Busulfan_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Busulfan perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Busulfan_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.0780193
GRAMD1B GRAM domain containing 1B 0.0701838
ERRFI1 ERBB receptor feedback inhibitor 1 0.0520119
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0517088
AKAP12 A kinase (PRKA) anchor protein 12 0.050961
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0489746
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0457355
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0389718
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0384368
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0374217
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0347946
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0344097
RIMS2 regulating synaptic membrane exocytosis 2 0.033008
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0317708
NIPBL Nipped-B homolog (Drosophila) 0.0298046
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0292244
OSMR oncostatin M receptor 0.0290274
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0280623
SSH2 slingshot protein phosphatase 2 0.0261371
TAS2R14 taste receptor, type 2, member 14 0.0256451
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0248731
EXOC4 exocyst complex component 4 0.0239832
PDE10A phosphodiesterase 10A 0.0236772
CDK17 cyclin-dependent kinase 17 0.0236608
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0231844
EXT1 exostosin glycosyltransferase 1 0.0227133
TPM3 tropomyosin 3 0.0226773
NCOA7 nuclear receptor coactivator 7 0.0222643
THSD4 thrombospondin, type I, domain containing 4 0.0221794
VCL vinculin 0.021244
JMJD1C jumonji domain containing 1C 0.0211898
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0210961
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0208599
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0206101
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0201827
KTN1 kinectin 1 (kinesin receptor) 0.0201749
EXOC6B exocyst complex component 6B 0.0197529
ADGRG6 adhesion G protein-coupled receptor G6 0.0192552
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0192171
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0189721
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0186075
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0185552
TFPI2 tissue factor pathway inhibitor 2 0.0180759
ANXA5 annexin A5 0.018023
TPM4 tropomyosin 4 0.0179883
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.017886
KIF5B kinesin family member 5B 0.0177109
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0171799
IL6ST interleukin 6 signal transducer 0.0169562
MARCHF4 membrane associated ring-CH-type finger 4 0.0168282
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0167649
WWOX WW domain containing oxidoreductase 0.01674
BZW1 basic leucine zipper and W2 domains 1 0.0165962
CDCP1 CUB domain containing protein 1 0.0164941
MAN1A2 mannosidase, alpha, class 1A, member 2 0.0161061
ATAD2 ATPase family, AAA domain containing 2 0.016075
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0158854
RTN4 reticulon 4 0.0158295
BCLAF1 BCL2-associated transcription factor 1 0.0158157
MACF1 microtubule-actin crosslinking factor 1 0.0158047
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.01555
DST dystonin 0.0155256
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0154799
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0152963
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0152288
PDE4D phosphodiesterase 4D, cAMP-specific 0.0151616
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0151603
PDLIM5 PDZ and LIM domain 5 0.0150926
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0149408
IPO7 importin 7 0.0149016
CALD1 caldesmon 1 0.014852
CXADR coxsackie virus and adenovirus receptor 0.0148504
DOCK5 dedicator of cytokinesis 5 0.0148176
TASOR2 transcription activation suppressor family member 2 0.0147886
VDAC1 voltage-dependent anion channel 1 0.0147504
IGF1R insulin-like growth factor 1 receptor 0.0147053
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.014428
MKI67 marker of proliferation Ki-67 0.0143359
STC1 stanniocalcin 1 0.0142876
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0140719
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0139609
ZSWIM6 zinc finger, SWIM-type containing 6 0.013925
TRIO trio Rho guanine nucleotide exchange factor 0.0138438
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0138071
NCOR1 nuclear receptor corepressor 1 0.0137683
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0136875
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0136127
SPIDR scaffolding protein involved in DNA repair 0.0135762
TWF1 twinfilin actin binding protein 1 0.0135351
FAF1 Fas (TNFRSF6) associated factor 1 0.0135332
DIAPH3 diaphanous-related formin 3 0.0135169
WDR43 WD repeat domain 43 0.0134892
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0134183
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0133042
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0132698
ERBIN erbb2 interacting protein 0.0132066
UBA6 ubiquitin-like modifier activating enzyme 6 0.0132
SPAG9 sperm associated antigen 9 0.0131907
CLDN1 claudin 1 0.013152
ATP13A3 ATPase type 13A3 0.0130034

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.113083
TMSB10 thymosin beta 10 -0.108833
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.085604
RPS19 ribosomal protein S19 -0.0488957
RPL35A ribosomal protein L35a -0.0480844
RPS3 ribosomal protein S3 -0.0469246
RPS8 ribosomal protein S8 -0.0454848
RPL23 ribosomal protein L23 -0.0452054
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.043744
MCL1 myeloid cell leukemia 1 -0.0418252
MT2A metallothionein 2A -0.0416968
RPS21 ribosomal protein S21 -0.0390278
EGR1 early growth response 1 -0.0389608
VIM vimentin -0.0354728
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0350093
TPI1 triosephosphate isomerase 1 -0.0336314
YBX3 Y box binding protein 3 -0.0313988
RPS27 ribosomal protein S27 -0.0310143
RPLP2 ribosomal protein, large, P2 -0.0308144
RPL37A ribosomal protein L37a -0.0283122
RPS12 ribosomal protein S12 -0.0273819
FTL ferritin, light polypeptide -0.0266938
RPL26 ribosomal protein L26 -0.0265869
RPS29 ribosomal protein S29 -0.0265254
PFN1 profilin 1 -0.0258315
RPL19 ribosomal protein L19 -0.0258187
RPS15 ribosomal protein S15 -0.0251754
RPL36 ribosomal protein L36 -0.0244132
RPLP1 ribosomal protein, large, P1 -0.0243739
TPT1 tumor protein, translationally-controlled 1 -0.0242262
RPL34 ribosomal protein L34 -0.024084
RPL37 ribosomal protein L37 -0.0236161
RPL31 ribosomal protein L31 -0.0233503
HLA-B major histocompatibility complex, class I, B -0.0232554
TPM2 tropomyosin 2 (beta) -0.0228586
IFI6 interferon, alpha-inducible protein 6 -0.0225892
RPS10 ribosomal protein S10 -0.02167
RPL8 ribosomal protein L8 -0.0216141
AEBP2 AE binding protein 2 -0.0214558
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0212664
COPA coatomer protein complex, subunit alpha -0.0208289
RPS6 ribosomal protein S6 -0.0200619
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0194109
RPS13 ribosomal protein S13 -0.0193394
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.019229
RPL18 ribosomal protein L18 -0.0191241
RSF1 remodeling and spacing factor 1 -0.0191146
RPS23 ribosomal protein S23 -0.018748
RNF213 ring finger protein 213 -0.0183782
KDM4B lysine (K)-specific demethylase 4B -0.0179459
RPS14 ribosomal protein S14 -0.0178416
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0177851
RPL28 ribosomal protein L28 -0.0176984
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0176753
RPL32 ribosomal protein L32 -0.0162909
RPL38 ribosomal protein L38 -0.0161632
RPL35 ribosomal protein L35 -0.016099
RPS17 ribosomal protein S17 -0.0160521
ATP5F1E ATP synthase F1 subunit epsilon -0.014941
RAB1A RAB1A, member RAS oncogene family -0.0148113
GSTP1 glutathione S-transferase pi 1 -0.0147913
RPS25 ribosomal protein S25 -0.0145777
CANX calnexin -0.014069
RPL9 ribosomal protein L9 -0.0140634
RPL11 ribosomal protein L11 -0.0139614
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0138563
RPL5 ribosomal protein L5 -0.0138008
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0137324
WSB1 WD repeat and SOCS box containing 1 -0.0135324
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.013335
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0131287
EIF1 eukaryotic translation initiation factor 1 -0.0128773
MT1E metallothionein 1E -0.0127667
INTS6 integrator complex subunit 6 -0.0127617
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0127535
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0127021
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0126199
RPS27A ribosomal protein S27a -0.0126124
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.012559
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0125555
NACA nascent polypeptide-associated complex alpha subunit -0.0124552
ZBTB7A zinc finger and BTB domain containing 7A -0.0122912
KMT2A lysine (K)-specific methyltransferase 2A -0.0122816
ATXN1 ataxin 1 -0.0120412
RPS4X ribosomal protein S4, X-linked -0.0120087
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0119141
CAMTA1 calmodulin binding transcription activator 1 -0.0118858
PMM2 phosphomannomutase 2 -0.0118753
RPL12 ribosomal protein L12 -0.0118448
WASF2 WAS protein family, member 2 -0.011704
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0116807
RPS24 ribosomal protein S24 -0.0113725
ZBTB20 zinc finger and BTB domain containing 20 -0.0113122
HYOU1 hypoxia up-regulated 1 -0.0112984
LRRC23 leucine rich repeat containing 23 -0.0110515
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0110061
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0110046
NCOR2 nuclear receptor corepressor 2 -0.0110042
BRD4 bromodomain containing 4 -0.0109761
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0109016