Busulfan_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Busulfan perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Busulfan_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B 0.125981
EGFR epidermal growth factor receptor 0.116739
PDE4D phosphodiesterase 4D, cAMP-specific 0.0961305
TXNRD1 thioredoxin reductase 1 0.0933591
CXCL8 chemokine (C-X-C motif) ligand 8 0.082989
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0770761
THSD4 thrombospondin, type I, domain containing 4 0.0758313
FAM13A family with sequence similarity 13, member A 0.0712876
MYOF myoferlin 0.0710379
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0701341
ERRFI1 ERBB receptor feedback inhibitor 1 0.0698758
ENO1 enolase 1, (alpha) 0.0665348
PM20D1 peptidase M20 domain containing 1 0.0647383
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0623061
ELL2 elongation factor, RNA polymerase II, 2 0.0594834
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0578524
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0564132
SLTM SAFB-like, transcription modulator 0.053771
CEMIP cell migration inducing protein, hyaluronan binding 0.0522558
SPAG9 sperm associated antigen 9 0.0522146
NAMPT nicotinamide phosphoribosyltransferase 0.0522042
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0513525
FNDC3B fibronectin type III domain containing 3B 0.0503151
ASPH aspartate beta-hydroxylase 0.0491356
TOP1 topoisomerase (DNA) I 0.0469324
GCLC glutamate-cysteine ligase, catalytic subunit 0.0465866
LDHA lactate dehydrogenase A 0.0453809
INTS6 integrator complex subunit 6 0.0451286
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.045069
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.040891
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0400588
RICTOR RPTOR independent companion of MTOR, complex 2 0.0399425
RUNX1 runt-related transcription factor 1 0.0398528
ARRDC3 arrestin domain containing 3 0.0396982
PCBP2 poly(rC) binding protein 2 0.0395247
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0395131
USP34 ubiquitin specific peptidase 34 0.0388274
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0384065
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0381888
HELZ helicase with zinc finger 0.0380784
SMAD3 SMAD family member 3 0.0377308
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0375119
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.037398
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0370219
MAP7 microtubule-associated protein 7 0.036426
PKM pyruvate kinase, muscle 0.0363914
GSK3B glycogen synthase kinase 3 beta 0.0358506
KTN1 kinectin 1 (kinesin receptor) 0.0358428
USP9X ubiquitin specific peptidase 9, X-linked 0.0354499
BIRC3 baculoviral IAP repeat containing 3 0.0353931
TBC1D22A TBC1 domain family, member 22A 0.0352412
KMT2E lysine (K)-specific methyltransferase 2E 0.0347973
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0338174
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0336251
CANX calnexin 0.0329553
MORF4L2 mortality factor 4 like 2 0.0323058
NPAS2 neuronal PAS domain protein 2 0.0322607
HBP1 HMG-box transcription factor 1 0.0316718
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0316261
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0315799
PGK1 phosphoglycerate kinase 1 0.0313421
PDLIM5 PDZ and LIM domain 5 0.0307504
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0303965
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0302946
VMP1 vacuole membrane protein 1 0.0300535
APLP2 amyloid beta (A4) precursor-like protein 2 0.0296519
RIMS2 regulating synaptic membrane exocytosis 2 0.0293875
MKI67 marker of proliferation Ki-67 0.0291364
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0290711
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0288649
ZNF638 zinc finger protein 638 0.0287133
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0284351
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0284109
RNF145 ring finger protein 145 0.0276359
MED13L mediator complex subunit 13-like 0.0275542
ANXA2 annexin A2 0.0273975
NIPBL Nipped-B homolog (Drosophila) 0.0272551
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0272147
JMJD1C jumonji domain containing 1C 0.0271345
GPHN gephyrin 0.0270928
UVRAG UV radiation resistance associated 0.0270638
NCKAP1 NCK-associated protein 1 0.0265124
SMYD3 SET and MYND domain containing 3 0.0260408
MATR3 matrin 3 0.0259875
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0258752
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0258331
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0258116
HOMER1 homer scaffolding protein 1 0.0257996
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0256705
ANKRD17 ankyrin repeat domain 17 0.0252975
TPD52 tumor protein D52 0.0252428
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0251634
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0249969
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0248542
NAP1L1 nucleosome assembly protein 1-like 1 0.0247136
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0245029
ANKRD11 ankyrin repeat domain 11 0.0244118
FNDC3A fibronectin type III domain containing 3A 0.0242248
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.024059
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.024027

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.0825853
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0595557
EGR1 early growth response 1 -0.0574622
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0574592
HLA-B major histocompatibility complex, class I, B -0.0424768
NDRG1 N-myc downstream regulated 1 -0.0423874
OSMR oncostatin M receptor -0.0415639
TRIM56 tripartite motif containing 56 -0.0400585
IFI6 interferon, alpha-inducible protein 6 -0.0397034
ACTG1 actin gamma 1 -0.0365577
LAMC2 laminin, gamma 2 -0.031097
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0305819
BLZF1 basic leucine zipper nuclear factor 1 -0.0297529
PATJ PATJ crumbs cell polarity complex component -0.0294559
CST3 cystatin C -0.0291316
RNF213 ring finger protein 213 -0.0286374
ZMYND8 zinc finger, MYND-type containing 8 -0.028268
AKR1C1 aldo-keto reductase family 1, member C1 -0.0269949
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0261295
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.025277
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.0243724
TPT1 tumor protein, translationally-controlled 1 -0.0231939
TJP1 tight junction protein 1 -0.0216463
ADGRF1 adhesion G protein-coupled receptor F1 -0.0215736
KRT18 keratin 18, type I -0.0212763
NPC1 Niemann-Pick disease, type C1 -0.0211628
MYO1D myosin ID -0.0201597
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0198684
RHOV ras homolog family member V -0.0197323
NSUN6 NOP2/Sun domain family, member 6 -0.0197063
SMIM31 small integral membrane protein 31 -0.019278
HM13 histocompatibility (minor) 13 -0.018661
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0185428
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0184437
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0184016
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0183463
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0181017
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0178962
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0178458
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0177091
S100A10 S100 calcium binding protein A10 -0.0169317
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0169201
ADAR adenosine deaminase, RNA-specific -0.0167345
LMO7 LIM domain 7 -0.0166299
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0164192
CCND1 cyclin D1 -0.0159329
PMP22 peripheral myelin protein 22 -0.0153599
NT5C2 5'-nucleotidase, cytosolic II -0.0153398
CAV1 caveolin 1, caveolae protein, 22kDa -0.0150295
TNS3 tensin 3 -0.014946
SP100 SP100 nuclear antigen -0.0147318
GOLGA3 golgin A3 -0.0142953
STAT2 signal transducer and activator of transcription 2, 113kDa -0.0142922
RIN2 Ras and Rab interactor 2 -0.0142398
LPP LIM domain containing preferred translocation partner in lipoma -0.0141471
MGAT4C MGAT4 family, member C -0.0141261
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0140919
AHNAK2 AHNAK nucleoprotein 2 -0.0140792
KRT19 keratin 19, type I -0.0138487
IFI44L interferon-induced protein 44-like -0.013817
PLSCR1 phospholipid scramblase 1 -0.0138138
RPL34 ribosomal protein L34 -0.0135297
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough -0.0134546
RPS21 ribosomal protein S21 -0.0133857
AHNAK AHNAK nucleoprotein -0.0133266
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0132562
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0131939
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0131934
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0130822
S100A9 S100 calcium binding protein A9 -0.012798
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa -0.0127486
MT1X metallothionein 1X -0.0126789
PLAUR plasminogen activator, urokinase receptor -0.0125735
S100A6 S100 calcium binding protein A6 -0.0125483
RAP2B RAP2B, member of RAS oncogene family -0.0125031
EFNA5 ephrin-A5 -0.0124783
PLEC plectin -0.0124323
CP ceruloplasmin (ferroxidase) -0.0123179
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.012219
GSE1 Gse1 coiled-coil protein -0.0121718
ANKRD12 ankyrin repeat domain 12 -0.0121527
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0118352
RAB27B RAB27B, member RAS oncogene family -0.0117022
SENP5 SUMO1/sentrin specific peptidase 5 -0.0116944
LRP10 low density lipoprotein receptor-related protein 10 -0.0116257
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.0116192
FRY furry homolog (Drosophila) -0.0116143
SDC4 syndecan 4 -0.0115448
ITGB5 integrin, beta 5 -0.0114716
GM2A GM2 ganglioside activator -0.0114238
IGFBP5 insulin-like growth factor binding protein 5 -0.0111368
IER5 immediate early response 5 -0.0110278
CDR2 cerebellar degeneration-related protein 2, 62kDa -0.0109188
ZNFX1 zinc finger, NFX1-type containing 1 -0.0107901
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0107705
DUSP5 dual specificity phosphatase 5 -0.010411
CASP4 caspase 4, apoptosis-related cysteine peptidase -0.0103878
CIB1 calcium and integrin binding 1 (calmyrin) -0.0103766
GOSR2 golgi SNAP receptor complex member 2 -0.0103647
LAP3 leucine aminopeptidase 3 -0.0103442