CARD11 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description caspase recruitment domain family, member 11|The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 84433)
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Genes

334 genes differentially expressed following the CARD11 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
OR2A1 olfactory receptor, family 2, subfamily A, member 1 3.63588
DDN dendrin 3.63588
GJB3 gap junction protein, beta 3, 31kDa 3.63588
CD300A CD300a molecule 3.63588
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 3.63588
SIGLEC9 sialic acid binding Ig-like lectin 9 3.63588
ASB12 ankyrin repeat and SOCS box containing 12 3.63588
OPRL1 opiate receptor-like 1 3.63588
SPINT3 serine peptidase inhibitor, Kunitz type, 3 3.63588
ANKRD34A ankyrin repeat domain 34A 3.63588
RIMBP2 RIMS binding protein 2 3.63588
HYAL4 hyaluronoglucosaminidase 4 3.63588
FGL2 fibrinogen-like 2 3.63588
RNF17 ring finger protein 17 3.63588
CD6 CD6 molecule 3.63588
ALB albumin 3.63588
MYO7A myosin VIIA 3.63588
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 3.63588
COLEC10 collectin sub-family member 10 (C-type lectin) 3.63588
SCGN secretagogin, EF-hand calcium binding protein 3.63588
BSND barttin CLCNK-type chloride channel accessory beta subunit 3.63588
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 3.63588
PCDH8 protocadherin 8 3.63588
TDRD6 tudor domain containing 6 3.63588
TDRD9 tudor domain containing 9 3.63588
RNF39 ring finger protein 39 3.63588
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 3.63588
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 3.63588
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 3.63588
PANO1 proapoptotic nucleolar protein 1 3.63588
PCDHGA12 protocadherin gamma subfamily A, 12 3.63588
PITX3 paired-like homeodomain 3 3.63588
ASCL3 achaete-scute family bHLH transcription factor 3 3.63588
OR14A2 olfactory receptor, family 14, subfamily A, member 2 3.63588
CPLX4 complexin 4 3.63588
MRC1 mannose receptor, C type 1 3.63588
LGALS4 lectin, galactoside-binding, soluble, 4 3.63588
DLX4 distal-less homeobox 4 3.63588
SPDYE11 speedy/RINGO cell cycle regulator family member E11 3.63588
OC90 otoconin 90 3.63588
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 3.63588
ADAT3 adenosine deaminase, tRNA-specific 3 3.63588
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 3.63588
LRRC63 leucine rich repeat containing 63 3.63588
BFSP2 beaded filament structural protein 2, phakinin 3.63588
TSPAN1 tetraspanin 1 3.63588
CHRDL2 chordin-like 2 3.63588
LOC124901872 uncharacterized LOC124901872 3.63588
ELOVL3 ELOVL fatty acid elongase 3 3.63588
ASB11 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase 3.63588
MLN motilin 3.63588
TBC1D3L TBC1 domain family, member 3L 3.63588
LMNTD2 lamin tail domain containing 2 3.63588
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 3.63588
ASB5 ankyrin repeat and SOCS box containing 5 3.63588
DOK7 docking protein 7 3.63588
RAB36 RAB36, member RAS oncogene family 3.63588
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 3.63588
PTH1R parathyroid hormone 1 receptor 3.63588
PLAAT2 phospholipase A and acyltransferase 2 3.63588
CIROZ ciliated left-right organizer protein containing ZP-N domains 3.63588
C8ORF90 chromosome 8 open reading frame 90 3.63588
SMIM45 small integral membrane protein 45 3.63588
POU2AF2 POU class 2 homeobox associating factor 2 3.63588
GARIN4 golgi associated RAB2 interactor family member 4 3.63588
TEX55 testis expressed 55 3.63588
CFAP206 cilia and flagella associated protein 206 3.63588
VXN vexin 3.63588
JAML junction adhesion molecule like 3.63588
RASD2 RASD family, member 2 3.63588
OR8G5 olfactory receptor, family 8, subfamily G, member 5 3.63588
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 3.63588
TBX5 T-box 5 3.63588
GZMM granzyme M (lymphocyte met-ase 1) 3.63588
AWAT1 acyl-CoA wax alcohol acyltransferase 1 3.63588
GOLGA7B golgin A7 family, member B 3.63588
TMEM233 transmembrane protein 233 3.63588
MAGEB1 melanoma antigen family B1 3.63588
RHOXF2 Rhox homeobox family, member 2 3.63588
KLHL33 kelch-like family member 33 3.63588
NKX2-6 NK2 homeobox 6 3.63588
KCNT1 potassium channel, sodium activated subfamily T, member 1 3.63588
OR2L2 olfactory receptor, family 2, subfamily L, member 2 3.63588
RASAL3 RAS protein activator like 3 3.63588
ASIC3 acid sensing (proton gated) ion channel 3 3.63588
PLEK2 pleckstrin 2 3.63588
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 3.63588
OOSP1 oocyte secreted protein 1, pseudogene 3.63588
IL1R1 interleukin 1 receptor, type I 3.63588
SAA2 serum amyloid A2 3.63588
UTS2 urotensin 2 3.63588
PGLYRP2 peptidoglycan recognition protein 2 3.63588
CCR9 chemokine (C-C motif) receptor 9 3.63588
PCDHA3 protocadherin alpha 3 3.63588
JMJD1C jumonji domain containing 1C 3.63588
TIGIT T cell immunoreceptor with Ig and ITIM domains 3.63588
C9ORF64 chromosome 9 open reading frame 64 3.63588
NOX3 NADPH oxidase 3 3.63588
HOGA1 4-hydroxy-2-oxoglutarate aldolase 1 3.63588
PRAMEF12 PRAME family member 12 3.63588
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 3.63588
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 3.63588
BPIFB1 BPI fold containing family B, member 1 3.63588
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 3.63588
F2RL2 coagulation factor II (thrombin) receptor-like 2 3.63588
AQP7 aquaporin 7 3.63588
KLHL1 kelch-like family member 1 3.63588
MORC1 MORC family CW-type zinc finger 1 3.63588
CABP5 calcium binding protein 5 3.63588
LRCOL1 leucine rich colipase-like 1 3.63588
ENDOU endonuclease, polyU-specific 3.63588
KRTAP5-10 keratin associated protein 5-10 3.63588
GAGE10 G antigen 10 3.63588
NIM1K NIM1 serine/threonine protein kinase 3.63588
LCT lactase 3.63588
EFCAB3 EF-hand calcium binding domain 3 3.63588
CDH10 cadherin 10, type 2 (T2-cadherin) 3.63588
MAB21L3 mab-21-like 3 (C. elegans) 3.63588
ADGRD1 adhesion G protein-coupled receptor D1 3.63588
TRIM7 tripartite motif containing 7 3.63588
GSC2 goosecoid homeobox 2 3.63588
NKX6-3 NK6 homeobox 3 3.63588
TSPAN19 tetraspanin 19 3.63588
KLHDC1 kelch domain containing 1 3.63588
SYT5 synaptotagmin V 3.63588
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 3.63588
NLRP14 NLR family, pyrin domain containing 14 3.63588
RPAP2 RNA polymerase II associated protein 2 3.63588
PRSS33 protease, serine, 33 3.63588
URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase 3.63588
CCL17 chemokine (C-C motif) ligand 17 3.63588
SIAH3 siah E3 ubiquitin protein ligase family member 3 3.63588
ITGA8 integrin, alpha 8 3.63588
FAM135B family with sequence similarity 135, member B 3.63588
KLK3 kallikrein-related peptidase 3 3.63588
PRPH peripherin 3.63588
SAMD9 sterile alpha motif domain containing 9 3.63588
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3.63588
ART1 ADP-ribosyltransferase 1 3.63588
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 3.63588
HEPN1 hepatocellular carcinoma, down-regulated 1 3.63588
CSF3R colony stimulating factor 3 receptor (granulocyte) 3.63588
PF4V1 platelet factor 4 variant 1 3.63588
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 3.63588
C9ORF57 chromosome 9 open reading frame 57 3.63588
SNTN sentan, cilia apical structure protein 3.63588
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 3.63588
CD8A CD8a molecule 3.63588
GCM1 glial cells missing homolog 1 (Drosophila) 3.63588
OR13A1 olfactory receptor, family 13, subfamily A, member 1 3.63588
RP1 retinitis pigmentosa 1 (autosomal dominant) 3.63588
C10ORF90 chromosome 10 open reading frame 90 3.63588
PRSS56 protease, serine, 56 3.63588
TRAF3IP3 TRAF3 interacting protein 3 3.63588
IFITM10 interferon induced transmembrane protein 10 3.63588
TRPM2 transient receptor potential cation channel, subfamily M, member 2 3.63588
SFRP4 secreted frizzled-related protein 4 3.57531
DBNL drebrin-like 3.41245
TSC22D2 TSC22 domain family, member 2 3.41245
NIFK nucleolar protein interacting with the FHA domain of MKI67 3.25209
TMOD1 tropomodulin 1 3.19583
PODXL podocalyxin-like 3.1245
CDC20B cell division cycle 20B 3.05399
IGSF6 immunoglobulin superfamily, member 6 2.95437
CC2D1A coiled-coil and C2 domain containing 1A 2.9012
F2R coagulation factor II (thrombin) receptor 2.89443
LIN28B lin-28 homolog B (C. elegans) 2.88267
PELI2 pellino E3 ubiquitin protein ligase family member 2 2.79305
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.73828
DLGAP2 discs, large (Drosophila) homolog-associated protein 2 2.73828
RUFY4 RUN and FYVE domain containing 4 2.68863
STKLD1 serine/threonine kinase-like domain containing 1 2.68863
OXSM 3-oxoacyl-ACP synthase, mitochondrial 2.68863
SLITRK3 SLIT and NTRK-like family, member 3 2.68863
ANGPT4 angiopoietin 4 2.68863
ACTL8 actin-like 8 2.68863
RUNDC3B RUN domain containing 3B 2.66636
NKX3-1 NK3 homeobox 1 2.66636
AFF4 AF4/FMR2 family, member 4 2.66636
ZNF609 zinc finger protein 609 2.66636
BCL3 B-cell CLL/lymphoma 3 2.66508
ANKRD24 ankyrin repeat domain 24 2.60415
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.58023
ZCCHC9 zinc finger, CCHC domain containing 9 2.52334
AMER2 APC membrane recruitment protein 2 2.48854
RGL4 ral guanine nucleotide dissociation stimulator-like 4 2.48854
KIF4B kinesin family member 4B 2.48854
MSRB3 methionine sulfoxide reductase B3 2.48279
GTF2A1L general transcription factor IIA, 1-like 2.46062
C1ORF216 chromosome 1 open reading frame 216 2.43166
SLC16A6 solute carrier family 16, member 6 2.42812
SFSWAP splicing factor, suppressor of white-apricot family 2.41796
ANO10 anoctamin 10 2.3938
GDF6 growth differentiation factor 6 2.34087
GPHA2 glycoprotein hormone alpha 2 2.34087
FOXB1 forkhead box B1 2.34087
SNAP23 synaptosomal-associated protein, 23kDa 2.34087
DMXL2 Dmx-like 2 2.31335
MARS2 methionyl-tRNA synthetase 2, mitochondrial 2.31306
REV1 REV1, polymerase (DNA directed) 2.28792
AK8 adenylate kinase 8 2.26189
PKM pyruvate kinase, muscle 2.25388
UBE2Z ubiquitin-conjugating enzyme E2Z 2.2237
SPATA33 spermatogenesis associated 33 2.22295
MYPOP Myb-related transcription factor, partner of profilin 2.18995
SH2B2 SH2B adaptor protein 2 2.18404
BRINP1 bone morphogenetic protein/retinoic acid inducible neural-specific 1 2.17339
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 2.1569
CTCF CCCTC-binding factor (zinc finger protein) 2.1569
MUC19 mucin 19, oligomeric 2.15059
ZNF296 zinc finger protein 296 2.15059
RALY RALY heterogeneous nuclear ribonucleoprotein 2.12292
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 2.11475
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 2.08957
BOD1 biorientation of chromosomes in cell division 1 2.0647
ACBD5 acyl-CoA binding domain containing 5 2.0595
ELAVL1 ELAV like RNA binding protein 1 2.05623
DGCR8 DGCR8 microprocessor complex subunit 2.04999
MYO10 myosin X 2.04285
TCF19 transcription factor 19 2.03671
TMEM106C transmembrane protein 106C 2.03316
A1BG alpha-1-B glycoprotein 2.02702
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) 2.02064
RLF rearranged L-myc fusion 2.00923
PTPRM protein tyrosine phosphatase, receptor type, M 2.00185
SH3GLB1 SH3-domain GRB2-like endophilin B1 2.00031

decreased expression

Symbol Name Standardized Value
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase -3.63588
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2 -3.63588
CARD11 caspase recruitment domain family, member 11 -3.63588
TSKS testis-specific serine kinase substrate -3.63588
GAL galanin/GMAP prepropeptide -3.63588
NTNG2 netrin G2 -3.63588
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 -3.63588
C11ORF52 chromosome 11 open reading frame 52 -3.63588
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 -3.63588
SBSPON somatomedin B and thrombospondin, type 1 domain containing -3.63588
ARHGEF35 Rho guanine nucleotide exchange factor (GEF) 35 -3.42978
HSPA1L heat shock 70kDa protein 1-like -3.41245
GPR12 G protein-coupled receptor 12 -3.41245
FAM43B family with sequence similarity 43, member B -3.41245
ZFP28 ZFP28 zinc finger protein -3.41245
EPOP elongin BC and polycomb repressive complex 2 associated protein -3.41245
CRYAB crystallin, alpha B -3.41245
PCDHB9 protocadherin beta 9 -3.41245
BTK Bruton agammaglobulinemia tyrosine kinase -3.41245
NOTO notochord homeobox -3.41245
PSD2 pleckstrin and Sec7 domain containing 2 -3.41245
HYPK huntingtin interacting protein K -3.41245
CLEC4D C-type lectin domain family 4, member D -3.41245
PRDM6 PR domain containing 6 -3.41245
ZGLP1 zinc finger, GATA-like protein 1 -3.41245
SPI1 Spi-1 proto-oncogene -3.41245
MISP3 MISP family member 3 -3.41245
PLAAT4 phospholipase A and acyltransferase 4 -3.41245
MYADML2 myeloid-associated differentiation marker-like 2 -3.41245
GFY golgi-associated, olfactory signaling regulator -3.41245
SPACA9 sperm acrosome associated 9 -3.41245
SPRR2F small proline-rich protein 2F -3.41245
RGPD5 RANBP2-like and GRIP domain containing 5 -3.41245
TEKT2 tektin 2 (testicular) -3.41245
BEAN1 brain expressed, associated with NEDD4, 1 -3.41245
CER1 cerberus 1, DAN family BMP antagonist -3.41245
MTMR10 myotubularin related protein 10 -3.38125
ZNF536 zinc finger protein 536 -3.26022
PELI3 pellino E3 ubiquitin protein ligase family member 3 -3.26022
MLXIPL MLX interacting protein-like -3.20878
CA8 carbonic anhydrase VIII -2.98935
POLR2H polymerase (RNA) II (DNA directed) polypeptide H -2.98537
PCGF1 polycomb group ring finger 1 -2.93465
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -2.93465
COQ6 coenzyme Q6 monooxygenase -2.90629
RHBDD1 rhomboid domain containing 1 -2.90582
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -2.8752
ECH1 enoyl CoA hydratase 1, peroxisomal -2.86837
MOSPD3 motile sperm domain containing 3 -2.85368
COL5A3 collagen, type V, alpha 3 -2.7774
PRELID1 PRELI domain containing 1 -2.76792
ZBTB43 zinc finger and BTB domain containing 43 -2.72945
SRSF6 serine/arginine-rich splicing factor 6 -2.72605
PRPF31 pre-mRNA processing factor 31 -2.68863
FAF1 Fas (TNFRSF6) associated factor 1 -2.65429
FDXR ferredoxin reductase -2.61379
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 -2.52334
PCDHB16 protocadherin beta 16 -2.52334
HSPA12B heat shock 70kD protein 12B -2.4913
DNAAF19 dynein axonemal assembly factor 19 -2.4913
BRD7 bromodomain containing 7 -2.45041
BEND4 BEN domain containing 4 -2.43041
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 -2.42541
ZBTB5 zinc finger and BTB domain containing 5 -2.41796
SLC38A4 solute carrier family 38, member 4 -2.37234
TCF24 transcription factor 24 -2.37171
WDR49 WD repeat domain 49 -2.36061
SPINK5 serine peptidase inhibitor, Kazal type 5 -2.35311
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) -2.32773
CCDC88B coiled-coil domain containing 88B -2.32033
CPNE9 copine family member IX -2.31769
PCLAF PCNA clamp associated factor -2.29982
XKR5 XK, Kell blood group complex subunit-related family, member 5 -2.29664
VSTM2B V-set and transmembrane domain containing 2B -2.29004
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma -2.29004
LACC1 laccase (multicopper oxidoreductase) domain containing 1 -2.27726
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene) -2.26189
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12 -2.25687
STAG2 stromal antigen 2 -2.2536
FREM3 FRAS1 related extracellular matrix 3 -2.2536
KCTD18 potassium channel tetramerization domain containing 18 -2.25151
SEC14L2 SEC14-like 2 (S. cerevisiae) -2.24492
MAGT1 magnesium transporter 1 -2.22156
CDH12 cadherin 12, type 2 (N-cadherin 2) -2.19702
NUTM2G NUT family member 2G -2.19702
PCSK1 proprotein convertase subtilisin/kexin type 1 -2.19702
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 -2.18968
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -2.17339
SCG5 secretogranin V -2.16707
THAP4 THAP domain containing 4 -2.1581
NPAS2 neuronal PAS domain protein 2 -2.15449
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -2.13983
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 -2.13854
BASP1 brain abundant, membrane attached signal protein 1 -2.12791
SMCO2 single-pass membrane protein with coiled-coil domains 2 -2.11475
USP27X ubiquitin specific peptidase 27, X-linked -2.11475
ASPG asparaginase -2.11475
DYNLT2 dynein light chain Tctex-type 2 -2.11475
NGFR nerve growth factor receptor -2.11475
JSRP1 junctional sarcoplasmic reticulum protein 1 -2.11475
SCAMP4 secretory carrier membrane protein 4 -2.09388
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 -2.0647
CFAP96 cilia and flagella associated protein 96 -2.0484
MRPL18 mitochondrial ribosomal protein L18 -2.04717
CDC40 cell division cycle 40 -2.02516
TENM2 teneurin transmembrane protein 2 -2.00923
XYLT1 xylosyltransferase I -2.00717
CLGN calmegin -2.00687