CASP4 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description caspase 4, apoptosis-related cysteine peptidase|This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 837)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GNF2_CASP4
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Genes

24 co-expressed genes for CASP4 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa
B2M beta-2-microglobulin
CASP4 caspase 4, apoptosis-related cysteine peptidase
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
DAZAP2 DAZ associated protein 2
ELF4 E74-like factor 4 (ets domain transcription factor)
GMFG glia maturation factor, gamma
GMIP GEM interacting protein
HCLS1 hematopoietic cell-specific Lyn substrate 1
HLA-B major histocompatibility complex, class I, B
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ICAM3 intercellular adhesion molecule 3
IQGAP1 IQ motif containing GTPase activating protein 1
LAPTM5 lysosomal protein transmembrane 5
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1
RIN3 Ras and Rab interactor 3
SELL selectin L
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
WAS Wiskott-Aldrich syndrome
ZCCHC6 zinc finger, CCHC domain containing 6
ZFP36L2 ZFP36 ring finger protein-like 2