CAD Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase|The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015] (NCBI Entrez Gene Database, 790)
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Genes

330 genes differentially expressed following the CAD gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CD6 CD6 molecule 3.77648
CEP295NL CEP295 N-terminal like 3.77648
SIGLEC5 sialic acid binding Ig-like lectin 5 3.77648
ASB12 ankyrin repeat and SOCS box containing 12 3.77648
GPR26 G protein-coupled receptor 26 3.77648
GPR20 G protein-coupled receptor 20 3.77648
GPR22 G protein-coupled receptor 22 3.77648
SFTPB surfactant protein B 3.77648
GNAT3 guanine nucleotide binding protein, alpha transducing 3 3.77648
C1ORF146 chromosome 1 open reading frame 146 3.77648
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 3.77648
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 3.77648
OLIG3 oligodendrocyte transcription factor 3 3.77648
INHBB inhibin, beta B 3.77648
SPINK4 serine peptidase inhibitor, Kazal type 4 3.77648
TMEM176A transmembrane protein 176A 3.77648
CAMP cathelicidin antimicrobial peptide 3.77648
MAGEA6 melanoma antigen family A6 3.77648
FOXA2 forkhead box A2 3.77648
SOX18 SRY (sex determining region Y)-box 18 3.77648
GJB5 gap junction protein, beta 5, 31.1kDa 3.77648
LRRC56 leucine rich repeat containing 56 3.77648
C9ORF152 chromosome 9 open reading frame 152 3.77648
TMEM71 transmembrane protein 71 3.77648
FAM9C family with sequence similarity 9, member C 3.77648
FAM9B family with sequence similarity 9, member B 3.77648
KRTAP5-2 keratin associated protein 5-2 3.77648
ERAP2 endoplasmic reticulum aminopeptidase 2 3.77648
MEIG1 meiosis/spermiogenesis associated 1 3.77648
PITX2 paired-like homeodomain 2 3.77648
TMEM52B transmembrane protein 52B 3.77648
IRX4 iroquois homeobox 4 3.77648
ICAM5 intercellular adhesion molecule 5, telencephalin 3.77648
CDRT15 CMT1A duplicated region transcript 15 3.77648
SP6 Sp6 transcription factor 3.77648
AIRE autoimmune regulator 3.77648
UBA7 ubiquitin-like modifier activating enzyme 7 3.77648
CLEC5A C-type lectin domain family 5, member A 3.77648
OC90 otoconin 90 3.77648
ADAT3 adenosine deaminase, tRNA-specific 3 3.77648
TMEM121 transmembrane protein 121 3.77648
ATOH7 atonal homolog 7 (Drosophila) 3.77648
AVP arginine vasopressin 3.77648
BMP5 bone morphogenetic protein 5 3.77648
GALR3 galanin receptor 3 3.77648
NLRP12 NLR family, pyrin domain containing 12 3.77648
GPR6 G protein-coupled receptor 6 3.77648
CIMIP2B ciliary microtubule inner protein 2B 3.77648
GK3 glycerol kinase 3 3.77648
MYOCOS myocilin opposite strand 3.77648
PHF24 PHD finger protein 24 3.77648
ERVW-1 endogenous retrovirus group W, member 1 3.77648
PLG plasminogen 3.77648
GBP6 guanylate binding protein family, member 6 3.77648
CLEC10A C-type lectin domain family 10, member A 3.77648
OPRM1 opioid receptor, mu 1 3.77648
LTB4R2 leukotriene B4 receptor 2 3.77648
BNIP5 BCL2 interacting protein 5 3.77648
H3C15 H3 clustered histone 15 3.77648
CFAP299 cilia and flagella associated protein 299 3.77648
CIMIP2C ciliary microtubule inner protein 2C 3.77648
EXOC1L exocyst complex component 1 like 3.77648
MAP3K4-AS1 MAP3K4 antisense RNA 1 3.77648
SPMIP8 sperm microtubule inner protein 8 3.77648
C20ORF204 chromosome 20 open reading frame 204 3.77648
SHISAL2A shisa like 2A 3.77648
MINDY4B MINDY family member 4B 3.77648
LY6L lymphocyte antigen 6 family member L 3.77648
CPHXL cytoplasmic polyadenylated homeobox like 3.77648
CLDN16 claudin 16 3.77648
TMPRSS7 transmembrane protease, serine 7 3.77648
TLR4 toll-like receptor 4 3.77648
HAPLN2 hyaluronan and proteoglycan link protein 2 3.77648
C3ORF80 chromosome 3 open reading frame 80 3.77648
CCDC17 coiled-coil domain containing 17 3.77648
LOC124901449 uncharacterized LOC124901449 3.77648
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 3.77648
SPDYE6 speedy/RINGO cell cycle regulator family member E6 3.77648
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 3.77648
SLC22A10 solute carrier family 22, member 10 3.77648
TFEC transcription factor EC 3.77648
RNF113B ring finger protein 113B 3.77648
C12ORF54 chromosome 12 open reading frame 54 3.77648
FOXC1 forkhead box C1 3.77648
CMKLR1 chemerin chemokine-like receptor 1 3.77648
CLEC6A C-type lectin domain family 6, member A 3.77648
LTK leukocyte receptor tyrosine kinase 3.77648
PXDC1 PX domain containing 1 3.77648
SAMD11 sterile alpha motif domain containing 11 3.77648
SAA2 serum amyloid A2 3.77648
CSN2 casein beta 3.77648
MYOT myotilin 3.77648
NRN1 neuritin 1 3.77648
PCDHGB5 protocadherin gamma subfamily B, 5 3.77648
GOLGA8K golgin A8 family, member K 3.77648
PRM3 protamine 3 3.77648
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 3.77648
FAM177B family with sequence similarity 177, member B 3.77648
MEFV Mediterranean fever 3.77648
TRIM55 tripartite motif containing 55 3.77648
POU2AF1 POU class 2 associating factor 1 3.77648
BAHCC1 BAH domain and coiled-coil containing 1 3.77648
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 3.77648
KLHL41 kelch-like family member 41 3.77648
SMIM23 small integral membrane protein 23 3.77648
GCOM1 GRINL1A complex locus 1 3.77648
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 3.77648
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 3.77648
GFI1B growth factor independent 1B transcription repressor 3.77648
KRTAP19-1 keratin associated protein 19-1 3.77648
OR56A4 olfactory receptor, family 56, subfamily A, member 4 3.77648
EDN2 endothelin 2 3.77648
BTNL3 butyrophilin-like 3 3.77648
HHLA2 HERV-H LTR-associating 2 3.77648
CTAGE9 CTAGE family, member 9 3.77648
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 3.77648
MARCO macrophage receptor with collagenous structure 3.77648
PTHLH parathyroid hormone-like hormone 3.77648
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 3.77648
VAV1 vav 1 guanine nucleotide exchange factor 3.77648
NOBOX NOBOX oogenesis homeobox 3.77648
RGS4 regulator of G-protein signaling 4 3.77648
KLHDC1 kelch domain containing 1 3.77648
CFAP126 cilia and flagella associated protein 126 3.77648
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 3.77648
INSL6 insulin-like 6 3.77648
FGB fibrinogen beta chain 3.77648
LY96 lymphocyte antigen 96 3.77648
OCM oncomodulin 3.77648
CNGB3 cyclic nucleotide gated channel beta 3 3.77648
PLA2G5 phospholipase A2, group V 3.77648
PDZRN4 PDZ domain containing ring finger 4 3.77648
KLK11 kallikrein-related peptidase 11 3.77648
KLK12 kallikrein-related peptidase 12 3.77648
FAM135B family with sequence similarity 135, member B 3.77648
GBX2 gastrulation brain homeobox 2 3.77648
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 3.77648
SLCO2B1 solute carrier organic anion transporter family, member 2B1 3.77648
SPTA1 spectrin, alpha, erythrocytic 1 3.77648
APOD apolipoprotein D 3.77648
HLA-G major histocompatibility complex, class I, G 3.77648
RHAG Rh-associated glycoprotein 3.77648
CALML6 calmodulin-like 6 3.77648
IER5L immediate early response 5-like 3.77648
APOL3 apolipoprotein L, 3 3.77648
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 3.77648
MC5R melanocortin 5 receptor 3.77648
MMP3 matrix metallopeptidase 3 3.77648
LPAR5 lysophosphatidic acid receptor 5 3.77648
PLGLB2 plasminogen-like B2 3.77648
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 3.77648
GPR50 G protein-coupled receptor 50 3.77648
A1CF APOBEC1 complementation factor 3.77648
CLNK cytokine-dependent hematopoietic cell linker 3.77648
PF4V1 platelet factor 4 variant 1 3.77648
MBOAT4 membrane bound O-acyltransferase domain containing 4 3.77648
STAB1 stabilin 1 3.77648
GREM1 gremlin 1, DAN family BMP antagonist 3.77648
TMEM132E transmembrane protein 132E 3.77648
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 3.77648
MYOZ2 myozenin 2 3.77648
SCN7A sodium channel, voltage gated, type VII alpha subunit 3.70588
CSMD3 CUB and Sushi multiple domains 3 3.70588
DGUOK deoxyguanosine kinase 3.62582
RHBDF1 rhomboid 5 homolog 1 (Drosophila) 3.29727
SMG6 SMG6 nonsense mediated mRNA decay factor 3.10906
CRYGB crystallin, gamma B 3.05519
MEX3D mex-3 RNA binding family member D 3.01364
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 3.01364
PFDN5 prefoldin subunit 5 3.00616
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 3.00541
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 2.95486
SPEG SPEG complex locus 2.95486
ADRA2B adrenoceptor alpha 2B 2.87262
PROB1 proline-rich basic protein 1 2.86048
GPR137C G protein-coupled receptor 137C 2.84066
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein 2.80917
SCRT2 scratch family zinc finger 2 2.80917
NGEF neuronal guanine nucleotide exchange factor 2.80917
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.80917
RPA4 replication protein A4, 30kDa 2.80917
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 2.61806
DAGLA diacylglycerol lipase, alpha 2.59731
PHB2 prohibitin 2 2.59731
IFI27L1 interferon, alpha-inducible protein 27-like 1 2.58339
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) 2.57155
CLTB clathrin, light chain B 2.5423
COQ10A coenzyme Q10 homolog A (S. cerevisiae) 2.53427
JMJD8 jumonji domain containing 8 2.52914
INTS1 integrator complex subunit 1 2.51444
SRSF5 serine/arginine-rich splicing factor 5 2.49383
C19ORF53 chromosome 19 open reading frame 53 2.44488
C9ORF43 chromosome 9 open reading frame 43 2.43532
MROH8 maestro heat-like repeat family member 8 2.39957
SERP2 stress-associated endoplasmic reticulum protein family member 2 2.3508
TMEM80 transmembrane protein 80 2.34889
GSDMA gasdermin A 2.34876
SCAF4 SR-related CTD-associated factor 4 2.32271
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 2.31
SIM1 single-minded family bHLH transcription factor 1 2.31
RTN4IP1 reticulon 4 interacting protein 1 2.28695
CLDN10 claudin 10 2.28525
FAM169A family with sequence similarity 169, member A 2.2841
WASHC1 WASH complex subunit 1 2.27359
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 2.27359
RBM8A RNA binding motif protein 8A 2.26296
ZNF775 zinc finger protein 775 2.21082
USP18 ubiquitin specific peptidase 18 2.21082
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 2.18325
MOCS3 molybdenum cofactor synthesis 3 2.18207
SLCO6A1 solute carrier organic anion transporter family, member 6A1 2.16564
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa 2.16564
CCDC150 coiled-coil domain containing 150 2.16564
ASCC1 activating signal cointegrator 1 complex subunit 1 2.16564
FZD8 frizzled class receptor 8 2.16564
SEC31A SEC31 homolog A (S. cerevisiae) 2.15925
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa 2.14055
RNF125 ring finger protein 125, E3 ubiquitin protein ligase 2.13883
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 2.13478
CCDC110 coiled-coil domain containing 110 2.12106
POLR3H polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) 2.11717
PTGES3L prostaglandin E synthase 3 (cytosolic)-like 2.11465
ATOX1 antioxidant 1 copper chaperone 2.11073
HSCB HscB mitochondrial iron-sulfur cluster co-chaperone 2.10047
ATRN attractin 2.05851
TRDN triadin 2.05742
RUNX2 runt-related transcription factor 2 2.04541
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase 2.03864
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein 2.03688
MYOF myoferlin 2.03306
ANAPC11 anaphase promoting complex subunit 11 2.02668
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 2.02668
FRMPD4 FERM and PDZ domain containing 4 2.01039
ASPH aspartate beta-hydroxylase 2.00149

decreased expression

Symbol Name Standardized Value
CRIP2 cysteine-rich protein 2 -3.77648
TAMALIN trafficking regulator and scaffold protein tamalin -3.77648
GLRA1 glycine receptor, alpha 1 -3.77648
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 -3.77648
ZMYND10 zinc finger, MYND-type containing 10 -3.63318
LRRC32 leucine rich repeat containing 32 -3.63318
BMX BMX non-receptor tyrosine kinase -3.63318
SHBG sex hormone-binding globulin -3.63318
GAL3ST2 galactose-3-O-sulfotransferase 2 -3.63318
IL17C interleukin 17C -3.63318
PRSS50 protease, serine, 50 -3.63318
CARD9 caspase recruitment domain family, member 9 -3.63318
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 -3.63318
GH1 growth hormone 1 -3.63318
CLPSL1 colipase-like 1 -3.63318
MAGED4 melanoma antigen family D4 -3.63318
GYS2 glycogen synthase 2 (liver) -3.63318
POU5F2 POU domain class 5, transcription factor 2 -3.63318
MR1 major histocompatibility complex, class I-related -3.63318
PLPP4 phospholipid phosphatase 4 -3.63318
GJA9 gap junction protein, alpha 9, 59kDa -3.63318
PCDHA7 protocadherin alpha 7 -3.63318
IL1A interleukin 1, alpha -3.63318
TBXA2R thromboxane A2 receptor -3.63318
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -3.63318
GJA4 gap junction protein, alpha 4, 37kDa -3.63318
CLEC4A C-type lectin domain family 4, member A -3.63318
APOB apolipoprotein B -3.63318
CD5 CD5 molecule -3.63318
S100A2 S100 calcium binding protein A2 -3.63318
CRTAC1 cartilage acidic protein 1 -3.63318
FSTL4 follistatin-like 4 -3.4638
SUN2 Sad1 and UNC84 domain containing 2 -3.43387
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B -3.42648
TBC1D15 TBC1 domain family, member 15 -3.09278
TENM1 teneurin transmembrane protein 1 -3.06284
TCTN1 tectonic family member 1 -2.90058
HRH3 histamine receptor H3 -2.84797
CPN1 carboxypeptidase N, polypeptide 1 -2.84797
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit -2.81973
GPX7 glutathione peroxidase 7 -2.73252
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.52914
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 -2.49383
ZNF611 zinc finger protein 611 -2.48719
ZNF69 zinc finger protein 69 -2.46189
GNB5 guanine nucleotide binding protein (G protein), beta 5 -2.44932
MED13L mediator complex subunit 13-like -2.44488
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 -2.44488
GDF15 growth differentiation factor 15 -2.43964
FAM89A family with sequence similarity 89, member A -2.43532
LRRC4 leucine rich repeat containing 4 -2.43338
ADORA1 adenosine A1 receptor -2.39957
FSD2 fibronectin type III and SPRY domain containing 2 -2.39957
MYRF myelin regulatory factor -2.39957
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 -2.39957
PGLYRP1 peptidoglycan recognition protein 1 -2.39957
TICAM1 toll-like receptor adaptor molecule 1 -2.39957
PLAC8 placenta-specific 8 -2.39957
SNX31 sorting nexin 31 -2.38396
USP47 ubiquitin specific peptidase 47 -2.32205
CISD1 CDGSH iron sulfur domain 1 -2.27565
SNAP25 synaptosomal-associated protein, 25kDa -2.27359
PCDH20 protocadherin 20 -2.27359
SHANK1 SH3 and multiple ankyrin repeat domains 1 -2.27359
RBP2 retinol binding protein 2, cellular -2.27359
MYZAP myocardial zonula adherens protein -2.27359
IFI27 interferon, alpha-inducible protein 27 -2.27359
IDUA iduronidase, alpha-L- -2.27359
PIWIL2 piwi-like RNA-mediated gene silencing 2 -2.27359
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.27359
SLC25A19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 -2.26873
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 -2.26676
GINM1 glycoprotein integral membrane 1 -2.25938
TTC31 tetratricopeptide repeat domain 31 -2.25675
CDAN1 codanin 1 -2.22184
MAP7D1 MAP7 domain containing 1 -2.21786
TNNI3K TNNI3 interacting kinase -2.21082
PDE9A phosphodiesterase 9A -2.17443
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2 -2.16564
ULBP3 UL16 binding protein 3 -2.16564
INHBE inhibin, beta E -2.16564
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.16564
NUDT14 nudix (nucleoside diphosphate linked moiety X)-type motif 14 -2.15925
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -2.13478
NFYB nuclear transcription factor Y, beta -2.08799
FREM3 FRAS1 related extracellular matrix 3 -2.07536
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 -2.07042
DENND4C DENN/MADD domain containing 4C -2.06792
DNAH11 dynein, axonemal, heavy chain 11 -2.06792
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -2.03233
WNK2 WNK lysine deficient protein kinase 2 -2.03189
PAGR1 PAXIP1 associated glutamate-rich protein 1 -2.02672
MAT1A methionine adenosyltransferase I, alpha -2.02668
AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 -2.02467
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) -2.01287
STK26 serine/threonine protein kinase 26 -2.00896