CACNA1A Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description calcium channel, voltage-dependent, P/Q type, alpha 1A subunit|Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to (CAG)n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the (CAG)n-repeats occur in the 3' UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-16 to 21-28 in the coding region is associated with spinocerebellar ataxia 6. [provided by RefSeq, Mar 2010] (NCBI Entrez Gene Database, 773)
External Link http://www.ncbi.nlm.nih.gov/gene/773
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276 interacting proteins for CACNA1A from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABI1 abl-interactor 1
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTN1 actinin, alpha 1
ACTN2 actinin, alpha 2
ACTN3 actinin, alpha 3 (gene/pseudogene)
ADGRL1 adhesion G protein-coupled receptor L1
AGRN agrin
AKAP9 A kinase (PRKA) anchor protein 9
ALDOA aldolase A, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
AP2M1 adaptor-related protein complex 2, mu 1 subunit
ARHGAP22 Rho GTPase activating protein 22
ARHGAP35 Rho GTPase activating protein 35
ARID1A AT rich interactive domain 1A (SWI-like)
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASNA1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
ATF7 activating transcription factor 7
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL6 B-cell CLL/lymphoma 6
BTG3 BTG family, member 3
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1
C1QTNF1 C1q and tumor necrosis factor related protein 1
CABP1 calcium binding protein 1
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CKAP5 cytoskeleton associated protein 5
CNGA1 cyclic nucleotide gated channel alpha 1
CNGB1 cyclic nucleotide gated channel beta 1
CPLX1 complexin 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRMP1 collapsin response mediator protein 1
CSMD1 CUB and Sushi multiple domains 1
CSNK2B casein kinase 2, beta polypeptide
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DES desmin
DLG4 discs, large homolog 4 (Drosophila)
DMD dystrophin
DNAH9 dynein, axonemal, heavy chain 9
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DROSHA drosha, ribonuclease type III
E2F3 E2F transcription factor 3
EBF1 early B-cell factor 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EHMT2 euchromatic histone-lysine N-methyltransferase 2
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF3A eukaryotic translation initiation factor 3, subunit A
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
ELF1 E74-like factor 1 (ets domain transcription factor)
EPHB6 EPH receptor B6
ERCC5 excision repair cross-complementation group 5
FBLN1 fibulin 1
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4
GNG10 guanine nucleotide binding protein (G protein), gamma 10
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNG5 guanine nucleotide binding protein (G protein), gamma 5
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GNG8 guanine nucleotide binding protein (G protein), gamma 8
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
GRN granulin
HDAC4 histone deacetylase 4
HDAC5 histone deacetylase 5
HDAC9 histone deacetylase 9
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HELZ2 helicase with zinc finger 2, transcriptional coactivator
HHATL hedgehog acyltransferase-like
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HNF1A HNF1 homeobox A
HSF4 heat shock transcription factor 4
HSPG2 heparan sulfate proteoglycan 2
IDI2 isopentenyl-diphosphate delta isomerase 2
IP6K1 inositol hexakisphosphate kinase 1
ITGA1 integrin, alpha 1
ITGB5 integrin, beta 5
JAG2 jagged 2
KALRN kalirin, RhoGEF kinase
KDM2A lysine (K)-specific demethylase 2A
KDM5B lysine (K)-specific demethylase 5B
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIAA1191 KIAA1191
KIF13B kinesin family member 13B
KLHL1 kelch-like family member 1
KMT2B lysine (K)-specific methyltransferase 2B
LAMB1 laminin, beta 1
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LMOD1 leiomodin 1 (smooth muscle)
LPAR2 lysophosphatidic acid receptor 2
LPAR4 lysophosphatidic acid receptor 4
LRP1 low density lipoprotein receptor-related protein 1
LSM1 LSM1, U6 small nuclear RNA associated
LTBP1 latent transforming growth factor beta binding protein 1
LTBP3 latent transforming growth factor beta binding protein 3
LTBP4 latent transforming growth factor beta binding protein 4
MANBAL mannosidase, beta A, lysosomal-like
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MATK megakaryocyte-associated tyrosine kinase
MATN2 matrilin 2
MED23 mediator complex subunit 23
MEGF6 multiple EGF-like-domains 6
MEGF8 multiple EGF-like-domains 8
MIA3 melanoma inhibitory activity family, member 3
MOAP1 modulator of apoptosis 1
MTMR6 myotubularin related protein 6
MYBPC1 myosin binding protein C, slow type
MYBPC2 myosin binding protein C, fast type
MYBPC3 myosin binding protein C, cardiac
MYH11 myosin, heavy chain 11, smooth muscle
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic
MYH6 myosin, heavy chain 6, cardiac muscle, alpha
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal
MYL1 myosin, light chain 1, alkali; skeletal, fast
MYL12B myosin, light chain 12B, regulatory
MYL2 myosin, light chain 2, regulatory, cardiac, slow
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
MYL9 myosin, light chain 9, regulatory
NCOR2 nuclear receptor corepressor 2
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
NEB nebulin
NEFL neurofilament, light polypeptide
NELFCD negative elongation factor complex member C/D
NELL1 NEL-like 1 (chicken)
NELL2 NEL-like 2 (chicken)
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NKRF NFKB repressing factor
NOTCH1 notch 1
NOXA1 NADPH oxidase activator 1
OLA1 Obg-like ATPase 1
OLIG1 oligodendrocyte transcription factor 1
OSBPL1A oxysterol binding protein-like 1A
PANX3 pannexin 3
PARP12 poly (ADP-ribose) polymerase family, member 12
PCDH9 protocadherin 9
PCSK5 proprotein convertase subtilisin/kexin type 5
PCSK6 proprotein convertase subtilisin/kexin type 6
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PMM1 phosphomannomutase 1
POU2F3 POU class 2 homeobox 3
PPAP2B phosphatidic acid phosphatase type 2B
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PPIG peptidylprolyl isomerase G (cyclophilin G)
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PPP1R12C protein phosphatase 1, regulatory subunit 12C
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCG protein kinase C, gamma
PRKCH protein kinase C, eta
PRKCI protein kinase C, iota
PRKCQ protein kinase C, theta
PRKCZ protein kinase C, zeta
PRKX protein kinase, X-linked
PTGDS prostaglandin D2 synthase 21kDa (brain)
PUF60 poly-U binding splicing factor 60KDa
PXN paxillin
PYGB phosphorylase, glycogen; brain
PYGL phosphorylase, glycogen, liver
PYGM phosphorylase, glycogen, muscle
RAB3A RAB3A, member RAS oncogene family
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RASGRP4 RAS guanyl releasing protein 4
RBM12B RNA binding motif protein 12B
RHO rhodopsin
RIMBP2 RIMS binding protein 2
RIMS1 regulating synaptic membrane exocytosis 1
RPL31 ribosomal protein L31
RPS17 ribosomal protein S17
SAE1 SUMO1 activating enzyme subunit 1
SCP2 sterol carrier protein 2
SENP7 SUMO1/sentrin specific peptidase 7
SIN3A SIN3 transcription regulator family member A
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SMO smoothened, frizzled class receptor
SNAP25 synaptosomal-associated protein, 25kDa
SORBS1 sorbin and SH3 domain containing 1
SORBS3 sorbin and SH3 domain containing 3
SPEN spen family transcriptional repressor
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRRM4 serine/arginine repetitive matrix 4
SRSF1 serine/arginine-rich splicing factor 1
STX1A syntaxin 1A (brain)
STXBP1 syntaxin binding protein 1
SUMF2 sulfatase modifying factor 2
SYT1 synaptotagmin I
SYT5 synaptotagmin V
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCAP titin-cap
TELO2 telomere maintenance 2
TLN1 talin 1
TMOD1 tropomodulin 1
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNNC1 troponin C type 1 (slow)
TNNC2 troponin C type 2 (fast)
TNNI1 troponin I type 1 (skeletal, slow)
TNNI2 troponin I type 2 (skeletal, fast)
TNNI3 troponin I type 3 (cardiac)
TNNT1 troponin T type 1 (skeletal, slow)
TNNT2 troponin T type 2 (cardiac)
TNNT3 troponin T type 3 (skeletal, fast)
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TPM3 tropomyosin 3
TPM4 tropomyosin 4
TRAF3IP3 TRAF3 interacting protein 3
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSPAN7 tetraspanin 7
TTN titin
TUBB2B tubulin, beta 2B class IIb
UBC ubiquitin C
UNC13B unc-13 homolog B (C. elegans)
UQCRC2 ubiquinol-cytochrome c reductase core protein II
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast)
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VARS valyl-tRNA synthetase
VCL vinculin
VIM vimentin
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae)
VWF von Willebrand factor
WBP1 WW domain binding protein 1
WDR35 WD repeat domain 35
WNK4 WNK lysine deficient protein kinase 4
WNT16 wingless-type MMTV integration site family, member 16
YLPM1 YLP motif containing 1
YY1 YY1 transcription factor
ZCCHC17 zinc finger, CCHC domain containing 17
ZMYND8 zinc finger, MYND-type containing 8
ZNF233 zinc finger protein 233
ZNF443 zinc finger protein 443