CASP8 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description caspase 8, apoptosis-related cysteine peptidase|This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 841)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GNF2_CASP8
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Genes

27 co-expressed genes for CASP8 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ATM ATM serine/threonine kinase
BIN2 bridging integrator 2
BTN3A1 butyrophilin, subfamily 3, member A1
BTN3A2 butyrophilin, subfamily 3, member A2
BTN3A3 butyrophilin, subfamily 3, member A3
C11ORF21 chromosome 11 open reading frame 21
CASP8 caspase 8, apoptosis-related cysteine peptidase
CYTH1 cytohesin 1
CYTIP cytohesin 1 interacting protein
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
FYB FYN binding protein
GIMAP4 GTPase, IMAP family member 4
GIMAP6 GTPase, IMAP family member 6
HECA headcase homolog (Drosophila)
HMHA1 histocompatibility (minor) HA-1
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
MBNL1 muscleblind-like splicing regulator 1
PARP8 poly (ADP-ribose) polymerase family, member 8
PTPRC protein tyrosine phosphatase, receptor type, C
RNF44 ring finger protein 44
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SNRK SNF related kinase
STK10 serine/threonine kinase 10
STK38 serine/threonine kinase 38
TMC6 transmembrane channel-like 6
TRAF3IP3 TRAF3 interacting protein 3