Busulfan_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Busulfan perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Busulfan_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.275082
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.220661
IGFBP1 insulin-like growth factor binding protein 1 0.118799
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.113191
PDLIM5 PDZ and LIM domain 5 0.10164
EHBP1 EH domain binding protein 1 0.0995063
FNDC3B fibronectin type III domain containing 3B 0.0855862
MBNL2 muscleblind-like splicing regulator 2 0.0849985
SVIL supervillin 0.0849665
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0847866
FAT1 FAT atypical cadherin 1 0.075618
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.072011
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0629222
PARD3 par-3 family cell polarity regulator 0.0616561
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0615978
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0614155
AHR aryl hydrocarbon receptor 0.0613359
FAM107B family with sequence similarity 107, member B 0.0607718
PTCHD4 patched domain containing 4 0.0585111
MBNL1 muscleblind-like splicing regulator 1 0.056606
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0554926
AHSG alpha-2-HS-glycoprotein 0.0549928
LCOR ligand dependent nuclear receptor corepressor 0.0548889
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.054873
FOXP1 forkhead box P1 0.0547532
DSTN destrin (actin depolymerizing factor) 0.0539082
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0530361
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0530079
GK glycerol kinase 0.0526453
PCBP2 poly(rC) binding protein 2 0.0503171
TXNRD1 thioredoxin reductase 1 0.0487394
NAP1L1 nucleosome assembly protein 1-like 1 0.0486121
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0485281
ITGAV integrin, alpha V 0.0477237
JMJD1C jumonji domain containing 1C 0.0469645
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0466498
FBF1 Fas (TNFRSF6) binding factor 1 0.0464361
CCL20 chemokine (C-C motif) ligand 20 0.0463641
APOB apolipoprotein B 0.0454611
GRB10 growth factor receptor-bound protein 10 0.0454474
TRIO trio Rho guanine nucleotide exchange factor 0.0447962
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0429517
CRY1 cryptochrome circadian clock 1 0.042256
PAWR PRKC, apoptosis, WT1, regulator 0.0420732
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0401569
MAML2 mastermind-like 2 (Drosophila) 0.039329
LMO7 LIM domain 7 0.0389688
GCLC glutamate-cysteine ligase, catalytic subunit 0.0376979
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.036996
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0367519
RPLP0 ribosomal protein, large, P0 0.0362962
CNKSR3 CNKSR family member 3 0.0361185
LRMDA leucine rich melanocyte differentiation associated 0.0359021
TOP1 topoisomerase (DNA) I 0.0355447
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0346358
MALRD1 MAM and LDL receptor class A domain containing 1 0.0345844
SOD2 superoxide dismutase 2, mitochondrial 0.0345295
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0336516
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0335883
CDK6 cyclin-dependent kinase 6 0.0334326
ANKRD17 ankyrin repeat domain 17 0.0325208
BIRC6 baculoviral IAP repeat containing 6 0.0322462
PUM1 pumilio RNA-binding family member 1 0.0319933
KMT2E lysine (K)-specific methyltransferase 2E 0.0318075
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0313066
ARHGAP21 Rho GTPase activating protein 21 0.0312112
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0308052
CUL3 cullin 3 0.0303428
LPP LIM domain containing preferred translocation partner in lipoma 0.0302675
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0302529
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0301104
KYNU kynureninase 0.0300958
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0300827
DENND4A DENN/MADD domain containing 4A 0.0297604
AKAP13 A kinase (PRKA) anchor protein 13 0.0295949
PERP PERP, TP53 apoptosis effector 0.0295698
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0295652
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0293058
RAI14 retinoic acid induced 14 0.0289766
ZBTB20 zinc finger and BTB domain containing 20 0.0289516
JAK1 Janus kinase 1 0.0289275
ZSWIM6 zinc finger, SWIM-type containing 6 0.0287316
GOLGA4 golgin A4 0.0286851
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0286757
ARL5B ADP-ribosylation factor-like 5B 0.0286686
SAMD4A sterile alpha motif domain containing 4A 0.0285407
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0284586
HSPH1 heat shock 105kDa/110kDa protein 1 0.0281694
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0278464
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0276987
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 0.0274757
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0274047
UBE2D1 ubiquitin-conjugating enzyme E2D 1 0.0274009
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0271982
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0269535
WDFY2 WD repeat and FYVE domain containing 2 0.0268164
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0268131
NRIP1 nuclear receptor interacting protein 1 0.0267908
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0267329
ZNF644 zinc finger protein 644 0.0266365

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.177916
MT2A metallothionein 2A -0.118615
TPT1 tumor protein, translationally-controlled 1 -0.0737248
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0675992
FN1 fibronectin 1 -0.056535
TMSB10 thymosin beta 10 -0.051389
H1-0 H1.0 linker histone -0.0481401
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0426966
NDRG1 N-myc downstream regulated 1 -0.0382424
TF transferrin -0.0362421
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0360721
PTPRF protein tyrosine phosphatase, receptor type, F -0.0339023
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0336001
VCL vinculin -0.0323871
STC2 stanniocalcin 2 -0.0323367
PEG3 paternally expressed 3 -0.0320855
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0318701
RBM39 RNA binding motif protein 39 -0.0313377
RNASET2 ribonuclease T2 -0.0311647
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0310777
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0305154
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0304374
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0303123
ZHX2 zinc fingers and homeoboxes 2 -0.0297374
MAPK13 mitogen-activated protein kinase 13 -0.0293564
ZMYND8 zinc finger, MYND-type containing 8 -0.0286008
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0278102
RPS21 ribosomal protein S21 -0.0276974
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0273572
AHNAK AHNAK nucleoprotein -0.027199
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0267741
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0261535
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0261229
TM4SF1 transmembrane 4 L six family member 1 -0.0254416
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0252799
PLEC plectin -0.0250999
KDM4B lysine (K)-specific demethylase 4B -0.0248926
NPAS2 neuronal PAS domain protein 2 -0.0247031
ATP10A ATPase, class V, type 10A -0.024674
RUNX1 runt-related transcription factor 1 -0.0246416
KIAA1217 KIAA1217 -0.0244994
MX2 MX dynamin-like GTPase 2 -0.0232805
KDM7A lysine (K)-specific demethylase 7A -0.0232613
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0231607
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0230781
RRBP1 ribosome binding protein 1 -0.0226275
RPS12 ribosomal protein S12 -0.0226108
ENO2 enolase 2 (gamma, neuronal) -0.0224926
PDGFB platelet-derived growth factor beta polypeptide -0.0221552
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0220712
LPCAT1 lysophosphatidylcholine acyltransferase 1 -0.0220558
SDC4 syndecan 4 -0.0219457
PRELID2 PRELI domain containing 2 -0.0218703
IFITM1 interferon induced transmembrane protein 1 -0.0216495
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0212668
HOOK2 hook microtubule-tethering protein 2 -0.0210099
RIGI RNA sensor RIG-I -0.0209802
RNF213 ring finger protein 213 -0.0209059
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0208656
GNAS GNAS complex locus -0.0206241
RPL38 ribosomal protein L38 -0.020532
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0197613
CANX calnexin -0.0196842
PGK1 phosphoglycerate kinase 1 -0.0195633
NINL ninein-like -0.0194337
CTSB cathepsin B -0.0193864
ANGPTL8 angiopoietin like 8 -0.0191847
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.0191102
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0188369
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0186377
TMEM123 transmembrane protein 123 -0.0185994
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 -0.0185128
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 -0.0185057
ISG15 ISG15 ubiquitin-like modifier -0.0184985
COL7A1 collagen, type VII, alpha 1 -0.0184756
APOA2 apolipoprotein A-II -0.018397
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0181796
RPLP1 ribosomal protein, large, P1 -0.0181138
IFI6 interferon, alpha-inducible protein 6 -0.017981
SOX4 SRY (sex determining region Y)-box 4 -0.0179679
SCARB1 scavenger receptor class B, member 1 -0.0178063
CXXC5 CXXC finger protein 5 -0.0177757
RPS19 ribosomal protein S19 -0.0177736
SDC2 syndecan 2 -0.0177425
OSMR oncostatin M receptor -0.0175318
RPL36A ribosomal protein L36a -0.0173767
MACF1 microtubule-actin crosslinking factor 1 -0.0173332
MTUS1 microtubule associated tumor suppressor 1 -0.0172785
RPL37A ribosomal protein L37a -0.0171889
S100P S100 calcium binding protein P -0.0169688
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 -0.0167917
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.0166597
LDHA lactate dehydrogenase A -0.0165614
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 -0.0164616
RPL37 ribosomal protein L37 -0.0164562
HM13 histocompatibility (minor) 13 -0.0164037
METTL9 methyltransferase like 9 -0.0163882
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0163599
ARID3A AT rich interactive domain 3A (BRIGHT-like) -0.0162293
TMEM51 transmembrane protein 51 -0.0161718