| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase|The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015] (NCBI Entrez Gene Database, 790) |
| External Link | https://ncbi.nlm.nih.gov/gene/790 |
| Similar Terms | |
| Downloads & Tools |
498 genes differentially expressed following the CAD gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GOLM1 | golgi membrane protein 1 | 0.0117609 |
| G0S2 | G0/G1 switch 2 | 0.0111654 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0105046 |
| LY96 | lymphocyte antigen 96 | 0.0102062 |
| RCBTB2 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 | 0.0100298 |
| MMP1 | matrix metallopeptidase 1 | 0.00954358 |
| LTF | lactotransferrin | 0.00953583 |
| ALOX5 | arachidonate 5-lipoxygenase | 0.00949756 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | 0.00938193 |
| MET | MET proto-oncogene, receptor tyrosine kinase | 0.00894436 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.00882613 |
| NIBAN1 | niban apoptosis regulator 1 | 0.00865848 |
| GSDME | gasdermin E | 0.00858867 |
| COL6A3 | collagen, type VI, alpha 3 | 0.00852456 |
| ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | 0.00844364 |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 0.00819828 |
| CFB | complement factor B | 0.0080714 |
| LPAR1 | lysophosphatidic acid receptor 1 | 0.00798274 |
| RGL1 | ral guanine nucleotide dissociation stimulator-like 1 | 0.00792749 |
| STC2 | stanniocalcin 2 | 0.00790856 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.00789163 |
| ABHD3 | abhydrolase domain containing 3 | 0.00782474 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | 0.00782425 |
| S100P | S100 calcium binding protein P | 0.00781891 |
| GNAS | GNAS complex locus | 0.00780708 |
| LOXL2 | lysyl oxidase-like 2 | 0.00751172 |
| DERA | deoxyribose-phosphate aldolase (putative) | 0.00746583 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.00743601 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.00739432 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.00735634 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | 0.00734618 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.00729015 |
| LPAR6 | lysophosphatidic acid receptor 6 | 0.0072285 |
| BST2 | bone marrow stromal cell antigen 2 | 0.00721664 |
| UQCR11 | ubiquinol-cytochrome c reductase, complex III subunit XI | 0.00718205 |
| CFI | complement factor I | 0.00716485 |
| COL6A1 | collagen, type VI, alpha 1 | 0.00712859 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.00709829 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.00709263 |
| GPX1 | glutathione peroxidase 1 | 0.007073 |
| CNTN1 | contactin 1 | 0.00706878 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.00706201 |
| DPYD | dihydropyrimidine dehydrogenase | 0.00704035 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.00698858 |
| CAV2 | caveolin 2 | 0.00695073 |
| RPS27L | ribosomal protein S27-like | 0.00688581 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | 0.0068728 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.00682238 |
| IFI44L | interferon-induced protein 44-like | 0.00679071 |
| SULT1C2 | sulfotransferase family, cytosolic, 1C, member 2 | 0.00667499 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.00666811 |
| CSRP1 | cysteine and glycine-rich protein 1 | 0.00661008 |
| ERBIN | erbb2 interacting protein | 0.00659339 |
| MTRR | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | 0.00656841 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.00644947 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) | 0.0063868 |
| SNAI2 | snail family zinc finger 2 | 0.00637974 |
| PDLIM4 | PDZ and LIM domain 4 | 0.00636579 |
| AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | 0.00635369 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.00633692 |
| FSTL1 | follistatin-like 1 | 0.00626537 |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 | 0.00624306 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.00617258 |
| PLAAT3 | phospholipase A and acyltransferase 3 | 0.00610426 |
| ZNF395 | zinc finger protein 395 | 0.00608272 |
| RIN2 | Ras and Rab interactor 2 | 0.00607985 |
| HOXA10 | homeobox A10 | 0.00605444 |
| TPST2 | tyrosylprotein sulfotransferase 2 | 0.00603324 |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | 0.00602188 |
| LRRC17 | leucine rich repeat containing 17 | 0.00601833 |
| PTN | pleiotrophin | 0.0060145 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.00599624 |
| COL6A2 | collagen, type VI, alpha 2 | 0.00599421 |
| FZD2 | frizzled class receptor 2 | 0.00592564 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | 0.00592012 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 0.00591971 |
| PCLAF | PCNA clamp associated factor | 0.00591409 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.00591325 |
| NELL1 | NEL-like 1 (chicken) | 0.00587043 |
| MICU2 | mitochondrial calcium uptake 2 | 0.00585417 |
| IFI30 | interferon, gamma-inducible protein 30 | 0.00582953 |
| NUSAP1 | nucleolar and spindle associated protein 1 | 0.00580121 |
| HHEX | hematopoietically expressed homeobox | 0.00579992 |
| UQCRQ | ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa | 0.00578578 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | 0.00576038 |
| IFI44 | interferon-induced protein 44 | 0.00575494 |
| CD320 | CD320 molecule | 0.00572985 |
| NRN1 | neuritin 1 | 0.00572668 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.00571224 |
| COL5A2 | collagen, type V, alpha 2 | 0.00569378 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.0056885 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.00565815 |
| IFITM2 | interferon induced transmembrane protein 2 | 0.00565356 |
| PCOLCE | procollagen C-endopeptidase enhancer | 0.00564685 |
| POLDIP2 | polymerase (DNA-directed), delta interacting protein 2 | 0.00561791 |
| RRAGD | Ras-related GTP binding D | 0.00560132 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.00559336 |
| SNAP23 | synaptosomal-associated protein, 23kDa | 0.0055621 |
| NDUFB1 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa | 0.00556138 |
| RAB8A | RAB8A, member RAS oncogene family | 0.00555711 |
| NID1 | nidogen 1 | 0.00553368 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.00553086 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.00549547 |
| PNMA2 | paraneoplastic Ma antigen 2 | 0.00547713 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.00547283 |
| RETREG1 | reticulophagy regulator 1 | 0.00545783 |
| NKX3-1 | NK3 homeobox 1 | 0.00545704 |
| PAX6 | paired box 6 | 0.00544757 |
| CCNA2 | cyclin A2 | 0.00544699 |
| DYNLL1 | dynein, light chain, LC8-type 1 | 0.005435 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | 0.00542551 |
| EIF5A | eukaryotic translation initiation factor 5A | 0.00541933 |
| GLRX | glutaredoxin (thioltransferase) | 0.00540381 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | 0.00540261 |
| ANK2 | ankyrin 2, neuronal | 0.00540089 |
| SLC7A7 | solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 | 0.00537135 |
| INSR | insulin receptor | 0.00537094 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.00535758 |
| GDPD5 | glycerophosphodiester phosphodiesterase domain containing 5 | 0.00535734 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.00534848 |
| POLR1D | polymerase (RNA) I polypeptide D, 16kDa | 0.00534455 |
| SLC25A46 | solute carrier family 25, member 46 | 0.00534428 |
| SLC46A3 | solute carrier family 46, member 3 | 0.00532425 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.00526531 |
| PLK2 | polo-like kinase 2 | 0.00525608 |
| SORD | sorbitol dehydrogenase | 0.00525329 |
| LAT2 | linker for activation of T cells family, member 2 | 0.00524096 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.00523999 |
| POLR2L | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa | 0.00523948 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.00521926 |
| S100A11 | S100 calcium binding protein A11 | 0.00521233 |
| STAB1 | stabilin 1 | 0.00520952 |
| POSTN | periostin, osteoblast specific factor | 0.00519451 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.00518932 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.00518785 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | 0.00515415 |
| PGGHG | protein-glucosylgalactosylhydroxylysine glucosidase | 0.0051209 |
| F13A1 | coagulation factor XIII, A1 polypeptide | 0.00511068 |
| ZBTB18 | zinc finger and BTB domain containing 18 | 0.00509791 |
| P2RX5 | purinergic receptor P2X, ligand gated ion channel, 5 | 0.00509023 |
| KLHL9 | kelch-like family member 9 | 0.00508759 |
| TAF10 | TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa | 0.00507495 |
| ALG8 | ALG8, alpha-1,3-glucosyltransferase | 0.00506794 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.00506684 |
| MKNK1 | MAP kinase interacting serine/threonine kinase 1 | 0.00506202 |
| SUCLG2 | succinate-CoA ligase, GDP-forming, beta subunit | 0.00505326 |
| TWIST1 | twist family bHLH transcription factor 1 | 0.00504755 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.00504728 |
| FGG | fibrinogen gamma chain | 0.00503734 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.00501453 |
| CD99 | CD99 molecule | 0.00500629 |
| FGA | fibrinogen alpha chain | 0.00499823 |
| COX7C | cytochrome c oxidase subunit VIIc | 0.004997 |
| PCDH9 | protocadherin 9 | 0.00499668 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.00498899 |
| ADRB2 | adrenoceptor beta 2, surface | 0.00498492 |
| TENM3 | teneurin transmembrane protein 3 | 0.0049784 |
| MAN1C1 | mannosidase, alpha, class 1C, member 1 | 0.00496978 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.00495156 |
| MEIS2 | Meis homeobox 2 | 0.00494527 |
| CAPN3 | calpain 3, (p94) | 0.0049397 |
| PAX5 | paired box 5 | 0.00493664 |
| KLF2 | Kruppel-like factor 2 | 0.00493222 |
| SOX11 | SRY (sex determining region Y)-box 11 | 0.00492117 |
| NAV2 | neuron navigator 2 | 0.0049076 |
| LAMB1 | laminin, beta 1 | 0.00490345 |
| VEGFA | vascular endothelial growth factor A | 0.00487164 |
| TNFSF13B | tumor necrosis factor (ligand) superfamily, member 13b | 0.00486684 |
| PLAT | plasminogen activator, tissue | 0.00486394 |
| ANKRD10 | ankyrin repeat domain 10 | 0.00484379 |
| CTSH | cathepsin H | 0.0048347 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | 0.00483416 |
| MELK | maternal embryonic leucine zipper kinase | 0.00483384 |
| FPR1 | formyl peptide receptor 1 | 0.00481616 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.00481181 |
| HLA-DMB | major histocompatibility complex, class II, DM beta | 0.00480076 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | 0.00480051 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.00479724 |
| TRIP6 | thyroid hormone receptor interactor 6 | 0.00479247 |
| SFN | stratifin | 0.00478345 |
| NCF1C | neutrophil cytosolic factor 1C pseudogene | 0.0047785 |
| NMU | neuromedin U | 0.0047774 |
| PHF11 | PHD finger protein 11 | 0.00477591 |
| MCCC2 | methylcrotonoyl-CoA carboxylase 2 (beta) | 0.00477245 |
| PRDX2 | peroxiredoxin 2 | 0.00476945 |
| ZFPM2 | zinc finger protein, FOG family member 2 | 0.00476711 |
| ITM2B | integral membrane protein 2B | 0.00476258 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | 0.00476026 |
| TPP1 | tripeptidyl peptidase I | 0.00475099 |
| COLEC12 | collectin sub-family member 12 | 0.00474713 |
| OSBPL3 | oxysterol binding protein-like 3 | 0.0047377 |
| BMP2 | bone morphogenetic protein 2 | 0.00473561 |
| MARCKSL1 | MARCKS-like 1 | 0.00473197 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | 0.00472745 |
| FASTKD3 | FAST kinase domains 3 | 0.00472296 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.00470198 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | 0.00469852 |
| CA2 | carbonic anhydrase II | 0.0046843 |
| GDF15 | growth differentiation factor 15 | 0.00468175 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.00467926 |
| TCTA | T-cell leukemia translocation altered | 0.00467893 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.00467479 |
| VCL | vinculin | 0.0046734 |
| POU2AF1 | POU class 2 associating factor 1 | 0.00466948 |
| FOXO1 | forkhead box O1 | 0.00465883 |
| AMOTL2 | angiomotin like 2 | 0.00465533 |
| CSRP2 | cysteine and glycine-rich protein 2 | 0.00465408 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.00462913 |
| C5AR1 | complement component 5a receptor 1 | 0.0046102 |
| ALB | albumin | 0.0046101 |
| CD22 | CD22 molecule | 0.00460645 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | 0.00459783 |
| ABHD6 | abhydrolase domain containing 6 | 0.00458627 |
| HDHD5 | haloacid dehalogenase like hydrolase domain containing 5 | 0.00454873 |
| SHOX2 | short stature homeobox 2 | 0.00453986 |
| DDX10 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 | 0.0045286 |
| ADGRF5 | adhesion G protein-coupled receptor F5 | 0.00452404 |
| IRF9 | interferon regulatory factor 9 | 0.00451183 |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | 0.00451015 |
| MRPS31 | mitochondrial ribosomal protein S31 | 0.00450957 |
| ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | 0.0044987 |
| CPB1 | carboxypeptidase B1 (tissue) | 0.00449848 |
| CD58 | CD58 molecule | 0.00449019 |
| CDA | cytidine deaminase | 0.00447812 |
| C1ORF54 | chromosome 1 open reading frame 54 | 0.00447193 |
| CPS1 | carbamoyl-phosphate synthase 1, mitochondrial | 0.00447151 |
| COL1A2 | collagen, type I, alpha 2 | 0.00447097 |
| NDUFS4 | NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) | 0.00446772 |
| CTSZ | cathepsin Z | 0.00446364 |
| SCG5 | secretogranin V | 0.00445725 |
| LY86 | lymphocyte antigen 86 | 0.00445606 |
| SLC35G2 | solute carrier family 35, member G2 | 0.00445577 |
| CST1 | cystatin SN | 0.00445316 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.00444864 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.00444829 |
| MMP2 | matrix metallopeptidase 2 | 0.00444406 |
| NPM3 | nucleophosmin/nucleoplasmin 3 | 0.00444104 |
| CTSL | cathepsin L | 0.00443987 |
| LOX | lysyl oxidase | 0.00443908 |
| MFSD10 | major facilitator superfamily domain containing 10 | 0.00443784 |
| CD81 | CD81 molecule | 0.00443583 |
| NID2 | nidogen 2 (osteonidogen) | 0.0044321 |
| MMP9 | matrix metallopeptidase 9 | 0.00443192 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.00443086 |
| SMARCD3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 | 0.00442896 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | 0.00441719 |
| ZMAT3 | zinc finger, matrin-type 3 | 0.00440687 |
| MRPL40 | mitochondrial ribosomal protein L40 | 0.0043995 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.00439739 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PROM1 | prominin 1 | -0.0140354 |
| MAP7 | microtubule-associated protein 7 | -0.0138238 |
| ESRP1 | epithelial splicing regulatory protein 1 | -0.0100377 |
| TUBA1A | tubulin, alpha 1a | -0.00984143 |
| TUBB6 | tubulin, beta 6 class V | -0.00973695 |
| EPCAM | epithelial cell adhesion molecule | -0.00914497 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.00880196 |
| PUF60 | poly-U binding splicing factor 60KDa | -0.00848568 |
| KRT20 | keratin 20, type I | -0.00825762 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.00781173 |
| IDO1 | indoleamine 2,3-dioxygenase 1 | -0.00777384 |
| STK10 | serine/threonine kinase 10 | -0.00775237 |
| NPR3 | natriuretic peptide receptor 3 | -0.00773647 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | -0.00766305 |
| LXN | latexin | -0.00763854 |
| DLK1 | delta-like 1 homolog (Drosophila) | -0.00751714 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -0.00741052 |
| GNPTAB | N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits | -0.00738454 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | -0.00731091 |
| PCSK1N | proprotein convertase subtilisin/kexin type 1 inhibitor | -0.00731063 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.00726448 |
| SOSTDC1 | sclerostin domain containing 1 | -0.00708238 |
| CHRDL1 | chordin-like 1 | -0.00687625 |
| TXNDC9 | thioredoxin domain containing 9 | -0.00687094 |
| RGCC | regulator of cell cycle | -0.00676919 |
| TSPAN13 | tetraspanin 13 | -0.00676858 |
| PLK1 | polo-like kinase 1 | -0.00672679 |
| PWP1 | PWP1 homolog (S. cerevisiae) | -0.00671561 |
| LAPTM4B | lysosomal protein transmembrane 4 beta | -0.00662826 |
| WDR61 | WD repeat domain 61 | -0.00659695 |
| MAL | mal, T-cell differentiation protein | -0.0065809 |
| SCGB1A1 | secretoglobin, family 1A, member 1 (uteroglobin) | -0.00658055 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | -0.0065056 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.00639946 |
| CLU | clusterin | -0.00629054 |
| PRTN3 | proteinase 3 | -0.00628044 |
| PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | -0.00624916 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | -0.00624345 |
| SPON1 | spondin 1, extracellular matrix protein | -0.00621491 |
| BMP7 | bone morphogenetic protein 7 | -0.00620019 |
| BCL11A | B-cell CLL/lymphoma 11A (zinc finger protein) | -0.00613765 |
| KIAA0125 | KIAA0125 | -0.00612454 |
| GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | -0.00606118 |
| CLCA4 | chloride channel accessory 4 | -0.00602226 |
| KLF6 | Kruppel-like factor 6 | -0.00599349 |
| CYB561 | cytochrome b561 | -0.005983 |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | -0.0059174 |
| CLCA1 | chloride channel accessory 1 | -0.00586134 |
| IL12RB2 | interleukin 12 receptor, beta 2 | -0.00584078 |
| ATP8B4 | ATPase, class I, type 8B, member 4 | -0.00580927 |
| HIPK1 | homeodomain interacting protein kinase 1 | -0.00579751 |
| DENND2D | DENN/MADD domain containing 2D | -0.00578973 |
| L1TD1 | LINE-1 type transposase domain containing 1 | -0.00577394 |
| EIF4A3 | eukaryotic translation initiation factor 4A3 | -0.00576009 |
| PHACTR2 | phosphatase and actin regulator 2 | -0.00574328 |
| MUC2 | mucin 2, oligomeric mucus/gel-forming | -0.00573451 |
| EMX2 | empty spiracles homeobox 2 | -0.00571635 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.00570705 |
| C3ORF14 | chromosome 3 open reading frame 14 | -0.00569033 |
| ELANE | elastase, neutrophil expressed | -0.00568784 |
| CRIP2 | cysteine-rich protein 2 | -0.00567644 |
| MYB | v-myb avian myeloblastosis viral oncogene homolog | -0.00566685 |
| SPINK4 | serine peptidase inhibitor, Kazal type 4 | -0.00566187 |
| DUSP2 | dual specificity phosphatase 2 | -0.00564608 |
| HIST1H2BD | histone cluster 1, H2bd | -0.00561263 |
| LEFTY1 | left-right determination factor 1 | -0.0055373 |
| INAVA | innate immunity activator | -0.00553554 |
| CD59 | CD59 molecule, complement regulatory protein | -0.00547742 |
| SLC27A2 | solute carrier family 27 (fatty acid transporter), member 2 | -0.00545521 |
| PLAGL1 | pleiomorphic adenoma gene-like 1 | -0.00544804 |
| APOD | apolipoprotein D | -0.00544792 |
| GAS1 | growth arrest-specific 1 | -0.00543987 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -0.00543398 |
| FASN | fatty acid synthase | -0.00540857 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | -0.0053924 |
| CCR7 | chemokine (C-C motif) receptor 7 | -0.00538598 |
| EHF | ets homologous factor | -0.00537614 |
| SLC38A1 | solute carrier family 38, member 1 | -0.00536951 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) | -0.00536193 |
| CDS1 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 | -0.00533089 |
| NPTX2 | neuronal pentraxin II | -0.00529074 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | -0.00523888 |
| PNMA8A | PNMA family member 8A | -0.00523782 |
| MPO | myeloperoxidase | -0.00523289 |
| ASRGL1 | asparaginase like 1 | -0.00520574 |
| IFNG | interferon, gamma | -0.00520424 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.00520273 |
| VANGL1 | VANGL planar cell polarity protein 1 | -0.00519526 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | -0.00517217 |
| CCL14 | chemokine (C-C motif) ligand 14 | -0.00516656 |
| ADAM28 | ADAM metallopeptidase domain 28 | -0.00513998 |
| CD8A | CD8a molecule | -0.00510849 |
| VAV3 | vav 3 guanine nucleotide exchange factor | -0.00508269 |
| ERMP1 | endoplasmic reticulum metallopeptidase 1 | -0.00506997 |
| CCND2 | cyclin D2 | -0.00506439 |
| EPHA1 | EPH receptor A1 | -0.00505289 |
| NAPG | N-ethylmaleimide-sensitive factor attachment protein, gamma | -0.00504804 |
| SIK1 | salt-inducible kinase 1 | -0.00503272 |
| CD200 | CD200 molecule | -0.00496563 |
| FLT3 | fms-related tyrosine kinase 3 | -0.00496555 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | -0.00491031 |
| FAR2 | fatty acyl CoA reductase 2 | -0.0048986 |
| MEIS1 | Meis homeobox 1 | -0.00486127 |
| UPK1A | uroplakin 1A | -0.00485399 |
| CD2 | CD2 molecule | -0.00481399 |
| CPA3 | carboxypeptidase A3 (mast cell) | -0.00479273 |
| AMMECR1 | Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 | -0.00478307 |
| FABP4 | fatty acid binding protein 4, adipocyte | -0.00475682 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | -0.00472879 |
| ILF2 | interleukin enhancer binding factor 2 | -0.0047222 |
| ELF5 | E74-like factor 5 (ets domain transcription factor) | -0.00471543 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.00471374 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.00471045 |
| SLC15A2 | solute carrier family 15 (oligopeptide transporter), member 2 | -0.00471031 |
| CD1E | CD1e molecule | -0.00470566 |
| CDC123 | cell division cycle 123 | -0.00469931 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | -0.00468863 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.00468779 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.00467242 |
| CDH3 | cadherin 3, type 1, P-cadherin (placental) | -0.00465822 |
| CHEK1 | checkpoint kinase 1 | -0.00463722 |
| ITM2C | integral membrane protein 2C | -0.00463607 |
| CCT2 | chaperonin containing TCP1, subunit 2 (beta) | -0.00463549 |
| BSPRY | B-box and SPRY domain containing | -0.00463465 |
| PITRM1 | pitrilysin metallopeptidase 1 | -0.00462305 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.00461647 |
| IFT57 | intraflagellar transport 57 | -0.00461546 |
| ORC1 | origin recognition complex, subunit 1 | -0.00460483 |
| MYCL | v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog | -0.00460173 |
| GUCY2C | guanylate cyclase 2C | -0.00457975 |
| CHKB | choline kinase beta | -0.00457579 |
| ICA1 | islet cell autoantigen 1, 69kDa | -0.00456773 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | -0.00456683 |
| ARL1 | ADP-ribosylation factor-like 1 | -0.00456657 |
| EAF2 | ELL associated factor 2 | -0.00456296 |
| GZMK | granzyme K (granzyme 3; tryptase II) | -0.00455879 |
| AQP1 | aquaporin 1 (Colton blood group) | -0.00454021 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | -0.00449773 |
| ATG101 | autophagy related 101 | -0.00448158 |
| AGBL5 | ATP/GTP binding protein-like 5 | -0.00447464 |
| SLAMF7 | SLAM family member 7 | -0.00447158 |
| SQLE | squalene epoxidase | -0.00447005 |
| WFDC1 | WAP four-disulfide core domain 1 | -0.00444918 |
| TUBD1 | tubulin, delta 1 | -0.00443903 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | -0.00443456 |
| PARPBP | PARP1 binding protein | -0.00441895 |
| HOPX | HOP homeobox | -0.00441022 |
| DACH1 | dachshund family transcription factor 1 | -0.00440751 |
| TMPRSS2 | transmembrane protease, serine 2 | -0.00440709 |
| COPS7A | COP9 signalosome subunit 7A | -0.00440173 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.00439844 |
| IVNS1ABP | influenza virus NS1A binding protein | -0.00439605 |
| LYZ | lysozyme | -0.00438692 |
| TANK | TRAF family member-associated NFKB activator | -0.00438614 |
| SLC47A1 | solute carrier family 47 (multidrug and toxin extrusion), member 1 | -0.00437741 |
| GRHL2 | grainyhead-like 2 (Drosophila) | -0.00436944 |
| IRF6 | interferon regulatory factor 6 | -0.00436302 |
| PRR15L | proline rich 15-like | -0.00435605 |
| PCYOX1 | prenylcysteine oxidase 1 | -0.00435383 |
| PSMA5 | proteasome (prosome, macropain) subunit, alpha type, 5 | -0.00434343 |
| ACKR1 | atypical chemokine receptor 1 (Duffy blood group) | -0.00433797 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.00433322 |
| ABCF1 | ATP-binding cassette, sub-family F (GCN20), member 1 | -0.00430716 |
| MFGE8 | milk fat globule-EGF factor 8 protein | -0.00427929 |
| SPINK2 | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) | -0.00427816 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.00427355 |
| ZYX | zyxin | -0.00426984 |
| CXCL11 | chemokine (C-X-C motif) ligand 11 | -0.00426068 |
| GDI2 | GDP dissociation inhibitor 2 | -0.00425388 |
| MCOLN1 | mucolipin 1 | -0.00424544 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | -0.00424199 |
| FCER1A | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | -0.00423576 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | -0.00420821 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -0.0042078 |
| CXADR | coxsackie virus and adenovirus receptor | -0.00419428 |
| RAB21 | RAB21, member RAS oncogene family | -0.00417749 |
| VTCN1 | V-set domain containing T cell activation inhibitor 1 | -0.00416387 |
| CLDN8 | claudin 8 | -0.00415067 |
| SEC13 | SEC13 homolog (S. cerevisiae) | -0.00414059 |
| GPX2 | glutathione peroxidase 2 | -0.00414037 |
| AOC3 | amine oxidase, copper containing 3 | -0.00413043 |
| CYTIP | cytohesin 1 interacting protein | -0.00411541 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | -0.00410865 |
| EPS8L1 | EPS8-like 1 | -0.00410725 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.00410436 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.00409641 |
| SFPQ | splicing factor proline/glutamine-rich | -0.00409242 |
| NGFRAP1 | nerve growth factor receptor (TNFRSF16) associated protein 1 | -0.00409073 |
| ZNF204P | zinc finger protein 204, pseudogene | -0.00408153 |
| FGFR4 | fibroblast growth factor receptor 4 | -0.00407687 |
| FAM107A | family with sequence similarity 107, member A | -0.0040758 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -0.00407119 |
| BEX1 | brain expressed, X-linked 1 | -0.00406437 |
| CDCA8 | cell division cycle associated 8 | -0.00403946 |
| FBL | fibrillarin | -0.00402879 |
| CD48 | CD48 molecule | -0.00402798 |
| IRF4 | interferon regulatory factor 4 | -0.00402568 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | -0.00400868 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.0040045 |
| ZNF165 | zinc finger protein 165 | -0.00400377 |
| KRT23 | keratin 23, type I | -0.00398888 |
| NEBL | nebulette | -0.00398049 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | -0.00396566 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | -0.00395602 |
| GPR171 | G protein-coupled receptor 171 | -0.00394532 |
| PIR | pirin (iron-binding nuclear protein) | -0.00394473 |
| XPO7 | exportin 7 | -0.00394443 |
| PTPN7 | protein tyrosine phosphatase, non-receptor type 7 | -0.00394096 |
| CCR2 | chemokine (C-C motif) receptor 2 | -0.00393773 |
| TMEM246 | transmembrane protein 246 | -0.00393343 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | -0.00393176 |
| MFSD6 | major facilitator superfamily domain containing 6 | -0.00392683 |
| ERAP2 | endoplasmic reticulum aminopeptidase 2 | -0.00392435 |
| TLK2 | tousled-like kinase 2 | -0.00391525 |
| ABHD4 | abhydrolase domain containing 4 | -0.00390914 |
| TXNL4B | thioredoxin-like 4B | -0.00389677 |
| LTA4H | leukotriene A4 hydrolase | -0.00388233 |
| SLC39A6 | solute carrier family 39 (zinc transporter), member 6 | -0.00387747 |
| PTBP2 | polypyrimidine tract binding protein 2 | -0.00387594 |
| PSMB4 | proteasome (prosome, macropain) subunit, beta type, 4 | -0.00386907 |
| ATG5 | autophagy related 5 | -0.00386805 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | -0.00385663 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.00384233 |
| USP11 | ubiquitin specific peptidase 11 | -0.00383665 |
| TNFRSF17 | tumor necrosis factor receptor superfamily, member 17 | -0.00383502 |
| COL4A6 | collagen, type IV, alpha 6 | -0.00383395 |
| NANOG | Nanog homeobox | -0.00383133 |
| SI | sucrase-isomaltase (alpha-glucosidase) | -0.00383019 |
| FHL1 | four and a half LIM domains 1 | -0.00382858 |
| BPGM | 2,3-bisphosphoglycerate mutase | -0.00382155 |
| ODC1 | ornithine decarboxylase 1 | -0.00381253 |
| MBOAT7 | membrane bound O-acyltransferase domain containing 7 | -0.00381086 |
| TOR1A | torsin family 1, member A (torsin A) | -0.00381002 |
| CLIC3 | chloride intracellular channel 3 | -0.00380065 |
| KRT7 | keratin 7, type II | -0.00379294 |
| CTSC | cathepsin C | -0.00378893 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | -0.00378634 |
| BPTF | bromodomain PHD finger transcription factor | -0.00378579 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | -0.00378372 |
| MYCN | v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog | -0.00378216 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | -0.00378023 |
| GPR18 | G protein-coupled receptor 18 | -0.00377541 |
| B4GALT4 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 | -0.0037705 |
| SYT1 | synaptotagmin I | -0.00376177 |
| SF3B5 | splicing factor 3b, subunit 5, 10kDa | -0.00375131 |
| RAN | RAN, member RAS oncogene family | -0.00375084 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.0037498 |
| FOXK2 | forkhead box K2 | -0.00374979 |
| KLF4 | Kruppel-like factor 4 (gut) | -0.00374508 |
