CAT Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description catalase|This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009] (NCBI Entrez Gene Database, 847)
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Genes

335 genes differentially expressed following the CAT gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NCAN neurocan 2.12856
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 2.12856
PRICKLE4 prickle homolog 4 (Drosophila) 2.12856
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 2.12856
PGAM2 phosphoglycerate mutase 2 (muscle) 2.12856
TRIM13 tripartite motif containing 13 2.12856
GFRA3 GDNF family receptor alpha 3 2.12856
EPPIN epididymal peptidase inhibitor 2.12856
PCDHB1 protocadherin beta 1 2.12856
TM4SF1 transmembrane 4 L six family member 1 2.12856
GPR158 G protein-coupled receptor 158 2.12856
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.12856
IL5RA interleukin 5 receptor, alpha 2.12856
MRPL53 mitochondrial ribosomal protein L53 2.12856
SLC46A2 solute carrier family 46, member 2 2.12856
NPM3 nucleophosmin/nucleoplasmin 3 2.12856
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.12856
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 2.12856
NHP2 NHP2 ribonucleoprotein 2.12856
COL19A1 collagen, type XIX, alpha 1 2.12856
TMPRSS11D transmembrane protease, serine 11D 2.12856
FAM187B family with sequence similarity 187, member B 2.12856
AGTR1 angiotensin II receptor, type 1 2.12856
EGFLAM EGF-like, fibronectin type III and laminin G domains 2.12856
FNBP4 formin binding protein 4 2.12856
PARP3 poly (ADP-ribose) polymerase family, member 3 2.12856
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 2.12856
VTN vitronectin 2.12856
FGD2 FYVE, RhoGEF and PH domain containing 2 2.12856
SKOR1 SKI family transcriptional corepressor 1 2.12856
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.12856
NLRP10 NLR family, pyrin domain containing 10 2.12856
TMEM79 transmembrane protein 79 2.12856
FRRS1 ferric-chelate reductase 1 2.12856
SPNS2 spinster homolog 2 (Drosophila) 2.12856
RGPD3 RANBP2-like and GRIP domain containing 3 2.12856
FAM229A family with sequence similarity 229, member A 2.12856
ACVRL1 activin A receptor type II-like 1 2.12856
ZNF345 zinc finger protein 345 2.12856
C1GALT1C1L C1GALT1-specific chaperone 1 like 2.12856
MISP mitotic spindle positioning 2.12856
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 2.12856
ATOH1 atonal homolog 1 (Drosophila) 2.12856
MPL MPL proto-oncogene, thrombopoietin receptor 2.12856
PCDH8 protocadherin 8 2.12856
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 2.12856
PTH2 parathyroid hormone 2 2.12856
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 2.12856
NEU4 sialidase 4 2.12856
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 2.12856
SHCBP1L SHC SH2-domain binding protein 1-like 2.12856
GPR26 G protein-coupled receptor 26 2.12856
TAL2 T-cell acute lymphocytic leukemia 2 2.12856
SLC23A3 solute carrier family 23, member 3 2.12856
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 2.12856
TGFB3 transforming growth factor, beta 3 2.12856
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 2.12856
C11ORF87 chromosome 11 open reading frame 87 2.12856
THRSP thyroid hormone responsive 2.12856
CLCN4 chloride channel, voltage-sensitive 4 2.12856
GDA guanine deaminase 2.12856
SPMIP10 sperm microtubule inner protein 10 2.12856
ALDOB aldolase B, fructose-bisphosphate 2.12856
ZAR1 zygote arrest 1 2.12856
UNC93A unc-93 homolog A (C. elegans) 2.12856
ROPN1B rhophilin associated tail protein 1B 2.12856
CCER2 coiled-coil glutamate-rich protein 2 2.12856
ALX4 ALX homeobox 4 2.12856
DOK7 docking protein 7 2.12856
OR52E5 olfactory receptor, family 52, subfamily E, member 5 2.12856
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase 2.12856
TEP1 telomerase-associated protein 1 2.12856
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 2.12856
LAMA4 laminin, alpha 4 2.12856
UBE2QL1 ubiquitin-conjugating enzyme E2Q family-like 1 2.12856
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 2.12856
GPAT3 glycerol-3-phosphate acyltransferase 3 2.12856
CIROZ ciliated left-right organizer protein containing ZP-N domains 2.12856
THSD8 thrombospondin type 1 domain containing 8 2.12856
ANKRD42-DT ANKRD42 divergent transcript 2.12856
SYT15B synaptotagmin 15B 2.12856
CIMAP1C ciliary microtubule associated protein 1C 2.12856
H4C12 H4 clustered histone 12 2.12856
H4C14 H4 clustered histone 14 2.12856
RHEX regulator of hemoglobinization and erythroid cell expansion 2.12856
SMIM43 small integral membrane protein 43 2.12856
TMEM272 transmembrane protein 272 2.12856
CCDC197 coiled-coil domain containing 197 2.12856
SELENON selenoprotein N 2.12856
ARSL arylsulfatase L 2.12856
DYNAP dynactin associated protein 2.12856
HNF1A HNF1 homeobox A 2.12856
GDF10 growth differentiation factor 10 2.12856
OVOL3 ovo-like zinc finger 3 2.12856
SIM2 single-minded family bHLH transcription factor 2 2.12856
CXCL16 chemokine (C-X-C motif) ligand 16 2.12856
TMEM235 transmembrane protein 235 2.12856
INO80E INO80 complex subunit E 2.12856
NXPE1 neurexophilin and PC-esterase domain family, member 1 2.12856
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 2.12856
MAGEB1 melanoma antigen family B1 2.12856
MAGEB2 melanoma antigen family B2 2.12856
LTBP2 latent transforming growth factor beta binding protein 2 2.12856
PCDHB13 protocadherin beta 13 2.12856
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.12856
C12ORF54 chromosome 12 open reading frame 54 2.12856
PRRT4 proline-rich transmembrane protein 4 2.12856
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1 2.12856
WDR93 WD repeat domain 93 2.12856
PXDC1 PX domain containing 1 2.12856
NOXA1 NADPH oxidase activator 1 2.12856
GPR85 G protein-coupled receptor 85 2.12856
PNPLA1 patatin-like phospholipase domain containing 1 2.12856
COPE coatomer protein complex, subunit epsilon 2.12856
FAM131C family with sequence similarity 131, member C 2.12856
PTH parathyroid hormone 2.12856
NR0B1 nuclear receptor subfamily 0, group B, member 1 2.12856
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.12856
CCDC121 coiled-coil domain containing 121 2.12856
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.12856
RHOXF2 Rhox homeobox family, member 2 2.12856
ANKRD62 ankyrin repeat domain 62 2.12856
GOLGA6D golgin A6 family, member D 2.12856
TMED6 transmembrane emp24 protein transport domain containing 6 2.12856
DRD3 dopamine receptor D3 2.12856
PREP prolyl endopeptidase 2.12856
BAHCC1 BAH domain and coiled-coil containing 1 2.12856
FOXE1 forkhead box E1 2.12856
LRRN2 leucine rich repeat neuronal 2 2.12856
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 2.12856
KISS1 KiSS-1 metastasis-suppressor 2.12856
ACY1 aminoacylase 1 2.12856
SIAH3 siah E3 ubiquitin protein ligase family member 3 2.12856
PLA1A phospholipase A1 member A 2.12856
KLK10 kallikrein-related peptidase 10 2.12856
KLHL41 kelch-like family member 41 2.12856
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 2.12856
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 2.12856
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 2.12856
LMNB2 lamin B2 2.12856
GPATCH2L G patch domain containing 2-like 2.12856
LRCOL1 leucine rich colipase-like 1 2.12856
NACA2 nascent polypeptide-associated complex alpha subunit 2 2.12856
GP2 glycoprotein 2 (zymogen granule membrane) 2.12856
EFCAB6 EF-hand calcium binding domain 6 2.12856
MAMDC4 MAM domain containing 4 2.12856
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) 2.12856
NOX3 NADPH oxidase 3 2.12856
SMIM23 small integral membrane protein 23 2.12856
HOGA1 4-hydroxy-2-oxoglutarate aldolase 1 2.12856
PTDSS1 phosphatidylserine synthase 1 2.12856
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 2.12856
OTP orthopedia homeobox 2.12856
SHANK1 SH3 and multiple ankyrin repeat domains 1 2.12856
C10ORF105 chromosome 10 open reading frame 105 2.12856
UNC5B unc-5 homolog B (C. elegans) 2.12856
FKBP1C FK506 binding protein 1C 2.12856
LIF leukemia inhibitory factor 2.12856
ZNF835 zinc finger protein 835 2.12856
MACROD1 MACRO domain containing 1 2.12856
BEX2 brain expressed X-linked 2 2.12856
EIF4E1B eukaryotic translation initiation factor 4E family member 1B 2.12856
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 2.12856
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 2.12856
CALM3 calmodulin 3 (phosphorylase kinase, delta) 2.12856
ADCY2 adenylate cyclase 2 (brain) 2.12856
PCDHAC2 protocadherin alpha subfamily C, 2 2.12856
PRR35 proline rich 35 2.12856
PLCL1 phospholipase C-like 1 2.12856
TF transferrin 2.12856
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 2.12856
DMRT2 doublesex and mab-3 related transcription factor 2 2.12856
DEFA6 defensin, alpha 6, Paneth cell-specific 2.12856
PHF23 PHD finger protein 23 2.12856
BCL2L15 BCL2-like 15 2.12856
RGS4 regulator of G-protein signaling 4 2.12856
LYPD5 LY6/PLAUR domain containing 5 2.12856
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 2.12856
SLC25A34 solute carrier family 25, member 34 2.12856
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.12856
CHST6 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 2.12856
CSNK2A3 casein kinase 2, alpha 3 polypeptide 2.12856
PODN podocan 2.12856
GPR78 G protein-coupled receptor 78 2.12856
AMELX amelogenin, X-linked 2.12856
EBI3 Epstein-Barr virus induced 3 2.12856
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 2.12856
TCF3 transcription factor 3 2.12856
OR6B3 olfactory receptor, family 6, subfamily B, member 3 2.12856
NFRKB nuclear factor related to kappaB binding protein 2.12856
APOA1 apolipoprotein A-I 2.12856
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 2.12856
LPO lactoperoxidase 2.12856
POPDC2 popeye domain containing 2 2.12856
OR14A2 olfactory receptor, family 14, subfamily A, member 2 2.12856
METTL21C methyltransferase like 21C 2.12856
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 2.12856
RNF39 ring finger protein 39 2.12856
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 2.12856
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.12856
PRDM1 PR domain containing 1, with ZNF domain 2.12856
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 2.12856
IL18R1 interleukin 18 receptor 1 2.12856
ANKRD42 ankyrin repeat domain 42 2.12856
BOLA2 bolA family member 2 2.12856
COL2A1 collagen, type II, alpha 1 2.12856
TECTA tectorin alpha 2.12856
CAMK1G calcium/calmodulin-dependent protein kinase IG 2.12856
PCDHGA11 protocadherin gamma subfamily A, 11 2.12856
SCIN scinderin 2.12856
FOXG1 forkhead box G1 2.12856
AHSG alpha-2-HS-glycoprotein 2.12856
METTL2A methyltransferase like 2A 2.12856
SZT2 seizure threshold 2 homolog (mouse) 2.12856
CARNS1 carnosine synthase 1 2.12856
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 2.12856
RFC3 replication factor C (activator 1) 3, 38kDa 2.12856
ZBED6 zinc finger, BED-type containing 6 2.12856
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 2.12856
LRRC74B leucine rich repeat containing 74B 2.12856
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 2.12856
PLGLB1 plasminogen-like B1 2.12856
CCNY cyclin Y 2.12856
SLITRK3 SLIT and NTRK-like family, member 3 2.12856
NTSR1 neurotensin receptor 1 (high affinity) 2.12856
ABHD1 abhydrolase domain containing 1 2.12856
MAPK15 mitogen-activated protein kinase 15 2.12856
PPP1R3A protein phosphatase 1, regulatory subunit 3A 2.12856
PADI1 peptidyl arginine deiminase, type I 2.12856
BARD1 BRCA1 associated RING domain 1 2.12856
ZXDB zinc finger, X-linked, duplicated B 2.12856
TGM1 transglutaminase 1 2.12856
CARD9 caspase recruitment domain family, member 9 2.12856
TOMM5 translocase of outer mitochondrial membrane 5 homolog (yeast) 2.12856
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 2.12647
STK32B serine/threonine kinase 32B 2.11058
NUDT16 nudix (nucleoside diphosphate linked moiety X)-type motif 16 2.10867
GRTP1 growth hormone regulated TBC protein 1 2.10697
MRPS34 mitochondrial ribosomal protein S34 2.09319
MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2.0833
COL9A1 collagen, type IX, alpha 1 2.06013
TEF thyrotrophic embryonic factor 2.05492
PNO1 partner of NOB1 homolog (S. cerevisiae) 2.05264
LTB4R leukotriene B4 receptor 2.04214
ATF6 activating transcription factor 6 2.0261
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 2.0235
SHBG sex hormone-binding globulin 2.00446
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 2.00446

decreased expression

Symbol Name Standardized Value
GRID2 glutamate receptor, ionotropic, delta 2 -2.51267
MARCHF9 membrane associated ring-CH-type finger 9 -2.12856
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 -2.12856
CNTNAP5 contactin associated protein-like 5 -2.12856
NIPSNAP3A nipsnap homolog 3A (C. elegans) -2.12856
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -2.12856
ELAVL3 ELAV like neuron-specific RNA binding protein 3 -2.12856
TMEM9B TMEM9 domain family, member B -2.12856
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -2.12856
ORAI1 ORAI calcium release-activated calcium modulator 1 -2.12856
CA7 carbonic anhydrase VII -2.12856
ZNF354B zinc finger protein 354B -2.12856
SGTB small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta -2.12856
SMC1B structural maintenance of chromosomes 1B -2.12856
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 -2.12856
MANEAL mannosidase, endo-alpha-like -2.12856
DPYSL5 dihydropyrimidinase-like 5 -2.12856
PBDC1 polysaccharide biosynthesis domain containing 1 -2.12856
FLT4 fms-related tyrosine kinase 4 -2.12856
PCDHB16 protocadherin beta 16 -2.12856
CCDC12 coiled-coil domain containing 12 -2.12856
CIBAR1 CBY1 interacting BAR domain containing 1 -2.12856
CFAP418 cilia and flagella associated protein 418 -2.12856
DOP1A DOP1 leucine zipper like protein A -2.12856
RADX RPA1 related single stranded DNA binding protein, X-linked -2.12856
RIOX1 ribosomal oxygenase 1 -2.12856
HTRA2 HtrA serine peptidase 2 -2.12856
F11R F11 receptor -2.12856
UNC80 unc-80 homolog (C. elegans) -2.12856
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 -2.12856
PALLD palladin, cytoskeletal associated protein -2.12856
C19ORF47 chromosome 19 open reading frame 47 -2.12856
PRRT1 proline-rich transmembrane protein 1 -2.12856
DEPDC1 DEP domain containing 1 -2.12856
ZIC5 Zic family member 5 -2.12856
SCAND3 SCAN domain containing 3 -2.12856
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 -2.12856
FIGN fidgetin -2.12856
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 -2.12856
ZNF112 zinc finger protein 112 -2.12856
TRAPPC11 trafficking protein particle complex 11 -2.12856
GRK6 G protein-coupled receptor kinase 6 -2.12856
MTFR2 mitochondrial fission regulator 2 -2.12856
MIEF2 mitochondrial elongation factor 2 -2.12856
ANKRD33B ankyrin repeat domain 33B -2.12856
ZNF426 zinc finger protein 426 -2.12856
IL18 interleukin 18 -2.12856
KHDC1 KH homology domain containing 1 -2.12856
DCTN1 dynactin 1 -2.12856
ARL13B ADP-ribosylation factor-like 13B -2.12856
COL27A1 collagen, type XXVII, alpha 1 -2.12856
FAT3 FAT atypical cadherin 3 -2.12856
CALCOCO1 calcium binding and coiled-coil domain 1 -2.12856
C3ORF62 chromosome 3 open reading frame 62 -2.12856
SPATA13 spermatogenesis associated 13 -2.12856
ELP6 elongator acetyltransferase complex subunit 6 -2.12856
SAMD4A sterile alpha motif domain containing 4A -2.12856
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) -2.12856
BAIAP2 BAI1-associated protein 2 -2.12856
NIPSNAP1 nipsnap homolog 1 (C. elegans) -2.12856
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 -2.12856
ZNF319 zinc finger protein 319 -2.12856
PAQR7 progestin and adipoQ receptor family member VII -2.12856
INPP5D inositol polyphosphate-5-phosphatase, 145kDa -2.12856
WDR25 WD repeat domain 25 -2.12856
KIF1A kinesin family member 1A -2.12856
KAT2B K(lysine) acetyltransferase 2B -2.12856
DISP2 dispatched homolog 2 (Drosophila) -2.12856
DOC2B double C2-like domains, beta -2.12856
CAV1 caveolin 1, caveolae protein, 22kDa -2.12856
TULP4 tubby like protein 4 -2.12856
ARL15 ADP-ribosylation factor-like 15 -2.12856
CYTH2 cytohesin 2 -2.12647
DENND3 DENN/MADD domain containing 3 -2.11332
MTRF1 mitochondrial translational release factor 1 -2.10475
AMOT angiomotin -2.10417
APMAP adipocyte plasma membrane associated protein -2.09316
SRSF12 serine/arginine-rich splicing factor 12 -2.08705
PMM2 phosphomannomutase 2 -2.05796
TP53BP1 tumor protein p53 binding protein 1 -2.05113
RAB17 RAB17, member RAS oncogene family -2.04214
TIA1 TIA1 cytotoxic granule-associated RNA binding protein -2.02207
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -2.02207
SERHL2 serine hydrolase-like 2 -2.01222
CHD1 chromodomain helicase DNA binding protein 1 -2.00876
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 -2.00616
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa -2.0004