| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/9821383 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in CA-074 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KLHL23 | kelch-like family member 23 | 2.87 |
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | 1.94 |
| LRP5 | low density lipoprotein receptor-related protein 5 | 1.89 |
| TTN | titin | 1.85 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.88 |
| SBSN | suprabasin | 0.84 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.81 |
| PAH | phenylalanine hydroxylase | 0.59 |
| ETV6 | ets variant 6 | 0.56 |
| ZNF362 | zinc finger protein 362 | 0.53 |
| KDM6B | lysine (K)-specific demethylase 6B | 0.5 |
| RNF6 | ring finger protein (C3H2C3 type) 6 | 0.49 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.49 |
| RITA1 | RBPJ interacting and tubulin associated 1 | 0.49 |
| ASB7 | ankyrin repeat and SOCS box containing 7 | 0.43 |
| ZNF33A | zinc finger protein 33A | 0.43 |
| SOX6 | SRY (sex determining region Y)-box 6 | 0.43 |
| BRF2 | BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit | 0.43 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.41 |
| CRTC3 | CREB regulated transcription coactivator 3 | 0.41 |
| TSNARE1 | t-SNARE domain containing 1 | 0.41 |
| NFIB | nuclear factor I/B | 0.4 |
| KLK6 | kallikrein-related peptidase 6 | 0.39 |
| TBC1D2B | TBC1 domain family, member 2B | 0.39 |
| FLII | flightless I homolog (Drosophila) | 0.39 |
| TMEM159 | transmembrane protein 159 | 0.38 |
| LOXL2 | lysyl oxidase-like 2 | 0.38 |
| CEP89 | centrosomal protein 89kDa | 0.38 |
| CHST12 | carbohydrate (chondroitin 4) sulfotransferase 12 | 0.38 |
| ANKRD16 | ankyrin repeat domain 16 | 0.37 |
| RCHY1 | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase | 0.37 |
| RNF113A | ring finger protein 113A | 0.37 |
| HAL | histidine ammonia-lyase | 0.37 |
| FAM104A | family with sequence similarity 104, member A | 0.36 |
| IGF1R | insulin-like growth factor 1 receptor | 0.35 |
| ARHGAP44 | Rho GTPase activating protein 44 | 0.35 |
| MKRN3 | makorin ring finger protein 3 | 0.35 |
| SH2B2 | SH2B adaptor protein 2 | 0.35 |
| ABHD13 | abhydrolase domain containing 13 | 0.34 |
| CDA | cytidine deaminase | 0.34 |
| ADM | adrenomedullin | 0.34 |
| MFSD5 | major facilitator superfamily domain containing 5 | 0.34 |
| SS18L1 | synovial sarcoma translocation gene on chromosome 18-like 1 | 0.34 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.34 |
| ZMYM5 | zinc finger, MYM-type 5 | 0.34 |
| HHEX | hematopoietically expressed homeobox | 0.33 |
| SDHAF3 | succinate dehydrogenase complex assembly factor 3 | 0.33 |
| MTHFR | methylenetetrahydrofolate reductase (NAD(P)H) | 0.33 |
| RUNX2 | runt-related transcription factor 2 | 0.33 |
| GABPB1 | GA binding protein transcription factor, beta subunit 1 | 0.33 |
| USP31 | ubiquitin specific peptidase 31 | 0.33 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | 0.33 |
| ARL6IP6 | ADP-ribosylation factor-like 6 interacting protein 6 | 0.32 |
| DZIP3 | DAZ interacting zinc finger protein 3 | 0.32 |
| MSL3P1 | male-specific lethal 3 homolog (Drosophila) pseudogene 1 | 0.31 |
| CADPS2 | Ca++-dependent secretion activator 2 | 0.31 |
| FASTK | Fas-activated serine/threonine kinase | 0.31 |
| CHURC1 | churchill domain containing 1 | 0.31 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.31 |
| EPDR1 | ependymin related 1 | 0.31 |
| NDFIP2 | Nedd4 family interacting protein 2 | 0.31 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | 0.3 |
| PPP1R11 | protein phosphatase 1, regulatory (inhibitor) subunit 11 | 0.3 |
| ZBTB33 | zinc finger and BTB domain containing 33 | 0.3 |
| KLC1 | kinesin light chain 1 | 0.3 |
| SNAPC3 | small nuclear RNA activating complex, polypeptide 3, 50kDa | 0.29 |
| CTSB | cathepsin B | 0.29 |
| PIGH | phosphatidylinositol glycan anchor biosynthesis, class H | 0.29 |
| DENND5A | DENN/MADD domain containing 5A | 0.29 |
| MRPL20 | mitochondrial ribosomal protein L20 | 0.29 |
| CTSH | cathepsin H | 0.29 |
| CDC34 | cell division cycle 34 | 0.29 |
| ENO1 | enolase 1, (alpha) | 0.29 |
| BCOR | BCL6 corepressor | 0.28 |
| CNTRL | centriolin | 0.28 |
| UQCRH | ubiquinol-cytochrome c reductase hinge protein | 0.28 |
| RNF187 | ring finger protein 187 | 0.28 |
| STK19 | serine/threonine kinase 19 | 0.28 |
| CHTF8 | CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) | 0.28 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | 0.28 |
| CTSV | cathepsin V | 0.27 |
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.27 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.27 |
| ZFP1 | ZFP1 zinc finger protein | 0.27 |
| METAP1D | methionyl aminopeptidase type 1D (mitochondrial) | 0.27 |
| BIN1 | bridging integrator 1 | 0.27 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | 0.27 |
| GOLGA1 | golgin A1 | 0.27 |
| KBTBD11 | kelch repeat and BTB (POZ) domain containing 11 | 0.27 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.27 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.27 |
| NEMP1 | nuclear envelope integral membrane protein 1 | 0.27 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 0.27 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.27 |
| MT1F | metallothionein 1F | 0.26 |
| BCL6 | B-cell CLL/lymphoma 6 | 0.26 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.26 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.26 |
| AMOTL2 | angiomotin like 2 | 0.26 |
| NUDT8 | nudix (nucleoside diphosphate linked moiety X)-type motif 8 | 0.26 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZFP37 | ZFP37 zinc finger protein | -1.33 |
| SRD5A3 | steroid 5 alpha-reductase 3 | -0.69 |
| ABCD1 | ATP-binding cassette, sub-family D (ALD), member 1 | -0.65 |
| TMEM260 | transmembrane protein 260 | -0.56 |
| TTC21B | tetratricopeptide repeat domain 21B | -0.55 |
| ATXN7L3 | ataxin 7-like 3 | -0.54 |
| FLCN | folliculin | -0.5 |
| CBARP | CACN subunit beta associated regulatory protein | -0.5 |
| CD82 | CD82 molecule | -0.49 |
| SPHK2 | sphingosine kinase 2 | -0.49 |
| ARG2 | arginase 2 | -0.45 |
| CASZ1 | castor zinc finger 1 | -0.44 |
| TMEM208 | transmembrane protein 208 | -0.42 |
| JMJD4 | jumonji domain containing 4 | -0.41 |
| HBA1 | hemoglobin, alpha 1 | -0.41 |
| UBIAD1 | UbiA prenyltransferase domain containing 1 | -0.41 |
| SCYL3 | SCY1-like 3 (S. cerevisiae) | -0.4 |
| ZNF282 | zinc finger protein 282 | -0.39 |
| ACTN3 | actinin, alpha 3 (gene/pseudogene) | -0.36 |
| ZNF496 | zinc finger protein 496 | -0.36 |
| MAN2C1 | mannosidase, alpha, class 2C, member 1 | -0.36 |
| ADSS1 | adenylosuccinate synthase 1 | -0.35 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.35 |
| KPTN | kaptin (actin binding protein) | -0.34 |
| SYBU | syntabulin (syntaxin-interacting) | -0.34 |
| LRRK2 | leucine-rich repeat kinase 2 | -0.34 |
| CNIH4 | cornichon family AMPA receptor auxiliary protein 4 | -0.34 |
| ZCCHC24 | zinc finger, CCHC domain containing 24 | -0.33 |
| ONECUT3 | one cut homeobox 3 | -0.32 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | -0.32 |
| REX1BD | required for excision 1-B domain containing | -0.31 |
| TMEM104 | transmembrane protein 104 | -0.31 |
| HSH2D | hematopoietic SH2 domain containing | -0.31 |
| CABLES2 | Cdk5 and Abl enzyme substrate 2 | -0.31 |
| ZDHHC12 | zinc finger, DHHC-type containing 12 | -0.31 |
| TRAPPC6B | trafficking protein particle complex 6B | -0.3 |
| PTPN18 | protein tyrosine phosphatase, non-receptor type 18 (brain-derived) | -0.3 |
| ULK1 | unc-51 like autophagy activating kinase 1 | -0.3 |
| WDYHV1 | WDYHV motif containing 1 | -0.29 |
| MIPOL1 | mirror-image polydactyly 1 | -0.29 |
| SNAP91 | synaptosomal-associated protein, 91kDa | -0.29 |
| TMEM51 | transmembrane protein 51 | -0.29 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | -0.29 |
| TMOD2 | tropomodulin 2 (neuronal) | -0.28 |
| PTMA | prothymosin, alpha | -0.28 |
| JPT1 | Jupiter microtubule associated homolog 1 | -0.28 |
| CLDND1 | claudin domain containing 1 | -0.28 |
| OIP5 | Opa interacting protein 5 | -0.28 |
| CROCC2 | ciliary rootlet coiled-coil, rootletin family member 2 | -0.27 |
| IMPAD1 | inositol monophosphatase domain containing 1 | -0.27 |
| HSPA1L | heat shock 70kDa protein 1-like | -0.27 |
| PLEKHA8 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 | -0.27 |
| ASTE1 | asteroid homolog 1 (Drosophila) | -0.27 |
| PARPBP | PARP1 binding protein | -0.27 |
| VPS13D | vacuolar protein sorting 13 homolog D (S. cerevisiae) | -0.26 |
| ATP9B | ATPase, class II, type 9B | -0.26 |
| SIAH1 | siah E3 ubiquitin protein ligase 1 | -0.26 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | -0.26 |
| ARL13B | ADP-ribosylation factor-like 13B | -0.26 |
| SMIM26 | small integral membrane protein 26 | -0.26 |
| LARGE2 | LARGE xylosyl- and glucuronyltransferase 2 | -0.26 |
| ALG13 | ALG13, UDP-N-acetylglucosaminyltransferase subunit | -0.26 |
| MADD | MAP-kinase activating death domain | -0.25 |
| PRMT6 | protein arginine methyltransferase 6 | -0.25 |
| FCHO1 | FCH domain only 1 | -0.25 |
| SLC12A8 | solute carrier family 12, member 8 | -0.25 |
| CUX2 | cut-like homeobox 2 | -0.25 |
| TMPPE | transmembrane protein with metallophosphoesterase domain | -0.25 |
| PKLR | pyruvate kinase, liver and RBC | -0.24 |
| KDELR3 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 | -0.24 |
| BRSK1 | BR serine/threonine kinase 1 | -0.24 |
| TMEM161A | transmembrane protein 161A | -0.24 |
| MSMO1 | methylsterol monooxygenase 1 | -0.24 |
| ZNF280B | zinc finger protein 280B | -0.23 |
| MKRN4P | makorin ring finger protein 4, pseudogene | -0.23 |
| HOXB9 | homeobox B9 | -0.23 |
| PAQR7 | progestin and adipoQ receptor family member VII | -0.23 |
| NOC4L | nucleolar complex associated 4 homolog (S. cerevisiae) | -0.23 |
| ARID3B | AT rich interactive domain 3B (BRIGHT-like) | -0.23 |
| INPP5K | inositol polyphosphate-5-phosphatase K | -0.23 |
| CRYL1 | crystallin, lambda 1 | -0.22 |
| DAD1 | defender against cell death 1 | -0.22 |
| SGCB | sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) | -0.22 |
| JRKL | JRK-like | -0.22 |
| ATE1 | arginyltransferase 1 | -0.22 |
| DSCAML1 | Down syndrome cell adhesion molecule like 1 | -0.22 |
| DFFB | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) | -0.22 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.22 |
| SIGMAR1 | sigma non-opioid intracellular receptor 1 | -0.21 |
| FAM171B | family with sequence similarity 171, member B | -0.21 |
| GABPB2 | GA binding protein transcription factor, beta subunit 2 | -0.21 |
| SLX4 | SLX4 structure-specific endonuclease subunit | -0.21 |
| PPP1R2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | -0.21 |
| CDCA3 | cell division cycle associated 3 | -0.21 |
| ASAP3 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 | -0.21 |
| BCDIN3D | BCDIN3 domain containing | -0.21 |
| MRPL55 | mitochondrial ribosomal protein L55 | -0.21 |
| PIK3CD | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta | -0.21 |
| ST6GALNAC4 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 | -0.21 |
