Busulfan_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Busulfan perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Busulfan_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.0749272
GLIS3 GLIS family zinc finger 3 0.0567797
DST dystonin 0.0512598
HDAC9 histone deacetylase 9 0.0480035
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0451043
INTS6 integrator complex subunit 6 0.0438974
CDH13 cadherin 13 0.0435463
SOD2 superoxide dismutase 2, mitochondrial 0.0394811
HMGA2 high mobility group AT-hook 2 0.0387036
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0357817
PTPRK protein tyrosine phosphatase, receptor type, K 0.0340435
BICC1 BicC family RNA binding protein 1 0.0337165
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0326045
ZSWIM6 zinc finger, SWIM-type containing 6 0.0322781
PDE10A phosphodiesterase 10A 0.0317449
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0317411
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0252752
USP9X ubiquitin specific peptidase 9, X-linked 0.024776
MACF1 microtubule-actin crosslinking factor 1 0.0244663
FNIP1 folliculin interacting protein 1 0.0240912
SPAG9 sperm associated antigen 9 0.0231166
SLC35F3 solute carrier family 35, member F3 0.0224518
CADM1 cell adhesion molecule 1 0.0222963
TMEM132D transmembrane protein 132D 0.0218381
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0217703
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0213677
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0209261
AHNAK AHNAK nucleoprotein 0.0209114
TLE4 transducin-like enhancer of split 4 0.0207126
COL6A3 collagen, type VI, alpha 3 0.0206704
KYNU kynureninase 0.0206411
EFNA5 ephrin-A5 0.0204855
RAI14 retinoic acid induced 14 0.0204342
ATXN1 ataxin 1 0.0202979
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.020198
ZBTB38 zinc finger and BTB domain containing 38 0.0201214
BIRC3 baculoviral IAP repeat containing 3 0.0200326
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0196285
SMYD3 SET and MYND domain containing 3 0.0190918
INHBA inhibin, beta A 0.0188327
ZFAND3 zinc finger, AN1-type domain 3 0.0186951
VCAN versican 0.0186455
SPDYA speedy/RINGO cell cycle regulator family member A 0.0182903
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0182366
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0181901
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0181538
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0176019
NAP1L1 nucleosome assembly protein 1-like 1 0.017338
PHF3 PHD finger protein 3 0.0171685
PTK2 protein tyrosine kinase 2 0.0171463
CDK13 cyclin-dependent kinase 13 0.0171127
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.016861
AFF3 AF4/FMR2 family, member 3 0.0167231
KDM3A lysine (K)-specific demethylase 3A 0.016646
OSBPL8 oxysterol binding protein-like 8 0.0165929
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0165922
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0163284
GLS2 glutaminase 2 (liver, mitochondrial) 0.0162807
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0160269
UBAP2 ubiquitin associated protein 2 0.0156856
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0154138
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.015372
FRMPD4 FERM and PDZ domain containing 4 0.0153639
ZCCHC7 zinc finger, CCHC domain containing 7 0.0153206
FAM20C family with sequence similarity 20, member C 0.0152726
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0151954
EHBP1 EH domain binding protein 1 0.015125
QKI QKI, KH domain containing, RNA binding 0.0150052
CCBE1 collagen and calcium binding EGF domains 1 0.0148921
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.014875
AFDN afadin, adherens junction formation factor 0.014849
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.014842
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0147107
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0146882
SDK1 sidekick cell adhesion molecule 1 0.0146618
STAG2 stromal antigen 2 0.0146529
PRKCA protein kinase C, alpha 0.0146389
LPP LIM domain containing preferred translocation partner in lipoma 0.0145955
TIAM2 T-cell lymphoma invasion and metastasis 2 0.0143433
TRIP12 thyroid hormone receptor interactor 12 0.0143379
NF1 neurofibromin 1 0.0143113
IARS1 isoleucyl-tRNA synthetase 1 0.0142982
UBASH3B ubiquitin associated and SH3 domain containing B 0.0140874
SOX5 SRY (sex determining region Y)-box 5 0.0140533
ASPH aspartate beta-hydroxylase 0.0139516
KDM4C lysine (K)-specific demethylase 4C 0.0139293
DENND1A DENN/MADD domain containing 1A 0.0138509
AEBP2 AE binding protein 2 0.0137019
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0136636
GOLGB1 golgin B1 0.0136179
PSD3 pleckstrin and Sec7 domain containing 3 0.0135682
PICALM phosphatidylinositol binding clathrin assembly protein 0.0134285
WDR27 WD repeat domain 27 0.0132674
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0132254
RASAL2 RAS protein activator like 2 0.0131908
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0131834
SDCBP syndecan binding protein (syntenin) 0.0130955
KAT6B K(lysine) acetyltransferase 6B 0.0129585
MED13 mediator complex subunit 13 0.0129574
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0127328

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.24025
VIM vimentin -0.234112
FTL ferritin, light polypeptide -0.146884
HLA-B major histocompatibility complex, class I, B -0.139762
TMSB10 thymosin beta 10 -0.132334
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.117859
MT2A metallothionein 2A -0.113973
RPS6 ribosomal protein S6 -0.0930938
B2M beta-2-microglobulin -0.0925286
NAMPT nicotinamide phosphoribosyltransferase -0.0851821
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0753961
NDRG1 N-myc downstream regulated 1 -0.0713349
CD44 CD44 molecule (Indian blood group) -0.0683495
RPS12 ribosomal protein S12 -0.0638963
RPS19 ribosomal protein S19 -0.0630789
FTH1 ferritin, heavy polypeptide 1 -0.0623012
RPLP2 ribosomal protein, large, P2 -0.0563452
EGR1 early growth response 1 -0.0553179
RPLP1 ribosomal protein, large, P1 -0.0550277
EIF1 eukaryotic translation initiation factor 1 -0.0528367
RPL35A ribosomal protein L35a -0.050973
HLA-A major histocompatibility complex, class I, A -0.0508765
LDHA lactate dehydrogenase A -0.0492539
IFITM3 interferon induced transmembrane protein 3 -0.0491558
RPS8 ribosomal protein S8 -0.0473073
PTMA prothymosin, alpha -0.0472055
RPS23 ribosomal protein S23 -0.0471873
RPL23 ribosomal protein L23 -0.0462781
RPL19 ribosomal protein L19 -0.0455404
IFI6 interferon, alpha-inducible protein 6 -0.0441487
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0436552
RPS13 ribosomal protein S13 -0.0429572
RPL36 ribosomal protein L36 -0.0418373
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0417622
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.041487
RPL37A ribosomal protein L37a -0.0409305
RPL36A ribosomal protein L36a -0.0401324
UGCG UDP-glucose ceramide glucosyltransferase -0.0401046
ENO1 enolase 1, (alpha) -0.0399247
RPS3 ribosomal protein S3 -0.0363963
MSN moesin -0.0361444
RPL12 ribosomal protein L12 -0.0360178
RTN4 reticulon 4 -0.0359506
C3 complement component 3 -0.0345715
S100A9 S100 calcium binding protein A9 -0.0343881
RPL11 ribosomal protein L11 -0.0339465
RPL7A ribosomal protein L7a -0.0338083
ELL2 elongation factor, RNA polymerase II, 2 -0.0337893
RPL9 ribosomal protein L9 -0.0333746
PGK1 phosphoglycerate kinase 1 -0.032951
TXNIP thioredoxin interacting protein -0.0327806
PKM pyruvate kinase, muscle -0.0323228
RPS4X ribosomal protein S4, X-linked -0.0322035
RPL35 ribosomal protein L35 -0.032059
TPM4 tropomyosin 4 -0.0318228
VEGFA vascular endothelial growth factor A -0.0314269
RPS10 ribosomal protein S10 -0.031159
ADM adrenomedullin -0.030955
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0308889
RPL32 ribosomal protein L32 -0.0306077
LOC112694756 uncharaterized LOC112694756 -0.0304172
BASP1 brain abundant, membrane attached signal protein 1 -0.0302622
IFITM1 interferon induced transmembrane protein 1 -0.0301422
RPS14 ribosomal protein S14 -0.0294138
RPS21 ribosomal protein S21 -0.0293782
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0289824
ANXA2 annexin A2 -0.0285982
RPS27 ribosomal protein S27 -0.0284694
RPL31 ribosomal protein L31 -0.0282562
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0281305
KLF6 Kruppel-like factor 6 -0.0281174
RPS29 ribosomal protein S29 -0.0280264
RACK1 receptor for activated C kinase 1 -0.0278091
RPL5 ribosomal protein L5 -0.0272013
RPL26 ribosomal protein L26 -0.0271445
ACTG1 actin gamma 1 -0.0270465
STAT1 signal transducer and activator of transcription 1, 91kDa -0.027045
CCNL1 cyclin L1 -0.0268664
RPL28 ribosomal protein L28 -0.0265805
DSTN destrin (actin depolymerizing factor) -0.0264478
RPS25 ribosomal protein S25 -0.0261803
CDCP1 CUB domain containing protein 1 -0.0259635
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0258359
TPT1 tumor protein, translationally-controlled 1 -0.0258017
ICAM1 intercellular adhesion molecule 1 -0.0257945
ZMYND8 zinc finger, MYND-type containing 8 -0.0256166
ENO2 enolase 2 (gamma, neuronal) -0.0256021
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0255617
RPL37 ribosomal protein L37 -0.0254527
PLIN2 perilipin 2 -0.0253314
RPL8 ribosomal protein L8 -0.0252107
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0251168
IGFBP3 insulin-like growth factor binding protein 3 -0.0249988
KTN1 kinectin 1 (kinesin receptor) -0.0249945
PFN1 profilin 1 -0.0243513
RPL10A ribosomal protein L10a -0.0241707
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0239878
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0238809
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0237256
VDAC1 voltage-dependent anion channel 1 -0.0234235