CASP2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description caspase 2, apoptosis-related cysteine peptidase|This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] (NCBI Entrez Gene Database, 835)
External Link http://www.ncbi.nlm.nih.gov/gene/835
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Genes

54 interacting proteins for CASP2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
BID BH3 interacting domain death agonist
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP14 caspase 14, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCND3 cyclin D3
CFLAR CASP8 and FADD-like apoptosis regulator
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CRYAB crystallin, alpha B
CSNK2A1 casein kinase 2, alpha 1 polypeptide
DCTN1 dynactin 1
DSP desmoplakin
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
ELAVL1 ELAV like RNA binding protein 1
GOLGA3 golgin A3
GRB2 growth factor receptor-bound protein 2
HNF4A hepatocyte nuclear factor 4, alpha
HTT huntingtin
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LMNA lamin A/C
LMNB1 lamin B1
LMNB2 lamin B2
MADD MAP-kinase activating death domain
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MZB1 marginal zone B and B1 cell-specific protein
NGF nerve growth factor (beta polypeptide)
NGFR nerve growth factor receptor
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NLRP1 NLR family, pyrin domain containing 1
NOD1 nucleotide-binding oligomerization domain containing 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NRF1 nuclear respiratory factor 1
ONECUT1 one cut homeobox 1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RAI1 retinoic acid induced 1
RB1 retinoblastoma 1
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RPL30 ribosomal protein L30
RXRA retinoid X receptor, alpha
SUMO1 small ubiquitin-like modifier 1
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRADD TNFRSF1A-associated via death domain
TRAF2 TNF receptor-associated factor 2
UBC ubiquitin C
UBE2I ubiquitin-conjugating enzyme E2I