C4BPB Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description complement component 4 binding protein, beta|This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 725)
External Link http://www.ncbi.nlm.nih.gov/gene/725
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Genes

71 interacting proteins for C4BPB from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
A1BG alpha-1-B glycoprotein
A2M alpha-2-macroglobulin
AHSG alpha-2-HS-glycoprotein
ALB albumin
AMBP alpha-1-microglobulin/bikunin precursor
APCS amyloid P component, serum
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOA4 apolipoprotein A-IV
APOC1 apolipoprotein C-I
APOC2 apolipoprotein C-II
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APOM apolipoprotein M
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C3 complement component 3
C4A complement component 4A (Rodgers blood group)
C4BPA complement component 4 binding protein, alpha
C6 complement component 6
C9 complement component 9
CD5L CD5 molecule-like
CFB complement factor B
CFH complement factor H
CLU clusterin
COL6A6 collagen, type VI, alpha 6
CP ceruloplasmin (ferroxidase)
DNA2 DNA replication helicase/nuclease 2
DUOX1 dual oxidase 1
EPYC epiphycan
F2 coagulation factor II (thrombin)
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FN1 fibronectin 1
GC group-specific component (vitamin D binding protein)
GCC2 GRIP and coiled-coil domain containing 2
HP haptoglobin
HPR haptoglobin-related protein
HRG histidine-rich glycoprotein
IGFALS insulin-like growth factor binding protein, acid labile subunit
IGHG2 immunoglobulin heavy constant gamma 2 (G2m marker)
IGLC2 immunoglobulin lambda constant 2 (Kern-Oz- marker)
IGLL5 immunoglobulin lambda-like polypeptide 5
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4
KIAA0753 KIAA0753
KIRREL kin of IRRE like (Drosophila)
KLC1 kinesin light chain 1
KNG1 kininogen 1
LBP lipopolysaccharide binding protein
LUM lumican
OPTN optineurin
ORM2 orosomucoid 2
PLG plasminogen
PON1 paraoxonase 1
PON3 paraoxonase 3
PROS1 protein S (alpha)
SAA2 serum amyloid A2
SAA4 serum amyloid A4, constitutive
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SHBG sex hormone-binding globulin
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
TRIM33 tripartite motif containing 33
TTR transthyretin
UBC ubiquitin C
UBE2L3 ubiquitin-conjugating enzyme E2L 3
VTN vitronectin
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