| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | caspase 8, apoptosis-related cysteine peptidase|This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 841) |
| External Link | https://ncbi.nlm.nih.gov/gene/841 |
| Similar Terms | |
| Downloads & Tools |
498 genes differentially expressed following the CASP8 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MAP7 | microtubule-associated protein 7 | 0.0164431 |
| ADM | adrenomedullin | 0.0152762 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0151199 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 0.014978 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0140984 |
| S100A8 | S100 calcium binding protein A8 | 0.0133104 |
| AQP3 | aquaporin 3 (Gill blood group) | 0.0131053 |
| S100P | S100 calcium binding protein P | 0.0125239 |
| KRT17 | keratin 17, type I | 0.0124136 |
| S100A7 | S100 calcium binding protein A7 | 0.0121318 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0120426 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.0117501 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | 0.01166 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0116023 |
| KRT5 | keratin 5, type II | 0.0109517 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.0109172 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0107114 |
| PERP | PERP, TP53 apoptosis effector | 0.0101846 |
| KRT23 | keratin 23, type I | 0.00980779 |
| CXADR | coxsackie virus and adenovirus receptor | 0.00940349 |
| KRT14 | keratin 14, type I | 0.00940234 |
| S100A2 | S100 calcium binding protein A2 | 0.00939605 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.00931326 |
| CLTB | clathrin, light chain B | 0.00929945 |
| KRT6B | keratin 6B, type II | 0.00912932 |
| CGA | glycoprotein hormones, alpha polypeptide | 0.00898341 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | 0.00890806 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | 0.00887189 |
| S100A9 | S100 calcium binding protein A9 | 0.008869 |
| PROM1 | prominin 1 | 0.00884022 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 0.00883669 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.00878724 |
| TRIM29 | tripartite motif containing 29 | 0.00876567 |
| ECM1 | extracellular matrix protein 1 | 0.00859633 |
| TMEM45A | transmembrane protein 45A | 0.0085715 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.00857144 |
| PDLIM1 | PDZ and LIM domain 1 | 0.00856728 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0084705 |
| MMD | monocyte to macrophage differentiation-associated | 0.00842847 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.00841161 |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 0.00806777 |
| LYPD3 | LY6/PLAUR domain containing 3 | 0.00800166 |
| SPRR3 | small proline-rich protein 3 | 0.00791782 |
| UPK1B | uroplakin 1B | 0.00789155 |
| S100A10 | S100 calcium binding protein A10 | 0.00783183 |
| ERGIC2 | ERGIC and golgi 2 | 0.00783058 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.00782981 |
| DSP | desmoplakin | 0.0077904 |
| GSTM3 | glutathione S-transferase mu 3 (brain) | 0.00777317 |
| CD59 | CD59 molecule, complement regulatory protein | 0.00772837 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 0.00762395 |
| TNFAIP6 | tumor necrosis factor, alpha-induced protein 6 | 0.0074929 |
| RRAGD | Ras-related GTP binding D | 0.0074586 |
| LYZ | lysozyme | 0.00744793 |
| KRT10 | keratin 10, type I | 0.00738062 |
| TM4SF4 | transmembrane 4 L six family member 4 | 0.00735173 |
| GCH1 | GTP cyclohydrolase 1 | 0.00734526 |
| MRPL18 | mitochondrial ribosomal protein L18 | 0.00732734 |
| DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | 0.00732409 |
| HOXC6 | homeobox C6 | 0.00727945 |
| DNAJC6 | DnaJ (Hsp40) homolog, subfamily C, member 6 | 0.00725321 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0072514 |
| SPRR1B | small proline-rich protein 1B | 0.00723881 |
| BID | BH3 interacting domain death agonist | 0.00723139 |
| CLEC2B | C-type lectin domain family 2, member B | 0.00721336 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | 0.00721197 |
| TUBB2B | tubulin, beta 2B class IIb | 0.00719459 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.00715028 |
| HSPA1A | heat shock 70kDa protein 1A | 0.00713935 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.00709851 |
| PLIN2 | perilipin 2 | 0.00706907 |
| CHPT1 | choline phosphotransferase 1 | 0.00704868 |
| SCRG1 | stimulator of chondrogenesis 1 | 0.00704665 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | 0.00699084 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.00698513 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | 0.0069759 |
| SRPRB | signal recognition particle receptor, B subunit | 0.00696263 |
| DEFA5 | defensin, alpha 5, Paneth cell-specific | 0.00695374 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | 0.00693258 |
| CD36 | CD36 molecule (thrombospondin receptor) | 0.00693022 |
| KYNU | kynureninase | 0.00690265 |
| MAGEA3 | melanoma antigen family A3 | 0.00685266 |
| HBB | hemoglobin, beta | 0.00684753 |
| UGT2B28 | UDP glucuronosyltransferase 2 family, polypeptide B28 | 0.00684169 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | 0.00683626 |
| FST | follistatin | 0.00681187 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.00680906 |
| SLCO3A1 | solute carrier organic anion transporter family, member 3A1 | 0.00680366 |
| SLC35G2 | solute carrier family 35, member G2 | 0.00679619 |
| FNDC3B | fibronectin type III domain containing 3B | 0.00674091 |
| APOB | apolipoprotein B | 0.00673484 |
| CNR1 | cannabinoid receptor 1 (brain) | 0.00672889 |
| ATF3 | activating transcription factor 3 | 0.00670733 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.00668919 |
| ZNF721 | zinc finger protein 721 | 0.0066823 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.00665872 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.00663132 |
| PPBP | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | 0.00656841 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 0.00655098 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.00654769 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0065383 |
| LPIN1 | lipin 1 | 0.00652866 |
| FABP1 | fatty acid binding protein 1, liver | 0.00651844 |
| HIST1H2BD | histone cluster 1, H2bd | 0.00646736 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.00646334 |
| NPR3 | natriuretic peptide receptor 3 | 0.006419 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.00641734 |
| ABHD4 | abhydrolase domain containing 4 | 0.00641441 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.00641209 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.00639834 |
| ANXA1 | annexin A1 | 0.0063958 |
| PEG3 | paternally expressed 3 | 0.00638856 |
| QPRT | quinolinate phosphoribosyltransferase | 0.00636314 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.00633512 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.00632935 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.00631836 |
| DDX21 | DEAD (Asp-Glu-Ala-Asp) box helicase 21 | 0.0063153 |
| PPA1 | pyrophosphatase (inorganic) 1 | 0.0062326 |
| TFRC | transferrin receptor | 0.00623082 |
| GNAS | GNAS complex locus | 0.00622435 |
| BTG3 | BTG family, member 3 | 0.00621319 |
| TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | 0.00619866 |
| ALDOB | aldolase B, fructose-bisphosphate | 0.00619576 |
| SST | somatostatin | 0.00619302 |
| TCP1 | t-complex 1 | 0.00617813 |
| KRT6A | keratin 6A, type II | 0.00615763 |
| PSCA | prostate stem cell antigen | 0.00614925 |
| STOM | stomatin | 0.00614083 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | 0.00611059 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.00610603 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.00608406 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | 0.00608103 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.00606384 |
| PITX3 | paired-like homeodomain 3 | 0.00603432 |
| CFD | complement factor D (adipsin) | 0.00602172 |
| GLDC | glycine dehydrogenase (decarboxylating) | 0.00601901 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.00600678 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | 0.00600605 |
| ZNF160 | zinc finger protein 160 | 0.00598613 |
| ARMCX3 | armadillo repeat containing, X-linked 3 | 0.00596572 |
| PRDX4 | peroxiredoxin 4 | 0.0059589 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.00595841 |
| PKP1 | plakophilin 1 | 0.00595766 |
| TXNIP | thioredoxin interacting protein | 0.00594257 |
| RPP40 | ribonuclease P/MRP 40kDa subunit | 0.00593842 |
| EIF5A | eukaryotic translation initiation factor 5A | 0.00592777 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | 0.0059264 |
| H1-2 | H1.2 linker histone, cluster member | 0.00588037 |
| SNAI2 | snail family zinc finger 2 | 0.00586846 |
| CALML5 | calmodulin-like 5 | 0.00583768 |
| MT1X | metallothionein 1X | 0.00583107 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 0.00582666 |
| MAPK6 | mitogen-activated protein kinase 6 | 0.00581773 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | 0.00581716 |
| KLF6 | Kruppel-like factor 6 | 0.00580751 |
| YIF1A | Yip1 interacting factor homolog A (S. cerevisiae) | 0.00578798 |
| ANKRD28 | ankyrin repeat domain 28 | 0.00575803 |
| BAALC | brain and acute leukemia, cytoplasmic | 0.00574121 |
| CRABP1 | cellular retinoic acid binding protein 1 | 0.00573175 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | 0.00572916 |
| UCHL3 | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) | 0.00571863 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.00571722 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.00570473 |
| VNN1 | vanin 1 | 0.00569203 |
| DEFA6 | defensin, alpha 6, Paneth cell-specific | 0.00566036 |
| RBKS | ribokinase | 0.00563972 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.00562133 |
| PF4 | platelet factor 4 | 0.00561326 |
| SPRR2B | small proline-rich protein 2B | 0.00560976 |
| SPRR1A | small proline-rich protein 1A | 0.00558867 |
| SLC27A2 | solute carrier family 27 (fatty acid transporter), member 2 | 0.00558576 |
| MMP1 | matrix metallopeptidase 1 | 0.00557251 |
| VPS35 | vacuolar protein sorting 35 homolog (S. cerevisiae) | 0.00554273 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | 0.0055127 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | 0.00549772 |
| CXCL6 | chemokine (C-X-C motif) ligand 6 | 0.00549653 |
| TUFT1 | tuftelin 1 | 0.00549075 |
| NSG1 | neuron specific gene family member 1 | 0.00548633 |
| GRB7 | growth factor receptor-bound protein 7 | 0.00547255 |
| RAB29 | RAB29, member RAS oncogene family | 0.00544356 |
| DSG3 | desmoglein 3 | 0.00543416 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | 0.00543129 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.00542546 |
| GPX2 | glutathione peroxidase 2 | 0.00541596 |
| PDE10A | phosphodiesterase 10A | 0.00541516 |
| CNIH4 | cornichon family AMPA receptor auxiliary protein 4 | 0.00540488 |
| LYVE1 | lymphatic vessel endothelial hyaluronan receptor 1 | 0.00539839 |
| MT1G | metallothionein 1G | 0.00539339 |
| MAFG | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G | 0.00539213 |
| TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 0.0053884 |
| ENPEP | glutamyl aminopeptidase (aminopeptidase A) | 0.00538192 |
| TIMP4 | TIMP metallopeptidase inhibitor 4 | 0.00537373 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.00537227 |
| RAB9A | RAB9A, member RAS oncogene family | 0.00536654 |
| PDLIM2 | PDZ and LIM domain 2 (mystique) | 0.00535745 |
| RAB1A | RAB1A, member RAS oncogene family | 0.00535642 |
| FOXO4 | forkhead box O4 | 0.00535544 |
| TPD52 | tumor protein D52 | 0.00535385 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.00535072 |
| APOA1 | apolipoprotein A-I | 0.00534524 |
| DNM1L | dynamin 1-like | 0.00534323 |
| SGCE | sarcoglycan, epsilon | 0.00534177 |
| HOMER1 | homer scaffolding protein 1 | 0.0053412 |
| FKBP11 | FK506 binding protein 11, 19 kDa | 0.00533947 |
| REG1A | regenerating islet-derived 1 alpha | 0.00533207 |
| LEPROT | leptin receptor overlapping transcript | 0.00530336 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) | 0.00527918 |
| ITGAV | integrin, alpha V | 0.00524217 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | 0.00522451 |
| STX7 | syntaxin 7 | 0.0052189 |
| MT1F | metallothionein 1F | 0.00521092 |
| PLK1 | polo-like kinase 1 | 0.00519961 |
| PPP1R14B | protein phosphatase 1, regulatory (inhibitor) subunit 14B | 0.00519918 |
| KCNJ15 | potassium channel, inwardly rectifying subfamily J, member 15 | 0.00519877 |
| RPS27L | ribosomal protein S27-like | 0.0051961 |
| SH3GLB1 | SH3-domain GRB2-like endophilin B1 | 0.00518805 |
| ELF1 | E74-like factor 1 (ets domain transcription factor) | 0.00518791 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.00518099 |
| SPINK2 | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) | 0.0051761 |
| MT1H | metallothionein 1H | 0.00517454 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0051659 |
| PDE1A | phosphodiesterase 1A, calmodulin-dependent | 0.00514168 |
| SLC31A2 | solute carrier family 31 (copper transporter), member 2 | 0.00513756 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | 0.00512147 |
| ATP6V1A | ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A | 0.00511171 |
| KCMF1 | potassium channel modulatory factor 1 | 0.00510485 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.00510411 |
| DUSP11 | dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) | 0.00510309 |
| MAGEA12 | melanoma antigen family A12 | 0.0051002 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.00507795 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.00506218 |
| GTF2H2B | general transcription factor IIH, polypeptide 2B (pseudogene) | 0.00505661 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.00505585 |
| DLX2 | distal-less homeobox 2 | 0.00505583 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.00505213 |
| TAC1 | tachykinin, precursor 1 | 0.00503393 |
| UNC45A | unc-45 homolog A (C. elegans) | 0.0050267 |
| KRT8 | keratin 8, type II | 0.00502381 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | 0.00502074 |
| LXN | latexin | 0.00502036 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.00501553 |
| EFNA1 | ephrin-A1 | 0.00501268 |
| CTSC | cathepsin C | 0.0050038 |
| APOD | apolipoprotein D | 0.00499395 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.00499383 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | 0.00497976 |
| LGALSL | lectin, galactoside-binding-like | 0.00497742 |
| SYNM | synemin, intermediate filament protein | 0.00497565 |
| ADIRF | adipogenesis regulatory factor | 0.00496836 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -0.0158211 |
| MLPH | melanophilin | -0.0136491 |
| WFDC2 | WAP four-disulfide core domain 2 | -0.0128133 |
| NEFH | neurofilament, heavy polypeptide | -0.0123496 |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | -0.0116645 |
| EGR2 | early growth response 2 | -0.0114553 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.0114406 |
| TGM2 | transglutaminase 2 | -0.0113144 |
| MSMB | microseminoprotein, beta- | -0.0112194 |
| ITGA4 | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | -0.0110597 |
| CAPG | capping protein (actin filament), gelsolin-like | -0.0109 |
| CTSH | cathepsin H | -0.00996051 |
| CYBB | cytochrome b-245, beta polypeptide | -0.00985641 |
| SELENBP1 | selenium binding protein 1 | -0.00983409 |
| SFRP4 | secreted frizzled-related protein 4 | -0.00978695 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.00957375 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.00952886 |
| CHKB | choline kinase beta | -0.0093943 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | -0.00920053 |
| EFNB2 | ephrin-B2 | -0.00917752 |
| GOLM1 | golgi membrane protein 1 | -0.00917495 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | -0.00915978 |
| CD81 | CD81 molecule | -0.00915642 |
| LEF1 | lymphoid enhancer-binding factor 1 | -0.00901923 |
| ANOS1 | anosmin 1 | -0.00884048 |
| TNS1 | tensin 1 | -0.00878306 |
| TRIB2 | tribbles pseudokinase 2 | -0.00876371 |
| FXYD6 | FXYD domain containing ion transport regulator 6 | -0.00869627 |
| COG7 | component of oligomeric golgi complex 7 | -0.00857793 |
| HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 | -0.00857039 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | -0.00838248 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | -0.00831387 |
| ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | -0.00830066 |
| COL9A2 | collagen, type IX, alpha 2 | -0.00826793 |
| MNDA | myeloid cell nuclear differentiation antigen | -0.00822297 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | -0.00803792 |
| RTN1 | reticulon 1 | -0.00802704 |
| WDR7 | WD repeat domain 7 | -0.00796987 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.00795702 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | -0.00790755 |
| NISCH | nischarin | -0.00790597 |
| EPHX1 | epoxide hydrolase 1, microsomal (xenobiotic) | -0.0078904 |
| TADA2A | transcriptional adaptor 2A | -0.00781275 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | -0.00781106 |
| COL4A3 | collagen, type IV, alpha 3 (Goodpasture antigen) | -0.00780442 |
| RARRES2 | retinoic acid receptor responder (tazarotene induced) 2 | -0.00774443 |
| TRRAP | transformation/transcription domain-associated protein | -0.00768061 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.00767299 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.00765076 |
| LAPTM5 | lysosomal protein transmembrane 5 | -0.00764491 |
| KLK2 | kallikrein-related peptidase 2 | -0.00763817 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.00758362 |
| CLEC4A | C-type lectin domain family 4, member A | -0.00755491 |
| GPR183 | G protein-coupled receptor 183 | -0.00755144 |
| PCP4 | Purkinje cell protein 4 | -0.0074936 |
| APMAP | adipocyte plasma membrane associated protein | -0.00749258 |
| ENTPD1 | ectonucleoside triphosphate diphosphohydrolase 1 | -0.0074292 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.00730481 |
| CTSZ | cathepsin Z | -0.00722173 |
| ESR1 | estrogen receptor 1 | -0.00719698 |
| COL4A5 | collagen, type IV, alpha 5 | -0.00713343 |
| FHOD3 | formin homology 2 domain containing 3 | -0.00710996 |
| LTBP2 | latent transforming growth factor beta binding protein 2 | -0.0070899 |
| KCTD12 | potassium channel tetramerization domain containing 12 | -0.00696277 |
| CCR2 | chemokine (C-C motif) receptor 2 | -0.00694325 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.00694114 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | -0.00693929 |
| CUX2 | cut-like homeobox 2 | -0.00692999 |
| A2M | alpha-2-macroglobulin | -0.00692644 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.0068395 |
| CDC42BPB | CDC42 binding protein kinase beta (DMPK-like) | -0.0067958 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.00675584 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | -0.00673801 |
| RXRA | retinoid X receptor, alpha | -0.0067238 |
| PARM1 | prostate androgen-regulated mucin-like protein 1 | -0.00672349 |
| POU2AF1 | POU class 2 associating factor 1 | -0.00670903 |
| ALOX5AP | arachidonate 5-lipoxygenase-activating protein | -0.0066603 |
| AK1 | adenylate kinase 1 | -0.00665995 |
| PTGER4 | prostaglandin E receptor 4 (subtype EP4) | -0.00663929 |
| KLK3 | kallikrein-related peptidase 3 | -0.00662425 |
| SULF1 | sulfatase 1 | -0.00661139 |
| RTN3 | reticulon 3 | -0.0065514 |
| GRAMD4 | GRAM domain containing 4 | -0.00654609 |
| AUTS2 | autism susceptibility candidate 2 | -0.00654591 |
| IRS1 | insulin receptor substrate 1 | -0.00652028 |
| ACP3 | acid phosphatase 3 | -0.00651085 |
| COL16A1 | collagen, type XVI, alpha 1 | -0.00649871 |
| ITGB2 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | -0.00649349 |
| CST7 | cystatin F (leukocystatin) | -0.00648009 |
| NKX3-1 | NK3 homeobox 1 | -0.00638852 |
| LAMP3 | lysosomal-associated membrane protein 3 | -0.00638427 |
| FGL2 | fibrinogen-like 2 | -0.00635824 |
| DPYD | dihydropyrimidine dehydrogenase | -0.00634723 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -0.00633759 |
| OGFOD3 | 2-oxoglutarate and iron-dependent oxygenase domain containing 3 | -0.00629648 |
| LTA4H | leukotriene A4 hydrolase | -0.00628621 |
| GIMAP4 | GTPase, IMAP family member 4 | -0.00628508 |
| SETBP1 | SET binding protein 1 | -0.00627855 |
| C7 | complement component 7 | -0.0062677 |
| TRIM13 | tripartite motif containing 13 | -0.00622518 |
| SOX11 | SRY (sex determining region Y)-box 11 | -0.00622094 |
| AEBP1 | AE binding protein 1 | -0.00622078 |
| FKBP9 | FK506 binding protein 9, 63 kDa | -0.00620774 |
| CYP2B6 | cytochrome P450, family 2, subfamily B, polypeptide 6 | -0.00619784 |
| MYB | v-myb avian myeloblastosis viral oncogene homolog | -0.00619123 |
| SORD | sorbitol dehydrogenase | -0.00618867 |
| CD86 | CD86 molecule | -0.00618541 |
| NCAPD3 | non-SMC condensin II complex, subunit D3 | -0.00614555 |
| ATP6V0E2 | ATPase, H+ transporting V0 subunit e2 | -0.00612487 |
| SPRY2 | sprouty homolog 2 (Drosophila) | -0.00611533 |
| ARMCX2 | armadillo repeat containing, X-linked 2 | -0.00610998 |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 | -0.00610393 |
| HSD17B6 | hydroxysteroid (17-beta) dehydrogenase 6 | -0.00608035 |
| RRBP1 | ribosome binding protein 1 | -0.00602641 |
| ECHDC2 | enoyl CoA hydratase domain containing 2 | -0.00597535 |
| GFRA1 | GDNF family receptor alpha 1 | -0.00596996 |
| TM6SF1 | transmembrane 6 superfamily member 1 | -0.00595868 |
| PAGE4 | P antigen family, member 4 (prostate associated) | -0.00595651 |
| TFF3 | trefoil factor 3 (intestinal) | -0.00595433 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -0.00594711 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | -0.0059035 |
| ZNF423 | zinc finger protein 423 | -0.00589953 |
| RRM1 | ribonucleotide reductase M1 | -0.00588764 |
| RNASE6 | ribonuclease, RNase A family, k6 | -0.00588481 |
| GPR18 | G protein-coupled receptor 18 | -0.00587014 |
| RASGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) | -0.00586991 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.00586254 |
| TENM4 | teneurin transmembrane protein 4 | -0.00585819 |
| KLHDC10 | kelch domain containing 10 | -0.00585508 |
| CDK14 | cyclin-dependent kinase 14 | -0.00584337 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | -0.00580609 |
| SAMSN1 | SAM domain, SH3 domain and nuclear localization signals 1 | -0.00580102 |
| FCGR2B | Fc fragment of IgG, low affinity IIb, receptor (CD32) | -0.00579942 |
| HCLS1 | hematopoietic cell-specific Lyn substrate 1 | -0.0057752 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.00574895 |
| KANK2 | KN motif and ankyrin repeat domains 2 | -0.00574723 |
| BCAT2 | branched chain amino-acid transaminase 2, mitochondrial | -0.00574667 |
| PLPP3 | phospholipid phosphatase 3 | -0.00574612 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -0.00572557 |
| PFKM | phosphofructokinase, muscle | -0.00571626 |
| BCL2 | B-cell CLL/lymphoma 2 | -0.00568981 |
| BTK | Bruton agammaglobulinemia tyrosine kinase | -0.00568782 |
| NUMA1 | nuclear mitotic apparatus protein 1 | -0.00568691 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -0.00563178 |
| DMXL2 | Dmx-like 2 | -0.0056204 |
| CD9 | CD9 molecule | -0.00560622 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | -0.00560304 |
| POLR2J | polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa | -0.00559944 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -0.00558541 |
| CHD7 | chromodomain helicase DNA binding protein 7 | -0.00558127 |
| TTC39A | tetratricopeptide repeat domain 39A | -0.00556887 |
| LST1 | leukocyte specific transcript 1 | -0.00554412 |
| MAGED1 | melanoma antigen family D1 | -0.00553976 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.00551445 |
| NKG7 | natural killer cell granule protein 7 | -0.00550918 |
| GMPR | guanosine monophosphate reductase | -0.00550192 |
| NELL1 | NEL-like 1 (chicken) | -0.0054987 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | -0.00548779 |
| NAGA | N-acetylgalactosaminidase, alpha- | -0.00548214 |
| LTF | lactotransferrin | -0.00547087 |
| MYH10 | myosin, heavy chain 10, non-muscle | -0.00546437 |
| FBLN1 | fibulin 1 | -0.00545444 |
| CIZ1 | CDKN1A interacting zinc finger protein 1 | -0.00544959 |
| MYOF | myoferlin | -0.00544693 |
| SMAD7 | SMAD family member 7 | -0.00544209 |
| ZWINT | ZW10 interacting kinetochore protein | -0.00543921 |
| YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta | -0.00542476 |
| MCM7 | minichromosome maintenance complex component 7 | -0.00540737 |
| CTSD | cathepsin D | -0.00540549 |
| NEO1 | neogenin 1 | -0.00540546 |
| FCER2 | Fc fragment of IgE, low affinity II, receptor for (CD23) | -0.0053999 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | -0.00539363 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | -0.00538888 |
| FLRT3 | fibronectin leucine rich transmembrane protein 3 | -0.00538547 |
| ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) | -0.00538059 |
| DCAF16 | DDB1 and CUL4 associated factor 16 | -0.00537674 |
| TCEAL4 | transcription elongation factor A (SII)-like 4 | -0.00536758 |
| PCYOX1 | prenylcysteine oxidase 1 | -0.00535323 |
| HPN | hepsin | -0.00534494 |
| HMG20B | high mobility group 20B | -0.00533178 |
| TRMT5 | tRNA methyltransferase 5 | -0.00533034 |
| GALNT6 | polypeptide N-acetylgalactosaminyltransferase 6 | -0.00532949 |
| CLEC7A | C-type lectin domain family 7, member A | -0.00532649 |
| H2AX | H2A.X variant histone | -0.00530411 |
| SLAMF7 | SLAM family member 7 | -0.00529697 |
| ADGRA2 | adhesion G protein-coupled receptor A2 | -0.00529428 |
| RAB38 | RAB38, member RAS oncogene family | -0.00529362 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | -0.00529356 |
| PNMA1 | paraneoplastic Ma antigen 1 | -0.00528486 |
| PDLIM7 | PDZ and LIM domain 7 (enigma) | -0.00528415 |
| NCAM1 | neural cell adhesion molecule 1 | -0.00528153 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.00526569 |
| BNC2 | basonuclin 2 | -0.00526394 |
| G0S2 | G0/G1 switch 2 | -0.00526372 |
| DIPK1A | divergent protein kinase domain 1A | -0.00525273 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | -0.00523755 |
| PER3 | period circadian clock 3 | -0.00523125 |
| OGN | osteoglycin | -0.00523098 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0052273 |
| PTPN22 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | -0.00522585 |
| GATAD1 | GATA zinc finger domain containing 1 | -0.00522111 |
| TCTA | T-cell leukemia translocation altered | -0.00519618 |
| PSMF1 | proteasome (prosome, macropain) inhibitor subunit 1 (PI31) | -0.00518399 |
| IGF1 | insulin-like growth factor 1 (somatomedin C) | -0.00517734 |
| FMO2 | flavin containing monooxygenase 2 (non-functional) | -0.00517016 |
| TBL1X | transducin (beta)-like 1X-linked | -0.00516481 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.00514862 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | -0.00513289 |
| BSCL2 | Berardinelli-Seip congenital lipodystrophy 2 (seipin) | -0.00512634 |
| POLR2L | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa | -0.00511169 |
| TMEM131L | transmembrane 131 like | -0.00510892 |
| TAF6 | TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa | -0.00510443 |
| SFTPA2 | surfactant protein A2 | -0.00508937 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) | -0.00508836 |
| FCN1 | ficolin (collagen/fibrinogen domain containing) 1 | -0.00508485 |
| HMGB2 | high mobility group box 2 | -0.00507372 |
| KIF1B | kinesin family member 1B | -0.00507259 |
| NBL1 | neuroblastoma 1, DAN family BMP antagonist | -0.00506828 |
| MFAP2 | microfibrillar-associated protein 2 | -0.00506107 |
| TM7SF2 | transmembrane 7 superfamily member 2 | -0.00505485 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | -0.00504969 |
| NACC2 | NACC family member 2, BEN and BTB (POZ) domain containing | -0.0050473 |
| CETN2 | centrin, EF-hand protein, 2 | -0.00503994 |
| LRIG1 | leucine-rich repeats and immunoglobulin-like domains 1 | -0.00503611 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | -0.0050266 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | -0.00502411 |
| PAK1IP1 | PAK1 interacting protein 1 | -0.00502183 |
| SIX1 | SIX homeobox 1 | -0.00502102 |
| CAMK1 | calcium/calmodulin-dependent protein kinase I | -0.00501488 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.00500459 |
| TMSB15A | thymosin beta 15a | -0.00498947 |
| MICAL1 | microtubule associated monooxygenase, calponin and LIM domain containing 1 | -0.00498468 |
| AMPD3 | adenosine monophosphate deaminase 3 | -0.00498279 |
| TMEM176B | transmembrane protein 176B | -0.00498159 |
| PLEKHO1 | pleckstrin homology domain containing, family O member 1 | -0.00497773 |
| LDB2 | LIM domain binding 2 | -0.00496239 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.00495443 |
| USP14 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) | -0.00495157 |
| HDAC6 | histone deacetylase 6 | -0.00494438 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | -0.004931 |
| LTB | lymphotoxin beta (TNF superfamily, member 3) | -0.0049196 |
| PLN | phospholamban | -0.00491049 |
| POSTN | periostin, osteoblast specific factor | -0.00490717 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.00489961 |
| CLNS1A | chloride channel, nucleotide-sensitive, 1A | -0.00489881 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.00489726 |
| GIMAP6 | GTPase, IMAP family member 6 | -0.00489404 |
| ARPC1A | actin related protein 2/3 complex, subunit 1A, 41kDa | -0.00489021 |
| CPOX | coproporphyrinogen oxidase | -0.00488744 |
