CA2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description carbonic anhydrase II|The protein encoded by this gene is one of several isozymes of carbonic anhydrase, which catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014] (NCBI Entrez Gene Database, 760)
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Genes

338 genes differentially expressed following the CA2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
AMDHD1 amidohydrolase domain containing 1 2.89778
TLE2 transducin-like enhancer of split 2 2.89778
PKD1L1 polycystic kidney disease 1 like 1 2.89778
MEDAG mesenteric estrogen-dependent adipogenesis 2.89778
SAXO5 stabilizer of axonemal microtubules 5 2.89778
SPATA22 spermatogenesis associated 22 2.89778
LYG2 lysozyme G-like 2 2.89778
NDP Norrie disease (pseudoglioma) 2.89778
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.88714
COL9A2 collagen, type IX, alpha 2 2.88714
PRSS21 protease, serine, 21 (testisin) 2.88714
BTC betacellulin 2.88714
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 2.88714
GREP1 glycine rich extracellular protein 1 2.88714
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.88714
CYGB cytoglobin 2.88714
MEIS1 Meis homeobox 1 2.88714
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 2.88714
GSTT4 glutathione S-transferase theta 4 2.88714
UNC13C unc-13 homolog C (C. elegans) 2.84846
GPRC5D G protein-coupled receptor, class C, group 5, member D 2.84846
CAPNS2 calpain, small subunit 2 2.84846
FABP1 fatty acid binding protein 1, liver 2.84846
PCDHB7 protocadherin beta 7 2.84846
DEGS2 delta(4)-desaturase, sphingolipid 2 2.84846
KNG1 kininogen 1 2.84846
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.84846
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 2.84846
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.84846
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 2.84846
TMEM176A transmembrane protein 176A 2.84846
GPR52 G protein-coupled receptor 52 2.84846
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 2.84846
SCN2B sodium channel, voltage gated, type II beta subunit 2.84846
STKLD1 serine/threonine kinase-like domain containing 1 2.84846
CLEC19A C-type lectin domain family 19, member A 2.84846
GMFG glia maturation factor, gamma 2.84846
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.84846
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.84846
CPB2 carboxypeptidase B2 (plasma) 2.84846
MPO myeloperoxidase 2.84846
CPLX1 complexin 1 2.84846
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 2.84846
NMUR1 neuromedin U receptor 1 2.84846
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 2.84846
TDRD9 tudor domain containing 9 2.84846
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 2.84846
OR10A3 olfactory receptor, family 10, subfamily A, member 3 2.84846
FOXR1 forkhead box R1 2.84846
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 2.84846
GRP gastrin-releasing peptide 2.84846
PAX6 paired box 6 2.84846
MANSC4 MANSC domain containing 4 2.84846
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.84846
GPR22 G protein-coupled receptor 22 2.84846
PTGFR prostaglandin F receptor (FP) 2.84846
PMCH pro-melanin-concentrating hormone 2.84846
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 2.84846
ITK IL2-inducible T-cell kinase 2.84846
CLDN16 claudin 16 2.84846
CCER2 coiled-coil glutamate-rich protein 2 2.84846
MYH1 myosin, heavy chain 1, skeletal muscle, adult 2.84846
CXCL13 chemokine (C-X-C motif) ligand 13 2.84846
OTOR otoraplin 2.84846
FIMP1 fertilization-influencing membrane protein 1 2.84846
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 2.84846
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.84846
IQCF1 IQ motif containing F1 2.84846
OPRM1 opioid receptor, mu 1 2.84846
ROPN1B rhophilin associated tail protein 1B 2.84846
H3-5 H3.5 histone 2.84846
SPMIP10 sperm microtubule inner protein 10 2.84846
THSD8 thrombospondin type 1 domain containing 8 2.84846
H4C15 H4 clustered histone 15 2.84846
ACP7 acid phosphatase 7, tartrate resistant (putative) 2.84846
MYMK myomaker, myoblast fusion factor 2.84846
GLYATL1B glycine-N-acyltransferase like 1B 2.84846
TENT5D terminal nucleotidyltransferase 5D 2.84846
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.84846
ANGPTL8 angiopoietin like 8 2.84846
ADRB1 adrenoceptor beta 1 2.84846
OR52E4 olfactory receptor, family 52, subfamily E, member 4 2.84846
MIA melanoma inhibitory activity 2.84846
TMEM235 transmembrane protein 235 2.84846
MEOX2 mesenchyme homeobox 2 2.84846
CKM creatine kinase, muscle 2.84846
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.84846
SLC35D3 solute carrier family 35, member D3 2.84846
HHEX hematopoietically expressed homeobox 2.84846
HBA2 hemoglobin, alpha 2 2.84846
CFL1 cofilin 1 (non-muscle) 2.84846
CCR3 chemokine (C-C motif) receptor 3 2.84846
SASH3 SAM and SH3 domain containing 3 2.84846
SAA4 serum amyloid A4, constitutive 2.84846
C4ORF50 chromosome 4 open reading frame 50 2.84846
MROH5 maestro heat-like repeat family member 5 2.84846
PRG4 proteoglycan 4 2.84846
ARMC12 armadillo repeat containing 12 2.84846
FMR1NB fragile X mental retardation 1 neighbor 2.84846
STARD6 StAR-related lipid transfer (START) domain containing 6 2.84846
SAMD11 sterile alpha motif domain containing 11 2.84846
PTH parathyroid hormone 2.84846
PGA5 pepsinogen 5, group I (pepsinogen A) 2.84846
CST11 cystatin 11 2.84846
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 2.84846
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 2.84846
PRM1 protamine 1 2.84846
GOLGA6A golgin A6 family, member A 2.84846
CALHM3 calcium homeostasis modulator 3 2.84846
PKDREJ polycystin (PKD) family receptor for egg jelly 2.84846
NPBWR1 neuropeptides B/W receptor 1 2.84846
APOC2 apolipoprotein C-II 2.84846
MAB21L2 mab-21-like 2 (C. elegans) 2.84846
MAB21L1 mab-21-like 1 (C. elegans) 2.84846
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 2.84846
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.84846
CYSLTR1 cysteinyl leukotriene receptor 1 2.84846
MPZL2 myelin protein zero-like 2 2.84846
STAB1 stabilin 1 2.84846
LRRC46 leucine rich repeat containing 46 2.84846
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.84846
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.84846
NLRC3 NLR family, CARD domain containing 3 2.84846
LDLRAD3 low density lipoprotein receptor class A domain containing 3 2.84846
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 2.84846
THTPA thiamine triphosphatase 2.84846
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.84846
IL19 interleukin 19 2.84846
IL1B interleukin 1, beta 2.84846
PGR progesterone receptor 2.84846
DCT dopachrome tautomerase 2.84846
NYX nyctalopin 2.84846
CNR2 cannabinoid receptor 2 (macrophage) 2.84846
GBX2 gastrulation brain homeobox 2 2.84846
DENND2D DENN/MADD domain containing 2D 2.84846
CLEC18B C-type lectin domain family 18, member B 2.84846
CLEC18A C-type lectin domain family 18, member A 2.84846
GJC2 gap junction protein, gamma 2, 47kDa 2.84846
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 2.84846
SYNGR4 synaptogyrin 4 2.84846
NTN5 netrin 5 2.84846
PRDM9 PR domain containing 9 2.84846
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 2.84846
ZNF596 zinc finger protein 596 2.84846
ITGA10 integrin, alpha 10 2.84846
CT55 cancer/testis antigen 55 2.84846
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 2.84846
TF transferrin 2.84846
AMN amnion associated transmembrane protein 2.84846
DMRT1 doublesex and mab-3 related transcription factor 1 2.84846
SPHKAP SPHK1 interactor, AKAP domain containing 2.84846
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 2.84846
WFDC8 WAP four-disulfide core domain 8 2.84846
ANKRD30B ankyrin repeat domain 30B 2.84846
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 2.84846
TMPRSS12 transmembrane (C-terminal) protease, serine 12 2.84846
RBP4 retinol binding protein 4, plasma 2.84846
PRAP1 proline-rich acidic protein 1 2.84846
POTEI POTE ankyrin domain family, member I 2.84846
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 2.84846
PRRX1 paired related homeobox 1 2.84846
DSPP dentin sialophosphoprotein 2.84846
C5AR2 complement component 5a receptor 2 2.84846
ADRA1B adrenoceptor alpha 1B 2.84846
TGM6 transglutaminase 6 2.84846
CD33 CD33 molecule 2.84846
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 2.84846
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 2.84846
ASCL5 achaete-scute family bHLH transcription factor 5 2.84846
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 2.84846
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 2.84846
ANGPTL3 angiopoietin-like 3 2.84846
PADI1 peptidyl arginine deiminase, type I 2.84846
TGM7 transglutaminase 7 2.84846
LIMS3 LIM and senescent cell antigen-like domains 3 2.84846
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.84846
FGF7 fibroblast growth factor 7 2.84846
ALOX5AP arachidonate 5-lipoxygenase-activating protein 2.84846
TMPRSS15 transmembrane protease, serine 15 2.84846
DBX2 developing brain homeobox 2 2.84846
PDCD1 programmed cell death 1 2.84846
IER5L immediate early response 5-like 2.84846
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 2.84846
C9ORF50 chromosome 9 open reading frame 50 2.84846
ZFAND2B zinc finger, AN1-type domain 2B 2.83521
BEST2 bestrophin 2 2.70347
CCNJL cyclin J-like 2.55918
ANAPC16 anaphase promoting complex subunit 16 2.52629
PDS5A PDS5 cohesin associated factor A 2.50631
TMEM126B transmembrane protein 126B 2.47587
ZWINT ZW10 interacting kinetochore protein 2.47117
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 2.42802
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 2.3921
CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 2.38948
OSBP oxysterol binding protein 2.37732
MYL11 myosin light chain 11 2.36199
NRBP2 nuclear receptor binding protein 2 2.36199
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 2.33901
NFAM1 NFAT activating protein with ITAM motif 1 2.33901
FOXN3 forkhead box N3 2.33901
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 2.33102
SNX11 sorting nexin 11 2.32892
LMAN2 lectin, mannose-binding 2 2.32892
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 2.32892
CLIC5 chloride intracellular channel 5 2.32892
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 2.32892
PCDHA6 protocadherin alpha 6 2.32198
MEGF9 multiple EGF-like-domains 9 2.31619
ASCL2 achaete-scute family bHLH transcription factor 2 2.30906
LAMB3 laminin, beta 3 2.30906
NAPSA napsin A aspartic peptidase 2.30906
OSBPL6 oxysterol binding protein-like 6 2.29222
METTL13 methyltransferase like 13 2.26267
MRPL41 mitochondrial ribosomal protein L41 2.24292
TOM1 target of myb1 (chicken) 2.19212
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 2.18759
ATE1 arginyltransferase 1 2.15544
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 2.15276
MBNL1 muscleblind-like splicing regulator 1 2.15248
ITGA1 integrin, alpha 1 2.14129
STAC SH3 and cysteine rich domain 2.13514
FANCA Fanconi anemia, complementation group A 2.1229
LEMD2 LEM domain containing 2 2.11972
TRMT9B tRNA methyltransferase 9B (putative) 2.11972
PCLAF PCNA clamp associated factor 2.10242
SPATA33 spermatogenesis associated 33 2.05353
P4HB prolyl 4-hydroxylase, beta polypeptide 2.03188
DGCR8 DGCR8 microprocessor complex subunit 2.02091
TSPAN15 tetraspanin 15 2.01538
FCGRT Fc fragment of IgG, receptor, transporter, alpha 2.01031
NEBL nebulette 2.00289

decreased expression

Symbol Name Standardized Value
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 -2.89778
NDNF neuron-derived neurotrophic factor -2.88714
ZNF841 zinc finger protein 841 -2.88714
ADM5 adrenomedullin 5 (putative) -2.88714
TSGA10IP testis specific, 10 interacting protein -2.88714
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -2.88714
CORT cortistatin -2.88714
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) -2.88714
ESR1 estrogen receptor 1 -2.84846
SHE Src homology 2 domain containing E -2.84846
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 -2.84846
LMNTD1 lamin tail domain containing 1 -2.84846
TNS2 tensin 2 -2.84846
IL17REL interleukin 17 receptor E-like -2.84846
SGCZ sarcoglycan, zeta -2.84846
TUBB1 tubulin, beta 1 class VI -2.84846
FCMR Fc fragment of IgM receptor -2.84846
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 -2.84846
ZBTB12 zinc finger and BTB domain containing 12 -2.84846
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 -2.84846
HPCAL4 hippocalcin like 4 -2.84846
RNASEH1 ribonuclease H1 -2.84846
USF2 upstream transcription factor 2, c-fos interacting -2.84846
LRRC55 leucine rich repeat containing 55 -2.84846
AMBP alpha-1-microglobulin/bikunin precursor -2.84846
OLFM3 olfactomedin 3 -2.84846
SEMG1 semenogelin I -2.84846
SNX31 sorting nexin 31 -2.84846
PTGR1 prostaglandin reductase 1 -2.84846
CCDC9B coiled-coil domain containing 9B -2.84846
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 -2.84846
PCDHGA4 protocadherin gamma subfamily A, 4 -2.84846
EGR2 early growth response 2 -2.84846
SFRP4 secreted frizzled-related protein 4 -2.84846
RASL11A RAS-like, family 11, member A -2.84846
TNNI3K TNNI3 interacting kinase -2.84846
OPTC opticin -2.84846
ADAM7 ADAM metallopeptidase domain 7 -2.84846
SCT secretin -2.84846
DPH1 diphthamide biosynthesis 1 -2.84846
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -2.82154
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae) -2.79688
CCDC181 coiled-coil domain containing 181 -2.7878
NLRP7 NLR family, pyrin domain containing 7 -2.63339
INSM1 insulinoma-associated 1 -2.63339
IPO13 importin 13 -2.61876
PNMA6A paraneoplastic Ma antigen family member 6A -2.57186
ENTREP3 endosomal transmembrane epsin interactor 3 -2.566
CADM2 cell adhesion molecule 2 -2.51615
GIGYF1 GRB10 interacting GYF protein 1 -2.47587
TMEM33 transmembrane protein 33 -2.47587
AHSP alpha hemoglobin stabilizing protein -2.46193
CC2D2B coiled-coil and C2 domain containing 2B -2.43506
POPDC3 popeye domain containing 3 -2.43506
CREB3L4 cAMP responsive element binding protein 3-like 4 -2.4009
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) -2.32914
MTMR1 myotubularin related protein 1 -2.32703
ELMO2 engulfment and cell motility 2 -2.32198
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -2.31619
MRPL18 mitochondrial ribosomal protein L18 -2.29467
LRRC47 leucine rich repeat containing 47 -2.28884
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 -2.28718
KCTD11 potassium channel tetramerization domain containing 11 -2.26859
MATN3 matrilin 3 -2.26726
C4ORF51 chromosome 4 open reading frame 51 -2.26267
H3C2 H3 clustered histone 2 -2.26267
STARD3 StAR-related lipid transfer (START) domain containing 3 -2.26267
IL17RC interleukin 17 receptor C -2.26267
F8A1 coagulation factor VIII-associated 1 -2.26267
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -2.26267
STOM stomatin -2.26231
ANKEF1 ankyrin repeat and EF-hand domain containing 1 -2.23806
DHX33 DEAH (Asp-Glu-Ala-His) box polypeptide 33 -2.22828
TONSL tonsoku-like, DNA repair protein -2.22773
BZW1 basic leucine zipper and W2 domains 1 -2.22773
RHOG ras homolog family member G -2.19412
SMG8 SMG8 nonsense mediated mRNA decay factor -2.19412
PANK1 pantothenate kinase 1 -2.18759
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 -2.17358
NACAD NAC alpha domain containing -2.17358
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -2.17358
FRMD1 FERM domain containing 1 -2.17358
SLCO2A1 solute carrier organic anion transporter family, member 2A1 -2.15544
TMEM165 transmembrane protein 165 -2.15276
DBNL drebrin-like -2.15276
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa -2.15248
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -2.14432
C11ORF68 chromosome 11 open reading frame 68 -2.13029
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25 -2.13029
USP53 ubiquitin specific peptidase 53 -2.09937
TRDN triadin -2.09579
ISOC1 isochorismatase domain containing 1 -2.05365
CCDC159 coiled-coil domain containing 159 -2.03727
MBOAT2 membrane bound O-acyltransferase domain containing 2 -2.03727
BAIAP2L2 BAI1-associated protein 2-like 2 -2.03727
FER1L6 fer-1-like family member 6 -2.03727
SLX9 SLX9 ribosome biogenesis factor -2.03727
C6ORF52 chromosome 6 open reading frame 52 -2.03727
ACSS3 acyl-CoA synthetase short-chain family member 3 -2.03727
FGF23 fibroblast growth factor 23 -2.03727
WFDC3 WAP four-disulfide core domain 3 -2.03727
ESYT2 extended synaptotagmin-like protein 2 -2.02711
ERV3-1-ZNF117 ERV3-1-ZNF117 readthrough -2.02711
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -2.02091
UNC80 unc-80 homolog (C. elegans) -2.01188
SULT4A1 sulfotransferase family 4A, member 1 -2.01188
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) -2.01031