CASP3 Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description caspase 3, apoptosis-related cysteine peptidase|This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 836)
External Link http://www.ncbi.nlm.nih.gov/gene/836
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188 interacting proteins for hub protein CASP3 from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
ACIN1 apoptotic chromatin condensation inducer 1
ACTA1 actin, alpha 1, skeletal muscle
ADD1 adducin 1 (alpha)
AFP alpha-fetoprotein
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AKAP8 A kinase (PRKA) anchor protein 8
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
APAF1 apoptotic peptidase activating factor 1
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATG4D autophagy related 4D, cysteine peptidase
ATN1 atrophin 1
ATXN3 ataxin 3
BCAP31 B-cell receptor-associated protein 31
BCAR1 breast cancer anti-estrogen resistance 1
BCL2 B-cell CLL/lymphoma 2
BID BH3 interacting domain death agonist
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BIRC5 baculoviral IAP repeat containing 5
BIRC6 baculoviral IAP repeat containing 6
BIRC7 baculoviral IAP repeat containing 7
BLM Bloom syndrome, RecQ helicase-like
BMX BMX non-receptor tyrosine kinase
BRCA1 breast cancer 1, early onset
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP12 caspase 12 (gene/pseudogene)
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAST calpastatin
CD247 CD247 molecule
CDC27 cell division cycle 27
CDC42 cell division cycle 42
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK11A cyclin-dependent kinase 11A
CDK11B cyclin-dependent kinase 11B
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFLAR CASP8 and FADD-like apoptosis regulator
COPS6 COP9 signalosome subunit 6
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTTN cortactin
DBNL drebrin-like
DCC DCC netrin 1 receptor
DCTN1 dynactin 1
DEDD death effector domain containing
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DSG3 desmoglein 3
EGFR epidermal growth factor receptor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF3J eukaryotic translation initiation factor 3, subunit J
EIF4B eukaryotic translation initiation factor 4B
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
FBXW11 F-box and WD repeat domain containing 11
FYN FYN proto-oncogene, Src family tyrosine kinase
GAS2 growth arrest-specific 2
GATA1 GATA binding protein 1 (globin transcription factor 1)
GMNN geminin, DNA replication inhibitor
GOLGA3 golgin A3
GORASP1 golgi reassembly stacking protein 1, 65kDa
GRIPAP1 GRIP1 associated protein 1
GSN gelsolin
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)
GZMM granzyme M (lymphocyte met-ase 1)
HCLS1 hematopoietic cell-specific Lyn substrate 1
HDAC7 histone deacetylase 7
HIP1 huntingtin interacting protein 1
HMGB1 high mobility group box 1
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HTT huntingtin
IL16 interleukin 16
IL18 interleukin 18
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
IL33 interleukin 33
KCNIP3 Kv channel interacting protein 3, calsenilin
KRT18 keratin 18, type I
KRT8 keratin 8, type II
KSR1 kinase suppressor of ras 1
LMNB1 lamin B1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MAPK9 mitogen-activated protein kinase 9
MAPT microtubule-associated protein tau
MAVS mitochondrial antiviral signaling protein
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MEF2A myocyte enhancer factor 2A
MEF2B myocyte enhancer factor 2B
MET MET proto-oncogene, receptor tyrosine kinase
MLH1 mutL homolog 1
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow
NAIP NLR family, apoptosis inhibitory protein
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFE2L2 nuclear factor, erythroid 2-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NMT2 N-myristoyltransferase 2
NUCB2 nucleobindin 2
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PARG poly (ADP-ribose) glycohydrolase
PARP1 poly (ADP-ribose) polymerase 1
PDE10A phosphodiesterase 10A
PDE5A phosphodiesterase 5A, cGMP-specific
PICALM phosphatidylinositol binding clathrin assembly protein
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PKN1 protein kinase N1
PKN2 protein kinase N2
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRKCQ protein kinase C, theta
PRKCZ protein kinase C, zeta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PROKR1 prokineticin receptor 1
PSEN1 presenilin 1
PSEN2 presenilin 2
PSIP1 PC4 and SFRS1 interacting protein 1
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PTBP1 polypyrimidine tract binding protein 1
PTEN phosphatase and tensin homolog
PTGES3 prostaglandin E synthase 3 (cytosolic)
PTMA prothymosin, alpha
PXN paxillin
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD51 RAD51 recombinase
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RB1 retinoblastoma 1
RBX1 ring-box 1, E3 ubiquitin protein ligase
RFC1 replication factor C (activator 1) 1, 145kDa
RNF2 ring finger protein 2
RNF7 ring finger protein 7
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
SARS2 seryl-tRNA synthetase 2, mitochondrial
SLK STE20-like kinase
SP1 Sp1 transcription factor
SPTAN1 spectrin, alpha, non-erythrocytic 1
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
SRF serum response factor (c-fos serum response element-binding transcription factor)
SRP72 signal recognition particle 72kDa
STK24 serine/threonine kinase 24
STK3 serine/threonine kinase 3
STK4 serine/threonine kinase 4
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGM2 transglutaminase 2
THAP11 THAP domain containing 11
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TOP1 topoisomerase (DNA) I
TRAF1 TNF receptor-associated factor 1
TRAF3 TNF receptor-associated factor 3
UBE4B ubiquitination factor E4B
USO1 USO1 vesicle transport factor
VAV1 vav 1 guanine nucleotide exchange factor
VIM vimentin
WEE1 WEE1 G2 checkpoint kinase
WNK3 WNK lysine deficient protein kinase 3
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon