CASP1 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description caspase 1, apoptosis-related cysteine peptidase|This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012] (NCBI Entrez Gene Database, 834)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GNF2_CASP1
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Genes

111 co-expressed genes for CASP1 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
AIF1 allograft inflammatory factor 1
AOAH acyloxyacyl hydrolase (neutrophil)
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ARRB2 arrestin, beta 2
BST1 bone marrow stromal cell antigen 1
C20ORF24 chromosome 20 open reading frame 24
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCR1 chemokine (C-C motif) receptor 1
CD1D CD1d molecule
CD302 CD302 molecule
CD33 CD33 molecule
CD44 CD44 molecule (Indian blood group)
CD86 CD86 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CFP complement factor properdin
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLEC4A C-type lectin domain family 4, member A
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CNPY3 canopy FGF signaling regulator 3
COTL1 coactosin-like F-actin binding protein 1
CPPED1 calcineurin-like phosphoesterase domain containing 1
CPVL carboxypeptidase, vitellogenic-like
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTSS cathepsin S
CYBB cytochrome b-245, beta polypeptide
DAZAP2 DAZ associated protein 2
DPEP2 dipeptidase 2
DUSP1 dual specificity phosphatase 1
EVI2A ecotropic viral integration site 2A
EVI2B ecotropic viral integration site 2B
FAM105A family with sequence similarity 105, member A
FBXL5 F-box and leucine-rich repeat protein 5
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FES FES proto-oncogene, tyrosine kinase
FGL2 fibrinogen-like 2
FGR FGR proto-oncogene, Src family tyrosine kinase
FKBP15 FK506 binding protein 15, 133kDa
FMNL1 formin-like 1
GABARAP GABA(A) receptor-associated protein
GMFG glia maturation factor, gamma
GMIP GEM interacting protein
HCK HCK proto-oncogene, Src family tyrosine kinase
HCLS1 hematopoietic cell-specific Lyn substrate 1
HK3 hexokinase 3 (white cell)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IER2 immediate early response 2
IFNGR1 interferon gamma receptor 1
IGSF6 immunoglobulin superfamily, member 6
IL10RA interleukin 10 receptor, alpha
IQGAP1 IQ motif containing GTPase activating protein 1
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JUNB jun B proto-oncogene
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast)
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LST1 leukocyte specific transcript 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MCL1 myeloid cell leukemia 1
MFSD1 major facilitator superfamily domain containing 1
MNDA myeloid cell nuclear differentiation antigen
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MX2 MX dynamin-like GTPase 2
MYD88 myeloid differentiation primary response 88
MYO1F myosin IF
NAAA N-acylethanolamine acid amidase
NAIP NLR family, apoptosis inhibitory protein
NCF2 neutrophil cytosolic factor 2
NOD2 nucleotide-binding oligomerization domain containing 2
PECAM1 platelet/endothelial cell adhesion molecule 1
PILRA paired immunoglobin-like type 2 receptor alpha
PLBD1 phospholipase B domain containing 1
PLCB2 phospholipase C, beta 2
PLSCR1 phospholipid scramblase 1
PPT1 palmitoyl-protein thioesterase 1
PRKCD protein kinase C, delta
PSAP prosaposin
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1
PYCARD PYD and CARD domain containing
RGS2 regulator of G-protein signaling 2
RHOG ras homolog family member G
RIN3 Ras and Rab interactor 3
S100A4 S100 calcium binding protein A4
SAMHD1 SAM domain and HD domain 1
SELL selectin L
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SKAP2 src kinase associated phosphoprotein 2
STX11 syntaxin 11
TBXAS1 thromboxane A synthase 1 (platelet)
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
THEMIS2 thymocyte selection associated family member 2
TKT transketolase
TLR2 toll-like receptor 2
TLR8 toll-like receptor 8
TMEM127 transmembrane protein 127
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TYMP thymidine phosphorylase
TYROBP TYRO protein tyrosine kinase binding protein
USP3 ubiquitin specific peptidase 3
VNN1 vanin 1
ZDHHC7 zinc finger, DHHC-type containing 7