Busulfan_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Busulfan perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Busulfan_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.152634
IGFBP3 insulin-like growth factor binding protein 3 0.108193
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0881346
CXCL8 chemokine (C-X-C motif) ligand 8 0.086274
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0741546
ATP13A3 ATPase type 13A3 0.0653796
VCAN versican 0.063906
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0589017
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.056397
TPM4 tropomyosin 4 0.0552335
IL6ST interleukin 6 signal transducer 0.0533988
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.051726
POSTN periostin, osteoblast specific factor 0.0469302
LDHA lactate dehydrogenase A 0.0457397
LOX lysyl oxidase 0.0450134
ASPH aspartate beta-hydroxylase 0.0417011
COL3A1 collagen, type III, alpha 1 0.0413324
CALU calumenin 0.0393605
VEGFC vascular endothelial growth factor C 0.0389683
ENO1 enolase 1, (alpha) 0.0375039
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0361584
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0359783
COL1A2 collagen, type I, alpha 2 0.0359765
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0353949
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0344754
DPYD dihydropyrimidine dehydrogenase 0.0330778
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0326151
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0316707
SAMD9 sterile alpha motif domain containing 9 0.0315327
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0306842
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0301618
CANX calnexin 0.0298904
SPAG9 sperm associated antigen 9 0.0296815
SQLE squalene epoxidase 0.0285727
BZW1 basic leucine zipper and W2 domains 1 0.0277484
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0275975
HMGA2 high mobility group AT-hook 2 0.0272717
CD44 CD44 molecule (Indian blood group) 0.0270265
FAT1 FAT atypical cadherin 1 0.0267938
PIEZO2 piezo-type mechanosensitive ion channel component 2 0.0266814
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0266748
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0266025
HMCN1 hemicentin 1 0.0265186
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0258791
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0255887
FTH1 ferritin, heavy polypeptide 1 0.0254517
ARHGAP29 Rho GTPase activating protein 29 0.0251573
RAD21 RAD21 homolog (S. pombe) 0.0250491
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0243745
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0243516
DST dystonin 0.0243241
KIF5B kinesin family member 5B 0.0237674
LAMB1 laminin, beta 1 0.0235
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0231249
ELL2 elongation factor, RNA polymerase II, 2 0.0228705
RLF rearranged L-myc fusion 0.0227195
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0226584
NCKAP1 NCK-associated protein 1 0.0224359
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0223094
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.022144
ATL1 atlastin GTPase 1 0.0220806
FXR1 fragile X mental retardation, autosomal homolog 1 0.0219805
ANTXR2 anthrax toxin receptor 2 0.0219543
TFG TRK-fused gene 0.0219077
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0218728
ANXA2 annexin A2 0.0217839
SOD2 superoxide dismutase 2, mitochondrial 0.0217295
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0217014
USP3 ubiquitin specific peptidase 3 0.0216769
ICAM1 intercellular adhesion molecule 1 0.0216264
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0214797
ERBIN erbb2 interacting protein 0.021068
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0210208
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0204346
TMEM123 transmembrane protein 123 0.02024
TXNRD1 thioredoxin reductase 1 0.0202026
JAK2 Janus kinase 2 0.0201643
COL12A1 collagen, type XII, alpha 1 0.0198233
NPEPPS aminopeptidase puromycin sensitive 0.0197422
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0197346
NBAS neuroblastoma amplified sequence 0.019604
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0194822
NAMPT nicotinamide phosphoribosyltransferase 0.0193907
PCM1 pericentriolar material 1 0.0193673
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0193241
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0192414
BHLHE40 basic helix-loop-helix family, member e40 0.0192072
WWTR1 WW domain containing transcription regulator 1 0.0191948
ARRDC3 arrestin domain containing 3 0.0190097
TMSB4X thymosin beta 4, X-linked 0.0188846
TRIP12 thyroid hormone receptor interactor 12 0.018851
FNBP1L formin binding protein 1-like 0.0188258
LMAN1 lectin, mannose-binding, 1 0.0188094
KPNB1 karyopherin (importin) beta 1 0.0187358
TAOK1 TAO kinase 1 0.0186556
SEPTIN7 septin 7 0.0186421
SDCBP syndecan binding protein (syntenin) 0.0185035
CAVIN1 caveolae associated protein 1 0.0183118
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0182392
STC1 stanniocalcin 1 0.0181688

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.358788
MT2A metallothionein 2A -0.238123
TMSB10 thymosin beta 10 -0.149263
COL5A1 collagen, type V, alpha 1 -0.145352
CDH13 cadherin 13 -0.141478
TRIO trio Rho guanine nucleotide exchange factor -0.122367
VEGFA vascular endothelial growth factor A -0.117005
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.108853
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.09816
JARID2 jumonji, AT rich interactive domain 2 -0.0868229
COL7A1 collagen, type VII, alpha 1 -0.073408
TGFBI transforming growth factor, beta-induced, 68kDa -0.0725109
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0698459
COL1A1 collagen, type I, alpha 1 -0.0679934
EXT1 exostosin glycosyltransferase 1 -0.067791
COL6A2 collagen, type VI, alpha 2 -0.0630941
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0621356
FTL ferritin, light polypeptide -0.059935
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0586345
RUNX1 runt-related transcription factor 1 -0.054787
PLEC plectin -0.054194
CMIP c-Maf inducing protein -0.0541749
MYH9 myosin, heavy chain 9, non-muscle -0.0541606
COL6A1 collagen, type VI, alpha 1 -0.0514175
NAV1 neuron navigator 1 -0.0501712
PDE10A phosphodiesterase 10A -0.0491565
RPL35A ribosomal protein L35a -0.0471954
RPS19 ribosomal protein S19 -0.0461945
HLA-B major histocompatibility complex, class I, B -0.0444842
CALR calreticulin -0.0412971
ATXN1 ataxin 1 -0.0411152
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0408441
S100A9 S100 calcium binding protein A9 -0.0400782
MT1X metallothionein 1X -0.0390631
KDM4B lysine (K)-specific demethylase 4B -0.0389684
IFI6 interferon, alpha-inducible protein 6 -0.0381064
RPS8 ribosomal protein S8 -0.0368643
PRELID2 PRELI domain containing 2 -0.0363125
PSD3 pleckstrin and Sec7 domain containing 3 -0.0352802
CADM1 cell adhesion molecule 1 -0.0348537
FNDC3B fibronectin type III domain containing 3B -0.0347347
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0343075
RPS6 ribosomal protein S6 -0.0337022
ANKRD12 ankyrin repeat domain 12 -0.0336393
RPL23 ribosomal protein L23 -0.0326532
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.032422
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0319268
RPL36 ribosomal protein L36 -0.0318985
RPLP2 ribosomal protein, large, P2 -0.0313831
STC2 stanniocalcin 2 -0.0313804
HM13 histocompatibility (minor) 13 -0.0306671
TIMP3 TIMP metallopeptidase inhibitor 3 -0.02949
EGFR epidermal growth factor receptor -0.0294755
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0294318
PDIA5 protein disulfide isomerase family A, member 5 -0.0293936
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0293282
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0289694
TPT1 tumor protein, translationally-controlled 1 -0.028954
ENO2 enolase 2 (gamma, neuronal) -0.0288915
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0283864
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0283081
SETD5 SET domain containing 5 -0.0283032
MTSS1 metastasis suppressor 1 -0.0282193
EPHB1 EPH receptor B1 -0.0280559
HSPG2 heparan sulfate proteoglycan 2 -0.028046
CAMTA1 calmodulin binding transcription activator 1 -0.0280436
ACTG1 actin gamma 1 -0.0280424
PTPRF protein tyrosine phosphatase, receptor type, F -0.0280087
RPL31 ribosomal protein L31 -0.0277839
LMNA lamin A/C -0.0275634
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0275414
SLC22A23 solute carrier family 22, member 23 -0.0272587
RPL28 ribosomal protein L28 -0.0270803
TBC1D22A TBC1 domain family, member 22A -0.0269294
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0268716
NCOR2 nuclear receptor corepressor 2 -0.0267384
SQSTM1 sequestosome 1 -0.0264605
B2M beta-2-microglobulin -0.0263702
RPS21 ribosomal protein S21 -0.0261436
SMYD3 SET and MYND domain containing 3 -0.0254428
GRB10 growth factor receptor-bound protein 10 -0.0251465
CABIN1 calcineurin binding protein 1 -0.0250329
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0248803
DGKI diacylglycerol kinase, iota -0.0243642
RRBP1 ribosome binding protein 1 -0.0242698
TNS1 tensin 1 -0.0241213
PTMA prothymosin, alpha -0.023637
RNF220 ring finger protein 220 -0.0232438
MYO9B myosin IXB -0.0231693
IARS1 isoleucyl-tRNA synthetase 1 -0.0227369
KCTD16 potassium channel tetramerization domain containing 16 -0.0225601
NAV2 neuron navigator 2 -0.0225575
RPS17 ribosomal protein S17 -0.0225126
ANKRD11 ankyrin repeat domain 11 -0.022384
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0223434
RPS12 ribosomal protein S12 -0.0223299
GPC6 glypican 6 -0.022249
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0220804
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0219773
FNIP1 folliculin interacting protein 1 -0.0218782