Busulfan_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Busulfan perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Busulfan_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZSWIM6 zinc finger, SWIM-type containing 6 0.0418247
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0416289
INTS6 integrator complex subunit 6 0.0346519
CXCL8 chemokine (C-X-C motif) ligand 8 0.0298966
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.025857
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0237717
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0220076
FAT1 FAT atypical cadherin 1 0.0156179
FAM13A family with sequence similarity 13, member A 0.0142577
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0134765
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0131111
SUCO SUN domain containing ossification factor 0.0123585
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0123581
ANKRD28 ankyrin repeat domain 28 0.012337
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0122979
ATF6 activating transcription factor 6 0.0122369
LRRC23 leucine rich repeat containing 23 0.0118426
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0116948
HOMER1 homer scaffolding protein 1 0.0110401
SIRT1 sirtuin 1 0.0109049
GLS2 glutaminase 2 (liver, mitochondrial) 0.010888
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0108309
HELZ helicase with zinc finger 0.0108048
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0108007
RUNX1 runt-related transcription factor 1 0.0105696
SOD2 superoxide dismutase 2, mitochondrial 0.0104162
NALF1 NALCN channel auxiliary factor 1 0.0102636
COG5 component of oligomeric golgi complex 5 0.0102504
GPHN gephyrin 0.0100384
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0100038
BIRC3 baculoviral IAP repeat containing 3 0.00997698
FGF18 fibroblast growth factor 18 0.00983868
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.00971934
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.00964777
PGM3 phosphoglucomutase 3 0.00956114
RCOR1 REST corepressor 1 0.00942631
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.00941335
MCTP1 multiple C2 domains, transmembrane 1 0.00936816
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.00932702
POU2F2 POU class 2 homeobox 2 0.00928749
TUFT1 tuftelin 1 0.00908724
FERMT2 fermitin family member 2 0.00905122
ESYT2 extended synaptotagmin-like protein 2 0.0090292
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.00895293
UBA6 ubiquitin-like modifier activating enzyme 6 0.00895115
SCFD1 sec1 family domain containing 1 0.00875544
ATF3 activating transcription factor 3 0.00865314
SFPQ splicing factor proline/glutamine-rich 0.00854048
ABLIM1 actin binding LIM protein 1 0.00852997
HILPDA hypoxia inducible lipid droplet-associated 0.00846397
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.00844559
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.00838583
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.00832266
IFRD1 interferon-related developmental regulator 1 0.00831905
UBAP2 ubiquitin associated protein 2 0.00804364
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.00800467
ZCCHC7 zinc finger, CCHC domain containing 7 0.00798931
RNF145 ring finger protein 145 0.00796274
ELOVL5 ELOVL fatty acid elongase 5 0.00784731
RYBP RING1 and YY1 binding protein 0.00783973
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.00783401
GMDS GDP-mannose 4,6-dehydratase 0.00764891
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.00757981
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.00756695
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa 0.00743949
TRA2A transformer 2 alpha homolog (Drosophila) 0.00733349
EPB41L5 erythrocyte membrane protein band 4.1 like 5 0.00728994
ARRDC3 arrestin domain containing 3 0.00726769
QKI QKI, KH domain containing, RNA binding 0.0072537
GPATCH2L G patch domain containing 2-like 0.00714874
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.00714848
ERO1B endoplasmic reticulum oxidoreductase 1 beta 0.00712069
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.00710001
SGMS2 sphingomyelin synthase 2 0.00700654
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.00698323
NEBL nebulette 0.00697979
ZNF451 zinc finger protein 451 0.00683549
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0067997
NBAS neuroblastoma amplified sequence 0.00679215
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.00673187
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.00666575
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0066528
KDM3B lysine (K)-specific demethylase 3B 0.0065648
LARP1B La ribonucleoprotein domain family, member 1B 0.00648518
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.00643085
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.00642354
ZC3H12C zinc finger CCCH-type containing 12C 0.00641858
SPDYA speedy/RINGO cell cycle regulator family member A 0.00639906
PEAK1 pseudopodium-enriched atypical kinase 1 0.00639245
DTNA dystrobrevin, alpha 0.00631843
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0063044
FAM107B family with sequence similarity 107, member B 0.00623823
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.00622357
HSPH1 heat shock 105kDa/110kDa protein 1 0.00621629
PDE7A phosphodiesterase 7A 0.00620079
NEK1 NIMA-related kinase 1 0.00607587
PLEKHA6 pleckstrin homology domain containing, family A member 6 0.00601015
SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) 0.0059443
EYA1 EYA transcriptional coactivator and phosphatase 1 0.00589368
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.00588136

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.367245
NRG1 neuregulin 1 -0.202926
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.182601
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.176281
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.173252
HMGA2 high mobility group AT-hook 2 -0.102939
PTMA prothymosin, alpha -0.0995303
TMSB10 thymosin beta 10 -0.0951017
TMEM156 transmembrane protein 156 -0.0877151
ITGA1 integrin, alpha 1 -0.0836822
NAMPT nicotinamide phosphoribosyltransferase -0.0791208
IFI27 interferon, alpha-inducible protein 27 -0.0773817
SQSTM1 sequestosome 1 -0.0767867
MT2A metallothionein 2A -0.0747401
OSMR oncostatin M receptor -0.0745065
HLA-B major histocompatibility complex, class I, B -0.0741016
ASPH aspartate beta-hydroxylase -0.0738846
GLIS3 GLIS family zinc finger 3 -0.0713907
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0703827
SYT1 synaptotagmin I -0.066188
NRP1 neuropilin 1 -0.0652363
FTL ferritin, light polypeptide -0.0647753
TMSB4X thymosin beta 4, X-linked -0.0647476
SOX4 SRY (sex determining region Y)-box 4 -0.0632307
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0628238
S100A6 S100 calcium binding protein A6 -0.0625907
VCL vinculin -0.0579256
RAI14 retinoic acid induced 14 -0.0541849
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0508157
VIM vimentin -0.050647
EXT1 exostosin glycosyltransferase 1 -0.0505881
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0500848
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0499681
PRRC2C proline-rich coiled-coil 2C -0.0478154
B2M beta-2-microglobulin -0.0470773
MYH9 myosin, heavy chain 9, non-muscle -0.0469199
KLHL5 kelch-like family member 5 -0.0433254
RUNX2 runt-related transcription factor 2 -0.0431209
HIPK2 homeodomain interacting protein kinase 2 -0.0427479
ETV1 ets variant 1 -0.0423289
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0423191
NTN4 netrin 4 -0.0422795
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0406464
CANX calnexin -0.0401426
AKAP12 A kinase (PRKA) anchor protein 12 -0.0395928
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0393778
TPT1 tumor protein, translationally-controlled 1 -0.0381095
MAP1B microtubule-associated protein 1B -0.0380547
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0351578
STC2 stanniocalcin 2 -0.0347327
TPI1 triosephosphate isomerase 1 -0.0326778
ETV6 ets variant 6 -0.0322298
PKM pyruvate kinase, muscle -0.0322246
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0320769
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0318959
ZMYND8 zinc finger, MYND-type containing 8 -0.0318135
ACTG1 actin gamma 1 -0.0313725
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0312842
RNF213 ring finger protein 213 -0.0310965
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0308124
LOC102724023 ES1 protein homolog, mitochondrial -0.0307163
SMOX spermine oxidase -0.0301965
EFNA5 ephrin-A5 -0.030082
IFI16 interferon, gamma-inducible protein 16 -0.0299745
AHR aryl hydrocarbon receptor -0.0299578
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0296899
RRBP1 ribosome binding protein 1 -0.0296386
ZBTB20 zinc finger and BTB domain containing 20 -0.0291987
H1-0 H1.0 linker histone -0.0290784
ENO1 enolase 1, (alpha) -0.0289719
TSC22D1 TSC22 domain family, member 1 -0.0288929
SFTPA2 surfactant protein A2 -0.0285422
AOPEP aminopeptidase O (putative) -0.0284126
HPCAL1 hippocalcin-like 1 -0.0278859
ENO2 enolase 2 (gamma, neuronal) -0.0278354
LOC112694756 uncharaterized LOC112694756 -0.0268124
MKI67 marker of proliferation Ki-67 -0.0267192
MX2 MX dynamin-like GTPase 2 -0.0265915
AHNAK AHNAK nucleoprotein -0.0265138
HLA-A major histocompatibility complex, class I, A -0.0263227
PDE4D phosphodiesterase 4D, cAMP-specific -0.0260893
CALR calreticulin -0.0257555
CD44 CD44 molecule (Indian blood group) -0.0256295
FOXP1 forkhead box P1 -0.0252893
ZFP36L1 ZFP36 ring finger protein-like 1 -0.025229
CTSB cathepsin B -0.0250132
RAB31 RAB31, member RAS oncogene family -0.0248832
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0245745
AHNAK2 AHNAK nucleoprotein 2 -0.0245352
CAPN2 calpain 2, (m/II) large subunit -0.0244375
DNAH5 dynein, axonemal, heavy chain 5 -0.0244344
WWTR1 WW domain containing transcription regulator 1 -0.0243887
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0242857
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0241737
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0240254
TMEM165 transmembrane protein 165 -0.0239793
TPM4 tropomyosin 4 -0.0237609
SSH1 slingshot protein phosphatase 1 -0.0236719
RTN4 reticulon 4 -0.0236414
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.023552