CASP8 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description caspase 8, apoptosis-related cysteine peptidase|This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 841)
External Link http://www.ncbi.nlm.nih.gov/gene/841
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196 interacting proteins for CASP8 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACIN1 apoptotic chromatin condensation inducer 1
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
APAF1 apoptotic peptidase activating factor 1
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ATAD3A ATPase family, AAA domain containing 3A
ATN1 atrophin 1
BAG4 BCL2-associated athanogene 4
BAX BCL2-associated X protein
BCAP31 B-cell receptor-associated protein 31
BCL10 B-cell CLL/lymphoma 10
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BFAR bifunctional apoptosis regulator
BID BH3 interacting domain death agonist
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BIRC6 baculoviral IAP repeat containing 6
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CARD11 caspase recruitment domain family, member 11
CARD9 caspase recruitment domain family, member 9
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP14 caspase 14, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8AP2 caspase 8 associated protein 2
CASP9 caspase 9, apoptosis-related cysteine peptidase
CD14 CD14 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDK11A cyclin-dependent kinase 11A
CDK11B cyclin-dependent kinase 11B
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFLAR CASP8 and FADD-like apoptosis regulator
CHD3 chromodomain helicase DNA binding protein 3
CHUK conserved helix-loop-helix ubiquitous kinase
CLIP3 CAP-GLY domain containing linker protein 3
CLTC clathrin, heavy chain (Hc)
COPS6 COP9 signalosome subunit 6
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CRYAB crystallin, alpha B
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL3 cullin 3
DAP3 death associated protein 3
DAXX death-domain associated protein
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEDD death effector domain containing
DEDD2 death effector domain containing 2
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7
EDA2R ectodysplasin A2 receptor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EZR ezrin
FADD Fas (TNFRSF6)-associated via death domain
FAF1 Fas (TNFRSF6) associated factor 1
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FYN FYN proto-oncogene, Src family tyrosine kinase
GDI2 GDP dissociation inhibitor 2
GMEB1 glucocorticoid modulatory element binding protein 1
GRIA1 glutamate receptor, ionotropic, AMPA 1
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HDAC7 histone deacetylase 7
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3
HIP1 huntingtin interacting protein 1
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H')
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HTT huntingtin
IFIH1 interferon induced with helicase C domain 1
IFT57 intraflagellar transport 57
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
ILK integrin-linked kinase
IQGAP1 IQ motif containing GTPase activating protein 1
IRS4 insulin receptor substrate 4
KARS lysyl-tRNA synthetase
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast)
KRT18 keratin 18, type I
LRRK2 leucine-rich repeat kinase 2
LY96 lymphocyte antigen 96
LYN LYN proto-oncogene, Src family tyrosine kinase
MADD MAP-kinase activating death domain
MALT1 MALT1 paracaspase
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPT microtubule-associated protein tau
MAVS mitochondrial antiviral signaling protein
MSN moesin
MYO9A myosin IXA
NEFH neurofilament, heavy polypeptide
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NLRC4 NLR family, CARD domain containing 4
NOD1 nucleotide-binding oligomerization domain containing 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NR1H4 nuclear receptor subfamily 1, group H, member 4
NUCB1 nucleobindin 1
NUCB2 nucleobindin 2
NUCLEOLIN nucleolin multifunctional protein
OTUD7B OTU deubiquitinase 7B
PARK2 parkin RBR E3 ubiquitin protein ligase
PARK7 parkinson protein 7
PARP10 poly (ADP-ribose) polymerase family, member 10
PARP2 poly (ADP-ribose) polymerase 2
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PDIA6 protein disulfide isomerase family A, member 6
PEA15 phosphoprotein enriched in astrocytes 15
PIAS1 protein inhibitor of activated STAT, 1
PICALM phosphatidylinositol binding clathrin assembly protein
PLA2G4B phospholipase A2, group IVB (cytosolic)
PLEC plectin
PLIN4 perilipin 4
PRKCI protein kinase C, iota
PRKCZ protein kinase C, zeta
PSEN1 presenilin 1
PSEN2 presenilin 2
PTEN phosphatase and tensin homolog
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PYCARD PYD and CARD domain containing
RAB10 RAB10, member RAS oncogene family
RALBP1 ralA binding protein 1
RALGDS ral guanine nucleotide dissociation stimulator
RB1 retinoblastoma 1
RDX radixin
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
RHOA ras homolog family member A
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK2 receptor-interacting serine-threonine kinase 2
RIPK3 receptor-interacting serine-threonine kinase 3
RNF135 ring finger protein 135
RNF34 ring finger protein 34, E3 ubiquitin protein ligase
RPS27 ribosomal protein S27
RPS27L ribosomal protein S27-like
RYBP RING1 and YY1 binding protein
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa
SORBS1 sorbin and SH3 domain containing 1
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRF serum response factor (c-fos serum response element-binding transcription factor)
STK24 serine/threonine kinase 24
SUMO1 small ubiquitin-like modifier 1
SYF2 SYF2 pre-mRNA-splicing factor
TFCP2 transcription factor CP2
TICAM1 toll-like receptor adaptor molecule 1
TICAM2 toll-like receptor adaptor molecule 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TP53 tumor protein p53
TRADD TNFRSF1A-associated via death domain
TRAF1 TNF receptor-associated factor 1
TRAF2 TNF receptor-associated factor 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM25 tripartite motif containing 25
TRIM28 tripartite motif containing 28
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
TUBA1C tubulin, alpha 1c
TUBB tubulin, beta class I
UBB ubiquitin B
UBC ubiquitin C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2L3 ubiquitin-conjugating enzyme E2L 3
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1
UBR5 ubiquitin protein ligase E3 component n-recognin 5
USO1 USO1 vesicle transport factor
USP2 ubiquitin specific peptidase 2
USP54 ubiquitin specific peptidase 54
VIM vimentin
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YES1 YES proto-oncogene 1, Src family tyrosine kinase