Busulfan_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Busulfan perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Busulfan_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.081053
FAT1 FAT atypical cadherin 1 0.0669163
GMDS GDP-mannose 4,6-dehydratase 0.0585986
PTPRK protein tyrosine phosphatase, receptor type, K 0.0477676
LMO7 LIM domain 7 0.0463916
MBNL1 muscleblind-like splicing regulator 1 0.0389115
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0377272
EXT1 exostosin glycosyltransferase 1 0.0366354
CEMIP2 cell migration inducing hyaluronidase 2 0.03541
MED13 mediator complex subunit 13 0.0343582
PDLIM5 PDZ and LIM domain 5 0.0318984
ZSWIM6 zinc finger, SWIM-type containing 6 0.0311308
EPS8 epidermal growth factor receptor pathway substrate 8 0.0301417
SMYD3 SET and MYND domain containing 3 0.0295359
PARD3B par-3 family cell polarity regulator beta 0.0290716
CEMIP cell migration inducing protein, hyaluronan binding 0.0284638
PTEN phosphatase and tensin homolog 0.0284621
FHIT fragile histidine triad 0.0281114
GPHN gephyrin 0.02774
CADPS Ca++-dependent secretion activator 0.0273456
ECT2 epithelial cell transforming 2 0.0267489
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0267102
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.026317
POF1B premature ovarian failure, 1B 0.0262087
NEBL nebulette 0.0260006
KDM4C lysine (K)-specific demethylase 4C 0.025975
ASPH aspartate beta-hydroxylase 0.0250794
AFF1 AF4/FMR2 family, member 1 0.0250084
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0246751
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.02407
VCL vinculin 0.0239137
FNDC3B fibronectin type III domain containing 3B 0.0237942
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0235772
SLC38A2 solute carrier family 38, member 2 0.0229498
AKAP13 A kinase (PRKA) anchor protein 13 0.0226966
NALF1 NALCN channel auxiliary factor 1 0.0226545
ATXN1 ataxin 1 0.0223046
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0220476
PDZD8 PDZ domain containing 8 0.0217543
ANKRD17 ankyrin repeat domain 17 0.0210703
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0208598
MBNL2 muscleblind-like splicing regulator 2 0.0207314
USP9X ubiquitin specific peptidase 9, X-linked 0.0203366
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0202661
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0199731
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0194905
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0192955
NRXN3 neurexin 3 0.0191279
LPP LIM domain containing preferred translocation partner in lipoma 0.0188705
USP34 ubiquitin specific peptidase 34 0.0186025
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0185023
PELI1 pellino E3 ubiquitin protein ligase 1 0.0184044
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0182777
GSK3B glycogen synthase kinase 3 beta 0.0182489
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0179307
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0179227
PTPRG protein tyrosine phosphatase, receptor type, G 0.0178816
ERBIN erbb2 interacting protein 0.0178325
TRIM2 tripartite motif containing 2 0.0177761
CLCN3 chloride channel, voltage-sensitive 3 0.017767
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0176398
VMP1 vacuole membrane protein 1 0.0171846
ITGA6 integrin, alpha 6 0.0169919
ARHGAP21 Rho GTPase activating protein 21 0.0169119
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0168
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0166257
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0165762
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0165022
TRPS1 trichorhinophalangeal syndrome I 0.0163964
INTS6 integrator complex subunit 6 0.015937
MBD5 methyl-CpG binding domain protein 5 0.01587
SERINC5 serine incorporator 5 0.0158255
SFPQ splicing factor proline/glutamine-rich 0.0157879
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0157103
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.0156868
ARHGAP26 Rho GTPase activating protein 26 0.0155707
GLS2 glutaminase 2 (liver, mitochondrial) 0.0154657
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0152588
SIK3 SIK family kinase 3 0.0152338
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0150145
PRELID2 PRELI domain containing 2 0.0149483
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0149076
ARL15 ADP-ribosylation factor-like 15 0.0148537
ZNF644 zinc finger protein 644 0.0148004
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0147354
CCSER1 coiled-coil serine-rich protein 1 0.0146695
ARHGAP32 Rho GTPase activating protein 32 0.0146693
DSPP dentin sialophosphoprotein 0.0146549
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0146508
EXOC4 exocyst complex component 4 0.0146272
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0145179
AHR aryl hydrocarbon receptor 0.0145178
AEBP2 AE binding protein 2 0.0145091
TBC1D5 TBC1 domain family, member 5 0.0144953
MYO1E myosin IE 0.0144812
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.014457
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0144103
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0140443
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0139843
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0139016

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.342818
TMSB10 thymosin beta 10 -0.230939
TPT1 tumor protein, translationally-controlled 1 -0.171241
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.149965
RPS6 ribosomal protein S6 -0.138548
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.103978
RPL35A ribosomal protein L35a -0.0903945
RPS8 ribosomal protein S8 -0.0880372
RPS19 ribosomal protein S19 -0.0828504
RPS12 ribosomal protein S12 -0.0770508
S100A6 S100 calcium binding protein A6 -0.0769897
RPLP1 ribosomal protein, large, P1 -0.074369
FTL ferritin, light polypeptide -0.0718754
RPL34 ribosomal protein L34 -0.0698584
RPL9 ribosomal protein L9 -0.0610157
ACTG1 actin gamma 1 -0.0609581
RPLP2 ribosomal protein, large, P2 -0.0608952
RPS3 ribosomal protein S3 -0.0603358
RPL12 ribosomal protein L12 -0.0596856
RPL23 ribosomal protein L23 -0.0596238
KRT18 keratin 18, type I -0.059387
RPL26 ribosomal protein L26 -0.0585649
RPL37A ribosomal protein L37a -0.055839
NDRG1 N-myc downstream regulated 1 -0.0545805
MT2A metallothionein 2A -0.0544036
RPL36 ribosomal protein L36 -0.0538844
RPL31 ribosomal protein L31 -0.0526451
ANXA2 annexin A2 -0.0518292
B2M beta-2-microglobulin -0.0509657
RPS27A ribosomal protein S27a -0.0494512
RPS24 ribosomal protein S24 -0.0490499
S100A9 S100 calcium binding protein A9 -0.0482389
RPS13 ribosomal protein S13 -0.0467684
ONECUT3 one cut homeobox 3 -0.0461895
RPLP0 ribosomal protein, large, P0 -0.0449647
RPL11 ribosomal protein L11 -0.0449624
RPL19 ribosomal protein L19 -0.0439536
NPSR1 neuropeptide S receptor 1 -0.0438217
RPL7A ribosomal protein L7a -0.0429504
TPM4 tropomyosin 4 -0.0422646
RPS21 ribosomal protein S21 -0.0422454
RPS25 ribosomal protein S25 -0.0416663
RPS29 ribosomal protein S29 -0.0413182
RPL37 ribosomal protein L37 -0.0404118
RPS14 ribosomal protein S14 -0.0399303
RPL18 ribosomal protein L18 -0.0394989
RPL5 ribosomal protein L5 -0.0394401
TFF1 trefoil factor 1 -0.0385691
RPS23 ribosomal protein S23 -0.0383054
RPL8 ribosomal protein L8 -0.0374518
RPS27 ribosomal protein S27 -0.0371849
EPCAM epithelial cell adhesion molecule -0.0362671
TFF3 trefoil factor 3 (intestinal) -0.0360824
S100A10 S100 calcium binding protein A10 -0.0356719
FLNB filamin B, beta -0.0356381
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0352759
EIF1 eukaryotic translation initiation factor 1 -0.0351801
KRT19 keratin 19, type I -0.0348838
IER3 immediate early response 3 -0.0342673
RPS17 ribosomal protein S17 -0.0334729
RPL32 ribosomal protein L32 -0.0331457
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0327081
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0323427
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0321808
TNS4 tensin 4 -0.0321636
RPL36A ribosomal protein L36a -0.0320538
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0318892
RPL7 ribosomal protein L7 -0.0317392
S100P S100 calcium binding protein P -0.0313508
MYL12B myosin, light chain 12B, regulatory -0.0310313
RPL30 ribosomal protein L30 -0.0308824
ENO1 enolase 1, (alpha) -0.0308623
RPS16 ribosomal protein S16 -0.0307398
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0306113
PLAUR plasminogen activator, urokinase receptor -0.0303513
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0299286
SOX4 SRY (sex determining region Y)-box 4 -0.0298842
RPL27A ribosomal protein L27a -0.0298483
RPL38 ribosomal protein L38 -0.0298088
RPL13A ribosomal protein L13a -0.0293099
AREG amphiregulin -0.0290638
PGK1 phosphoglycerate kinase 1 -0.0287715
KLK10 kallikrein-related peptidase 10 -0.0285205
ITGB4 integrin, beta 4 -0.0281733
LMNA lamin A/C -0.0280819
RACK1 receptor for activated C kinase 1 -0.0275786
FERMT1 fermitin family member 1 -0.0273718
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0267784
HMGA1 high mobility group AT-hook 1 -0.02665
RPS2 ribosomal protein S2 -0.0265487
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0262573
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0262213
TPI1 triosephosphate isomerase 1 -0.0261008
RPS11 ribosomal protein S11 -0.0254483
RPL10A ribosomal protein L10a -0.0252558
RPS10 ribosomal protein S10 -0.0252411
RPL15 ribosomal protein L15 -0.0251144
RPS5 ribosomal protein S5 -0.024885
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0247481
ACTN4 actinin, alpha 4 -0.0246491