C4B Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description complement component 4B (Chido blood group)|This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 721)
External Link http://www.ncbi.nlm.nih.gov/gene/721
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Genes

29 interacting proteins for C4B from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C1QC complement component 1, q subcomponent, C chain
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C2 complement component 2
C3 complement component 3
C4A complement component 4A (Rodgers blood group)
C5 complement component 5
CD46 CD46 molecule, complement regulatory protein
CFI complement factor I
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FCN3 ficolin (collagen/fibrinogen domain containing) 3
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGHG2 immunoglobulin heavy constant gamma 2 (G2m marker)
IGHG3 immunoglobulin heavy constant gamma 3 (G3m marker)
IGHG4 immunoglobulin heavy constant gamma 4 (G4m marker)
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLC1 immunoglobulin lambda constant 1 (Mcg marker)
IGLC2 immunoglobulin lambda constant 2 (Kern-Oz- marker)
IGLC3 immunoglobulin lambda constant 3 (Kern-Oz+ marker)
IGLC6 immunoglobulin lambda constant 6 (Kern+Oz- marker, gene/pseudogene)
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MASP2 mannan-binding lectin serine peptidase 2
MBL2 mannose-binding lectin (protein C) 2, soluble