CAL-27 Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
Description Human tongue squamous cell carcinoma established from the poorly differentiated squamous cell carcinoma of the tongue removed from a 56-year-old man before treatment in 1982. (BRENDA Tissue and Enzyme Source Ontology, BTO_0000921)
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Genes

318 genes with high or low expression in CAL-27 relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 3.56916
CTSC cathepsin C 3.0355
S100A7 S100 calcium binding protein A7 2.87245
TRIM14 tripartite motif containing 14 2.72448
COMMD9 COMM domain containing 9 2.70731
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 2.70258
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.67315
PGLYRP4 peptidoglycan recognition protein 4 2.5774
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 2.54243
APIP APAF1 interacting protein 2.53109
MMP10 matrix metallopeptidase 10 2.51874
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 2.43571
NDRG2 NDRG family member 2 2.35869
LY6D lymphocyte antigen 6 complex, locus D 2.32667
MMP13 matrix metallopeptidase 13 2.29789
KYNU kynureninase 2.29452
NIT2 nitrilase family, member 2 2.24262
PDHX pyruvate dehydrogenase complex, component X 2.24165
TRIM44 tripartite motif containing 44 2.2366
SLC39A2 solute carrier family 39 (zinc transporter), member 2 2.20026
HIST1H2AG histone cluster 1, H2ag 2.15047
ERP44 endoplasmic reticulum protein 44 2.14154
CLDN1 claudin 1 2.13973
METTL17 methyltransferase like 17 2.13175
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.12367
SP110 SP110 nuclear body protein 2.10538
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.09313
TMEM33 transmembrane protein 33 2.07922
PLSCR1 phospholipid scramblase 1 2.07247
S100A8 S100 calcium binding protein A8 2.06272
JADE2 jade family PHD finger 2 2.05034
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 2.03106
RTP4 receptor (chemosensory) transporter protein 4 2.02918
ANKMY2 ankyrin repeat and MYND domain containing 2 2.02474
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 2.00897
SLC31A2 solute carrier family 31 (copper transporter), member 2 1.97573
CXCL10 chemokine (C-X-C motif) ligand 10 1.96457
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.96062
FAT2 FAT atypical cadherin 2 1.95859
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.94954
KRT15 keratin 15, type I 1.9494
WISP3 WNT1 inducible signaling pathway protein 3 1.94843
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) 1.93366
AQP3 aquaporin 3 (Gill blood group) 1.92995
STARD5 StAR-related lipid transfer (START) domain containing 5 1.92419
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 1.92297
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 1.9186
RHCG Rh family, C glycoprotein 1.91857
CASP4 caspase 4, apoptosis-related cysteine peptidase 1.91703
MMP12 matrix metallopeptidase 12 1.90945
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.90465
NCOA4 nuclear receptor coactivator 4 1.90022
IDO1 indoleamine 2,3-dioxygenase 1 1.89861
S100A9 S100 calcium binding protein A9 1.87529
ACPP acid phosphatase, prostate 1.86106
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 1.85713
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 1.85665
HIST1H2BC histone cluster 1, H2bc 1.83953
ITM2B integral membrane protein 2B 1.83947
SP100 SP100 nuclear antigen 1.83356
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 1.80703
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 1.80368
APOL2 apolipoprotein L, 2 1.80295
CD82 CD82 molecule 1.801
BID BH3 interacting domain death agonist 1.78017
CCNL1 cyclin L1 1.77662
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) 1.77313
TMPRSS11D transmembrane protease, serine 11D 1.75925
OLFM4 olfactomedin 4 1.75879
FBXO3 F-box protein 3 1.7575
UBE2L6 ubiquitin-conjugating enzyme E2L 6 1.75113
SPRR1B small proline-rich protein 1B 1.74336
TMEM9B TMEM9 domain family, member B 1.72977
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 1.72684
TMEM59 transmembrane protein 59 1.72049
XAF1 XIAP associated factor 1 1.71833
FXYD3 FXYD domain containing ion transport regulator 3 1.71743
TXNDC9 thioredoxin domain containing 9 1.71268
SAMD9 sterile alpha motif domain containing 9 1.70055
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 1.6982
MUC4 mucin 4, cell surface associated 1.69446
PERP PERP, TP53 apoptosis effector 1.69144
HIST1H2BD histone cluster 1, H2bd 1.68948
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 1.68371
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 1.68047
PCDH7 protocadherin 7 1.67822
NCK1 NCK adaptor protein 1 1.67407
CD47 CD47 molecule 1.67177
HIST1H3E histone cluster 1, H3e 1.67096
CYCS cytochrome c, somatic 1.65799
GLUL glutamate-ammonia ligase 1.65506
CLEC2B C-type lectin domain family 2, member B 1.65495
LALBA lactalbumin, alpha- 1.64897
RSAD2 radical S-adenosyl methionine domain containing 2 1.64192
IFI44 interferon-induced protein 44 1.63923
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 1.63135
MARCKS myristoylated alanine-rich protein kinase C substrate 1.62934
AHR aryl hydrocarbon receptor 1.62626
CAT catalase 1.62522
RNF13 ring finger protein 13 1.62459
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa 1.62003
MX2 MX dynamin-like GTPase 2 1.61919
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.60202
GDAP2 ganglioside induced differentiation associated protein 2 1.58679
DRD3 dopamine receptor D3 1.58644
DSC3 desmocollin 3 1.58406
RIPK4 receptor-interacting serine-threonine kinase 4 1.57823
CHMP3 charged multivesicular body protein 3 1.57785
CATR1 CATR tumorigenicity conversion 1 1.57567
MMP1 matrix metallopeptidase 1 1.56559
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) 1.5608
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 1.5584
CLCA4 chloride channel accessory 4 1.55602
PRKCG protein kinase C, gamma 1.55352
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13 1.5464
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 1.54464
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 1.54216
KRT9 keratin 9, type I 1.5378
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 1.53725
VENTX VENT homeobox 1.53198
ISG15 ISG15 ubiquitin-like modifier 1.53096
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 1.53085
FYB FYN binding protein 1.53077
HES2 hes family bHLH transcription factor 2 1.52852
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 1.52689
HLA-F major histocompatibility complex, class I, F 1.52464
IFI27 interferon, alpha-inducible protein 27 1.52196
CAV3 caveolin 3 1.52047
HIST1H2BE histone cluster 1, H2be 1.51637
KRT14 keratin 14, type I 1.51263
ACVR1 activin A receptor, type I 1.50693
DUOX2 dual oxidase 2 1.50621
ZNF211 zinc finger protein 211 1.5061
DPP3 dipeptidyl-peptidase 3 1.50326
IFIH1 interferon induced with helicase C domain 1 1.49827
CXCL9 chemokine (C-X-C motif) ligand 9 1.49773
OSTF1 osteoclast stimulating factor 1 1.49561
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 1.49551
SYPL1 synaptophysin-like 1 1.49454
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe) 1.49243
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 1.49242
DYNLT1 dynein, light chain, Tctex-type 1 1.4908
PIGV phosphatidylinositol glycan anchor biosynthesis, class V 1.48979
LIPA lipase A, lysosomal acid, cholesterol esterase 1.48369
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 1.48243
S100A12 S100 calcium binding protein A12 1.48119
WFDC2 WAP four-disulfide core domain 2 1.48099
HIST1H1T histone cluster 1, H1t 1.48028
TRIM22 tripartite motif containing 22 1.47827
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 1.47695
H2AFJ H2A histone family, member J 1.47641
MYO1B myosin IB 1.47212
RARG retinoic acid receptor, gamma 1.4635
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 1.46262
FAM120A family with sequence similarity 120A 1.46257
LOC650293 seven transmembrane helix receptor 1.45974
CLEC7A C-type lectin domain family 7, member A 1.4557
CD1E CD1e molecule 1.44634
SOD2 superoxide dismutase 2, mitochondrial 1.44279
KRT1 keratin 1, type II 1.44044
NMI N-myc (and STAT) interactor 1.4372
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 1.4346
HIST1H2BI histone cluster 1, H2bi 1.43218
MX1 MX dynamin-like GTPase 1 1.42823
GJB4 gap junction protein, beta 4, 30.3kDa 1.42601
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 1.42554
MAT2B methionine adenosyltransferase II, beta 1.42397

low expression

Symbol Name Standardized Value
TBC1D5 TBC1 domain family, member 5 -3.53725
MAPK8 mitogen-activated protein kinase 8 -3.53721
RAD54L2 RAD54-like 2 (S. cerevisiae) -3.09977
UBTF upstream binding transcription factor, RNA polymerase I -3.03614
SETD5 SET domain containing 5 -2.79897
B3GAT3 beta-1,3-glucuronyltransferase 3 -2.72233
RBPJ recombination signal binding protein for immunoglobulin kappa J region -2.70756
RAF1 Raf-1 proto-oncogene, serine/threonine kinase -2.68392
KLF12 Kruppel-like factor 12 -2.59791
TRPC3 transient receptor potential cation channel, subfamily C, member 3 -2.52432
PER1 period circadian clock 1 -2.5168
ANKRD26 ankyrin repeat domain 26 -2.48899
CHMP7 charged multivesicular body protein 7 -2.42822
POGZ pogo transposable element with ZNF domain -2.41305
CCNI cyclin I -2.40608
FGFR1 fibroblast growth factor receptor 1 -2.3993
CUL7 cullin 7 -2.39508
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 -2.37936
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa -2.34829
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) -2.32575
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 -2.31034
IQSEC1 IQ motif and Sec7 domain 1 -2.29477
POLG polymerase (DNA directed), gamma -2.20879
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 -2.20814
FOXK2 forkhead box K2 -2.16334
NSUN6 NOP2/Sun domain family, member 6 -2.14353
RNF41 ring finger protein 41, E3 ubiquitin protein ligase -2.09321
POU6F1 POU class 6 homeobox 1 -2.07819
KIAA0586 KIAA0586 -2.0397
BGLAP bone gamma-carboxyglutamate (gla) protein -2.02495
ARCN1 archain 1 -2.01605
MAP1S microtubule-associated protein 1S -1.99541
FRZB frizzled-related protein -1.99169
MAPT microtubule-associated protein tau -1.9851
NOL6 nucleolar protein 6 (RNA-associated) -1.98486
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -1.9628
PCBP4 poly(rC) binding protein 4 -1.95673
ATXN2L ataxin 2-like -1.95485
RSAD1 radical S-adenosyl methionine domain containing 1 -1.95072
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -1.94428
SCAP SREBF chaperone -1.94413
EIF4E eukaryotic translation initiation factor 4E -1.93669
ACVR2B activin A receptor, type IIB -1.92865
TOP3B topoisomerase (DNA) III beta -1.92736
HMG20A high mobility group 20A -1.92648
HABP4 hyaluronan binding protein 4 -1.92534
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 -1.91725
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 -1.91535
PLEKHO2 pleckstrin homology domain containing, family O member 2 -1.90947
ZKSCAN8 zinc finger with KRAB and SCAN domains 8 -1.9021
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) -1.89025
UIMC1 ubiquitin interaction motif containing 1 -1.87686
CRELD1 cysteine-rich with EGF-like domains 1 -1.85643
TOP2B topoisomerase (DNA) II beta 180kDa -1.83677
CEP135 centrosomal protein 135kDa -1.83277
RBM10 RNA binding motif protein 10 -1.8309
STX2 syntaxin 2 -1.82936
MYBBP1A MYB binding protein (P160) 1a -1.81814
MDM4 MDM4, p53 regulator -1.81171
DNALI1 dynein, axonemal, light intermediate chain 1 -1.80287
AGER advanced glycosylation end product-specific receptor -1.79792
ZNF202 zinc finger protein 202 -1.79564
CDKL3 cyclin-dependent kinase-like 3 -1.78454
DIXDC1 DIX domain containing 1 -1.78142
CCDC9 coiled-coil domain containing 9 -1.76824
FYN FYN proto-oncogene, Src family tyrosine kinase -1.75807
PLD3 phospholipase D family, member 3 -1.75189
KAT6A K(lysine) acetyltransferase 6A -1.74782
WAC WW domain containing adaptor with coiled-coil -1.7477
CBX5 chromobox homolog 5 -1.73427
ADGRL3 adhesion G protein-coupled receptor L3 -1.7229
GRIK2 glutamate receptor, ionotropic, kainate 2 -1.69977
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B -1.69325
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -1.68638
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -1.67633
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 -1.67519
HYOU1 hypoxia up-regulated 1 -1.67177
TNS2 tensin 2 -1.66694
RUFY3 RUN and FYVE domain containing 3 -1.66662
XPOT exportin, tRNA -1.65993
NCAM1 neural cell adhesion molecule 1 -1.65906
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 -1.65847
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 -1.65785
AP2A2 adaptor-related protein complex 2, alpha 2 subunit -1.65515
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 -1.65071
CLOCK clock circadian regulator -1.64971
TUBA3C tubulin, alpha 3c -1.64453
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha -1.64324
DPYSL2 dihydropyrimidinase-like 2 -1.64156
AMH anti-Mullerian hormone -1.63853
TBKBP1 TBK1 binding protein 1 -1.63593
PKN1 protein kinase N1 -1.63039
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain -1.62749
ZNF26 zinc finger protein 26 -1.62647
PRKCSH protein kinase C substrate 80K-H -1.62359
CRAT carnitine O-acetyltransferase -1.62035
CAMTA2 calmodulin binding transcription activator 2 -1.61658
PDGFRL platelet-derived growth factor receptor-like -1.61577
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 -1.61308
ALAS1 5'-aminolevulinate synthase 1 -1.61174
DDAH2 dimethylarginine dimethylaminohydrolase 2 -1.60965
BAZ1B bromodomain adjacent to zinc finger domain, 1B -1.60528
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 -1.58345
SARM1 sterile alpha and TIR motif containing 1 -1.58339
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -1.58047
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 -1.56844
PEG10 paternally expressed 10 -1.56541
CDK20 cyclin-dependent kinase 20 -1.55979
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -1.55145
PCDH11Y protocadherin 11 Y-linked -1.55022
CTTNBP2NL CTTNBP2 N-terminal like -1.54722
PPP2R1B protein phosphatase 2, regulatory subunit A, beta -1.54602
SNX27 sorting nexin family member 27 -1.54287
DNA2 DNA replication helicase/nuclease 2 -1.5421
UBE4A ubiquitination factor E4A -1.54127
ATXN7L1 ataxin 7-like 1 -1.53767
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 -1.531
FAM86C1 family with sequence similarity 86, member C1 -1.53073
WDR48 WD repeat domain 48 -1.53046
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 -1.53
CEP112 centrosomal protein 112kDa -1.52647
GNG13 guanine nucleotide binding protein (G protein), gamma 13 -1.52525
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 -1.52312
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 -1.52039
BAMBI BMP and activin membrane-bound inhibitor -1.5174
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 -1.51609
XPC xeroderma pigmentosum, complementation group C -1.5084
CLASP2 cytoplasmic linker associated protein 2 -1.50364
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) -1.50012
MAGEA8 melanoma antigen family A8 -1.49715
AGO3 argonaute RISC catalytic component 3 -1.49602
DDHD2 DDHD domain containing 2 -1.487
COPG1 coatomer protein complex, subunit gamma 1 -1.48673
ZSCAN16 zinc finger and SCAN domain containing 16 -1.48618
MAN2C1 mannosidase, alpha, class 2C, member 1 -1.48522
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme -1.48425
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) -1.47767
SIM2 single-minded family bHLH transcription factor 2 -1.46658
RNFT2 ring finger protein, transmembrane 2 -1.46478
PLCD1 phospholipase C, delta 1 -1.46294
PREPL prolyl endopeptidase-like -1.46282
HOXC8 homeobox C8 -1.45504
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1 -1.4485
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) -1.44809
CBX8 chromobox homolog 8 -1.43767
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 -1.43506
RHOF ras homolog family member F (in filopodia) -1.42708
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 -1.42672
ORAI2 ORAI calcium release-activated calcium modulator 2 -1.41993
RYBP RING1 and YY1 binding protein -1.41898
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B -1.41751