Busulfan_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Busulfan perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Busulfan_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL5A2 collagen, type V, alpha 2 0.0931976
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0891314
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0730319
NTM neurotrimin 0.0654365
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0640646
MKI67 marker of proliferation Ki-67 0.0560647
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0551571
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0510682
THBS1 thrombospondin 1 0.0500864
PCDH9 protocadherin 9 0.0449565
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0441496
COL3A1 collagen, type III, alpha 1 0.0412403
CENPF centromere protein F, 350/400kDa 0.0399239
TOP2A topoisomerase (DNA) II alpha 170kDa 0.038485
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0360792
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0347243
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0336161
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0315987
TENM3 teneurin transmembrane protein 3 0.030576
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0304951
MATR3 matrin 3 0.0298417
PDGFC platelet derived growth factor C 0.0295033
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0291778
YAP1 Yes-associated protein 1 0.0291075
EMP1 epithelial membrane protein 1 0.0287745
PROS1 protein S (alpha) 0.0280255
VCL vinculin 0.0278449
CKAP5 cytoskeleton associated protein 5 0.0277026
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.027246
FAM171B family with sequence similarity 171, member B 0.0259624
ANLN anillin, actin binding protein 0.0252345
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0252074
CLSPN claspin 0.0250627
TXNRD1 thioredoxin reductase 1 0.0250542
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.0250262
ZNF608 zinc finger protein 608 0.0245199
PDLIM5 PDZ and LIM domain 5 0.0244835
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0243967
ZNF711 zinc finger protein 711 0.0243738
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0243004
SMC4 structural maintenance of chromosomes 4 0.0238909
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.023729
SET SET nuclear proto-oncogene 0.0236933
RAD21 RAD21 homolog (S. pombe) 0.0232599
HSPH1 heat shock 105kDa/110kDa protein 1 0.0232328
GLO1 glyoxalase I 0.0230822
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0228501
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0228039
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0227972
DIAPH3 diaphanous-related formin 3 0.0226706
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0224992
CHD4 chromodomain helicase DNA binding protein 4 0.0222598
PRPF8 pre-mRNA processing factor 8 0.0221483
CCSER1 coiled-coil serine-rich protein 1 0.0220897
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0220507
HMGB2 high mobility group box 2 0.021956
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0219544
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0217411
CDK6 cyclin-dependent kinase 6 0.0217354
TRA2A transformer 2 alpha homolog (Drosophila) 0.0216203
MYEF2 myelin expression factor 2 0.0214459
UBQLN1 ubiquilin 1 0.0213236
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0213104
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0208343
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.0199337
FAT1 FAT atypical cadherin 1 0.0198019
RFC3 replication factor C (activator 1) 3, 38kDa 0.0197185
TMSB4X thymosin beta 4, X-linked 0.0197076
PCLO piccolo presynaptic cytomatrix protein 0.0196719
XPR1 xenotropic and polytropic retrovirus receptor 1 0.0195659
TAS2R14 taste receptor, type 2, member 14 0.0195212
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0194215
OLA1 Obg-like ATPase 1 0.0191672
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.018899
TPM3 tropomyosin 3 0.0188875
KNL1 kinetochore scaffold 1 0.0188378
SFRP4 secreted frizzled-related protein 4 0.0188245
KIF4A kinesin family member 4A 0.0186084
FUBP1 far upstream element (FUSE) binding protein 1 0.0185237
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0182611
USP3 ubiquitin specific peptidase 3 0.0182504
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0182336
ZBTB41 zinc finger and BTB domain containing 41 0.0181944
ELOVL5 ELOVL fatty acid elongase 5 0.0181618
EIF4A2 eukaryotic translation initiation factor 4A2 0.0180733
NBEA neurobeachin 0.018072
GOLGA4 golgin A4 0.0180688
LRMDA leucine rich melanocyte differentiation associated 0.0180512
NUSAP1 nucleolar and spindle associated protein 1 0.017792
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0177544
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.017752
LIN28B lin-28 homolog B (C. elegans) 0.0177413
ITSN2 intersectin 2 0.0176814
NKD1 naked cuticle homolog 1 (Drosophila) 0.0175874
TLK1 tousled-like kinase 1 0.0175447
KNTC1 kinetochore associated 1 0.017505
NPR2 natriuretic peptide receptor 2 0.0173994
LOC102724023 ES1 protein homolog, mitochondrial 0.0172824
GOLGB1 golgin B1 0.0172262
CCNA2 cyclin A2 0.0171812

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.213777
VIM vimentin -0.127396
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.118317
RPS16 ribosomal protein S16 -0.100422
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0974626
RPS6 ribosomal protein S6 -0.0915156
WSB1 WD repeat and SOCS box containing 1 -0.0847934
RPS8 ribosomal protein S8 -0.080161
RPL5 ribosomal protein L5 -0.0776642
MDK midkine (neurite growth-promoting factor 2) -0.075188
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0737979
RPL23 ribosomal protein L23 -0.0725886
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0725488
TPT1 tumor protein, translationally-controlled 1 -0.0676535
GARS1 glycyl-tRNA synthetase 1 -0.0674344
RPS12 ribosomal protein S12 -0.0665532
RPL35A ribosomal protein L35a -0.0655974
PHIP pleckstrin homology domain interacting protein -0.0627413
COL11A1 collagen, type XI, alpha 1 -0.0622143
COL1A2 collagen, type I, alpha 2 -0.059597
ANKRD12 ankyrin repeat domain 12 -0.0595826
PTMA prothymosin, alpha -0.0590827
GPC3 glypican 3 -0.0588383
PARD3B par-3 family cell polarity regulator beta -0.0560606
SMYD3 SET and MYND domain containing 3 -0.0553647
RPL37A ribosomal protein L37a -0.0530664
RPS13 ribosomal protein S13 -0.0525252
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0502947
ZFAND3 zinc finger, AN1-type domain 3 -0.0502756
RPL36A ribosomal protein L36a -0.0500769
ITGAV integrin, alpha V -0.0493283
RPL26 ribosomal protein L26 -0.0489772
ADGRV1 adhesion G protein-coupled receptor V1 -0.0472151
MRPS6 mitochondrial ribosomal protein S6 -0.0463577
SNX6 sorting nexin 6 -0.0460204
RPS19 ribosomal protein S19 -0.0450288
JMJD1C jumonji domain containing 1C -0.0445187
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0445012
NACA nascent polypeptide-associated complex alpha subunit -0.0443879
S100A9 S100 calcium binding protein A9 -0.0433372
RPL31 ribosomal protein L31 -0.0428881
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 -0.0423709
GSE1 Gse1 coiled-coil protein -0.0421796
RPS3 ribosomal protein S3 -0.0411455
PLPP1 phospholipid phosphatase 1 -0.0409574
CUX1 cut-like homeobox 1 -0.0407099
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0406707
FNDC3B fibronectin type III domain containing 3B -0.0393803
TBL1X transducin (beta)-like 1X-linked -0.0390809
PRRC2C proline-rich coiled-coil 2C -0.0390292
TENM2 teneurin transmembrane protein 2 -0.0386245
PFN1 profilin 1 -0.0381104
RAI1 retinoic acid induced 1 -0.0377612
RPS27A ribosomal protein S27a -0.0375473
FBXO17 F-box protein 17 -0.0368217
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0367818
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0366555
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0365446
CAMTA1 calmodulin binding transcription activator 1 -0.0365015
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0364926
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0364187
CNRIP1 cannabinoid receptor interacting protein 1 -0.0362777
SLC38A2 solute carrier family 38, member 2 -0.0361075
SLIT2 slit homolog 2 (Drosophila) -0.0361051
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0359667
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0357838
RPLP0 ribosomal protein, large, P0 -0.0356669
RPL9 ribosomal protein L9 -0.0353197
NCOR2 nuclear receptor corepressor 2 -0.0350245
PGK1 phosphoglycerate kinase 1 -0.0344814
EIF1 eukaryotic translation initiation factor 1 -0.0341974
CALR calreticulin -0.0339637
WASF2 WAS protein family, member 2 -0.0339049
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0328955
PBX3 pre-B-cell leukemia homeobox 3 -0.0327628
UBE2K ubiquitin-conjugating enzyme E2K -0.0326442
TMEM41B transmembrane protein 41B -0.0321663
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0318237
MED13L mediator complex subunit 13-like -0.031609
NEBL nebulette -0.0315456
SRP54 signal recognition particle 54kDa -0.0313283
MAP4 microtubule-associated protein 4 -0.0313193
RBM20 RNA binding motif protein 20 -0.0312809
RAB6A RAB6A, member RAS oncogene family -0.03121
HDAC9 histone deacetylase 9 -0.0310772
NPEPPS aminopeptidase puromycin sensitive -0.0310148
RPL37 ribosomal protein L37 -0.0310105
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0304159
BIRC6 baculoviral IAP repeat containing 6 -0.0303473
EEF1G eukaryotic translation elongation factor 1 gamma -0.0302699
RPL11 ribosomal protein L11 -0.0301683
GNAS GNAS complex locus -0.0300555
ISG15 ISG15 ubiquitin-like modifier -0.0300419
SRPK2 SRSF protein kinase 2 -0.0298228
UBC ubiquitin C -0.0297546
RPS25 ribosomal protein S25 -0.0295934
ATXN2 ataxin 2 -0.029532
SIK3 SIK family kinase 3 -0.0295031
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0294803
SAMD4A sterile alpha motif domain containing 4A -0.0292756