CAL-101 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/11625818
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Genes

198 proteins with high or low expression in CAL-101 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
PIP prolactin-induced protein 1.48
DNAH12 dynein, axonemal, heavy chain 12 0.92
SEMG1 semenogelin I 0.69
GREB1 growth regulation by estrogen in breast cancer 1 0.59
DUOX1 dual oxidase 1 0.58
FAM122B family with sequence similarity 122B 0.56
ZNF302 zinc finger protein 302 0.52
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.51
KLHL20 kelch-like family member 20 0.5
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 0.49
MT1F metallothionein 1F 0.48
FKBP1A FK506 binding protein 1A, 12kDa 0.48
SEMG2 semenogelin II 0.47
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 0.47
MAP2 microtubule-associated protein 2 0.46
SYTL2 synaptotagmin-like 2 0.46
H3C1 H3 clustered histone 1 0.45
FAM241B family with sequence similarity 241 member B 0.45
SPC24 SPC24, NDC80 kinetochore complex component 0.44
CCDC150 coiled-coil domain containing 150 0.43
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 0.43
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.42
MYO15A myosin XVA 0.42
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 0.42
IRS2 insulin receptor substrate 2 0.41
MT2A metallothionein 2A 0.41
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 0.4
PDLIM5 PDZ and LIM domain 5 0.39
TRIB1 tribbles pseudokinase 1 0.39
IRF9 interferon regulatory factor 9 0.38
ALPK3 alpha-kinase 3 0.38
GGACT gamma-glutamylamine cyclotransferase 0.38
ZNF776 zinc finger protein 776 0.37
UBAP1 ubiquitin associated protein 1 0.37
FBXL8 F-box and leucine-rich repeat protein 8 0.37
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 0.37
RBL2 retinoblastoma-like 2 0.36
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.36
PDE5A phosphodiesterase 5A, cGMP-specific 0.36
INAVA innate immunity activator 0.35
NR1H2 nuclear receptor subfamily 1, group H, member 2 0.35
CTNND2 catenin (cadherin-associated protein), delta 2 0.35
MOSPD1 motile sperm domain containing 1 0.34
CYBRD1 cytochrome b reductase 1 0.34
S100A5 S100 calcium binding protein A5 0.34
MCM9 minichromosome maintenance complex component 9 0.33
RNASEH2C ribonuclease H2, subunit C 0.33
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.33
OSER1 oxidative stress responsive serine-rich 1 0.32
VGF VGF nerve growth factor inducible 0.32
PRRX2 paired related homeobox 2 0.32
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 0.32
COQ8A coenzyme Q8A 0.32
RTN2 reticulon 2 0.32
DST dystonin 0.31
ZMAT3 zinc finger, matrin-type 3 0.31
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 0.31
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.31
MAGEE1 melanoma antigen family E1 0.3
ZNF395 zinc finger protein 395 0.3
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 0.3
B2M beta-2-microglobulin 0.3
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 0.3
FBXO34 F-box protein 34 0.3
ZNF28 zinc finger protein 28 0.29
DDAH2 dimethylarginine dimethylaminohydrolase 2 0.29
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.29
HSPA1L heat shock 70kDa protein 1-like 0.29
FAM117A family with sequence similarity 117, member A 0.29
MRFAP1 Morf4 family associated protein 1 0.29
GUCD1 guanylyl cyclase domain containing 1 0.29
PRR36 proline rich 36 0.29
TRAK1 trafficking protein, kinesin binding 1 0.29
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 0.29
ZNF696 zinc finger protein 696 0.29
HAGH hydroxyacylglutathione hydrolase 0.28
UNG uracil-DNA glycosylase 0.28
VMP1 vacuole membrane protein 1 0.28
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.28
SUSD2 sushi domain containing 2 0.28
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 0.28
SLC66A2 solute carrier family 66 member 2 0.28
ZNRD1 zinc ribbon domain containing 1 0.28
CTHRC1 collagen triple helix repeat containing 1 0.28
EPM2AIP1 EPM2A (laforin) interacting protein 1 0.27
POLE4 polymerase (DNA-directed), epsilon 4, accessory subunit 0.27
CEP76 centrosomal protein 76kDa 0.27
CYLD cylindromatosis (turban tumor syndrome) 0.27
SLC25A52 solute carrier family 25, member 52 0.27
PEX1 peroxisomal biogenesis factor 1 0.27
RWDD4 RWD domain containing 4 0.27
GSTM5 glutathione S-transferase mu 5 0.27
STYK1 serine/threonine/tyrosine kinase 1 0.27
ASF1B anti-silencing function 1B histone chaperone 0.27
SHMT1 serine hydroxymethyltransferase 1 (soluble) 0.27
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 0.27
FAM120C family with sequence similarity 120C 0.27
TSTD2 thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 0.27
ADGRF1 adhesion G protein-coupled receptor F1 0.26

low expression

Symbol Name Standardized Value
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 -1.02
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.76
FGA fibrinogen alpha chain -0.74
CES3 carboxylesterase 3 -0.69
HOXB9 homeobox B9 -0.59
SESN2 sestrin 2 -0.56
SH3RF2 SH3 domain containing ring finger 2 -0.53
PYGM phosphorylase, glycogen, muscle -0.51
UST uronyl-2-sulfotransferase -0.5
FBXO41 F-box protein 41 -0.49
NRP1 neuropilin 1 -0.48
ZNF175 zinc finger protein 175 -0.45
WSB2 WD repeat and SOCS box containing 2 -0.45
FGF19 fibroblast growth factor 19 -0.44
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.43
SCAND1 SCAN domain containing 1 -0.43
HGFAC HGF activator -0.4
DNAH8 dynein, axonemal, heavy chain 8 -0.4
RELT RELT tumor necrosis factor receptor -0.4
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.39
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.39
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A -0.39
PSAT1 phosphoserine aminotransferase 1 -0.39
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 -0.38
FBXO31 F-box protein 31 -0.38
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.38
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 -0.38
LSM11 LSM11, U7 small nuclear RNA associated -0.38
FAM86B2 family with sequence similarity 86, member B2 -0.38
FN1 fibronectin 1 -0.37
GRN granulin -0.36
MID2 midline 2 -0.36
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 -0.36
MYCBP MYC binding protein -0.36
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -0.34
PHLDB3 pleckstrin homology-like domain, family B, member 3 -0.34
PIWIL2 piwi-like RNA-mediated gene silencing 2 -0.34
AMMECR1L AMMECR1-like -0.34
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit -0.34
METTL4 methyltransferase like 4 -0.34
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) -0.33
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 -0.33
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3 -0.33
PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 -0.32
ATG4A autophagy related 4A, cysteine peptidase -0.32
TRAF3IP2 TRAF3 interacting protein 2 -0.32
FUT10 fucosyltransferase 10 (alpha (1,3) fucosyltransferase) -0.32
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.32
CEBPB CCAAT/enhancer binding protein (C/EBP), beta -0.32
ZNF410 zinc finger protein 410 -0.32
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa -0.32
CCNI cyclin I -0.32
PDCD5 programmed cell death 5 -0.31
UPP1 uridine phosphorylase 1 -0.31
SLC39A3 solute carrier family 39 (zinc transporter), member 3 -0.31
ACTN2 actinin, alpha 2 -0.31
ZBTB49 zinc finger and BTB domain containing 49 -0.31
STC2 stanniocalcin 2 -0.31
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.31
RIPK4 receptor-interacting serine-threonine kinase 4 -0.31
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -0.31
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 -0.31
CECR2 cat eye syndrome chromosome region, candidate 2 -0.3
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2 -0.3
SH2B2 SH2B adaptor protein 2 -0.3
FGF2 fibroblast growth factor 2 (basic) -0.3
BHLHA15 basic helix-loop-helix family, member a15 -0.3
CCDC73 coiled-coil domain containing 73 -0.29
IFITM3 interferon induced transmembrane protein 3 -0.29
TDG thymine-DNA glycosylase -0.29
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 -0.29
TUBE1 tubulin, epsilon 1 -0.29
MED26 mediator complex subunit 26 -0.28
SAT2 spermidine/spermine N1-acetyltransferase family member 2 -0.28
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A -0.28
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.28
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.28
VAV1 vav 1 guanine nucleotide exchange factor -0.27
DPY30 dpy-30 homolog (C. elegans) -0.27
EIF1AX eukaryotic translation initiation factor 1A, X-linked -0.27
APOB apolipoprotein B -0.27
GRK3 G protein-coupled receptor kinase 3 -0.27
KRT222 keratin 222, type II -0.27
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.27
CAPZB capping protein (actin filament) muscle Z-line, beta -0.26
CDK18 cyclin-dependent kinase 18 -0.26
NCKAP5L NCK-associated protein 5-like -0.26
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.26
PLD6 phospholipase D family, member 6 -0.26
SELENOW selenoprotein W -0.25
SLC35F6 solute carrier family 35, member F6 -0.25
PSPH phosphoserine phosphatase -0.25
GRPEL2 GrpE-like 2, mitochondrial (E. coli) -0.25
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 -0.25
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.25
LRFN3 leucine rich repeat and fibronectin type III domain containing 3 -0.25
LMCD1 LIM and cysteine-rich domains 1 -0.25
HSPA12B heat shock 70kD protein 12B -0.25
ACTN4 actinin, alpha 4 -0.24