CASP2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description caspase 2, apoptosis-related cysteine peptidase|This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] (NCBI Entrez Gene Database, 835)
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Genes

324 genes differentially expressed following the CASP2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
LGALS4 lectin, galactoside-binding, soluble, 4 3.17283
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 3.17283
TDRD6 tudor domain containing 6 3.17283
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 3.17283
SMIM17 small integral membrane protein 17 3.17283
CD53 CD53 molecule 3.17283
SSTR5 somatostatin receptor 5 3.17283
IL16 interleukin 16 3.17283
CCDC83 coiled-coil domain containing 83 3.17283
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 3.17283
MORC1 MORC family CW-type zinc finger 1 3.17283
NYX nyctalopin 3.17283
DNAI2 dynein, axonemal, intermediate chain 2 3.17283
SAMD15 sterile alpha motif domain containing 15 3.17283
ALOX15 arachidonate 15-lipoxygenase 3.17283
CFAP97D2 CFAP97 domain containing 2 3.17283
HRH4 histamine receptor H4 3.17283
APOB apolipoprotein B 3.17283
S100A14 S100 calcium binding protein A14 3.17283
CPHXL cytoplasmic polyadenylated homeobox like 3.17283
ERAP2 endoplasmic reticulum aminopeptidase 2 3.17283
TMEM51 transmembrane protein 51 3.11342
GPR52 G protein-coupled receptor 52 3.09465
OR2B6 olfactory receptor, family 2, subfamily B, member 6 3.09465
HEATR9 HEAT repeat containing 9 3.09465
HGD homogentisate 1,2-dioxygenase 3.09465
CELA3B chymotrypsin-like elastase family, member 3B 3.09465
GLUD2 glutamate dehydrogenase 2 3.09465
FABP1 fatty acid binding protein 1, liver 3.09465
ANKRD22 ankyrin repeat domain 22 3.09465
UTS2 urotensin 2 3.09465
CELF3 CUGBP, Elav-like family member 3 3.09465
OR8A1 olfactory receptor, family 8, subfamily A, member 1 3.09465
TRIM77 tripartite motif containing 77 3.09465
MOGAT3 monoacylglycerol O-acyltransferase 3 3.09465
SOWAHB sosondowah ankyrin repeat domain family member B 3.09465
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 3.09465
SETSIP SET-like protein 3.09465
SLC44A4 solute carrier family 44, member 4 3.09465
AADACL4 arylacetamide deacetylase-like 4 3.09465
SP9 Sp9 transcription factor 3.09465
STAP1 signal transducing adaptor family member 1 3.09465
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 3.09465
UNC45B unc-45 homolog B (C. elegans) 3.09465
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 3.09465
OR2AG2 olfactory receptor, family 2, subfamily AG, member 2 3.09465
GJB5 gap junction protein, beta 5, 31.1kDa 3.09465
MUC5B mucin 5B, oligomeric mucus/gel-forming 3.09465
PAX8 paired box 8 3.09465
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 3.09465
GUF1 GUF1 GTPase homolog (S. cerevisiae) 3.09465
SP7 Sp7 transcription factor 3.09465
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 3.09465
DNAJC5B DnaJ (Hsp40) homolog, subfamily C, member 5 beta 3.09465
CCN3 cellular communication network factor 3 3.09465
PTH1R parathyroid hormone 1 receptor 3.09465
C3AR1 complement component 3a receptor 1 3.09465
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 3.09465
PNLIPRP2 pancreatic lipase-related protein 2 3.09465
VGLL2 vestigial-like family member 2 3.09465
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 3.09465
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 3.09465
CCN4 cellular communication network factor 4 3.09465
DNAAF6 dynein axonemal assembly factor 6 3.09465
LY6S lymphocyte antigen 6 family member S 3.09465
SPDYE8 speedy/RINGO cell cycle regulator family member E8 3.09465
IRF2-DT IRF2 divergent transcript 3.09465
C1ORF232 chromosome 1 open reading frame 230 3.09465
SMIM45 small integral membrane protein 45 3.09465
H3-7 H3.7 histone (putative) 3.09465
ARMH2 armadillo like helical domain containing 2 3.09465
STPG3 sperm-tail PG-rich repeat containing 3 3.09465
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 3.09465
ASB4 ankyrin repeat and SOCS box containing 4 3.09465
CBLN3 cerebellin 3 precursor 3.09465
C1ORF87 chromosome 1 open reading frame 87 3.09465
PCDHA8 protocadherin alpha 8 3.09465
RAET1E retinoic acid early transcript 1E 3.09465
TAS2R3 taste receptor, type 2, member 3 3.09465
SIX3 SIX homeobox 3 3.09465
CD5 CD5 molecule 3.09465
CEMP1 cementum protein 1 3.09465
DNASE2B deoxyribonuclease II beta 3.09465
NHLRC4 NHL repeat containing 4 3.09465
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 3.09465
PCDHGC4 protocadherin gamma subfamily C, 4 3.09465
MFRP membrane frizzled-related protein 3.09465
STARD6 StAR-related lipid transfer (START) domain containing 6 3.09465
SAMD11 sterile alpha motif domain containing 11 3.09465
VCX3A variable charge, X-linked 3A 3.09465
CDSN corneodesmosin 3.09465
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 3.09465
SPMAP1 sperm microtubule associated protein 1 3.09465
HELT helt bHLH transcription factor 3.09465
DPRX divergent-paired related homeobox 3.09465
AQP7 aquaporin 7 3.09465
PIH1D2 PIH1 domain containing 2 3.09465
ERICH4 glutamate-rich 4 3.09465
CNTF ciliary neurotrophic factor 3.09465
VILL villin-like 3.09465
EREG epiregulin 3.09465
IL17REL interleukin 17 receptor E-like 3.09465
RREB1 ras responsive element binding protein 1 3.09465
VAX2 ventral anterior homeobox 2 3.09465
KRT12 keratin 12, type I 3.09465
ZMYND11 zinc finger, MYND-type containing 11 3.09465
PRSS55 protease, serine, 55 3.09465
ACSM4 acyl-CoA synthetase medium-chain family member 4 3.09465
MAPK11 mitogen-activated protein kinase 11 3.09465
FZD1 frizzled class receptor 1 3.09465
SH2D1B SH2 domain containing 1B 3.09465
CTAGE9 CTAGE family, member 9 3.09465
LMOD3 leiomodin 3 (fetal) 3.09465
TRIM55 tripartite motif containing 55 3.09465
CATIP ciliogenesis associated TTC17 interacting protein 3.09465
CDRT15L2 CMT1A duplicated region transcript 15-like 2 3.09465
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 3.09465
DEFB135 defensin, beta 135 3.09465
C16ORF78 chromosome 16 open reading frame 78 3.09465
CTXN2 cortexin 2 3.09465
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3.09465
WFDC9 WAP four-disulfide core domain 9 3.09465
KLF4 Kruppel-like factor 4 (gut) 3.09465
ARL13A ADP-ribosylation factor-like 13A 3.09465
OTOP1 otopetrin 1 3.09465
SH2D4B SH2 domain containing 4B 3.09465
NT5C1B 5'-nucleotidase, cytosolic IB 3.09465
RGS8 regulator of G-protein signaling 8 3.09465
DBX2 developing brain homeobox 2 3.09465
PODN podocan 3.09465
GOLGA8K golgin A8 family, member K 3.09465
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 3.09465
SLC51B solute carrier family 51, beta subunit 3.09465
TSKS testis-specific serine kinase substrate 3.09465
LRRC31 leucine rich repeat containing 31 3.09465
CCDC166 coiled-coil domain containing 166 3.09465
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 3.09465
IFNE interferon, epsilon 3.09465
TGM1 transglutaminase 1 3.09465
PPP1R3A protein phosphatase 1, regulatory subunit 3A 3.09465
LPO lactoperoxidase 3.09465
LY6G6C lymphocyte antigen 6 complex, locus G6C 3.09465
KCNK3 potassium channel, two pore domain subfamily K, member 3 3.09465
TMEM255A transmembrane protein 255A 3.09465
PAGE2B P antigen family, member 2B 3.09465
GPR149 G protein-coupled receptor 149 3.09465
NUTM2B NUT family member 2B 3.09465
MOBP myelin-associated oligodendrocyte basic protein 3.09465
ERVV-1 endogenous retrovirus group V, member 1 3.09465
CLEC18B C-type lectin domain family 18, member B 3.09465
LST1 leukocyte specific transcript 1 3.09465
LPAR5 lysophosphatidic acid receptor 5 3.09465
PSME3IP1 proteasome activator subunit 3 interacting protein 1 3.04504
TRIM73 tripartite motif containing 73 3.04504
LCN10 lipocalin 10 2.96172
TSPAN16 tetraspanin 16 2.96172
CENPP centromere protein P 2.87978
FBXL16 F-box and leucine-rich repeat protein 16 2.86841
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 2.86185
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 2.71702
FOXN3 forkhead box N3 2.71702
SIL1 SIL1 nucleotide exchange factor 2.68426
TIMP3 TIMP metallopeptidase inhibitor 3 2.65974
IPO8 importin 8 2.57054
C10ORF95 chromosome 10 open reading frame 95 2.57054
VAT1L vesicle amine transport 1-like 2.57054
VAMP5 vesicle-associated membrane protein 5 2.54528
GSTO2 glutathione S-transferase omega 2 2.52935
CPEB4 cytoplasmic polyadenylation element binding protein 4 2.51896
MMUT methylmalonyl-CoA mutase 2.4704
PECR peroxisomal trans-2-enoyl-CoA reductase 2.4171
RAB34 RAB34, member RAS oncogene family 2.41288
RFC5 replication factor C (activator 1) 5, 36.5kDa 2.40057
MTRFR mitochondrial translation release factor in rescue 2.34792
AANAT aralkylamine N-acetyltransferase 2.33736
SCARB1 scavenger receptor class B, member 1 2.33654
CEP78 centrosomal protein 78kDa 2.32366
ATG13 autophagy related 13 2.29174
ANKRD33B ankyrin repeat domain 33B 2.27349
KRABD2 KRAB domain containing 2 2.26344
HAGHL hydroxyacylglutathione hydrolase-like 2.25876
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 2.25786
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 2.25721
CLASP2 cytoplasmic linker associated protein 2 2.2429
GSAP gamma-secretase activating protein 2.22675
BBS1 Bardet-Biedl syndrome 1 2.18852
HSPA14 heat shock 70kDa protein 14 2.18346
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.18335
HYDIN HYDIN, axonemal central pair apparatus protein 2.17917
PTBP3 polypyrimidine tract binding protein 3 2.14661
SHANK3 SH3 and multiple ankyrin repeat domains 3 2.14138
SLF1 SMC5-SMC6 complex localization factor 1 2.11695
F11 coagulation factor XI 2.11589
LCN2 lipocalin 2 2.11589
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.11589
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) 2.11589
NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 2.11166
FAM185A family with sequence similarity 185, member A 2.10668
PAIP2B poly(A) binding protein interacting protein 2B 2.10216
IQGAP1 IQ motif containing GTPase activating protein 1 2.09685
C1ORF74 chromosome 1 open reading frame 74 2.06798
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 2.06467
TMEM117 transmembrane protein 117 2.05409
TMEM267 transmembrane protein 267 2.04704
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 2.01794
MEN1 multiple endocrine neoplasia I 2.01613
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.01093
MCM5 minichromosome maintenance complex component 5 2.00672
PCYT1B phosphate cytidylyltransferase 1, choline, beta 2.00611

decreased expression

Symbol Name Standardized Value
GBA1 glucosylceramidase beta 1 -3.17283
GLIS1 GLIS family zinc finger 1 -3.17283
SPX spexin hormone -3.17283
BAIAP3 BAI1-associated protein 3 -3.17283
LOC124902694 uncharacterized LOC124902694 -3.17283
DRD3 dopamine receptor D3 -3.17283
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 -3.17283
PLAC8 placenta-specific 8 -3.17283
KCNK2 potassium channel, two pore domain subfamily K, member 2 -3.09465
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 -3.09465
NIM1K NIM1 serine/threonine protein kinase -3.09465
PRDM16 PR domain containing 16 -3.09465
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 -3.09465
NPPC natriuretic peptide C -3.09465
IL5RA interleukin 5 receptor, alpha -3.09465
C5AR1 complement component 5a receptor 1 -3.09465
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -3.09465
OXCT2 3-oxoacid CoA transferase 2 -3.09465
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow -3.09465
SLCO1C1 solute carrier organic anion transporter family, member 1C1 -3.09465
LONRF2 LON peptidase N-terminal domain and ring finger 2 -3.09465
PGAP3 post-GPI attachment to proteins 3 -3.09465
MSC musculin -3.09465
TMEM86B transmembrane protein 86B -3.09465
PAX6 paired box 6 -3.09465
TCTN1 tectonic family member 1 -3.09465
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) -3.09465
COLEC10 collectin sub-family member 10 (C-type lectin) -3.09465
C1ORF105 chromosome 1 open reading frame 105 -3.09465
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2 -3.09465
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -3.09465
CLEC20A C-type lectin domain containing 20A -3.09465
DRC1 dynein regulatory complex subunit 1 -3.09465
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 -3.09465
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 -3.09465
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 -3.09465
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) -3.09465
MUC4 mucin 4, cell surface associated -3.09465
KLK4 kallikrein-related peptidase 4 -3.09465
C4ORF33 chromosome 4 open reading frame 33 -3.07642
INPP5B inositol polyphosphate-5-phosphatase, 75kDa -2.97659
SELENOP selenoprotein P -2.97246
H3C1 H3 clustered histone 1 -2.97246
GSS glutathione synthetase -2.93209
IL18BP interleukin 18 binding protein -2.923
HSPA2 heat shock 70kDa protein 2 -2.87978
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 -2.86954
PLPP2 phospholipid phosphatase 2 -2.86455
MRPL34 mitochondrial ribosomal protein L34 -2.84323
FDX1 ferredoxin 1 -2.68725
BRD3 bromodomain containing 3 -2.68352
ZNF469 zinc finger protein 469 -2.68352
SLC9C1 solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1 -2.68352
ANKRD16 ankyrin repeat domain 16 -2.65577
NYNRIN NYN domain and retroviral integrase containing -2.57765
EP400 E1A binding protein p400 -2.57054
DAPK2 death-associated protein kinase 2 -2.55995
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 -2.54499
ZNF593 zinc finger protein 593 -2.50391
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha -2.50238
MYCT1 myc target 1 -2.49803
KCNRG potassium channel regulator -2.49803
TLR2 toll-like receptor 2 -2.49803
EVI5L ecotropic viral integration site 5-like -2.49803
SIT1 signaling threshold regulating transmembrane adaptor 1 -2.48798
NR1I2 nuclear receptor subfamily 1, group I, member 2 -2.45396
EMC1 ER membrane protein complex subunit 1 -2.44148
FAM177A1 family with sequence similarity 177, member A1 -2.40892
SCFD2 sec1 family domain containing 2 -2.33736
C6ORF132 chromosome 6 open reading frame 132 -2.33736
ERAP1 endoplasmic reticulum aminopeptidase 1 -2.29733
TBC1D17 TBC1 domain family, member 17 -2.25876
TESK1 testis-specific kinase 1 -2.25876
PEX12 peroxisomal biogenesis factor 12 -2.22411
GPHA2 glycoprotein hormone alpha 2 -2.22411
KCNE5 potassium channel, voltage gated subfamily E regulatory beta subunit 5 -2.22411
LDAH lipid droplet associated hydrolase -2.21556
NALCN sodium leak channel, non selective -2.20917
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 -2.20155
FAM86B1 family with sequence similarity 86, member B1 -2.20155
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5 -2.19726
ZC3H11C zinc finger CCCH-type containing 11C -2.19726
ZBTB12 zinc finger and BTB domain containing 12 -2.19726
SLC10A4 solute carrier family 10, member 4 -2.19726
KLK8 kallikrein-related peptidase 8 -2.19726
REXO5 RNA exonuclease 5 -2.19726
ZNF502 zinc finger protein 502 -2.19428
SEZ6L2 seizure related 6 homolog (mouse)-like 2 -2.1793
INSL6 insulin-like 6 -2.17574
TRIM54 tripartite motif containing 54 -2.15985
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 -2.1521
PALD1 phosphatase domain containing, paladin 1 -2.14661
NUDT12 nudix (nucleoside diphosphate linked moiety X)-type motif 12 -2.1205
FBXO41 F-box protein 41 -2.11695
PTGR2 prostaglandin reductase 2 -2.11695
XPO4 exportin 4 -2.11695
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase -2.11695
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 -2.11695
TOMM6 translocase of outer mitochondrial membrane 6 homolog (yeast) -2.11166
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 -2.11166
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 -2.11166
SIPA1 signal-induced proliferation-associated 1 -2.10315
ACSL6 acyl-CoA synthetase long-chain family member 6 -2.08803
SLC26A3 solute carrier family 26 (anion exchanger), member 3 -2.08803
RASSF9 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 -2.08242
DCPS decapping enzyme, scavenger -2.07757
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 -2.07355
SEC11A SEC11 homolog A (S. cerevisiae) -2.06143
SORBS3 sorbin and SH3 domain containing 3 -2.04797
CD70 CD70 molecule -2.03988
ZNF446 zinc finger protein 446 -2.03988
DHCR24 24-dehydrocholesterol reductase -2.03339
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.01794
DNAH3 dynein, axonemal, heavy chain 3 -2.01093
FADD Fas (TNFRSF6)-associated via death domain -2.00611