Busulfan_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Busulfan perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Busulfan_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PM20D1 peptidase M20 domain containing 1 0.0965013
PDLIM5 PDZ and LIM domain 5 0.0566022
DST dystonin 0.0562618
EFNA5 ephrin-A5 0.0471589
TGFBR1 transforming growth factor, beta receptor 1 0.0386988
PDE10A phosphodiesterase 10A 0.0386591
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0378051
TRIO trio Rho guanine nucleotide exchange factor 0.0369409
CXCL8 chemokine (C-X-C motif) ligand 8 0.0362413
FNDC3B fibronectin type III domain containing 3B 0.034681
MYOF myoferlin 0.0314422
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0302586
LIMCH1 LIM and calponin homology domains 1 0.0301113
ELL2 elongation factor, RNA polymerase II, 2 0.0277567
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0266765
PTEN phosphatase and tensin homolog 0.0259063
PCBP2 poly(rC) binding protein 2 0.025527
ESYT2 extended synaptotagmin-like protein 2 0.0255119
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0246802
ERRFI1 ERBB receptor feedback inhibitor 1 0.0246627
COL8A1 collagen, type VIII, alpha 1 0.0232397
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0230184
KYNU kynureninase 0.0226396
PSD3 pleckstrin and Sec7 domain containing 3 0.0225608
IGFBP3 insulin-like growth factor binding protein 3 0.0225059
SAMD4A sterile alpha motif domain containing 4A 0.0218099
NEK7 NIMA-related kinase 7 0.0217661
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0207772
LSAMP limbic system-associated membrane protein 0.0200012
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0196682
ZSWIM6 zinc finger, SWIM-type containing 6 0.0195838
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0190673
SPAG9 sperm associated antigen 9 0.0190622
PDE7B phosphodiesterase 7B 0.0184595
EPHA4 EPH receptor A4 0.0184584
DOCK4 dedicator of cytokinesis 4 0.0182568
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0181684
UBA6 ubiquitin-like modifier activating enzyme 6 0.0178092
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0176771
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0174008
CENPF centromere protein F, 350/400kDa 0.0168341
EZR ezrin 0.0167882
CHD1 chromodomain helicase DNA binding protein 1 0.0167818
FAM13A family with sequence similarity 13, member A 0.0166424
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0164133
HELZ helicase with zinc finger 0.0161959
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.01591
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0154418
SMOC1 SPARC related modular calcium binding 1 0.0150364
FMNL2 formin-like 2 0.0149703
VMP1 vacuole membrane protein 1 0.0149664
NBAS neuroblastoma amplified sequence 0.0148579
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0147674
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.014682
NCKAP1 NCK-associated protein 1 0.0144962
AGTPBP1 ATP/GTP binding protein 1 0.0144446
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0144161
COL4A6 collagen, type IV, alpha 6 0.0138344
ANTXR1 anthrax toxin receptor 1 0.0137833
SLF1 SMC5-SMC6 complex localization factor 1 0.0137649
DNER delta/notch-like EGF repeat containing 0.0135999
WWTR1 WW domain containing transcription regulator 1 0.0133268
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0132623
PTPRD protein tyrosine phosphatase, receptor type, D 0.0131662
ZNF292 zinc finger protein 292 0.0128872
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0128763
TMX4 thioredoxin-related transmembrane protein 4 0.0128742
NUP58 nucleoporin 58 0.0127878
INTS6 integrator complex subunit 6 0.0126795
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0126161
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0126004
DGKD diacylglycerol kinase, delta 130kDa 0.0125739
CHL1 cell adhesion molecule L1-like 0.0125403
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0124453
MARCHF1 membrane associated ring-CH-type finger 1 0.0123314
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.0123178
CDC73 cell division cycle 73 0.0122628
PLCB4 phospholipase C, beta 4 0.012226
TPM3 tropomyosin 3 0.0122124
P3H2 prolyl 3-hydroxylase 2 0.0121137
COPA coatomer protein complex, subunit alpha 0.0120959
SPOPL speckle-type POZ protein-like 0.0120671
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0120238
RICTOR RPTOR independent companion of MTOR, complex 2 0.0119725
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0119409
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0117054
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0116916
CARD16 caspase recruitment domain family, member 16 0.0116862
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0116836
KMT2E lysine (K)-specific methyltransferase 2E 0.011392
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0110485
PPP1R3C protein phosphatase 1, regulatory subunit 3C 0.0110437
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0110102
MAP7 microtubule-associated protein 7 0.0109903
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0109029
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0107642
SPTBN1 spectrin, beta, non-erythrocytic 1 0.010622
JMJD1C jumonji domain containing 1C 0.0106113
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0105885
CD109 CD109 molecule 0.0105363

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.161507
TPT1 tumor protein, translationally-controlled 1 -0.158337
FN1 fibronectin 1 -0.141632
PTMA prothymosin, alpha -0.134234
VIM vimentin -0.129365
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.121212
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.103082
RPS24 ribosomal protein S24 -0.0869641
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0851365
RPLP1 ribosomal protein, large, P1 -0.0844344
RPS6 ribosomal protein S6 -0.0830588
TM4SF1 transmembrane 4 L six family member 1 -0.0813881
RPL35A ribosomal protein L35a -0.0805139
RPL26 ribosomal protein L26 -0.07253
RPL31 ribosomal protein L31 -0.0650341
RPL12 ribosomal protein L12 -0.0649901
RPL37A ribosomal protein L37a -0.0647935
RPS8 ribosomal protein S8 -0.0623684
RPS19 ribosomal protein S19 -0.0586018
RPL19 ribosomal protein L19 -0.0543923
RPS21 ribosomal protein S21 -0.0540077
RPS12 ribosomal protein S12 -0.053056
RPL36A ribosomal protein L36a -0.0528033
FTL ferritin, light polypeptide -0.0523483
RPL34 ribosomal protein L34 -0.0522318
RPS27A ribosomal protein S27a -0.0516643
RPL9 ribosomal protein L9 -0.0509896
RPLP0 ribosomal protein, large, P0 -0.0503771
RPL23 ribosomal protein L23 -0.0501317
RPS23 ribosomal protein S23 -0.0493749
S100A6 S100 calcium binding protein A6 -0.0491126
HLA-B major histocompatibility complex, class I, B -0.0487769
TFPI2 tissue factor pathway inhibitor 2 -0.0486817
RPS3 ribosomal protein S3 -0.0469731
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0445014
B2M beta-2-microglobulin -0.0425501
SOX4 SRY (sex determining region Y)-box 4 -0.0419662
RPLP2 ribosomal protein, large, P2 -0.0402014
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0397653
RPS14 ribosomal protein S14 -0.0395327
RPL38 ribosomal protein L38 -0.0394715
RPL11 ribosomal protein L11 -0.0379003
RPL37 ribosomal protein L37 -0.0373295
CTSL cathepsin L -0.0363835
WARS1 tryptophanyl-tRNA synthetase 1 -0.0360808
RPS17 ribosomal protein S17 -0.0353805
RPL36 ribosomal protein L36 -0.0346888
BASP1 brain abundant, membrane attached signal protein 1 -0.0345211
HLA-A major histocompatibility complex, class I, A -0.0335887
CDH13 cadherin 13 -0.0335845
RPS25 ribosomal protein S25 -0.033417
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0332096
RPS4X ribosomal protein S4, X-linked -0.0331748
S100A10 S100 calcium binding protein A10 -0.03315
NAP1L1 nucleosome assembly protein 1-like 1 -0.0330202
RPL7A ribosomal protein L7a -0.0328774
ACTG1 actin gamma 1 -0.0327997
RPS16 ribosomal protein S16 -0.0327701
RPS13 ribosomal protein S13 -0.0324288
RPS29 ribosomal protein S29 -0.0319169
RACK1 receptor for activated C kinase 1 -0.0311867
RPS11 ribosomal protein S11 -0.031037
SRGN serglycin -0.0310249
TBXT T-box transcription factor T -0.0299179
RPS27 ribosomal protein S27 -0.0290705
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0286219
ATP5F1E ATP synthase F1 subunit epsilon -0.0281493
STC1 stanniocalcin 1 -0.0278667
RPL35 ribosomal protein L35 -0.0277812
LMNA lamin A/C -0.0275648
ASTN2 astrotactin 2 -0.027314
EIF1 eukaryotic translation initiation factor 1 -0.0272667
EIF4A1 eukaryotic translation initiation factor 4A1 -0.026465
PCBP3 poly(rC) binding protein 3 -0.0264488
INHBA inhibin, beta A -0.0261126
RPL5 ribosomal protein L5 -0.0255801
AKR1C1 aldo-keto reductase family 1, member C1 -0.0252358
RPL32 ribosomal protein L32 -0.0249841
PRSS23 protease, serine, 23 -0.0247131
RPS28 ribosomal protein S28 -0.0243513
IFIH1 interferon induced with helicase C domain 1 -0.0240837
SMYD3 SET and MYND domain containing 3 -0.0238283
GNAS GNAS complex locus -0.0236599
RPL18 ribosomal protein L18 -0.023249
FOXC1 forkhead box C1 -0.023198
SFTPA2 surfactant protein A2 -0.0228288
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0225084
MT2A metallothionein 2A -0.0224011
PRRC2C proline-rich coiled-coil 2C -0.0221544
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0221131
RPS5 ribosomal protein S5 -0.0215305
RPS10 ribosomal protein S10 -0.0214369
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0214278
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0214
RPL30 ribosomal protein L30 -0.0212926
RSL1D1 ribosomal L1 domain containing 1 -0.0211927
RPS15 ribosomal protein S15 -0.0208751
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0207623
TMSB4X thymosin beta 4, X-linked -0.0204723
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0203122