Busulfan_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Busulfan perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Busulfan_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0800963
GRB10 growth factor receptor-bound protein 10 0.0782515
SMAD3 SMAD family member 3 0.0703339
HMGA2 high mobility group AT-hook 2 0.0674499
SDK1 sidekick cell adhesion molecule 1 0.0623319
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.059893
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0559209
EFNA5 ephrin-A5 0.055331
ZSWIM6 zinc finger, SWIM-type containing 6 0.0505227
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0503755
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0499796
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.049622
FNDC3B fibronectin type III domain containing 3B 0.0486558
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0485198
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0478676
TRIO trio Rho guanine nucleotide exchange factor 0.0449485
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0449261
SOD2 superoxide dismutase 2, mitochondrial 0.043632
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0432082
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0422581
CD44 CD44 molecule (Indian blood group) 0.0410825
ASPH aspartate beta-hydroxylase 0.041018
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0405696
AADAC arylacetamide deacetylase 0.0396243
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0393821
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0384468
LRMDA leucine rich melanocyte differentiation associated 0.0384125
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0376201
EXT1 exostosin glycosyltransferase 1 0.0373389
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0361372
INTS6 integrator complex subunit 6 0.0348547
NRG1 neuregulin 1 0.0347493
PARD3 par-3 family cell polarity regulator 0.0331664
CDH13 cadherin 13 0.0326001
CDK14 cyclin-dependent kinase 14 0.0314356
TAS2R14 taste receptor, type 2, member 14 0.0313911
MYO10 myosin X 0.0312622
ATXN1 ataxin 1 0.0299599
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0299471
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0299228
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0294723
NTN4 netrin 4 0.0287611
RAD51B RAD51 paralog B 0.0282054
MBNL1 muscleblind-like splicing regulator 1 0.0272551
MSRB3 methionine sulfoxide reductase B3 0.0265488
DPYD dihydropyrimidine dehydrogenase 0.0264659
DST dystonin 0.0263053
FER fer (fps/fes related) tyrosine kinase 0.0258344
PDLIM5 PDZ and LIM domain 5 0.0258219
PRKCA protein kinase C, alpha 0.025641
FAM107B family with sequence similarity 107, member B 0.0253666
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0251456
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0243805
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0241553
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0240016
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0236472
ZNF638 zinc finger protein 638 0.0227198
RICTOR RPTOR independent companion of MTOR, complex 2 0.0226316
NAP1L1 nucleosome assembly protein 1-like 1 0.0215836
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0215036
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.021457
MAML3 mastermind-like 3 (Drosophila) 0.0214251
DSCAM Down syndrome cell adhesion molecule 0.0213703
NCOA7 nuclear receptor coactivator 7 0.0208977
IGF1R insulin-like growth factor 1 receptor 0.0206959
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0204821
SOS1 son of sevenless homolog 1 (Drosophila) 0.0203597
IFI44L interferon-induced protein 44-like 0.0203334
GRIK5 glutamate receptor, ionotropic, kainate 5 0.0197753
GLIS3 GLIS family zinc finger 3 0.019572
SP100 SP100 nuclear antigen 0.0194778
GLS2 glutaminase 2 (liver, mitochondrial) 0.0192563
MED13 mediator complex subunit 13 0.0191423
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0190256
CCSER1 coiled-coil serine-rich protein 1 0.0187462
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0184522
KCTD16 potassium channel tetramerization domain containing 16 0.0183651
EHBP1 EH domain binding protein 1 0.0181991
PEAK1 pseudopodium-enriched atypical kinase 1 0.0181673
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0180033
MAML2 mastermind-like 2 (Drosophila) 0.0178555
RAI14 retinoic acid induced 14 0.0178496
WLS wntless Wnt ligand secretion mediator 0.0175094
MACF1 microtubule-actin crosslinking factor 1 0.0174963
ADIPOR2 adiponectin receptor 2 0.0174133
SSBP2 single-stranded DNA binding protein 2 0.0173417
FBN1 fibrillin 1 0.0171483
PTK2 protein tyrosine kinase 2 0.017096
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0169948
PCBP2 poly(rC) binding protein 2 0.0169297
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0166682
LOXL2 lysyl oxidase-like 2 0.0166532
GLCCI1 glucocorticoid induced 1 0.0166439
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0164678
ERRFI1 ERBB receptor feedback inhibitor 1 0.016435
EPS8 epidermal growth factor receptor pathway substrate 8 0.0163924
SAMD9 sterile alpha motif domain containing 9 0.0163337
LOX lysyl oxidase 0.0162479
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0161265
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 0.016085

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.107513
NAMPT nicotinamide phosphoribosyltransferase -0.0682591
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0568289
IGFBP3 insulin-like growth factor binding protein 3 -0.0564564
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0523553
VIM vimentin -0.0478246
MT2A metallothionein 2A -0.0457526
NPC1 Niemann-Pick disease, type C1 -0.0418491
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0415776
PTMA prothymosin, alpha -0.0412463
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0393934
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.03327
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0321896
PRRC2C proline-rich coiled-coil 2C -0.0309969
RAB27B RAB27B, member RAS oncogene family -0.0306503
ZEB2 zinc finger E-box binding homeobox 2 -0.0301784
S100A6 S100 calcium binding protein A6 -0.0282428
NRP1 neuropilin 1 -0.0281075
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0268406
SETD5 SET domain containing 5 -0.0255755
PDIA3 protein disulfide isomerase family A, member 3 -0.0247149
FTL ferritin, light polypeptide -0.0241964
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.023509
ZMYND8 zinc finger, MYND-type containing 8 -0.0230403
OSMR oncostatin M receptor -0.0229478
MAP1B microtubule-associated protein 1B -0.0229166
STC1 stanniocalcin 1 -0.0224571
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0217044
CDCP1 CUB domain containing protein 1 -0.0214763
AKAP12 A kinase (PRKA) anchor protein 12 -0.0214373
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0212725
RNF24 ring finger protein 24 -0.0211035
GOLGA4 golgin A4 -0.0205511
NDRG1 N-myc downstream regulated 1 -0.020187
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 -0.0197503
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0195302
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) -0.0193615
B2M beta-2-microglobulin -0.0191732
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0189901
ENO2 enolase 2 (gamma, neuronal) -0.0188448
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0187462
RPS19 ribosomal protein S19 -0.0185707
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0181726
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0179498
RNF149 ring finger protein 149 -0.0178588
ARHGAP5 Rho GTPase activating protein 5 -0.0178267
UGCG UDP-glucose ceramide glucosyltransferase -0.0177233
JMJD1C jumonji domain containing 1C -0.0176138
MRPS6 mitochondrial ribosomal protein S6 -0.0173947
HAS2 hyaluronan synthase 2 -0.0173089
GCC2 GRIP and coiled-coil domain containing 2 -0.0171689
DSE dermatan sulfate epimerase -0.0170841
LMAN1 lectin, mannose-binding, 1 -0.0169699
CAB39 calcium binding protein 39 -0.0165706
VEGFA vascular endothelial growth factor A -0.0163656
SOS2 son of sevenless homolog 2 (Drosophila) -0.0161961
KLF6 Kruppel-like factor 6 -0.0161718
DPYSL3 dihydropyrimidinase-like 3 -0.0160654
H1-0 H1.0 linker histone -0.0160559
SEC23A Sec23 homolog A (S. cerevisiae) -0.0158581
KMT2E lysine (K)-specific methyltransferase 2E -0.0156749
RTN4 reticulon 4 -0.0155714
SOX4 SRY (sex determining region Y)-box 4 -0.01533
RPS6 ribosomal protein S6 -0.0152865
KMT2A lysine (K)-specific methyltransferase 2A -0.0151612
TM4SF1 transmembrane 4 L six family member 1 -0.0147984
BMAL2 basic helix-loop-helix ARNT like 2 -0.0147332
IFI16 interferon, gamma-inducible protein 16 -0.0147052
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.0146607
PTGIS prostaglandin I2 (prostacyclin) synthase -0.0146506
SRSF11 serine/arginine-rich splicing factor 11 -0.01454
LUZP1 leucine zipper protein 1 -0.0145135
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0144409
SNX9 sorting nexin 9 -0.0144259
WASF2 WAS protein family, member 2 -0.0143922
IFI6 interferon, alpha-inducible protein 6 -0.0143804
RBM39 RNA binding motif protein 39 -0.0143489
LRRC49 leucine rich repeat containing 49 -0.0142783
ARL4C ADP-ribosylation factor-like 4C -0.0139733
CANX calnexin -0.0137733
WARS1 tryptophanyl-tRNA synthetase 1 -0.0135847
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0135723
POTEF POTE ankyrin domain family, member F -0.0135279
GOLPH3 golgi phosphoprotein 3 (coat-protein) -0.0131636
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.0131507
HMGA1 high mobility group AT-hook 1 -0.0131453
NUCB2 nucleobindin 2 -0.0130908
RPL36 ribosomal protein L36 -0.0130603
DUSP6 dual specificity phosphatase 6 -0.013046
AGFG1 ArfGAP with FG repeats 1 -0.0130219
ZBTB7A zinc finger and BTB domain containing 7A -0.01296
HM13 histocompatibility (minor) 13 -0.0129445
CLMP CXADR-like membrane protein -0.0128617
SRRM2 serine/arginine repetitive matrix 2 -0.0128511
EIF1 eukaryotic translation initiation factor 1 -0.0127295
ARID3B AT rich interactive domain 3B (BRIGHT-like) -0.0127247
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0126409
ADAM28 ADAM metallopeptidase domain 28 -0.0125585
PFN1 profilin 1 -0.0124145
ZFC3H1 zinc finger, C3H1-type containing -0.0124118