CAS-1 Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
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Genes

335 genes with high or low expression in CAS-1 relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
ZYX zyxin 2.98926
BMP1 bone morphogenetic protein 1 2.84153
COL1A1 collagen, type I, alpha 1 2.80471
LIMK1 LIM domain kinase 1 2.65406
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 2.64243
THY1 Thy-1 cell surface antigen 2.53978
FTO fat mass and obesity associated 2.50234
MAP4 microtubule-associated protein 4 2.49964
CNN2 calponin 2 2.49333
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 2.46322
CSNK1D casein kinase 1, delta 2.37844
HMOX1 heme oxygenase 1 2.35665
CH25H cholesterol 25-hydroxylase 2.31489
OPRD1 opioid receptor, delta 1 2.23699
CYB5R3 cytochrome b5 reductase 3 2.23198
GRIA3 glutamate receptor, ionotropic, AMPA 3 2.22756
PLXDC1 plexin domain containing 1 2.15829
CHMP6 charged multivesicular body protein 6 2.15063
DBN1 drebrin 1 2.13996
GLIPR1 GLI pathogenesis-related 1 2.10482
UBTD1 ubiquitin domain containing 1 2.09804
PEX26 peroxisomal biogenesis factor 26 2.09785
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 2.06421
TMUB2 transmembrane and ubiquitin-like domain containing 2 2.05894
WDR1 WD repeat domain 1 2.05846
COL8A2 collagen, type VIII, alpha 2 2.03667
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 2.03449
NF2 neurofibromin 2 (merlin) 2.0323
COL6A2 collagen, type VI, alpha 2 2.02922
RAB5C RAB5C, member RAS oncogene family 2.02526
OR11A1 olfactory receptor, family 11, subfamily A, member 1 2.0249
FKRP fukutin related protein 2.02328
EXOG endo/exonuclease (5'-3'), endonuclease G-like 2.01323
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 1.99982
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 1.99006
TAGLN transgelin 1.95827
SMTN smoothelin 1.95093
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 1.94255
NKIRAS2 NFKB inhibitor interacting Ras-like 2 1.9357
DPYSL4 dihydropyrimidinase-like 4 1.92924
PAMR1 peptidase domain containing associated with muscle regeneration 1 1.92736
MMP14 matrix metallopeptidase 14 (membrane-inserted) 1.91814
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 1.91687
BRD9 bromodomain containing 9 1.91382
G6PC3 glucose 6 phosphatase, catalytic, 3 1.90871
DGCR14 DiGeorge syndrome critical region gene 14 1.90053
FOXO4 forkhead box O4 1.87811
MAPRE1 microtubule-associated protein, RP/EB family, member 1 1.86859
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 1.86519
FOSL2 FOS-like antigen 2 1.86185
LOXL1 lysyl oxidase-like 1 1.85622
GALNS galactosamine (N-acetyl)-6-sulfatase 1.85585
COL6A1 collagen, type VI, alpha 1 1.85068
MAP3K14 mitogen-activated protein kinase kinase kinase 14 1.85013
VGLL4 vestigial-like family member 4 1.84625
ACTA2 actin, alpha 2, smooth muscle, aorta 1.84317
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 1.84175
CKAP4 cytoskeleton-associated protein 4 1.83067
MAPK7 mitogen-activated protein kinase 7 1.82944
GMEB2 glucocorticoid modulatory element binding protein 2 1.82522
ACTN1 actinin, alpha 1 1.81756
PLCG1 phospholipase C, gamma 1 1.81673
GDF5 growth differentiation factor 5 1.813
MAP7D1 MAP7 domain containing 1 1.81173
TATDN2 TatD DNase domain containing 2 1.79974
MYH9 myosin, heavy chain 9, non-muscle 1.78918
DCHS1 dachsous cadherin-related 1 1.7782
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 1.76745
KRT76 keratin 76, type II 1.75872
CHPF2 chondroitin polymerizing factor 2 1.75863
PCDHB8 protocadherin beta 8 1.73772
CENPB centromere protein B, 80kDa 1.73569
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 1.73471
TGFB1I1 transforming growth factor beta 1 induced transcript 1 1.72445
SMG6 SMG6 nonsense mediated mRNA decay factor 1.7205
RRBP1 ribosome binding protein 1 1.72011
RANBP3 RAN binding protein 3 1.71887
RGS3 regulator of G-protein signaling 3 1.71595
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 1.71219
PTRF polymerase I and transcript release factor 1.70967
PDLIM7 PDZ and LIM domain 7 (enigma) 1.70524
PKM pyruvate kinase, muscle 1.70468
PALLD palladin, cytoskeletal associated protein 1.7004
TPM4 tropomyosin 4 1.69778
KIFC3 kinesin family member C3 1.69766
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1 1.69763
ACTB actin, beta 1.69755
SCAMP4 secretory carrier membrane protein 4 1.69697
TUBA1C tubulin, alpha 1c 1.69649
TP53 tumor protein p53 1.68239
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 1.68223
FAM127A family with sequence similarity 127, member A 1.67617
COL1A2 collagen, type I, alpha 2 1.67591
PES1 pescadillo ribosomal biogenesis factor 1 1.67536
DACT1 dishevelled-binding antagonist of beta-catenin 1 1.6698
GJA5 gap junction protein, alpha 5, 40kDa 1.65858
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma 1.6537
SH3GL1 SH3-domain GRB2-like 1 1.65271
SHROOM2 shroom family member 2 1.64835
RGS4 regulator of G-protein signaling 4 1.64133
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 1.6393
HSPB6 heat shock protein, alpha-crystallin-related, B6 1.63896
MED27 mediator complex subunit 27 1.63691
COL6A3 collagen, type VI, alpha 3 1.63546
LMF2 lipase maturation factor 2 1.63105
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 1.61372
ADAM19 ADAM metallopeptidase domain 19 1.61026
CCDC92 coiled-coil domain containing 92 1.60938
KCTD17 potassium channel tetramerization domain containing 17 1.60512
RHOC ras homolog family member C 1.60298
TADA3 transcriptional adaptor 3 1.60219
TECPR2 tectonin beta-propeller repeat containing 2 1.59785
POM121L9P POM121 transmembrane nucleoporin-like 9, pseudogene 1.58587
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1 1.57995
SPAG11B sperm associated antigen 11B 1.57978
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) 1.57125
UBOX5 U-box domain containing 5 1.57016
FAM214B family with sequence similarity 214, member B 1.56577
UBB ubiquitin B 1.5632
LMAN2L lectin, mannose-binding 2-like 1.56313
EPS15P1 epidermal growth factor receptor pathway substrate 15 pseudogene 1 1.56012
CUEDC1 CUE domain containing 1 1.55579
HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 1.5549
PPP4R2 protein phosphatase 4, regulatory subunit 2 1.5491
MYLK myosin light chain kinase 1.54487
GAS6 growth arrest-specific 6 1.5377
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.53315
MXRA7 matrix-remodelling associated 7 1.53248
RBM15B RNA binding motif protein 15B 1.53182
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 1.52894
FLNA filamin A, alpha 1.52874
MED24 mediator complex subunit 24 1.52841
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) 1.52657
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 1.52616
LRRC17 leucine rich repeat containing 17 1.52594
IL26 interleukin 26 1.52534
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic) 1.52442
AKAP4 A kinase (PRKA) anchor protein 4 1.5239
GAS2L1 growth arrest-specific 2 like 1 1.52338
ASTN1 astrotactin 1 1.52227
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) 1.52185
GFRA4 GDNF family receptor alpha 4 1.52027
EXOC7 exocyst complex component 7 1.51983
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 1.51278
NT5DC3 5'-nucleotidase domain containing 3 1.51108
LPPR2 lipid phosphate phosphatase-related protein type 2 1.5108
MTCH1 mitochondrial carrier 1 1.51033
GHSR growth hormone secretagogue receptor 1.50672
MMP9 matrix metallopeptidase 9 1.50499
ADORA1 adenosine A1 receptor 1.49792
BGN biglycan 1.49207
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.48874
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 1.4885
MRC2 mannose receptor, C type 2 1.48551
RANGAP1 Ran GTPase activating protein 1 1.48342
NKX3-2 NK3 homeobox 2 1.47907
TBX10 T-box 10 1.47901
OR1A2 olfactory receptor, family 1, subfamily A, member 2 1.47854
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 1.47818
TNS1 tensin 1 1.47652
CLEC16A C-type lectin domain family 16, member A 1.46949
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 1.46572
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 1.4654
FZD2 frizzled class receptor 2 1.46453
MYOZ3 myozenin 3 1.46357
TMEM158 transmembrane protein 158 (gene/pseudogene) 1.46082
COL5A1 collagen, type V, alpha 1 1.4602
PIGT phosphatidylinositol glycan anchor biosynthesis, class T 1.45944
RAPSN receptor-associated protein of the synapse 1.45566
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1 1.45446
GATAD2A GATA zinc finger domain containing 2A 1.45441
NUP188 nucleoporin 188kDa 1.45439
KRT83 keratin 83, type II 1.45295
NMUR1 neuromedin U receptor 1 1.45202
CSNK1E casein kinase 1, epsilon 1.45134
PPP2R5B protein phosphatase 2, regulatory subunit B', beta 1.45033
MBD3 methyl-CpG binding domain protein 3 1.44888
RNF216 ring finger protein 216 1.44831
NAGLU N-acetylglucosaminidase, alpha 1.44602
OR7A5 olfactory receptor, family 7, subfamily A, member 5 1.44502
GPR132 G protein-coupled receptor 132 1.4433
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 1.44323
TMEM104 transmembrane protein 104 1.44263
FLOT1 flotillin 1 1.44046
TMEM127 transmembrane protein 127 1.4398
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 1.43756
CLIP2 CAP-GLY domain containing linker protein 2 1.43495
NCS1 neuronal calcium sensor 1 1.4337
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 1.43344
ARHGAP22 Rho GTPase activating protein 22 1.43121
CD101 CD101 molecule 1.42995
HYAL2 hyaluronoglucosaminidase 2 1.42626
TAGLN2 transgelin 2 1.42385
MKL1 megakaryoblastic leukemia (translocation) 1 1.42298
UNC45A unc-45 homolog A (C. elegans) 1.4221
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 1.42206

low expression

Symbol Name Standardized Value
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae) -3.53641
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 -3.32006
TMEM87A transmembrane protein 87A -2.88712
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa -2.64972
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -2.55353
CEP97 centrosomal protein 97kDa -2.43344
MTHFSD methenyltetrahydrofolate synthetase domain containing -2.4004
ASB7 ankyrin repeat and SOCS box containing 7 -2.33352
TMBIM4 transmembrane BAX inhibitor motif containing 4 -2.31376
TKFC triokinase/FMN cyclase -2.31115
RABEP1 rabaptin, RAB GTPase binding effector protein 1 -2.31042
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 -2.29863
SPATA5L1 spermatogenesis associated 5-like 1 -2.29204
ZNF7 zinc finger protein 7 -2.22398
EPB41 erythrocyte membrane protein band 4.1 -2.21832
TMPRSS15 transmembrane protease, serine 15 -2.16758
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced -2.1576
EXOC4 exocyst complex component 4 -2.13856
C1D C1D nuclear receptor corepressor -2.12956
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.06142
PLAA phospholipase A2-activating protein -2.05762
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 -2.05211
GHRHR growth hormone releasing hormone receptor -2.02949
MBD5 methyl-CpG binding domain protein 5 -2.01494
ACTR6 ARP6 actin-related protein 6 homolog (yeast) -1.99564
PAX4 paired box 4 -1.98508
ARID4A AT rich interactive domain 4A (RBP1-like) -1.98087
MEF2A myocyte enhancer factor 2A -1.97721
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta -1.96861
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B -1.96145
SPRR1A small proline-rich protein 1A -1.95763
PPCS phosphopantothenoylcysteine synthetase -1.9532
PRR4 proline rich 4 (lacrimal) -1.9384
NR4A2 nuclear receptor subfamily 4, group A, member 2 -1.92969
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 -1.8997
PRPF38B pre-mRNA processing factor 38B -1.89023
TMEM135 transmembrane protein 135 -1.87723
PUM1 pumilio RNA-binding family member 1 -1.86649
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -1.85625
ACOT11 acyl-CoA thioesterase 11 -1.85051
PTPN3 protein tyrosine phosphatase, non-receptor type 3 -1.82915
ZCCHC8 zinc finger, CCHC domain containing 8 -1.82368
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -1.81366
ICA1 islet cell autoantigen 1, 69kDa -1.80888
IFNAR1 interferon (alpha, beta and omega) receptor 1 -1.80758
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -1.80718
ZNF33B zinc finger protein 33B -1.80564
MRS2 MRS2 magnesium transporter -1.78917
ASIC3 acid sensing (proton gated) ion channel 3 -1.78588
RBM34 RNA binding motif protein 34 -1.77401
ISOC1 isochorismatase domain containing 1 -1.75808
ATF3 activating transcription factor 3 -1.74412
FAM60A family with sequence similarity 60, member A -1.74398
RPL11 ribosomal protein L11 -1.73862
MTERF4 mitochondrial transcription termination factor 4 -1.73814
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -1.73465
CDC14A cell division cycle 14A -1.73201
PPP1R12B protein phosphatase 1, regulatory subunit 12B -1.72868
NFE2L2 nuclear factor, erythroid 2-like 2 -1.724
TDP2 tyrosyl-DNA phosphodiesterase 2 -1.72383
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase -1.72199
HIPK3 homeodomain interacting protein kinase 3 -1.72154
ADIPOR1 adiponectin receptor 1 -1.72133
RPH3A rabphilin 3A -1.72002
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -1.71678
CCNT2 cyclin T2 -1.71422
THUMPD2 THUMP domain containing 2 -1.71234
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase -1.69953
GALK2 galactokinase 2 -1.69053
PTGER3 prostaglandin E receptor 3 (subtype EP3) -1.68388
HNF1B HNF1 homeobox B -1.68063
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain -1.67392
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -1.67259
CEPT1 choline/ethanolamine phosphotransferase 1 -1.67148
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -1.66553
YOD1 YOD1 deubiquitinase -1.65531
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) -1.65218
YIPF4 Yip1 domain family, member 4 -1.65018
CD46 CD46 molecule, complement regulatory protein -1.63377
TRIM66 tripartite motif containing 66 -1.62635
TOE1 target of EGR1, member 1 (nuclear) -1.62439
GCH1 GTP cyclohydrolase 1 -1.62084
TPD52 tumor protein D52 -1.61687
PRKCB protein kinase C, beta -1.60432
SYF2 SYF2 pre-mRNA-splicing factor -1.5996
E2F5 E2F transcription factor 5, p130-binding -1.59939
ORC4 origin recognition complex, subunit 4 -1.598
FA2H fatty acid 2-hydroxylase -1.58654
TFB2M transcription factor B2, mitochondrial -1.57018
EMC2 ER membrane protein complex subunit 2 -1.56318
QSER1 glutamine and serine rich 1 -1.56279
LEMD3 LEM domain containing 3 -1.56078
CUL7 cullin 7 -1.55999
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 -1.55991
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -1.55542
ZNF37BP zinc finger protein 37B, pseudogene -1.55483
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 -1.55466
SGK3 serum/glucocorticoid regulated kinase family, member 3 -1.55438
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa -1.55404
SCRN3 secernin 3 -1.55269
PTK2B protein tyrosine kinase 2 beta -1.55043
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -1.54712
FNBP4 formin binding protein 4 -1.54416
LOC642236 FSHD region gene 1 pseudogene -1.54252
SART3 squamous cell carcinoma antigen recognized by T cells 3 -1.53438
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 -1.52895
SYN2 synapsin II -1.52883
ZNF200 zinc finger protein 200 -1.52689
FANCL Fanconi anemia, complementation group L -1.52158
SERBP1 SERPINE1 mRNA binding protein 1 -1.52157
NR2E3 nuclear receptor subfamily 2, group E, member 3 -1.51568
CPB2 carboxypeptidase B2 (plasma) -1.51526
USP8 ubiquitin specific peptidase 8 -1.51316
GK glycerol kinase -1.51185
USP24 ubiquitin specific peptidase 24 -1.51122
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) -1.50346
GLB1L galactosidase, beta 1-like -1.48977
CDC42SE2 CDC42 small effector 2 -1.48844
BRWD1 bromodomain and WD repeat domain containing 1 -1.48736
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) -1.48611
KIAA0485 uncharacterized LOC57235 -1.48012
AK2 adenylate kinase 2 -1.47377
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) -1.47013
HNRNPF heterogeneous nuclear ribonucleoprotein F -1.46905
KRT32 keratin 32, type I -1.46115
RAB26 RAB26, member RAS oncogene family -1.45681
ATF7 activating transcription factor 7 -1.45034
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D -1.45007
SC5D sterol-C5-desaturase -1.44397
METAP2 methionyl aminopeptidase 2 -1.44365
PCBP1 poly(rC) binding protein 1 -1.43497
IMMT inner membrane protein, mitochondrial -1.43018
DARS2 aspartyl-tRNA synthetase 2, mitochondrial -1.42744
ZNF195 zinc finger protein 195 -1.42614
PCID2 PCI domain containing 2 -1.42545
ZSCAN32 zinc finger and SCAN domain containing 32 -1.42287
PCDHGA10 protocadherin gamma subfamily A, 10 -1.4213
LMTK1 lemur tail kinase 1 -1.41918
PHIP pleckstrin homology domain interacting protein -1.41632