc finger, MYND-type containing 8 -0.146476
PTMA prothymosin, alpha -0.143999
HLA-B major histocompatibility complex, class I, B -0.121255
EPSTI1 epithelial stromal interaction 1 (breast) -0.109395
LCN2 lipocalin 2 -0.0955714
NDRG1 N-myc downstream regulated 1 -0.0909315
TXNIP thioredoxin interacting protein -0.0897622
C6ORF132 chromosome 6 open reading frame 132 -0.0842762
EGR1 early growth response 1 -0.0831051
IFI6 interferon, alpha-inducible protein 6 -0.077424
MACC1 metastasis associated in colon cancer 1 -0.0773671
FTL ferritin, light polypeptide -0.0744011
IFI27 interferon, alpha-inducible protein 27 -0.0724547
RPS6 ribosomal protein S6 -0.0721937
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0701421
RPL35A ribosomal protein L35a -0.0684649
ERBIN erbb2 interacting protein -0.0666393
PKM pyruvate kinase, muscle -0.0666059
LOC102724023 ES1 protein homolog, mitochondrial -0.0648637
TMSB10 thymosin beta 10 -0.0648315
LYZ lysozyme -0.064304
RPL23 ribosomal protein L23 -0.0571806
MT2A metallothionein 2A -0.0566482
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0565121
HLA-A major histocompatibility complex, class I, A -0.055591
RHOBTB3 Rho-related BTB domain containing 3 -0.0551463
KRT19 keratin 19, type I -0.0540976
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0539148
PGK1 phosphoglycerate kinase 1 -0.0532503
SLC38A1 solute carrier family 38, member 1 -0.0528782
ZFP36L1 ZFP36 ring finger protein-like 1 -0.052754
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0522638
FTH1 ferritin, heavy polypeptide 1 -0.0520277
HLA-C major histocompatibility complex, class I, C -0.0516991
PTBP3 polypyrimidine tract binding protein 3 -0.0500188
KLF6 Kruppel-like factor 6 -0.0495663
RNF149 ring finger protein 149 -0.0488693
MX2 MX dynamin-like GTPase 2 -0.0459828
ACTG1 actin gamma 1 -0.0455855
RPL34 ribosomal protein L34 -0.0446054
LIMA1 LIM domain and actin binding 1 -0.0435699
LOC112694756 uncharaterized LOC112694756 -0.0434455
UBC ubiquitin C -0.04344
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0431874
EIF1 eukaryotic translation initiation factor 1 -0.0431449
JUN jun proto-oncogene -0.0424957
NPEPPS aminopeptidase puromycin sensitive -0.0420223
RPL19 ribosomal protein L19 -0.0419154
HLA-E major histocompatibility complex, class I, E -0.0416961
VMP1 vacuole membrane protein 1 -0.0412692
CSTB cystatin B (stefin B) -0.0408914
S100A6 S100 calcium binding protein A6 -0.0404309
IGFBP3 insulin-like growth factor binding protein 3 -0.0402112
SRRM2 serine/arginine repetitive matrix 2 -0.0401949
RPS19 ribosomal protein S19 -0.039593
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0393047
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0391883
TMPRSS4 transmembrane protease, serine 4 -0.0388552
H1-0 H1.0 linker histone -0.0387332
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0382435
PRRC2C proline-rich coiled-coil 2C -0.0381912
TPI1 triosephosphate isomerase 1 -0.0378457
CCNL1 cyclin L1 -0.0376072
TM4SF1 transmembrane 4 L six family member 1 -0.037449
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0370629
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0368576
POTEF POTE ankyrin domain family, member F -0.0367666
RPLP1 ribosomal protein, large, P1 -0.0365305
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0364862
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0361117
CLDN4 claudin 4 -0.036079
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0357492
RPS8 ribosomal protein S8 -0.0356709
TPM4 tropomyosin 4 -0.0356417
PDIA3 protein disulfide isomerase family A, member 3 -0.035599
PRKCA protein kinase C, alpha -0.0355816
S100A9 S100 calcium binding protein A9 -0.0350578
CST3 cystatin C -0.0348865
STS steroid sulfatase (microsomal), isozyme S -0.0348463
ENO1 enolase 1, (alpha) -0.0347786
LY6E lymphocyte antigen 6 complex, locus E -0.034715
GCC2 GRIP and coiled-coil domain containing 2 -0.0337899
H3-3B H3.3 histone B -0.0334956
IFITM3 interferon induced transmembrane protein 3 -0.0334928
SERF2 small EDRK-rich factor 2 -0.0332525
RBM39 RNA binding motif protein 39 -0.0331753
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0328651
LDHA lactate dehydrogenase A -0.03255
RBM25 RNA binding motif protein 25 -0.0325188
ITGA6 integrin, alpha 6 -0.0324667
ISG15 ISG15 ubiquitin-like modifier -0.032348
RAB7A RAB7A, member RAS oncogene family -0.0319879
RPS27 ribosomal protein S27 -0.0318878
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0318354
PERP PERP, TP53 apoptosis effector -0.0317778
ANXA4 annexin A4 -0.0315565
FNDC3B fibronectin type III domain containing 3B -0.0314225