CBFB Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description core-binding factor, beta subunit|The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 865)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GCM_CBFB
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Genes

94 co-expressed genes for CBFB from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
ACTG1 actin gamma 1
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATP5F1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
ATXN10 ataxin 10
BLMH bleomycin hydrolase
BRD8 bromodomain containing 8
CAPRIN1 cell cycle associated protein 1
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1
CBFB core-binding factor, beta subunit
CNOT7 CCR4-NOT transcription complex, subunit 7
COPS5 COP9 signalosome subunit 5
CSK c-src tyrosine kinase
CTCF CCCTC-binding factor (zinc finger protein)
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DOCK2 dedicator of cytokinesis 2
DUT deoxyuridine triphosphatase
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF3F eukaryotic translation initiation factor 3, subunit F
ERH enhancer of rudimentary homolog (Drosophila)
ESD esterase D
FAM111A family with sequence similarity 111, member A
FNBP1 formin binding protein 1
HDAC1 histone deacetylase 1
HMGN1 high mobility group nucleosome binding domain 1
HMHA1 histocompatibility (minor) HA-1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HNRNPF heterogeneous nuclear ribonucleoprotein F
HNRNPL heterogeneous nuclear ribonucleoprotein L
HNRNPM heterogeneous nuclear ribonucleoprotein M
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HPRT1 hypoxanthine phosphoribosyltransferase 1
IFI16 interferon, gamma-inducible protein 16
ILF2 interleukin enhancer binding factor 2
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
MAPRE1 microtubule-associated protein, RP/EB family, member 1
MCM3 minichromosome maintenance complex component 3
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
NAP1L1 nucleosome assembly protein 1-like 1
NASP nuclear autoantigenic sperm protein (histone-binding)
NCL nucleolin
NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
NONO non-POU domain containing, octamer-binding
PCBP1 poly(rC) binding protein 1
PFN1 profilin 1
POLG polymerase (DNA directed), gamma
POLR2G polymerase (RNA) II (DNA directed) polypeptide G
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PWP1 PWP1 homolog (S. cerevisiae)
RBBP4 retinoblastoma binding protein 4
RBM15 RNA binding motif protein 15
RBMX RNA binding motif protein, X-linked
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RNF4 ring finger protein 4
SET SET nuclear proto-oncogene
SLBP stem-loop binding protein
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
SMC1A structural maintenance of chromosomes 1A
SNRPA small nuclear ribonucleoprotein polypeptide A
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa
SNRPE small nuclear ribonucleoprotein polypeptide E
SNRPF small nuclear ribonucleoprotein polypeptide F
SRRM1 serine/arginine repetitive matrix 1
SRSF2 serine/arginine-rich splicing factor 2
SRSF9 serine/arginine-rich splicing factor 9
STMN1 stathmin 1
SUMO2 small ubiquitin-like modifier 2
TAOK3 TAO kinase 3
TBCB tubulin folding cofactor B
TCEA1 transcription elongation factor A (SII), 1
TP53 tumor protein p53
TRA2B transformer 2 beta homolog (Drosophila)
UBE2I ubiquitin-conjugating enzyme E2I
XPO1 exportin 1
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZBTB1 zinc finger and BTB domain containing 1
ZC3H15 zinc finger CCCH-type containing 15
ZNHIT3 zinc finger, HIT-type containing 3