Busulfan_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Busulfan perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Busulfan_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0491426
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0421484
ECT2 epithelial cell transforming 2 0.0368467
NAMPT nicotinamide phosphoribosyltransferase 0.0352291
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0309041
XPO1 exportin 1 0.0292598
ZNF292 zinc finger protein 292 0.0267773
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0264884
PCM1 pericentriolar material 1 0.0254761
NUP58 nucleoporin 58 0.0250185
FXR1 fragile X mental retardation, autosomal homolog 1 0.0243433
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0234128
CCNL1 cyclin L1 0.0226739
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0206115
TXNIP thioredoxin interacting protein 0.020558
PFN1 profilin 1 0.0205021
RNF145 ring finger protein 145 0.0196419
FN1 fibronectin 1 0.0187149
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0183194
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0181799
UBA6 ubiquitin-like modifier activating enzyme 6 0.0179713
QKI QKI, KH domain containing, RNA binding 0.0174329
NAV2 neuron navigator 2 0.0171886
POTEF POTE ankyrin domain family, member F 0.0169351
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0168874
KMT2E lysine (K)-specific methyltransferase 2E 0.0167654
NDRG1 N-myc downstream regulated 1 0.0166869
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0164975
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0161574
PCBP2 poly(rC) binding protein 2 0.0156027
SMC4 structural maintenance of chromosomes 4 0.0153772
CDC27 cell division cycle 27 0.0153016
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0152523
SPAG9 sperm associated antigen 9 0.0151277
DCAF6 DDB1 and CUL4 associated factor 6 0.0151255
TPX2 TPX2, microtubule-associated 0.0150545
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 0.0149755
FUBP1 far upstream element (FUSE) binding protein 1 0.0149206
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0147876
NCKAP1 NCK-associated protein 1 0.0147038
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0142401
CKAP2 cytoskeleton associated protein 2 0.0139914
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0138648
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0137042
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0136429
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0135111
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.01346
SFPQ splicing factor proline/glutamine-rich 0.0132849
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0132611
CDC73 cell division cycle 73 0.0131689
PDIA6 protein disulfide isomerase family A, member 6 0.0131198
ECPAS Ecm29 proteasome adaptor and scaffold 0.0130816
RAB6A RAB6A, member RAS oncogene family 0.0130613
MED13L mediator complex subunit 13-like 0.0130612
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0130115
HMGA1 high mobility group AT-hook 1 0.0129553
HELZ helicase with zinc finger 0.0129278
SRP54 signal recognition particle 54kDa 0.0127666
KDM6A lysine (K)-specific demethylase 6A 0.012756
KIF5C kinesin family member 5C 0.0126809
BIRC6 baculoviral IAP repeat containing 6 0.0126709
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0126659
GOLGA4 golgin A4 0.0126052
PTBP2 polypyrimidine tract binding protein 2 0.0125648
GSPT1 G1 to S phase transition 1 0.0125541
ZNF638 zinc finger protein 638 0.0125166
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0125029
MTF2 metal response element binding transcription factor 2 0.0123865
RAD23B RAD23 homolog B (S. cerevisiae) 0.0123732
PHIP pleckstrin homology domain interacting protein 0.0121959
PBX3 pre-B-cell leukemia homeobox 3 0.0121663
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0121374
SEC23A Sec23 homolog A (S. cerevisiae) 0.0121054
CENPF centromere protein F, 350/400kDa 0.0120823
ARRDC3 arrestin domain containing 3 0.0120783
CHD1 chromodomain helicase DNA binding protein 1 0.0120699
KIF23 kinesin family member 23 0.0119772
BRWD1 bromodomain and WD repeat domain containing 1 0.0117701
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0116537
SEPTIN7 septin 7 0.0116198
SUCO SUN domain containing ossification factor 0.0115978
PDS5B PDS5 cohesin associated factor B 0.0115817
PTK2 protein tyrosine kinase 2 0.0115593
B2M beta-2-microglobulin 0.0114998
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0114699
TRA2A transformer 2 alpha homolog (Drosophila) 0.0113959
SNX9 sorting nexin 9 0.011379
HILPDA hypoxia inducible lipid droplet-associated 0.0113757
TFG TRK-fused gene 0.0113541
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.011299
GPC6 glypican 6 0.0111003
YTHDC1 YTH domain containing 1 0.0110831
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0110738
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0110727
CKAP5 cytoskeleton associated protein 5 0.0110683
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0109862
PER1 period circadian clock 1 0.0109692
ADAM17 ADAM metallopeptidase domain 17 0.0109631
DSCAM Down syndrome cell adhesion molecule 0.0108218
ETV5 ets variant 5 0.0107928

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.215294
AHNAK AHNAK nucleoprotein -0.113225
PDE4B phosphodiesterase 4B, cAMP-specific -0.113086
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.109228
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0990244
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0909778
VCL vinculin -0.0860831
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0769246
BMP10 bone morphogenetic protein 10 -0.0748508
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0654028
CCND1 cyclin D1 -0.0599609
RPS6 ribosomal protein S6 -0.0578376
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0567193
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0556902
EGFR epidermal growth factor receptor -0.0551097
PDE4D phosphodiesterase 4D, cAMP-specific -0.0514285
TPT1 tumor protein, translationally-controlled 1 -0.0488045
FLNB filamin B, beta -0.0460361
TMSB4X thymosin beta 4, X-linked -0.0451924
DLG1 discs, large homolog 1 (Drosophila) -0.0429746
RPL35A ribosomal protein L35a -0.0427159
PKM pyruvate kinase, muscle -0.0426488
RPL19 ribosomal protein L19 -0.0422378
ZEB1 zinc finger E-box binding homeobox 1 -0.0367414
PYGB phosphorylase, glycogen; brain -0.0349931
RPS8 ribosomal protein S8 -0.0346585
FOXP1 forkhead box P1 -0.0345896
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0333624
RPLP1 ribosomal protein, large, P1 -0.0330473
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0330319
TM4SF1 transmembrane 4 L six family member 1 -0.0330084
GLI2 GLI family zinc finger 2 -0.0323955
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0317818
RPS13 ribosomal protein S13 -0.0316829
SQSTM1 sequestosome 1 -0.0306424
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0304774
ENO2 enolase 2 (gamma, neuronal) -0.0304219
RPL34 ribosomal protein L34 -0.0300253
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0297892
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0294014
RPL4 ribosomal protein L4 -0.028805
RPL31 ribosomal protein L31 -0.0280171
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.027652
S100A6 S100 calcium binding protein A6 -0.0268722
ARL4C ADP-ribosylation factor-like 4C -0.0267121
RPS29 ribosomal protein S29 -0.0266186
RPL37A ribosomal protein L37a -0.0263233
ANXA1 annexin A1 -0.0261416
GSE1 Gse1 coiled-coil protein -0.0256568
RPL26 ribosomal protein L26 -0.0256416
NPAS2 neuronal PAS domain protein 2 -0.025566
EIF1 eukaryotic translation initiation factor 1 -0.0255602
NBEA neurobeachin -0.0253344
RPL12 ribosomal protein L12 -0.0242151
CAMTA1 calmodulin binding transcription activator 1 -0.0241006
RPL36 ribosomal protein L36 -0.0236852
RPL37 ribosomal protein L37 -0.0236786
RPS27A ribosomal protein S27a -0.0233279
MYOF myoferlin -0.0232419
BMP2K BMP2 inducible kinase -0.0231258
GPATCH8 G patch domain containing 8 -0.0230498
TPM4 tropomyosin 4 -0.0226834
HSPB1 heat shock 27kDa protein 1 -0.0224224
RPS23 ribosomal protein S23 -0.0223399
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0223333
CLIP1 CAP-GLY domain containing linker protein 1 -0.0220505
SAMD4A sterile alpha motif domain containing 4A -0.0220114
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -0.0214658
UNC13A unc-13 homolog A (C. elegans) -0.0212163
RPS3 ribosomal protein S3 -0.0211075
RRBP1 ribosome binding protein 1 -0.0209218
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.020906
RPLP2 ribosomal protein, large, P2 -0.0207911
CUX1 cut-like homeobox 1 -0.0204781
TTC28 tetratricopeptide repeat domain 28 -0.0203705
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0199906
ZMYND8 zinc finger, MYND-type containing 8 -0.0199111
NCEH1 neutral cholesterol ester hydrolase 1 -0.0198394
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0195827
EFNA5 ephrin-A5 -0.0195031
RPS24 ribosomal protein S24 -0.0193546
MYL12B myosin, light chain 12B, regulatory -0.019286
ACTG1 actin gamma 1 -0.0191439
XKR6 XK, Kell blood group complex subunit-related family, member 6 -0.0190585
RPS25 ribosomal protein S25 -0.0188189
RPL23 ribosomal protein L23 -0.0187528
MYO5A myosin VA (heavy chain 12, myoxin) -0.018562
LDHA lactate dehydrogenase A -0.0183814
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.018228
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0181564
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0181364
RPS27 ribosomal protein S27 -0.0181168
PGK1 phosphoglycerate kinase 1 -0.0181133
RSL1D1 ribosomal L1 domain containing 1 -0.0179952
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0179579
KANK1 KN motif and ankyrin repeat domains 1 -0.0178076
LOXL3 lysyl oxidase-like 3 -0.0177487
TBCA tubulin folding cofactor A -0.0177325
ACBD6 acyl-CoA binding domain containing 6 -0.0177295
SOX6 SRY (sex determining region Y)-box 6 -0.0177141