CAST Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description calpastatin|The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010] (NCBI Entrez Gene Database, 831)
External Link http://www.ncbi.nlm.nih.gov/gene/831
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Genes

37 interacting proteins for CAST from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
CAPN1 calpain 1, (mu/I) large subunit
CAPN2 calpain 2, (m/II) large subunit
CAPNS1 calpain, small subunit 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
COPS4 COP9 signalosome subunit 4
COPS5 COP9 signalosome subunit 5
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CUL4A cullin 4A
ELAVL1 ELAV like RNA binding protein 1
EPB41L1 erythrocyte membrane protein band 4.1-like 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GRB2 growth factor receptor-bound protein 2
HTRA1 HtrA serine peptidase 1
KIAA0101 KIAA0101
KIF5B kinesin family member 5B
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
NCK1 NCK adaptor protein 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCG1 phospholipase C, gamma 1
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PSIP1 PC4 and SFRS1 interacting protein 1
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
RPP38 ribonuclease P/MRP 38kDa subunit
SART3 squamous cell carcinoma antigen recognized by T cells 3
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
UBC ubiquitin C