| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | complement component 4B (Chido blood group)|This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 721) |
| External Link | https://ncbi.nlm.nih.gov/gene/721 |
| Similar Terms | |
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500 genes differentially expressed following the C4B gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 0.0248944 |
| EGR1 | early growth response 1 | 0.0213812 |
| FABP4 | fatty acid binding protein 4, adipocyte | 0.0198734 |
| S100A8 | S100 calcium binding protein A8 | 0.0195153 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | 0.0193683 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0190548 |
| PI3 | peptidase inhibitor 3, skin-derived | 0.0189605 |
| S100A9 | S100 calcium binding protein A9 | 0.0180055 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0177817 |
| XPO7 | exportin 7 | 0.0173211 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0169838 |
| GALC | galactosylceramidase | 0.0169782 |
| KRT14 | keratin 14, type I | 0.0161983 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 0.0161888 |
| LXN | latexin | 0.0159046 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.0154126 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | 0.0152013 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.014965 |
| ANXA1 | annexin A1 | 0.0144962 |
| ADIRF | adipogenesis regulatory factor | 0.0144058 |
| NEBL | nebulette | 0.0142783 |
| CCN2 | cellular communication network factor 2 | 0.0142058 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0141746 |
| PTHLH | parathyroid hormone-like hormone | 0.0141161 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | 0.01372 |
| S1PR1 | sphingosine-1-phosphate receptor 1 | 0.013617 |
| BGN | biglycan | 0.0136008 |
| STC1 | stanniocalcin 1 | 0.0132105 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | 0.0131305 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | 0.0129417 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0127195 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0126318 |
| CYTIP | cytohesin 1 interacting protein | 0.0124355 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | 0.0123563 |
| S100A10 | S100 calcium binding protein A10 | 0.0123294 |
| RGS5 | regulator of G-protein signaling 5 | 0.0122898 |
| INHBA | inhibin, beta A | 0.0122883 |
| ATP1A2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide | 0.0121646 |
| ASS1 | argininosuccinate synthase 1 | 0.0121583 |
| MALL | mal, T-cell differentiation protein-like | 0.0120977 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0119642 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | 0.0119313 |
| CST7 | cystatin F (leukocystatin) | 0.011877 |
| HSPB8 | heat shock 22kDa protein 8 | 0.0118305 |
| CALB1 | calbindin 1, 28kDa | 0.0117073 |
| LCN2 | lipocalin 2 | 0.0116856 |
| S100A7 | S100 calcium binding protein A7 | 0.0116699 |
| EDNRB | endothelin receptor type B | 0.0116091 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.011607 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.0115225 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.0114464 |
| AOC1 | amine oxidase, copper containing 1 | 0.0114442 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.0112673 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0111652 |
| CSTA | cystatin A (stefin A) | 0.0111349 |
| TLR4 | toll-like receptor 4 | 0.0110805 |
| NKG7 | natural killer cell granule protein 7 | 0.0109611 |
| CRCT1 | cysteine-rich C-terminal 1 | 0.0109187 |
| SELE | selectin E | 0.0108536 |
| SFN | stratifin | 0.0108242 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.0107913 |
| LY6D | lymphocyte antigen 6 complex, locus D | 0.0106243 |
| TPK1 | thiamin pyrophosphokinase 1 | 0.0105793 |
| G0S2 | G0/G1 switch 2 | 0.0105061 |
| VWF | von Willebrand factor | 0.0104884 |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | 0.0104775 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | 0.0104639 |
| STC2 | stanniocalcin 2 | 0.0104222 |
| KCNJ16 | potassium channel, inwardly rectifying subfamily J, member 16 | 0.0103581 |
| IL1R2 | interleukin 1 receptor, type II | 0.0103268 |
| SYNPO | synaptopodin | 0.0103024 |
| DSG3 | desmoglein 3 | 0.0102841 |
| GSTP1 | glutathione S-transferase pi 1 | 0.0102118 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.0102049 |
| PIR | pirin (iron-binding nuclear protein) | 0.0101696 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | 0.0101551 |
| NRG1 | neuregulin 1 | 0.0101191 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0100769 |
| ABLIM1 | actin binding LIM protein 1 | 0.00992501 |
| CD38 | CD38 molecule | 0.00986692 |
| LIPG | lipase, endothelial | 0.0098438 |
| GAS6 | growth arrest-specific 6 | 0.00984079 |
| BPGM | 2,3-bisphosphoglycerate mutase | 0.0098048 |
| TARP | TCR gamma alternate reading frame protein | 0.00974958 |
| BMP2 | bone morphogenetic protein 2 | 0.00973172 |
| SPRR2B | small proline-rich protein 2B | 0.00971593 |
| ZNF423 | zinc finger protein 423 | 0.00969851 |
| PDZK1IP1 | PDZK1 interacting protein 1 | 0.00968387 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0096815 |
| ICAM2 | intercellular adhesion molecule 2 | 0.0096485 |
| PTGER4 | prostaglandin E receptor 4 (subtype EP4) | 0.00957813 |
| HIST1H2AC | histone cluster 1, H2ac | 0.00957589 |
| LEFTY1 | left-right determination factor 1 | 0.00956579 |
| STK10 | serine/threonine kinase 10 | 0.00956283 |
| CD93 | CD93 molecule | 0.00955646 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | 0.00947235 |
| FKBP11 | FK506 binding protein 11, 19 kDa | 0.0094472 |
| OLFM4 | olfactomedin 4 | 0.00942417 |
| KLRK1 | killer cell lectin-like receptor subfamily K, member 1 | 0.00942345 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | 0.0094138 |
| ARL4A | ADP-ribosylation factor-like 4A | 0.00941312 |
| CRYAB | crystallin, alpha B | 0.00939884 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.00934936 |
| PRSS3 | protease, serine, 3 | 0.00932006 |
| PPP1R16B | protein phosphatase 1, regulatory subunit 16B | 0.00924616 |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | 0.00922807 |
| UPP1 | uridine phosphorylase 1 | 0.00921757 |
| TIMP4 | TIMP metallopeptidase inhibitor 4 | 0.00918293 |
| PDLIM1 | PDZ and LIM domain 1 | 0.00913605 |
| KRT6A | keratin 6A, type II | 0.00909181 |
| JPT2 | Jupiter microtubule associated homolog 2 | 0.00908122 |
| KLK10 | kallikrein-related peptidase 10 | 0.00905559 |
| METRN | meteorin, glial cell differentiation regulator | 0.00903963 |
| MT1X | metallothionein 1X | 0.00903336 |
| CD69 | CD69 molecule | 0.00902467 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.00900227 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.00898338 |
| CD8A | CD8a molecule | 0.00896238 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.00896174 |
| CREM | cAMP responsive element modulator | 0.0089359 |
| FCGR3B | Fc fragment of IgG, low affinity IIIb, receptor (CD16b) | 0.00892554 |
| SRGN | serglycin | 0.00891921 |
| PLVAP | plasmalemma vesicle associated protein | 0.0089096 |
| FRZB | frizzled-related protein | 0.00890286 |
| LYZ | lysozyme | 0.00890117 |
| JAM2 | junctional adhesion molecule 2 | 0.00887373 |
| CLEC2B | C-type lectin domain family 2, member B | 0.00885467 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.00885409 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | 0.00883856 |
| UNC45A | unc-45 homolog A (C. elegans) | 0.00883164 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 0.00882682 |
| S100A12 | S100 calcium binding protein A12 | 0.00881462 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | 0.00881334 |
| C1GALT1 | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 | 0.008794 |
| SERPINB6 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 | 0.00878445 |
| NECTIN3 | nectin cell adhesion molecule 3 | 0.00856975 |
| IGFBP4 | insulin-like growth factor binding protein 4 | 0.00856435 |
| S100A11 | S100 calcium binding protein A11 | 0.00852498 |
| CAV2 | caveolin 2 | 0.00851618 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.00842508 |
| GZMH | granzyme H (cathepsin G-like 2, protein h-CCPX) | 0.00835777 |
| DSG1 | desmoglein 1 | 0.008343 |
| SLC16A4 | solute carrier family 16, member 4 | 0.00834264 |
| ADGRL4 | adhesion G protein-coupled receptor L4 | 0.0083341 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.00831963 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.00831475 |
| ANGPT2 | angiopoietin 2 | 0.00830708 |
| PLAAT3 | phospholipase A and acyltransferase 3 | 0.00830548 |
| EFNB2 | ephrin-B2 | 0.00828733 |
| ERAP2 | endoplasmic reticulum aminopeptidase 2 | 0.00827731 |
| CSRP2 | cysteine and glycine-rich protein 2 | 0.00825355 |
| RRAD | Ras-related associated with diabetes | 0.0082381 |
| SRI | sorcin | 0.00823077 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.00822093 |
| CSF2RB | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 0.00821222 |
| GIMAP6 | GTPase, IMAP family member 6 | 0.008206 |
| FZD5 | frizzled class receptor 5 | 0.0081795 |
| YPEL5 | yippee-like 5 (Drosophila) | 0.00817619 |
| RHOBTB1 | Rho-related BTB domain containing 1 | 0.00817183 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | 0.00814497 |
| AQP1 | aquaporin 1 (Colton blood group) | 0.00813504 |
| LEPR | leptin receptor | 0.00812959 |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 | 0.0081162 |
| EGR3 | early growth response 3 | 0.0081137 |
| SPRR1B | small proline-rich protein 1B | 0.00811236 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | 0.00811087 |
| KRT16 | keratin 16, type I | 0.00809796 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | 0.00809328 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.00808067 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.00807353 |
| HBEGF | heparin-binding EGF-like growth factor | 0.00806996 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.00806864 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.0080035 |
| NAV3 | neuron navigator 3 | 0.0079978 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 0.00799727 |
| NMB | neuromedin B | 0.00798745 |
| KDM5D | lysine (K)-specific demethylase 5D | 0.00796939 |
| FLRT3 | fibronectin leucine rich transmembrane protein 3 | 0.0079693 |
| BCL2A1 | BCL2-related protein A1 | 0.00795153 |
| FHL1 | four and a half LIM domains 1 | 0.00794268 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 0.00794067 |
| CD36 | CD36 molecule (thrombospondin receptor) | 0.00793575 |
| EMCN | endomucin | 0.00792676 |
| ESM1 | endothelial cell-specific molecule 1 | 0.00791542 |
| DNAJB4 | DnaJ (Hsp40) homolog, subfamily B, member 4 | 0.00790592 |
| ARL14 | ADP-ribosylation factor-like 14 | 0.00786284 |
| TMEM47 | transmembrane protein 47 | 0.00784627 |
| LTBP2 | latent transforming growth factor beta binding protein 2 | 0.00783321 |
| PLP1 | proteolipid protein 1 | 0.00782622 |
| CRYBG1 | crystallin beta-gamma domain containing 1 | 0.00781682 |
| ANXA2P2 | annexin A2 pseudogene 2 | 0.00781335 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.00781316 |
| THSD7A | thrombospondin, type I, domain containing 7A | 0.00780906 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | 0.00780623 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.00780239 |
| NMRK1 | nicotinamide riboside kinase 1 | 0.00779056 |
| MGP | matrix Gla protein | 0.00777187 |
| MAL | mal, T-cell differentiation protein | 0.00776893 |
| LTF | lactotransferrin | 0.00774302 |
| CD96 | CD96 molecule | 0.00773375 |
| RBM34 | RNA binding motif protein 34 | 0.00773023 |
| PRF1 | perforin 1 (pore forming protein) | 0.00772808 |
| KLF2 | Kruppel-like factor 2 | 0.00771536 |
| MCAM | melanoma cell adhesion molecule | 0.00771219 |
| CYTL1 | cytokine-like 1 | 0.0077118 |
| GATA6 | GATA binding protein 6 | 0.00771022 |
| REX1BD | required for excision 1-B domain containing | 0.00767859 |
| CA12 | carbonic anhydrase XII | 0.0076704 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 0.00766242 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | 0.00766021 |
| CXCL6 | chemokine (C-X-C motif) ligand 6 | 0.00765222 |
| BMP6 | bone morphogenetic protein 6 | 0.00763347 |
| LAMP3 | lysosomal-associated membrane protein 3 | 0.00763111 |
| SLC35D1 | solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 | 0.00761018 |
| KCNJ8 | potassium channel, inwardly rectifying subfamily J, member 8 | 0.00759991 |
| KLRB1 | killer cell lectin-like receptor subfamily B, member 1 | 0.00755602 |
| TRIM29 | tripartite motif containing 29 | 0.00753969 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.00751609 |
| JAK1 | Janus kinase 1 | 0.00750698 |
| GLA | galactosidase, alpha | 0.00750204 |
| C1ORF54 | chromosome 1 open reading frame 54 | 0.00749784 |
| BTN3A3 | butyrophilin, subfamily 3, member A3 | 0.00744607 |
| KCNN3 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 | 0.00744393 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.00742896 |
| HOPX | HOP homeobox | 0.00742742 |
| RGCC | regulator of cell cycle | 0.00742722 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 0.00741685 |
| IGLL1 | immunoglobulin lambda-like polypeptide 1 | 0.00740862 |
| KLK11 | kallikrein-related peptidase 11 | 0.00737207 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | 0.00736524 |
| VEGFC | vascular endothelial growth factor C | 0.00736088 |
| SAMSN1 | SAM domain, SH3 domain and nuclear localization signals 1 | 0.00735394 |
| TSPAN8 | tetraspanin 8 | 0.00733073 |
| OGA | O-GlcNAcase | 0.00731613 |
| FAM107A | family with sequence similarity 107, member A | 0.00730131 |
| SLPI | secretory leukocyte peptidase inhibitor | 0.00728387 |
| TPBG | trophoblast glycoprotein | 0.00727028 |
| CA4 | carbonic anhydrase IV | 0.00726334 |
| NPY1R | neuropeptide Y receptor Y1 | 0.00724552 |
| DEFB4A | defensin, beta 4A | 0.00724323 |
| COX7A1 | cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) | 0.00724207 |
| TAC1 | tachykinin, precursor 1 | 0.00723978 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.00723784 |
| SLC14A1 | solute carrier family 14 (urea transporter), member 1 (Kidd blood group) | 0.00723086 |
| KCNK12 | potassium channel, two pore domain subfamily K, member 12 | 0.00722176 |
| KCNJ15 | potassium channel, inwardly rectifying subfamily J, member 15 | 0.00721642 |
| NAP1L2 | nucleosome assembly protein 1-like 2 | 0.00718271 |
| ABCA8 | ATP-binding cassette, sub-family A (ABC1), member 8 | 0.0071797 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.00717193 |
| MAGEA3 | melanoma antigen family A3 | 0.00715405 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -0.0197145 |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | -0.0187495 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0181444 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | -0.0176389 |
| PEG3 | paternally expressed 3 | -0.017343 |
| TXLNA | taxilin alpha | -0.0170123 |
| PDGFC | platelet derived growth factor C | -0.0161015 |
| COPS7A | COP9 signalosome subunit 7A | -0.0160305 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | -0.0155293 |
| SDC2 | syndecan 2 | -0.015218 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | -0.0151429 |
| WASHC4 | WASH complex subunit 4 | -0.0145709 |
| EXPH5 | exophilin 5 | -0.01444 |
| RNF167 | ring finger protein 167 | -0.0141047 |
| EIF5A | eukaryotic translation initiation factor 5A | -0.0138055 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | -0.0137736 |
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | -0.0134981 |
| HOXB6 | homeobox B6 | -0.0134939 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | -0.0134827 |
| NVL | nuclear VCP-like | -0.0129433 |
| FAM3C | family with sequence similarity 3, member C | -0.012457 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0123019 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0119266 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0119024 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0118435 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | -0.0118209 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | -0.0116102 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0115833 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0115228 |
| PRKCB | protein kinase C, beta | -0.0113803 |
| SPTSSA | serine palmitoyltransferase, small subunit A | -0.0113693 |
| REEP1 | receptor accessory protein 1 | -0.0112764 |
| GANAB | glucosidase, alpha; neutral AB | -0.0111616 |
| SEPP1 | selenoprotein P, plasma, 1 | -0.0110952 |
| TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | -0.0109398 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -0.0108393 |
| THOC2 | THO complex 2 | -0.0106851 |
| KRT7 | keratin 7, type II | -0.010583 |
| HOXB2 | homeobox B2 | -0.0105593 |
| EMX2 | empty spiracles homeobox 2 | -0.0105205 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | -0.010499 |
| TOX3 | TOX high mobility group box family member 3 | -0.0104633 |
| CPS1 | carbamoyl-phosphate synthase 1, mitochondrial | -0.0103058 |
| PRSS8 | protease, serine, 8 | -0.010304 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.0103002 |
| PRKCSH | protein kinase C substrate 80K-H | -0.0101261 |
| HAMP | hepcidin antimicrobial peptide | -0.0100312 |
| RAMP1 | receptor (G protein-coupled) activity modifying protein 1 | -0.00989026 |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | -0.00983928 |
| MLF2 | myeloid leukemia factor 2 | -0.00978498 |
| NBPF10 | neuroblastoma breakpoint family, member 10 | -0.00976772 |
| DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | -0.00973647 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | -0.00971932 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.00971747 |
| RAPSN | receptor-associated protein of the synapse | -0.00970889 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -0.00969857 |
| MAT2A | methionine adenosyltransferase II, alpha | -0.00962351 |
| MAP7 | microtubule-associated protein 7 | -0.00958417 |
| C4BPB | complement component 4 binding protein, beta | -0.00954763 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | -0.00953134 |
| ALB | albumin | -0.00950219 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | -0.00949456 |
| NPTN | neuroplastin | -0.00935834 |
| PON3 | paraoxonase 3 | -0.00929271 |
| KRT19 | keratin 19, type I | -0.00924128 |
| C4BPA | complement component 4 binding protein, alpha | -0.00923951 |
| ESR1 | estrogen receptor 1 | -0.00922446 |
| RNF130 | ring finger protein 130 | -0.00915924 |
| RAB25 | RAB25, member RAS oncogene family | -0.00914512 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | -0.0091021 |
| RAB20 | RAB20, member RAS oncogene family | -0.009097 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | -0.00904274 |
| TBC1D9B | TBC1 domain family, member 9B (with GRAM domain) | -0.00903057 |
| TMEM165 | transmembrane protein 165 | -0.00901648 |
| SFTPA2 | surfactant protein A2 | -0.0090094 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.00897507 |
| TBL1X | transducin (beta)-like 1X-linked | -0.00894512 |
| H1-0 | H1.0 linker histone | -0.00893741 |
| GAS1 | growth arrest-specific 1 | -0.00885942 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.00883262 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | -0.00874778 |
| MOXD1 | monooxygenase, DBH-like 1 | -0.00872823 |
| WEE1 | WEE1 G2 checkpoint kinase | -0.00869897 |
| COL4A5 | collagen, type IV, alpha 5 | -0.00865033 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.00863544 |
| BLNK | B-cell linker | -0.00863095 |
| KCTD14 | potassium channel tetramerization domain containing 14 | -0.00862844 |
| AHSG | alpha-2-HS-glycoprotein | -0.00858468 |
| SNRPB | small nuclear ribonucleoprotein polypeptides B and B1 | -0.00853752 |
| KCND3 | potassium channel, voltage gated Shal related subfamily D, member 3 | -0.00851455 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.00848134 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | -0.00843978 |
| PTCH1 | patched 1 | -0.00840218 |
| DLK1 | delta-like 1 homolog (Drosophila) | -0.0083984 |
| FAIM | Fas apoptotic inhibitory molecule | -0.00839181 |
| DSE | dermatan sulfate epimerase | -0.00838972 |
| PTK7 | protein tyrosine kinase 7 (inactive) | -0.0083591 |
| C1RL | complement component 1, r subcomponent-like | -0.00832596 |
| GLUL | glutamate-ammonia ligase | -0.00831674 |
| CST3 | cystatin C | -0.00829352 |
| COL10A1 | collagen, type X, alpha 1 | -0.00825579 |
| ACP2 | acid phosphatase 2, lysosomal | -0.00824839 |
| FUS | FUS RNA binding protein | -0.00820398 |
| GCHFR | GTP cyclohydrolase I feedback regulator | -0.00812692 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | -0.00811078 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | -0.00809359 |
| TSPAN5 | tetraspanin 5 | -0.00807377 |
| GAMT | guanidinoacetate N-methyltransferase | -0.00803118 |
| PTPN3 | protein tyrosine phosphatase, non-receptor type 3 | -0.00797564 |
| MEIS1 | Meis homeobox 1 | -0.00793413 |
| HAL | histidine ammonia-lyase | -0.00790668 |
| SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 | -0.0078993 |
| APOB | apolipoprotein B | -0.00788 |
| PHB2 | prohibitin 2 | -0.00785461 |
| CD164 | CD164 molecule, sialomucin | -0.00784844 |
| LUM | lumican | -0.00783707 |
| BAD | BCL2-associated agonist of cell death | -0.00783676 |
| PLPP3 | phospholipid phosphatase 3 | -0.00781273 |
| GPM6A | glycoprotein M6A | -0.00780876 |
| ENO1 | enolase 1, (alpha) | -0.00780293 |
| GNAS | GNAS complex locus | -0.00776096 |
| OVOL2 | ovo-like zinc finger 2 | -0.00771146 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.00756981 |
| SH3BGRL | SH3 domain binding glutamate-rich protein like | -0.00754164 |
| FKBP5 | FK506 binding protein 5 | -0.00750524 |
| GPX1 | glutathione peroxidase 1 | -0.00749148 |
| HNMT | histamine N-methyltransferase | -0.00745654 |
| PTMS | parathymosin | -0.00744299 |
| NXN | nucleoredoxin | -0.00744 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.00742674 |
| NELL1 | NEL-like 1 (chicken) | -0.00739272 |
| NUMA1 | nuclear mitotic apparatus protein 1 | -0.00737162 |
| CHKA | choline kinase alpha | -0.00736824 |
| TRIB3 | tribbles pseudokinase 3 | -0.00733933 |
| TMEM63A | transmembrane protein 63A | -0.00731614 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | -0.00729502 |
| FGFR2 | fibroblast growth factor receptor 2 | -0.00728975 |
| DENND5A | DENN/MADD domain containing 5A | -0.00728843 |
| HPD | 4-hydroxyphenylpyruvate dioxygenase | -0.00727167 |
| FAM120A | family with sequence similarity 120A | -0.00726841 |
| CRLF1 | cytokine receptor-like factor 1 | -0.00725811 |
| PRPF19 | pre-mRNA processing factor 19 | -0.00725697 |
| L1CAM | L1 cell adhesion molecule | -0.00725385 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | -0.00724253 |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | -0.00723499 |
| TMEM39B | transmembrane protein 39B | -0.00717434 |
| KLHL23 | kelch-like family member 23 | -0.00715534 |
| SOCS1 | suppressor of cytokine signaling 1 | -0.00715249 |
| PDAP1 | PDGFA associated protein 1 | -0.00713051 |
| SLC34A2 | solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 | -0.00710298 |
| CHRNA3 | cholinergic receptor, nicotinic, alpha 3 (neuronal) | -0.00706918 |
| MOCOS | molybdenum cofactor sulfurase | -0.00705866 |
| MMP11 | matrix metallopeptidase 11 | -0.00705167 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | -0.00703853 |
| PDE10A | phosphodiesterase 10A | -0.0070369 |
| PHACTR2 | phosphatase and actin regulator 2 | -0.00701651 |
| CD82 | CD82 molecule | -0.00698965 |
| NAA15 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit | -0.00697786 |
| TP73-AS1 | TP73 antisense RNA 1 | -0.00697323 |
| F5 | coagulation factor V (proaccelerin, labile factor) | -0.00696723 |
| MMP7 | matrix metallopeptidase 7 | -0.00696408 |
| CLSTN3 | calsyntenin 3 | -0.00696251 |
| MUC16 | mucin 16, cell surface associated | -0.00696102 |
| ESRP2 | epithelial splicing regulatory protein 2 | -0.00695379 |
| IL17RB | interleukin 17 receptor B | -0.00690597 |
| TNC | tenascin C | -0.00690493 |
| MREG | melanoregulin | -0.00690166 |
| PUM1 | pumilio RNA-binding family member 1 | -0.0068998 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.00689125 |
| IRX5 | iroquois homeobox 5 | -0.00689078 |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | -0.00683637 |
| ADORA2B | adenosine A2b receptor | -0.00683502 |
| MRPS28 | mitochondrial ribosomal protein S28 | -0.00680987 |
| LRP5 | low density lipoprotein receptor-related protein 5 | -0.00679539 |
| NRGN | neurogranin (protein kinase C substrate, RC3) | -0.00679304 |
| LAMP2 | lysosomal-associated membrane protein 2 | -0.00678248 |
| APOA2 | apolipoprotein A-II | -0.00677661 |
| FCER2 | Fc fragment of IgE, low affinity II, receptor for (CD23) | -0.00677638 |
| TLN1 | talin 1 | -0.00676969 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.00674941 |
| LPCAT3 | lysophosphatidylcholine acyltransferase 3 | -0.00674895 |
| PTGES | prostaglandin E synthase | -0.00674529 |
| YBX3 | Y box binding protein 3 | -0.00672364 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.00671261 |
| MCUB | mitochondrial calcium uniporter dominant negative subunit beta | -0.00670637 |
| ADIPOR2 | adiponectin receptor 2 | -0.00669825 |
| PRPS2 | phosphoribosyl pyrophosphate synthetase 2 | -0.0066927 |
| BAG1 | BCL2-associated athanogene | -0.00669256 |
| KANK2 | KN motif and ankyrin repeat domains 2 | -0.00668987 |
| RBM3 | RNA binding motif (RNP1, RRM) protein 3 | -0.00667688 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.00666668 |
| GJB1 | gap junction protein, beta 1, 32kDa | -0.006654 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | -0.00665104 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.00663089 |
| SERPIND1 | serpin peptidase inhibitor, clade D (heparin cofactor), member 1 | -0.00660773 |
| UGT2B15 | UDP glucuronosyltransferase 2 family, polypeptide B15 | -0.00659845 |
| ITIH3 | inter-alpha-trypsin inhibitor heavy chain 3 | -0.00658463 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | -0.00657948 |
| BRD4 | bromodomain containing 4 | -0.00657392 |
| AK2 | adenylate kinase 2 | -0.00655196 |
| INPP5A | inositol polyphosphate-5-phosphatase, 40kDa | -0.00652915 |
| ASF1B | anti-silencing function 1B histone chaperone | -0.00652593 |
| ANXA6 | annexin A6 | -0.006505 |
| TMPRSS4 | transmembrane protease, serine 4 | -0.00650418 |
| PDE4A | phosphodiesterase 4A, cAMP-specific | -0.00648951 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0064592 |
| APOH | apolipoprotein H (beta-2-glycoprotein I) | -0.00645769 |
| APOA1 | apolipoprotein A-I | -0.00645746 |
| RETREG1 | reticulophagy regulator 1 | -0.00645699 |
| COBLL1 | cordon-bleu WH2 repeat protein-like 1 | -0.00645646 |
| PKM | pyruvate kinase, muscle | -0.00644857 |
| PRUNE1 | prune exopolyphosphatase 1 | -0.00644216 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | -0.00643682 |
| PAH | phenylalanine hydroxylase | -0.00642243 |
| PIKFYVE | phosphoinositide kinase, FYVE finger containing | -0.00642205 |
| NOP2 | NOP2 nucleolar protein | -0.00641326 |
| SHMT1 | serine hydroxymethyltransferase 1 (soluble) | -0.00640271 |
| DPYD | dihydropyrimidine dehydrogenase | -0.00640238 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.00638197 |
| MX2 | MX dynamin-like GTPase 2 | -0.00637378 |
| GCK | glucokinase (hexokinase 4) | -0.00637017 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | -0.00636746 |
| CYFIP1 | cytoplasmic FMR1 interacting protein 1 | -0.0063468 |
| ACTN1 | actinin, alpha 1 | -0.00634561 |
| HOXC6 | homeobox C6 | -0.00634016 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.00633766 |
| SERPINF2 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 | -0.0063197 |
| CHPT1 | choline phosphotransferase 1 | -0.00631808 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.00631242 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | -0.00630087 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | -0.00629237 |
| VTCN1 | V-set domain containing T cell activation inhibitor 1 | -0.00628912 |
| PRKCZ | protein kinase C, zeta | -0.00628037 |
| LMNB2 | lamin B2 | -0.00627906 |
| BSPRY | B-box and SPRY domain containing | -0.00627478 |
| GRAMD1C | GRAM domain containing 1C | -0.00626095 |
| MBOAT7 | membrane bound O-acyltransferase domain containing 7 | -0.006251 |
| HDAC9 | histone deacetylase 9 | -0.0062496 |
| LTBR | lymphotoxin beta receptor (TNFR superfamily, member 3) | -0.00624863 |
| PRDX2 | peroxiredoxin 2 | -0.00624273 |
| FKBP2 | FK506 binding protein 2, 13kDa | -0.00624142 |
| NNMT | nicotinamide N-methyltransferase | -0.00623171 |
| MARK2 | MAP/microtubule affinity-regulating kinase 2 | -0.00621639 |
| RMI1 | RecQ mediated genome instability 1 | -0.00619886 |
| CYP2B6 | cytochrome P450, family 2, subfamily B, polypeptide 6 | -0.00619651 |
| CPVL | carboxypeptidase, vitellogenic-like | -0.00618691 |
| TPM4 | tropomyosin 4 | -0.00618361 |
| EFNB3 | ephrin-B3 | -0.00618075 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | -0.0061774 |
| NUP43 | nucleoporin 43kDa | -0.00617721 |
