CAL62 Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
External Link https://depmap.org/portal/cell_line/ACH-000174
Similar Terms
Downloads & Tools

Genes

324 gene knockdowns changing fitness of CAL62 relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 17.5133
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) 10.4421
CDK17 cyclin-dependent kinase 17 8.23305
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 7.91976
FGD1 FYVE, RhoGEF and PH domain containing 1 7.7987
FBXL3 F-box and leucine-rich repeat protein 3 7.53828
ISG15 ISG15 ubiquitin-like modifier 7.30694
ETV5 ets variant 5 6.69673
BLVRA biliverdin reductase A 6.53677
FAM161B family with sequence similarity 161, member B 6.47222
WASL Wiskott-Aldrich syndrome-like 6.3708
LLGL1 lethal giant larvae homolog 1 (Drosophila) 6.25111
ZMIZ2 zinc finger, MIZ-type containing 2 6.19368
DUSP5 dual specificity phosphatase 5 6.15551
MYO10 myosin X 6.02305
RSU1 Ras suppressor protein 1 5.96157
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 5.93243
TBPL1 TBP-like 1 5.66276
STX12 syntaxin 12 5.57412
MIDEAS mitotic deacetylase associated SANT domain protein 5.56365
PRRC2B proline-rich coiled-coil 2B 5.47319
MARF1 meiosis regulator and mRNA stability factor 1 5.34565
SRC SRC proto-oncogene, non-receptor tyrosine kinase 5.31395
OR10A3 olfactory receptor, family 10, subfamily A, member 3 5.21543
RHBDD2 rhomboid domain containing 2 5.15721
KIF20B kinesin family member 20B 5.11393
ERBIN erbb2 interacting protein 5.09348
EDC3 enhancer of mRNA decapping 3 5.07903
MACO1 macoilin 1 5.06875
BRPF3 bromodomain and PHD finger containing, 3 4.98101
PDGFB platelet-derived growth factor beta polypeptide 4.8812
BHLHE40 basic helix-loop-helix family, member e40 4.85594
PDYN prodynorphin 4.77111
ADCY7 adenylate cyclase 7 4.69441
PAPOLG poly(A) polymerase gamma 4.68727
SLC35A5 solute carrier family 35, member A5 4.5693
BCAR3 breast cancer anti-estrogen resistance 3 4.4365
RHOG ras homolog family member G 4.43414
CNTROB centrobin, centrosomal BRCA2 interacting protein 4.38427
PCIF1 PDX1 C-terminal inhibiting factor 1 4.37282
CEP85L centrosomal protein 85kDa-like 4.17254
CSK c-src tyrosine kinase 4.13464
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 4.07999
KIF2A kinesin heavy chain member 2A 4.05684
SCAF8 SR-related CTD-associated factor 8 4.01514
SUN5 Sad1 and UNC84 domain containing 5 4.00737
ASB7 ankyrin repeat and SOCS box containing 7 4.00127
PEA15 phosphoprotein enriched in astrocytes 15 3.91791
VPS35L VPS35 endosomal protein sorting factor like 3.90082
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 3.85925
CDRT15L2 CMT1A duplicated region transcript 15-like 2 3.85172
ROGDI rogdi homolog (Drosophila) 3.83855
DIAPH1 diaphanous-related formin 1 3.80633
KIF2B kinesin family member 2B 3.7502
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 3.74161
CPQ carboxypeptidase Q 3.73276
LOC105375355 uroplakin-3b 3.69632
PTPN1 protein tyrosine phosphatase, non-receptor type 1 3.67353
BCAR1 breast cancer anti-estrogen resistance 1 3.63367
MNMIP1 manchette microtubule inner protein 1 3.62878
KLB klotho beta 3.6258
KLF10 Kruppel-like factor 10 3.62276
RCE1 Ras converting CAAX endopeptidase 1 3.61719
RGS6 regulator of G-protein signaling 6 3.57541
CREBBP CREB binding protein 3.54226
CAMK2B calcium/calmodulin-dependent protein kinase II beta 3.53236
SCAPER S-phase cyclin A-associated protein in the ER 3.52406
MCPH1 microcephalin 1 3.4974
CSAD cysteine sulfinic acid decarboxylase 3.46789
RBM6 RNA binding motif protein 6 3.45766
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1 3.43144
BIN2 bridging integrator 2 3.36644
CPNE1 copine I 3.36174
TTC14 tetratricopeptide repeat domain 14 3.35859
C12ORF49 chromosome 12 open reading frame 49 3.34645
CEP250 centrosomal protein 250kDa 3.34482
MARK3 MAP/microtubule affinity-regulating kinase 3 3.33914
BAG4 BCL2-associated athanogene 4 3.33781
VASP vasodilator-stimulated phosphoprotein 3.32111
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 3.3133
KDM4B lysine (K)-specific demethylase 4B 3.30944
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 3.29439
NPC1 Niemann-Pick disease, type C1 3.29394
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 3.27806
MTMR3 myotubularin related protein 3 3.27579
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 3.24829
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 3.24319
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 3.23943
ZG16 zymogen granule protein 16 3.23631
MAGEA4 melanoma antigen family A4 3.22572
EVA1A eva-1 homolog A (C. elegans) 3.22487
SLC45A2 solute carrier family 45, member 2 3.21962
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 3.21283
ARPC5L actin related protein 2/3 complex, subunit 5-like 3.18827
LCE3C late cornified envelope 3C 3.18608
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 3.17726
RRAS2 related RAS viral (r-ras) oncogene homolog 2 3.17187
SEPTIN2 septin 2 3.16252
PLA2G12A phospholipase A2, group XIIA 3.14048
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 3.13003
DDR1 discoidin domain receptor tyrosine kinase 1 3.12993
TEX22 testis expressed 22 3.12876
GTF2H5 general transcription factor IIH, polypeptide 5 3.1232
ZNF479 zinc finger protein 479 3.11228
ASNS asparagine synthetase (glutamine-hydrolyzing) 3.10066
RBBP7 retinoblastoma binding protein 7 3.07993
RAF1 Raf-1 proto-oncogene, serine/threonine kinase 3.06941
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 3.05169
MSL3 male-specific lethal 3 homolog (Drosophila) 3.04527
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 3.03005
H2BFWT H2B histone family, member W, testis-specific 3.02974
ZNF384 zinc finger protein 384 3.01823
FCAMR Fc receptor, IgA, IgM, high affinity 3.01189
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 3.01115
LYPLA2 lysophospholipase II 2.99751
ZNRD2 zinc ribbon domain containing 2 2.99328
SET SET nuclear proto-oncogene 2.96417
NTAQ1 N-terminal glutamine amidase 1 2.96102
OR5K3 olfactory receptor, family 5, subfamily K, member 3 2.9495
C1QL2 complement component 1, q subcomponent-like 2 2.93412
ECT2L epithelial cell transforming 2 like 2.93097
SUMO1 small ubiquitin-like modifier 1 2.9046
PGAM2 phosphoglycerate mutase 2 (muscle) 2.90375
CHSY1 chondroitin sulfate synthase 1 2.89715
R3HDM1 R3H domain containing 1 2.8868
TRPC7 transient receptor potential cation channel, subfamily C, member 7 2.8747
SLC22A17 solute carrier family 22, member 17 2.87216
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 2.8571
RAB21 RAB21, member RAS oncogene family 2.84175
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.84015
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 2.82123
RNASEH2B ribonuclease H2, subunit B 2.80025
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 2.79693
DTX2 deltex 2, E3 ubiquitin ligase 2.78463
ADGRB2 adhesion G protein-coupled receptor B2 2.77082
DRG2 developmentally regulated GTP binding protein 2 2.75432
DCP2 decapping mRNA 2 2.75295
TLK1 tousled-like kinase 1 2.74938
RAI14 retinoic acid induced 14 2.74624
DPH5 diphthamide biosynthesis 5 2.74018
ELAVL1 ELAV like RNA binding protein 1 2.72875
CDK3 cyclin-dependent kinase 3 2.72603
CCNY cyclin Y 2.72052
GNA13 guanine nucleotide binding protein (G protein), alpha 13 2.71777
CXCR5 chemokine (C-X-C motif) receptor 5 2.71481
ZNF800 zinc finger protein 800 2.7144
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 2.71286
SPNS1 spinster homolog 1 (Drosophila) 2.69976
CCM2 cerebral cavernous malformation 2 2.69655
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 2.69174
RXRA retinoid X receptor, alpha 2.66849
GPC2 glypican 2 2.65529
MTSS2 MTSS I-BAR domain containing 2 2.64692
ZFYVE1 zinc finger, FYVE domain containing 1 2.64373
UGT2B11 UDP glucuronosyltransferase 2 family, polypeptide B11 2.64141
KIAA1217 KIAA1217 2.64088
LUC7L2 LUC7-like 2 (S. cerevisiae) 2.63812
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 2.63393
BPIFB3 BPI fold containing family B, member 3 2.633
NOTCH4 notch 4 2.63133
ZC3HC1 zinc finger, C3HC-type containing 1 2.61657
PHF8 PHD finger protein 8 2.60943
CABIN1 calcineurin binding protein 1 2.60031
WFDC8 WAP four-disulfide core domain 8 2.59556
KLF3 Kruppel-like factor 3 (basic) 2.59465
SAMD4A sterile alpha motif domain containing 4A 2.58215
RGL3 ral guanine nucleotide dissociation stimulator-like 3 2.57783
CIB4 calcium and integrin binding family member 4 2.5704
DPP3 dipeptidyl-peptidase 3 2.56075
ZNF341 zinc finger protein 341 2.55464
EDC4 enhancer of mRNA decapping 4 2.55102
EIF4H eukaryotic translation initiation factor 4H 2.54469
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 2.54269
MCTP1 multiple C2 domains, transmembrane 1 2.53894
CHTOP chromatin target of PRMT1 2.5365
TCF7 transcription factor 7 (T-cell specific, HMG-box) 2.52974
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 2.52315
ZBTB12 zinc finger and BTB domain containing 12 2.52046
ADAT2 adenosine deaminase, tRNA-specific 2 2.51711
CNPY4 canopy FGF signaling regulator 4 2.50843
UBE4B ubiquitination factor E4B 2.49852
USP18 ubiquitin specific peptidase 18 2.49781
SOX12 SRY (sex determining region Y)-box 12 2.49561
PLEK pleckstrin 2.49288
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 2.4905
OTOP3 otopetrin 3 2.48319
STK11 serine/threonine kinase 11 2.48066
USP1 ubiquitin specific peptidase 1 2.47592
ATRN attractin 2.47272
PXK PX domain containing serine/threonine kinase 2.47101
C19ORF25 chromosome 19 open reading frame 25 2.46827
ZNF526 zinc finger protein 526 2.46641
SP1 Sp1 transcription factor 2.46555
ZER1 zyg-11 related, cell cycle regulator 2.45667
KIAA1257 KIAA1257 2.44363
BCL2L12 BCL2-like 12 (proline rich) 2.44153
ANKRD11 ankyrin repeat domain 11 2.43834
FRMD4A FERM domain containing 4A 2.42668
PRUNE1 prune exopolyphosphatase 1 2.42534
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 2.41968
MRPS36 mitochondrial ribosomal protein S36 2.41689
RYR1 ryanodine receptor 1 (skeletal) 2.41464
KRT72 keratin 72, type II 2.41131
IER2 immediate early response 2 2.40156
DOCK4 dedicator of cytokinesis 4 2.39624
OR8S1 olfactory receptor, family 8, subfamily S, member 1 2.39622
SLC22A25 solute carrier family 22, member 25 2.38732
TXNDC9 thioredoxin domain containing 9 2.37008
TM4SF18 transmembrane 4 L six family member 18 2.36817
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa 2.36431
RCSD1 RCSD domain containing 1 2.363
MYO7B myosin VIIB 2.36193
METTL15 methyltransferase like 15 2.36144
PXN paxillin 2.3594
PIAS1 protein inhibitor of activated STAT, 1 2.35558
ARL8B ADP-ribosylation factor-like 8B 2.35459
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 2.35363
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 2.34511
SELENOT selenoprotein T 2.33057
NAV2 neuron navigator 2 2.33039
DPEP2 dipeptidase 2 2.3298
SLC26A11 solute carrier family 26 (anion exchanger), member 11 2.32894
POTEF POTE ankyrin domain family, member F 2.32257
CRTAC1 cartilage acidic protein 1 2.31581
RBM7 RNA binding motif protein 7 2.31392
TTC5 tetratricopeptide repeat domain 5 2.31319
MIX23 mitochondrial matrix import factor 23 2.28953
BCL2L11 BCL2-like 11 (apoptosis facilitator) 2.28675
ERAP1 endoplasmic reticulum aminopeptidase 1 2.28646
C11ORF63 chromosome 11 open reading frame 63 2.28475
ZNF619 zinc finger protein 619 2.27525
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 2.25803
MARK2 MAP/microtubule affinity-regulating kinase 2 2.24604
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 2.2449
PRSS3 protease, serine, 3 2.23877
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.23877
LUZP1 leucine zipper protein 1 2.23684
IST1 increased sodium tolerance 1 homolog (yeast) 2.23236
MESD mesoderm development LRP chaperone 2.22249
GPATCH11 G patch domain containing 11 2.22073
PLAGL2 pleiomorphic adenoma gene-like 2 2.21805
RBM45 RNA binding motif protein 45 2.21729
UBALD1 UBA-like domain containing 1 2.21727
PRM2 protamine 2 2.21299
ZNFX1 zinc finger, NFX1-type containing 1 2.21221
CLEC18B C-type lectin domain family 18, member B 2.21185
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 2.21054
ACTR5 ARP5 actin-related protein 5 homolog (yeast) 2.19094
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 2.18989
LEMD2 LEM domain containing 2 2.18904
PCDH9 protocadherin 9 2.18429
ENGASE endo-beta-N-acetylglucosaminidase 2.17861
HDDC3 HD domain containing 3 2.17669
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 2.17565
GSTA1 glutathione S-transferase alpha 1 2.17295
PCM1 pericentriolar material 1 2.16959
PRR22 proline rich 22 2.16919
NEB nebulin 2.16881
PSG4 pregnancy specific beta-1-glycoprotein 4 2.16727
SH3BP1 SH3-domain binding protein 1 2.16146
SCAF11 SR-related CTD-associated factor 11 2.15776
CD86 CD86 molecule 2.15512
ITLN2 intelectin 2 2.1533
FLII flightless I homolog (Drosophila) 2.14601
GPRIN3 GPRIN family member 3 2.13607
LCN12 lipocalin 12 2.13397
PLAUR plasminogen activator, urokinase receptor 2.13233
RGMB repulsive guidance molecule family member b 2.1303
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 2.13014
DPF3 D4, zinc and double PHD fingers, family 3 2.12845
SEPHS1 selenophosphate synthetase 1 2.12794
ARMC12 armadillo repeat containing 12 2.12451
RNF148 ring finger protein 148 2.12297
AGO4 argonaute RISC catalytic component 4 2.11198
TRIR telomerase RNA component interacting RNase 2.11084
CARD14 caspase recruitment domain family, member 14 2.10894
LCE1B late cornified envelope 1B 2.10759
ACSL3 acyl-CoA synthetase long-chain family member 3 2.10753
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2.10703
RIPK3 receptor-interacting serine-threonine kinase 3 2.10669
RAMP3 receptor (G protein-coupled) activity modifying protein 3 2.10575
DBNL drebrin-like 2.1036
VAC14 Vac14 homolog (S. cerevisiae) 2.1028
SOX7 SRY (sex determining region Y)-box 7 2.09972
RFC1 replication factor C (activator 1) 1, 145kDa 2.09417
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) 2.09406
BPIFA3 BPI fold containing family A, member 3 2.09324
TGM3 transglutaminase 3 2.09309
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 2.09057
ACP3 acid phosphatase 3 2.0852
AASDH aminoadipate-semialdehyde dehydrogenase 2.08242
TNNT2 troponin T type 2 (cardiac) 2.07854
ZDHHC17 zinc finger, DHHC-type containing 17 2.07717
OR4D9 olfactory receptor, family 4, subfamily D, member 9 2.0769
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 2.07567
ORC2 origin recognition complex, subunit 2 2.07399
TMEM217 transmembrane protein 217 2.07333
MARCH10 membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase 2.07123
DNAL1 dynein, axonemal, light chain 1 2.06524
EXD2 exonuclease 3'-5' domain containing 2 2.06447
ZNF792 zinc finger protein 792 2.06355
SETD5 SET domain containing 5 2.06057
LTBP1 latent transforming growth factor beta binding protein 1 2.05972
SACK1A scaffolding CK1 anchoring protein A 2.04987
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa 2.04783
IFNA14 interferon, alpha 14 2.04727
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative) 2.0439
CCDC144A coiled-coil domain containing 144A 2.03973
TTYH2 tweety family member 2 2.03882
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 2.03128
FXYD7 FXYD domain containing ion transport regulator 7 2.03017
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 2.02165
ELOVL1 ELOVL fatty acid elongase 1 2.01802
GSTM2 glutathione S-transferase mu 2 (muscle) 2.01393
SP110 SP110 nuclear body protein 2.0136
MAPK14 mitogen-activated protein kinase 14 2.01317
PKD2L2 polycystic kidney disease 2-like 2 2.01277
GLTP glycolipid transfer protein 2.00698
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) 2.00687
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 2.00512
ILK integrin-linked kinase 2.00475
CSDE1 cold shock domain containing E1, RNA-binding 2.00172
PCP2 Purkinje cell protein 2 2.00154
CPNE9 copine family member IX 2.00077