Busulfan_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Busulfan perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Busulfan_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0304404
LUZP1 leucine zipper protein 1 0.02937
VCL vinculin 0.0288336
EMP1 epithelial membrane protein 1 0.0242497
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0223408
NEK7 NIMA-related kinase 7 0.0207685
DUSP6 dual specificity phosphatase 6 0.020727
AMOTL1 angiomotin like 1 0.0188593
BCL2L1 BCL2-like 1 0.018376
SMAD3 SMAD family member 3 0.0180934
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0179743
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0174692
PALM2AKAP2 PALM2 and AKAP2 fusion 0.017172
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0155461
LAMC2 laminin, gamma 2 0.0154984
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0154934
RIGI RNA sensor RIG-I 0.0149181
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0139654
SGMS2 sphingomyelin synthase 2 0.0136185
ASPH aspartate beta-hydroxylase 0.0135024
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0134432
FOXP1 forkhead box P1 0.0132818
ARHGAP29 Rho GTPase activating protein 29 0.0129098
PITPNB phosphatidylinositol transfer protein, beta 0.0121579
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0120144
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0117327
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0115875
CAPRIN2 caprin family member 2 0.0115822
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0115299
CLIC4 chloride intracellular channel 4 0.0111302
PDLIM5 PDZ and LIM domain 5 0.0108474
VMP1 vacuole membrane protein 1 0.0105109
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0102697
KIAA0040 KIAA0040 0.0102467
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0101115
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0100809
SPIDR scaffolding protein involved in DNA repair 0.0100119
SYNJ2 synaptojanin 2 0.00943393
MBD5 methyl-CpG binding domain protein 5 0.00928853
EHD4 EH-domain containing 4 0.00923201
PICALM phosphatidylinositol binding clathrin assembly protein 0.00911935
WEE1 WEE1 G2 checkpoint kinase 0.00903073
DOCK5 dedicator of cytokinesis 5 0.00901709
TXNRD1 thioredoxin reductase 1 0.00901541
GPATCH2L G patch domain containing 2-like 0.00892844
RAP1B RAP1B, member of RAS oncogene family 0.00885153
CTBP2 C-terminal binding protein 2 0.0087528
RB1 retinoblastoma 1 0.00870189
EGR1 early growth response 1 0.00862828
ARHGAP23 Rho GTPase activating protein 23 0.0086258
RIN2 Ras and Rab interactor 2 0.00860337
ANXA2 annexin A2 0.00858157
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.00851993
NRG1 neuregulin 1 0.00845824
ATAD2 ATPase family, AAA domain containing 2 0.00845511
ANXA1 annexin A1 0.00829011
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.00815748
ASXL1 additional sex combs like transcriptional regulator 1 0.00808948
SETX senataxin 0.00807978
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.00802236
ERRFI1 ERBB receptor feedback inhibitor 1 0.00792915
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.00785306
ACER3 alkaline ceramidase 3 0.00782383
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.00778864
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.00772343
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0076738
NUMB numb homolog (Drosophila) 0.00765406
RCOR1 REST corepressor 1 0.0076449
ZSWIM4 zinc finger, SWIM-type containing 4 0.00762708
SOX13 SRY (sex determining region Y)-box 13 0.00762217
EFCAB13 EF-hand calcium binding domain 13 0.00756144
RNF220 ring finger protein 220 0.00747779
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.00746085
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.00743087
COPB1 coatomer protein complex, subunit beta 1 0.00742092
SLIT2 slit homolog 2 (Drosophila) 0.0073559
INVS inversin 0.00734527
RLIM ring finger protein, LIM domain interacting 0.00732846
WAC WW domain containing adaptor with coiled-coil 0.00723457
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 0.00722188
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.00713391
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.00712243
GATAD2A GATA zinc finger domain containing 2A 0.00709327
MECOM MDS1 and EVI1 complex locus 0.0070733
RUNX1 runt-related transcription factor 1 0.00691707
PLK2 polo-like kinase 2 0.00691048
METTL15 methyltransferase like 15 0.00688083
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.00686889
RAD21 RAD21 homolog (S. pombe) 0.00680713
CSNK1G1 casein kinase 1, gamma 1 0.00680067
AFAP1L2 actin filament associated protein 1-like 2 0.00678126
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.00677014
TUT7 terminal uridylyl transferase 7 0.00671604
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.00668993
MLF1 myeloid leukemia factor 1 0.00664668
PDGFA platelet-derived growth factor alpha polypeptide 0.00664381
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.00660875
CRY1 cryptochrome circadian clock 1 0.00653853
RBMS2 RNA binding motif, single stranded interacting protein 2 0.00652836
ARL8B ADP-ribosylation factor-like 8B 0.0065044

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.140692
B2M beta-2-microglobulin -0.112628
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.101833
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.101688
RPS6 ribosomal protein S6 -0.0798439
RPS21 ribosomal protein S21 -0.0786425
HLA-B major histocompatibility complex, class I, B -0.072919
MT2A metallothionein 2A -0.0726788
PTMA prothymosin, alpha -0.0718438
MTSS1 metastasis suppressor 1 -0.0713044
NDRG1 N-myc downstream regulated 1 -0.0695645
TMSB10 thymosin beta 10 -0.0673861
CLU clusterin -0.0667722
TPT1 tumor protein, translationally-controlled 1 -0.0631602
RPS8 ribosomal protein S8 -0.0600615
RPLP2 ribosomal protein, large, P2 -0.0593524
RPS13 ribosomal protein S13 -0.0551476
RPL11 ribosomal protein L11 -0.0496601
TMSB4X thymosin beta 4, X-linked -0.0460402
FTH1 ferritin, heavy polypeptide 1 -0.0456013
SULF1 sulfatase 1 -0.0455458
RPL37 ribosomal protein L37 -0.0436861
RPS19 ribosomal protein S19 -0.0436859
GNAS GNAS complex locus -0.0432279
RPL23 ribosomal protein L23 -0.0427546
POTEF POTE ankyrin domain family, member F -0.0410307
S100A10 S100 calcium binding protein A10 -0.0403411
RPS24 ribosomal protein S24 -0.0397973
IFITM1 interferon induced transmembrane protein 1 -0.0383808
IFITM3 interferon induced transmembrane protein 3 -0.0382958
RPS25 ribosomal protein S25 -0.0372975
KIAA1217 KIAA1217 -0.0369241
RPLP1 ribosomal protein, large, P1 -0.0364896
PDE4D phosphodiesterase 4D, cAMP-specific -0.0354731
RPL35A ribosomal protein L35a -0.0353432
RPL34 ribosomal protein L34 -0.03534
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0351715
RPL8 ribosomal protein L8 -0.0349582
PGK1 phosphoglycerate kinase 1 -0.0346251
RPS3 ribosomal protein S3 -0.0344548
PSD3 pleckstrin and Sec7 domain containing 3 -0.0342077
LMO7 LIM domain 7 -0.0340879
PRRC2C proline-rich coiled-coil 2C -0.033981
S100A9 S100 calcium binding protein A9 -0.0339553
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0336323
STC1 stanniocalcin 1 -0.0335464
RPL31 ribosomal protein L31 -0.0333168
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0332015
TXNIP thioredoxin interacting protein -0.0331289
RPL19 ribosomal protein L19 -0.0329285
ZMYND8 zinc finger, MYND-type containing 8 -0.0327954
IGF2 insulin-like growth factor 2 -0.0325369
TSC22D1 TSC22 domain family, member 1 -0.0317617
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0302873
LDHA lactate dehydrogenase A -0.0302234
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0298223
RPL12 ribosomal protein L12 -0.0297622
FTL ferritin, light polypeptide -0.0294622
RPL37A ribosomal protein L37a -0.0294186
LMNA lamin A/C -0.0290139
IFI44L interferon-induced protein 44-like -0.0289094
RPL26 ribosomal protein L26 -0.0286558
TGM2 transglutaminase 2 -0.0286111
EXT1 exostosin glycosyltransferase 1 -0.0283564
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0279612
MDK midkine (neurite growth-promoting factor 2) -0.0278447
S100A6 S100 calcium binding protein A6 -0.0275222
HSPG2 heparan sulfate proteoglycan 2 -0.0275016
SULF2 sulfatase 2 -0.0271577
LOC112694756 uncharaterized LOC112694756 -0.0270646
RPS29 ribosomal protein S29 -0.0269398
SLC35F3 solute carrier family 35, member F3 -0.0265861
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -0.0260652
GOLGA4 golgin A4 -0.0259683
RPS12 ribosomal protein S12 -0.0257981
RPL36A ribosomal protein L36a -0.0255087
RPL5 ribosomal protein L5 -0.0254245
RPS23 ribosomal protein S23 -0.025415
RPS14 ribosomal protein S14 -0.0254074
IFI6 interferon, alpha-inducible protein 6 -0.0249913
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0248872
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0248805
WASF2 WAS protein family, member 2 -0.0246326
HLA-E major histocompatibility complex, class I, E -0.0245994
S100A11 S100 calcium binding protein A11 -0.0245391
SFTPA2 surfactant protein A2 -0.0243139
MT1X metallothionein 1X -0.0242958
IFI27 interferon, alpha-inducible protein 27 -0.0238897
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0237301
CSTB cystatin B (stefin B) -0.0237242
S100A2 S100 calcium binding protein A2 -0.0235596
HM13 histocompatibility (minor) 13 -0.023542
RPL35 ribosomal protein L35 -0.0234542
PLEC plectin -0.0234441
MYOF myoferlin -0.0232438
RACK1 receptor for activated C kinase 1 -0.0232223
RPL36 ribosomal protein L36 -0.0231283
NCOR2 nuclear receptor corepressor 2 -0.0230703
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0230449
CEMIP cell migration inducing protein, hyaluronan binding -0.0229586