CA1 Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description carbonic anhydrase I|Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This CA1 gene is closely linked to the CA2 and CA3 genes on chromosome 8. It encodes a cytosolic protein that is found at the highest level in erythrocytes. Allelic variants of this gene have been described in some populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] (NCBI Entrez Gene Database, 759)
External Link https://ncbi.nlm.nih.gov/gene/759
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Genes

498 genes differentially expressed following the CA1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
S100A8 S100 calcium binding protein A8 0.016162
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.0138547
TACSTD2 tumor-associated calcium signal transducer 2 0.0125519
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 0.0122493
CPA3 carboxypeptidase A3 (mast cell) 0.0117873
MAOA monoamine oxidase A 0.0113534
STOM stomatin 0.0112214
NUSAP1 nucleolar and spindle associated protein 1 0.0111982
MMP12 matrix metallopeptidase 12 0.0111809
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.0109135
TRIB2 tribbles pseudokinase 2 0.0107932
FGFR3 fibroblast growth factor receptor 3 0.0104697
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 0.0104024
KRT6A keratin 6A, type II 0.0103888
SRGN serglycin 0.010247
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.0102106
S100A2 S100 calcium binding protein A2 0.0101015
MNDA myeloid cell nuclear differentiation antigen 0.0100963
AQP3 aquaporin 3 (Gill blood group) 0.00995682
CDK14 cyclin-dependent kinase 14 0.00964608
ALCAM activated leukocyte cell adhesion molecule 0.00946823
ZBTB18 zinc finger and BTB domain containing 18 0.00945342
TGM2 transglutaminase 2 0.00917981
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) 0.00913795
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 0.00912061
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.00907387
CSTA cystatin A (stefin A) 0.00899371
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.0089917
KRT13 keratin 13, type I 0.00891377
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 0.00882058
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.00880491
OLFM4 olfactomedin 4 0.00871807
HBB hemoglobin, beta 0.00864204
GCLC glutamate-cysteine ligase, catalytic subunit 0.00837537
S100A9 S100 calcium binding protein A9 0.00835797
LAMP3 lysosomal-associated membrane protein 3 0.00832872
SPRR1B small proline-rich protein 1B 0.00831167
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 0.00819025
PBX1 pre-B-cell leukemia homeobox 1 0.00801865
ENO2 enolase 2 (gamma, neuronal) 0.00801395
CNTN1 contactin 1 0.0080132
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.00795277
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.00784475
SYNE2 spectrin repeat containing, nuclear envelope 2 0.00782943
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 0.00778113
ADAT1 adenosine deaminase, tRNA-specific 1 0.0077429
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 0.00770227
GLUL glutamate-ammonia ligase 0.00765137
FBXO11 F-box protein 11 0.00763384
TAL1 T-cell acute lymphocytic leukemia 1 0.00759649
CDH3 cadherin 3, type 1, P-cadherin (placental) 0.00756209
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.0074728
RRM2 ribonucleotide reductase M2 0.00744053
JAG1 jagged 1 0.00743206
ALOX5 arachidonate 5-lipoxygenase 0.00742869
UNC13B unc-13 homolog B (C. elegans) 0.00736841
AQP9 aquaporin 9 0.00736546
KIF20A kinesin family member 20A 0.00735833
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.00733845
XK X-linked Kx blood group 0.00733076
CD93 CD93 molecule 0.00729582
LYZ lysozyme 0.00727802
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.00727104
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.00722552
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 0.00721462
GCA grancalcin, EF-hand calcium binding protein 0.00719312
CST7 cystatin F (leukocystatin) 0.00716579
SMC2 structural maintenance of chromosomes 2 0.00715064
CAV2 caveolin 2 0.00711356
COPS7A COP9 signalosome subunit 7A 0.00710279
GMCL1 germ cell-less, spermatogenesis associated 1 0.007053
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 0.00703416
RAD23B RAD23 homolog B (S. cerevisiae) 0.00703267
LTA4H leukotriene A4 hydrolase 0.00701457
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 0.00693596
A2M alpha-2-macroglobulin 0.00693492
C1QB complement component 1, q subcomponent, B chain 0.00693209
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.00691644
CD9 CD9 molecule 0.00691219
RHOB ras homolog family member B 0.0068944
FBXW2 F-box and WD repeat domain containing 2 0.00689432
FBP1 fructose-1,6-bisphosphatase 1 0.00687225
ALOX5AP arachidonate 5-lipoxygenase-activating protein 0.0068265
TOP2A topoisomerase (DNA) II alpha 170kDa 0.00682478
AMACR alpha-methylacyl-CoA racemase 0.00682385
LRP4 low density lipoprotein receptor-related protein 4 0.00676543
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.00673705
UBXN7 UBX domain protein 7 0.00671972
VWF von Willebrand factor 0.00671828
CCNA2 cyclin A2 0.00670672
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein 0.00662506
HDAC6 histone deacetylase 6 0.00661785
FERMT1 fermitin family member 1 0.0066016
LBH limb bud and heart development 0.00659115
ERLIN2 ER lipid raft associated 2 0.006573
SORD sorbitol dehydrogenase 0.00655956
SPTBN1 spectrin, beta, non-erythrocytic 1 0.00655859
KRT6B keratin 6B, type II 0.00654207
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 0.00653185
ISCA1 iron-sulfur cluster assembly 1 0.006523
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.00652148
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.00650533
DPY19L1 dpy-19-like 1 (C. elegans) 0.00649835
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.0064968
SPRR3 small proline-rich protein 3 0.00648692
LMNB1 lamin B1 0.00648202
RTN1 reticulon 1 0.00647804
PDZD8 PDZ domain containing 8 0.00647488
MCM6 minichromosome maintenance complex component 6 0.00647356
TNS3 tensin 3 0.00644085
MPO myeloperoxidase 0.00643367
EIF4B eukaryotic translation initiation factor 4B 0.00642463
MKI67 marker of proliferation Ki-67 0.00638383
NES nestin 0.00638016
CAAP1 caspase activity and apoptosis inhibitor 1 0.0063475
APLP2 amyloid beta (A4) precursor-like protein 2 0.00634747
DDR2 discoidin domain receptor tyrosine kinase 2 0.00633099
AKAP7 A kinase (PRKA) anchor protein 7 0.00632321
CPOX coproporphyrinogen oxidase 0.00629171
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.00628957
DUT deoxyuridine triphosphatase 0.00627599
KIF18A kinesin family member 18A 0.00624209
MDM1 Mdm1 nuclear protein homolog (mouse) 0.00621438
SUB1 SUB1 homolog (S. cerevisiae) 0.00619777
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 0.006183
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.00618229
SYBU syntabulin (syntaxin-interacting) 0.00614108
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 0.00614063
PLPBP pyridoxal phosphate binding protein 0.00613475
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.00613036
LMO3 LIM domain only 3 (rhombotin-like 2) 0.00612371
HCLS1 hematopoietic cell-specific Lyn substrate 1 0.00612109
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.00609221
XPO7 exportin 7 0.0060875
R3HDM2 R3H domain containing 2 0.00608579
PSIP1 PC4 and SFRS1 interacting protein 1 0.00608177
CRYBG1 crystallin beta-gamma domain containing 1 0.00608129
AZU1 azurocidin 1 0.00607813
PRF1 perforin 1 (pore forming protein) 0.00606583
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0060624
GOLM1 golgi membrane protein 1 0.00605963
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.00604209
WDR7 WD repeat domain 7 0.00602776
KIAA0226L KIAA0226-like 0.00602776
LAPTM5 lysosomal protein transmembrane 5 0.0060245
PRPS2 phosphoribosyl pyrophosphate synthetase 2 0.00601145
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 0.00600443
NEK2 NIMA-related kinase 2 0.00597753
BRD3 bromodomain containing 3 0.0059775
GATA2 GATA binding protein 2 0.00597142
TSPAN6 tetraspanin 6 0.00596933
FECH ferrochelatase 0.00595317
KAT7 K(lysine) acetyltransferase 7 0.00595018
CNN3 calponin 3, acidic 0.0059476
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.00594694
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 0.00594347
RAPSN receptor-associated protein of the synapse 0.00593476
MTARC2 mitochondrial amidoxime reducing component 2 0.00592745
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.00592227
HLA-DOB major histocompatibility complex, class II, DO beta 0.00592001
KIF11 kinesin family member 11 0.00591786
GPSM2 G-protein signaling modulator 2 0.00591384
GANAB glucosidase, alpha; neutral AB 0.00590962
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 0.00589398
MYB v-myb avian myeloblastosis viral oncogene homolog 0.005873
SLC30A1 solute carrier family 30 (zinc transporter), member 1 0.00586482
PDE8B phosphodiesterase 8B 0.00584686
CANX calnexin 0.0058443
HMGB1 high mobility group box 1 0.00584153
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 0.00582829
GZMK granzyme K (granzyme 3; tryptase II) 0.00582101
PON2 paraoxonase 2 0.00579874
ERG v-ets avian erythroblastosis virus E26 oncogene homolog 0.00579627
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.00579141
CENPE centromere protein E, 312kDa 0.00577945
RRM1 ribonucleotide reductase M1 0.00576202
KIF14 kinesin family member 14 0.00575522
NCAN neurocan 0.00572781
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 0.00572772
METRN meteorin, glial cell differentiation regulator 0.00572214
ADORA2B adenosine A2b receptor 0.00571875
NDC1 NDC1 transmembrane nucleoporin 0.00571824
SDC1 syndecan 1 0.0057141
RCAN1 regulator of calcineurin 1 0.0057126
MLEC malectin 0.0057073
DCAF10 DDB1 and CUL4 associated factor 10 0.00569045
NFIB nuclear factor I/B 0.0056763
TTK TTK protein kinase 0.00566422
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 0.005653
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.00562082
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.00561765
LARS1 leucyl-tRNA synthetase 1 0.00560065
KDM3A lysine (K)-specific demethylase 3A 0.00558513
AK4 adenylate kinase 4 0.0055746
KDM5D lysine (K)-specific demethylase 5D 0.00556367
PLEK pleckstrin 0.00554843
GPD1L glycerol-3-phosphate dehydrogenase 1-like 0.00554032
ACP6 acid phosphatase 6, lysophosphatidic 0.0055318
TYROBP TYRO protein tyrosine kinase binding protein 0.00550703
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 0.00550563
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 0.00548234
CD27 CD27 molecule 0.00547868
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein 0.00547627
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 0.00546918
ZC3H4 zinc finger CCCH-type containing 4 0.00546686
SPARCL1 SPARC-like 1 (hevin) 0.00546624
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 0.00546444
ACP3 acid phosphatase 3 0.00546155
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.00545946
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 0.00545484
FRS2 fibroblast growth factor receptor substrate 2 0.00542433
ADNP2 ADNP homeobox 2 0.00542412
TIMELESS timeless circadian clock 0.00541895
LBR lamin B receptor 0.00539878
NME4 NME/NM23 nucleoside diphosphate kinase 4 0.00539043
SRRM1 serine/arginine repetitive matrix 1 0.00537516
RNF38 ring finger protein 38 0.00536968
TARBP1 TAR (HIV-1) RNA binding protein 1 0.00536662
LGALS13 lectin, galactoside-binding, soluble, 13 0.00536355
CETN2 centrin, EF-hand protein, 2 0.00535326
ELANE elastase, neutrophil expressed 0.00535291
FMO3 flavin containing monooxygenase 3 0.00534858
AGRN agrin 0.0053325
API5 apoptosis inhibitor 5 0.00533056
ITGA6 integrin, alpha 6 0.00532651
KDSR 3-ketodihydrosphingosine reductase 0.00532591
FAM3C family with sequence similarity 3, member C 0.00532556
RWDD3 RWD domain containing 3 0.00532444
IPO7 importin 7 0.00531858
PRTN3 proteinase 3 0.00529905
SFN stratifin 0.00528728
PLTP phospholipid transfer protein 0.0052542
PLEK2 pleckstrin 2 0.00525184
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 0.0052518
DSC2 desmocollin 2 0.00524619
PHB2 prohibitin 2 0.00523922
RPL36 ribosomal protein L36 0.00523478
SDC3 syndecan 3 0.00523328
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.00522838
PATZ1 POZ (BTB) and AT hook containing zinc finger 1 0.00522527
IRF2 interferon regulatory factor 2 0.00522457
RFC3 replication factor C (activator 1) 3, 38kDa 0.00521527
SFTPA2 surfactant protein A2 0.00521206
TSPAN7 tetraspanin 7 0.00520523
AHSP alpha hemoglobin stabilizing protein 0.00520103
FBXO3 F-box protein 3 0.00519519
DIRAS3 DIRAS family, GTP-binding RAS-like 3 0.00519316
SET SET nuclear proto-oncogene 0.00518051
YEATS4 YEATS domain containing 4 0.0051721
ZNF652 zinc finger protein 652 0.00516306

decreased expression

Symbol Name Standardized Value
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 -0.0157314
CRYAB crystallin, alpha B -0.0132133
HSPA1A heat shock 70kDa protein 1A -0.0129481
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.012404
TFPI2 tissue factor pathway inhibitor 2 -0.0116389
ADO 2-aminoethanethiol (cysteamine) dioxygenase -0.011392
RTN2 reticulon 2 -0.0112072
GPX3 glutathione peroxidase 3 -0.0111896
AMDHD2 amidohydrolase domain containing 2 -0.0110335
DCN decorin -0.0110212
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -0.0109554
HSPB8 heat shock 22kDa protein 8 -0.010934
SLC38A1 solute carrier family 38, member 1 -0.0107686
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -0.0107264
SPINK1 serine peptidase inhibitor, Kazal type 1 -0.0106533
TM4SF1 transmembrane 4 L six family member 1 -0.0105608
PDGFRA platelet-derived growth factor receptor, alpha polypeptide -0.0104954
KRT19 keratin 19, type I -0.0104616
GPC3 glypican 3 -0.0104177
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 -0.010349
POSTN periostin, osteoblast specific factor -0.0103449
KLK5 kallikrein-related peptidase 5 -0.010344
SGCE sarcoglycan, epsilon -0.0102258
PROM1 prominin 1 -0.0100181
CLTB clathrin, light chain B -0.00990283
ISG15 ISG15 ubiquitin-like modifier -0.0098856
SCG5 secretogranin V -0.00984474
ETFB electron-transfer-flavoprotein, beta polypeptide -0.00982549
CYBA cytochrome b-245, alpha polypeptide -0.00978876
IFI6 interferon, alpha-inducible protein 6 -0.00974034
AKR1C2 aldo-keto reductase family 1, member C2 -0.00963572
ATF3 activating transcription factor 3 -0.009483
BEX4 brain expressed, X-linked 4 -0.00942225
EGR2 early growth response 2 -0.00930826
MIR22HG MIR22 host gene -0.00916745
ASS1 argininosuccinate synthase 1 -0.00915801
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 -0.00910307
FST follistatin -0.00897227
MMP1 matrix metallopeptidase 1 -0.00895031
AZGP1 alpha-2-glycoprotein 1, zinc-binding -0.00883283
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.00865056
LPIN1 lipin 1 -0.00862351
SLC16A6 solute carrier family 16, member 6 -0.00858723
FABP4 fatty acid binding protein 4, adipocyte -0.00849692
TENT5A terminal nucleotidyltransferase 5A -0.00849157
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.00848863
SNAI2 snail family zinc finger 2 -0.00845532
ADGRG2 adhesion G protein-coupled receptor G2 -0.00836227
RHOBTB3 Rho-related BTB domain containing 3 -0.00835607
PEG10 paternally expressed 10 -0.0083197
KLF6 Kruppel-like factor 6 -0.00829151
ZFPM2 zinc finger protein, FOG family member 2 -0.00824743
SCGB2A1 secretoglobin, family 2A, member 1 -0.00814206
ANGPT1 angiopoietin 1 -0.00811993
RCAN2 regulator of calcineurin 2 -0.00809696
PEG3 paternally expressed 3 -0.00806335
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -0.00803852
MX1 MX dynamin-like GTPase 1 -0.00799479
F2RL1 coagulation factor II (thrombin) receptor-like 1 -0.00798976
SST somatostatin -0.0079559
IFI44 interferon-induced protein 44 -0.00791385
CTSK cathepsin K -0.00791133
S100A4 S100 calcium binding protein A4 -0.00791132
KIAA0125 KIAA0125 -0.00790322
PDE4DIP phosphodiesterase 4D interacting protein -0.00788579
AURKB aurora kinase B -0.00781357
COLEC12 collectin sub-family member 12 -0.0077945
VNN1 vanin 1 -0.00777927
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 -0.00776228
MAGEA3 melanoma antigen family A3 -0.00776068
LUM lumican -0.00775001
DLK1 delta-like 1 homolog (Drosophila) -0.00774832
IER5 immediate early response 5 -0.00764557
HMOX1 heme oxygenase 1 -0.00758791
SNX7 sorting nexin 7 -0.00757205
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 -0.00750534
AFP alpha-fetoprotein -0.00749005
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 -0.00748746
MFAP5 microfibrillar associated protein 5 -0.00743557
GBAP1 glucosidase, beta, acid pseudogene 1 -0.00741416
THBS2 thrombospondin 2 -0.00739567
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) -0.00736766
LIF leukemia inhibitory factor -0.0073289
IFI27 interferon, alpha-inducible protein 27 -0.00731084
POLR2D polymerase (RNA) II (DNA directed) polypeptide D -0.00730738
CCND1 cyclin D1 -0.00729679
SCGB1D2 secretoglobin, family 1D, member 2 -0.00726824
DDIT3 DNA-damage-inducible transcript 3 -0.00723372
STK10 serine/threonine kinase 10 -0.00722585
NUPR1 nuclear protein, transcriptional regulator, 1 -0.00722009
TNNC1 troponin C type 1 (slow) -0.00721468
TNNI2 troponin I type 2 (skeletal, fast) -0.00721285
CKM creatine kinase, muscle -0.00721041
PLAAT3 phospholipase A and acyltransferase 3 -0.00720273
COL9A3 collagen, type IX, alpha 3 -0.00720187
PIEZO2 piezo-type mechanosensitive ion channel component 2 -0.00718848
DYNLL1 dynein, light chain, LC8-type 1 -0.00715582
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 -0.00714539
CLEC2B C-type lectin domain family 2, member B -0.00706772
ELF4 E74-like factor 4 (ets domain transcription factor) -0.00704021
APOD apolipoprotein D -0.00702942
IFRD1 interferon-related developmental regulator 1 -0.0070294
CHGB chromogranin B -0.00702562
ECM1 extracellular matrix protein 1 -0.0070058
PPIF peptidylprolyl isomerase F -0.00699752
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding) -0.00699425
AKR1C1 aldo-keto reductase family 1, member C1 -0.00697991
NSG1 neuron specific gene family member 1 -0.00694737
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.00691225
RRAGD Ras-related GTP binding D -0.00687318
MB myoglobin -0.00678593
STAP2 signal transducing adaptor family member 2 -0.00677144
TENM3 teneurin transmembrane protein 3 -0.00675081
QPRT quinolinate phosphoribosyltransferase -0.00674139
PCOLCE procollagen C-endopeptidase enhancer -0.00672686
ACTA1 actin, alpha 1, skeletal muscle -0.00670258
FTH1 ferritin, heavy polypeptide 1 -0.0067009
TMPRSS4 transmembrane protease, serine 4 -0.00668019
TSPAN8 tetraspanin 8 -0.00665756
PTP4A3 protein tyrosine phosphatase type IVA, member 3 -0.00664835
FBLN5 fibulin 5 -0.00663399
TFF2 trefoil factor 2 -0.00663116
MAP7 microtubule-associated protein 7 -0.00662892
LY6E lymphocyte antigen 6 complex, locus E -0.00659454
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -0.00658366
FOLR1 folate receptor 1 (adult) -0.00654183
PFKP phosphofructokinase, platelet -0.0065279
LGALS1 lectin, galactoside-binding, soluble, 1 -0.00650142
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.00648816
CD36 CD36 molecule (thrombospondin receptor) -0.00647591
JMJD6 jumonji domain containing 6 -0.00647498
AKAP12 A kinase (PRKA) anchor protein 12 -0.00647469
GSTM3 glutathione S-transferase mu 3 (brain) -0.0064576
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 -0.00645241
PDGFRL platelet-derived growth factor receptor-like -0.00645018
JAM3 junctional adhesion molecule 3 -0.00644819
LRRC15 leucine rich repeat containing 15 -0.0063888
PDLIM5 PDZ and LIM domain 5 -0.00633461
WASL Wiskott-Aldrich syndrome-like -0.00632645
NVL nuclear VCP-like -0.00630049
CDA cytidine deaminase -0.00629346
PMP22 peripheral myelin protein 22 -0.0062737
SCGN secretagogin, EF-hand calcium binding protein -0.00626786
LAMA2 laminin, alpha 2 -0.00625313
KRT23 keratin 23, type I -0.00625
TNNI1 troponin I type 1 (skeletal, slow) -0.00621417
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -0.00621027
GPX7 glutathione peroxidase 7 -0.00618904
TIMP3 TIMP metallopeptidase inhibitor 3 -0.00618058
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle -0.00616279
L1CAM L1 cell adhesion molecule -0.00615589
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 -0.00611929
ANK2 ankyrin 2, neuronal -0.00611286
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0061036
ALDOA aldolase A, fructose-bisphosphate -0.00607758
CREM cAMP responsive element modulator -0.00607733
FN1 fibronectin 1 -0.00605902
WTAP Wilms tumor 1 associated protein -0.00605075
BANP BTG3 associated nuclear protein -0.00604004
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 -0.00603916
CCL2 chemokine (C-C motif) ligand 2 -0.00602964
CGA glycoprotein hormones, alpha polypeptide -0.00601541
GNG11 guanine nucleotide binding protein (G protein), gamma 11 -0.00600343
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.00600287
CXCL12 chemokine (C-X-C motif) ligand 12 -0.00597728
NRCAM neuronal cell adhesion molecule -0.00597289
SLPI secretory leukocyte peptidase inhibitor -0.00596513
BTF3P11 basic transcription factor 3 pseudogene 11 -0.00596207
SQSTM1 sequestosome 1 -0.00596053
CALML5 calmodulin-like 5 -0.00595769
MFAP2 microfibrillar-associated protein 2 -0.00594758
CALCA calcitonin-related polypeptide alpha -0.00592002
ANGPTL2 angiopoietin-like 2 -0.00591705
CNPY3 canopy FGF signaling regulator 3 -0.00591521
MLPH melanophilin -0.00591207
TUBA4A tubulin, alpha 4a -0.00588831
TIMP2 TIMP metallopeptidase inhibitor 2 -0.00588802
PHLDA2 pleckstrin homology-like domain, family A, member 2 -0.00588621
APOB apolipoprotein B -0.00585502
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) -0.00585116
IGFBP6 insulin-like growth factor binding protein 6 -0.00583709
UPP1 uridine phosphorylase 1 -0.00583588
CHKA choline kinase alpha -0.00583551
CLDN3 claudin 3 -0.00583297
MYOT myotilin -0.00582597
TWIST1 twist family bHLH transcription factor 1 -0.00582407
PDZRN3 PDZ domain containing ring finger 3 -0.00581915
KLK11 kallikrein-related peptidase 11 -0.00581143
PLK2 polo-like kinase 2 -0.00579705
COL14A1 collagen, type XIV, alpha 1 -0.00577781
QPCT glutaminyl-peptide cyclotransferase -0.00577393
SH3TC1 SH3 domain and tetratricopeptide repeats 1 -0.00576947
EVI2A ecotropic viral integration site 2A -0.00576596
INA internexin neuronal intermediate filament protein, alpha -0.00576385
PYCARD PYD and CARD domain containing -0.00575274
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.00575216
NYNRIN NYN domain and retroviral integrase containing -0.00574992
ZIC1 Zic family member 1 -0.00574908
CHP1 calcineurin-like EF-hand protein 1 -0.00574723
IL1R1 interleukin 1 receptor, type I -0.00574164
CD7 CD7 molecule -0.00573921
HSPA6 heat shock 70kDa protein 6 (HSP70B') -0.0057383
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.00573722
KLHL41 kelch-like family member 41 -0.00572168
XIC X chromosome inactivation center -0.00571098
PLK3 polo-like kinase 3 -0.00570206
PERP PERP, TP53 apoptosis effector -0.00570189
AP1M2 adaptor-related protein complex 1, mu 2 subunit -0.0056935
CASP10 caspase 10, apoptosis-related cysteine peptidase -0.00569308
TNNT1 troponin T type 1 (skeletal, slow) -0.00569279
G0S2 G0/G1 switch 2 -0.00568701
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 -0.0056851
MYRF myelin regulatory factor -0.00568388
LGALS2 lectin, galactoside-binding, soluble, 2 -0.00567961
TNNT3 troponin T type 3 (skeletal, fast) -0.00566904
DEFB1 defensin, beta 1 -0.00566271
GSN gelsolin -0.00565457
ADIPOQ adiponectin, C1Q and collagen domain containing -0.00565217
NXN nucleoredoxin -0.00563794
MAPK6 mitogen-activated protein kinase 6 -0.0056369
GCG glucagon -0.00563333
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 -0.00562736
TNNC2 troponin C type 2 (fast) -0.00561844
HAS2 hyaluronan synthase 2 -0.00561645
RELN reelin -0.0056162
MYL2 myosin, light chain 2, regulatory, cardiac, slow -0.00561362
KLF4 Kruppel-like factor 4 (gut) -0.00560836
CLEC3B C-type lectin domain family 3, member B -0.00559996
COL6A3 collagen, type VI, alpha 3 -0.0055867
LMNA lamin A/C -0.00558208
LYPD1 LY6/PLAUR domain containing 1 -0.00557428
CEL carboxyl ester lipase -0.00557315
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28 -0.00556897
ARMCX6 armadillo repeat containing, X-linked 6 -0.00556827
CCNE1 cyclin E1 -0.00553558
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -0.00552685
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) -0.00552236
CFH complement factor H -0.00550245
ZNHIT1 zinc finger, HIT-type containing 1 -0.00549579
IFI35 interferon-induced protein 35 -0.00549292
CCL8 chemokine (C-C motif) ligand 8 -0.00548415
CRIP1 cysteine-rich protein 1 (intestinal) -0.00548098
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa -0.00547985
HACD1 3-hydroxyacyl-CoA dehydratase 1 -0.00547658
PLLP plasmolipin -0.00546704
EPS8L1 EPS8-like 1 -0.00546453
IL6 interleukin 6 -0.00546061
APOA1 apolipoprotein A-I -0.00545488