| Dataset | GO Molecular Function Annotations 2025 |
| Category | structural or functional annotations |
| Type | molecular function |
| Description | Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families. (Gene Ontology, GO_0004662) |
| External Link | http://amigo.geneontology.org/amigo/term/GO:0004662 |
| Similar Terms | |
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2 genes performing the CAAX-protein geranylgeranyltransferase activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.
