CBL Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description Cbl proto-oncogene, E3 ubiquitin protein ligase|This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012] (NCBI Entrez Gene Database, 867)
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Genes

315 genes differentially expressed following the CBL gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ANKRD40CL ANKRD40 C-terminal like 2.7551
FAM221B family with sequence similarity 221, member B 2.7551
FRG2C FSHD region gene 2 family, member C 2.7551
CDH17 cadherin 17, LI cadherin (liver-intestine) 2.7551
EXTL1 exostosin-like glycosyltransferase 1 2.7551
RAD51AP2 RAD51 associated protein 2 2.7551
CER1 cerberus 1, DAN family BMP antagonist 2.7551
GCOM1 GRINL1A complex locus 1 2.7551
S100B S100 calcium binding protein B 2.7551
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 2.7551
TYROBP TYRO protein tyrosine kinase binding protein 2.7551
PRR22 proline rich 22 2.7551
SPMIP10 sperm microtubule inner protein 10 2.7551
PPP1R27 protein phosphatase 1, regulatory subunit 27 2.7551
ZNF436 zinc finger protein 436 2.7551
SPEGNB SPEG neighbor 2.7551
MMP20 matrix metallopeptidase 20 2.7551
NDRG1 N-myc downstream regulated 1 2.7551
CABP4 calcium binding protein 4 2.74077
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 2.74077
NANOS2 nanos homolog 2 (Drosophila) 2.74077
HCRTR1 hypocretin (orexin) receptor 1 2.74077
CFHR3 complement factor H-related 3 2.74077
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.74077
DNAJC5B DnaJ (Hsp40) homolog, subfamily C, member 5 beta 2.74077
OR52H1 olfactory receptor, family 52, subfamily H, member 1 2.74077
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 2.74077
COLEC10 collectin sub-family member 10 (C-type lectin) 2.74077
VWA5B2 von Willebrand factor A domain containing 5B2 2.74077
CDH5 cadherin 5, type 2 (vascular endothelium) 2.74077
MAP3K7CL MAP3K7 C-terminal like 2.74077
FGL1 fibrinogen-like 1 2.74077
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 2.74077
PBOV1 prostate and breast cancer overexpressed 1 2.74077
KCNRG potassium channel regulator 2.74077
INIP INTS3 and NABP interacting protein 2.74077
TTLL8 tubulin tyrosine ligase-like family member 8 2.74077
TMEM125 transmembrane protein 125 2.74077
PRDM16 PR domain containing 16 2.74077
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 2.74077
CPLX4 complexin 4 2.74077
PAX2 paired box 2 2.74077
OR2J2 olfactory receptor, family 2, subfamily J, member 2 2.74077
PON1 paraoxonase 1 2.74077
PDYN prodynorphin 2.74077
MILR1 mast cell immunoglobulin-like receptor 1 2.74077
CCNB1 cyclin B1 2.74077
MYBPC3 myosin binding protein C, cardiac 2.74077
C8ORF48 chromosome 8 open reading frame 48 2.74077
SLC25A41 solute carrier family 25, member 41 2.74077
OSR2 odd-skipped related transciption factor 2 2.74077
ASGR2 asialoglycoprotein receptor 2 2.74077
TAS2R3 taste receptor, type 2, member 3 2.74077
ZNF705B zinc finger protein 705B 2.74077
OR51M1 olfactory receptor, family 51, subfamily M, member 1 2.74077
TSPAN1 tetraspanin 1 2.74077
GRAP GRB2-related adaptor protein 2.74077
ADRB3 adrenoceptor beta 3 2.74077
FMOD fibromodulin 2.74077
SPRR2A small proline-rich protein 2A 2.74077
ADGRG7 adhesion G protein-coupled receptor G7 2.74077
CLDN16 claudin 16 2.74077
AVPR1A arginine vasopressin receptor 1A 2.74077
FAM90A24 family with sequence similarity 90 member A24 2.74077
CFAP276 cilia and flagella associated protein 276 2.74077
AKAIN1 A-kinase anchor inhibitor 1 2.74077
CTXND1 cortexin domain containing 1 2.74077
CD8B2 CD8b2 molecule 2.74077
NOTCH2NLB notch 2 N-terminal like B 2.74077
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 2.74077
GATA1 GATA binding protein 1 (globin transcription factor 1) 2.74077
DLK2 delta-like 2 homolog (Drosophila) 2.74077
ACE2 angiotensin I converting enzyme 2 2.74077
SLC22A10 solute carrier family 22, member 10 2.74077
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.74077
ATP13A5 ATPase type 13A5 2.74077
DMP1 dentin matrix acidic phosphoprotein 1 2.74077
PCDHB11 protocadherin beta 11 2.74077
CLDN9 claudin 9 2.74077
CCR6 chemokine (C-C motif) receptor 6 2.74077
PTP4A1 protein tyrosine phosphatase type IVA, member 1 2.74077
C10ORF67 chromosome 10 open reading frame 67 2.74077
ZIC4 Zic family member 4 2.74077
TACSTD2 tumor-associated calcium signal transducer 2 2.74077
TFEC transcription factor EC 2.74077
TBX3 T-box 3 2.74077
GLIPR1L2 GLI pathogenesis-related 1 like 2 2.74077
PGLYRP4 peptidoglycan recognition protein 4 2.74077
FGFBP2 fibroblast growth factor binding protein 2 2.74077
GDF9 growth differentiation factor 9 2.74077
PPIAL4H peptidylprolyl isomerase A like 4H 2.74077
EDN3 endothelin 3 2.74077
MUC16 mucin 16, cell surface associated 2.74077
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 2.74077
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 2.74077
PRR35 proline rich 35 2.74077
LRRC74B leucine rich repeat containing 74B 2.74077
OCM oncomodulin 2.74077
NR5A1 nuclear receptor subfamily 5, group A, member 1 2.74077
CETP cholesteryl ester transfer protein, plasma 2.74077
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.74077
CASQ2 calsequestrin 2 (cardiac muscle) 2.74077
MMEL1 membrane metallo-endopeptidase-like 1 2.74077
HLA-DMB major histocompatibility complex, class II, DM beta 2.74077
OPN1SW opsin 1 (cone pigments), short-wave-sensitive 2.74077
RAP1GAP2 RAP1 GTPase activating protein 2 2.74077
GPR50 G protein-coupled receptor 50 2.74077
BRDT bromodomain, testis-specific 2.74077
ZBP1 Z-DNA binding protein 1 2.74077
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 2.74077
GP5 glycoprotein V (platelet) 2.74077
PTGES3 prostaglandin E synthase 3 (cytosolic) 2.74077
PALMD palmdelphin 2.74077
SLC52A3 solute carrier family 52 (riboflavin transporter), member 3 2.74077
CLEC7A C-type lectin domain family 7, member A 2.74077
TBPL2 TATA box binding protein like 2 2.74077
C11ORF16 chromosome 11 open reading frame 16 2.74077
HSF5 heat shock transcription factor family member 5 2.74077
POU2AF1 POU class 2 associating factor 1 2.74077
PCDHGA2 protocadherin gamma subfamily A, 2 2.74077
CLN5 ceroid-lipofuscinosis, neuronal 5 2.74077
AOC1 amine oxidase, copper containing 1 2.74077
TEN1 TEN1 CST complex subunit 2.74077
BHLHA15 basic helix-loop-helix family, member a15 2.74077
NACA2 nascent polypeptide-associated complex alpha subunit 2 2.74077
SPAG8 sperm associated antigen 8 2.74077
GOLGA8K golgin A8 family, member K 2.74077
SPAG6 sperm associated antigen 6 2.74077
GOLGA8R golgin A8 family, member R 2.74077
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.74077
FAM181B family with sequence similarity 181, member B 2.74077
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 2.74077
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.74077
ADRA2A adrenoceptor alpha 2A 2.74077
TEX29 testis expressed 29 2.74077
CFI complement factor I 2.74077
LPA lipoprotein, Lp(a) 2.74077
PASD1 PAS domain containing 1 2.74077
HMX1 H6 family homeobox 1 2.74077
GAS2L2 growth arrest-specific 2 like 2 2.74077
CLEC18A C-type lectin domain family 18, member A 2.74077
HIGD1C HIG1 hypoxia inducible domain family, member 1C 2.74077
SPDEF SAM pointed domain containing ETS transcription factor 2.74077
TPH1 tryptophan hydroxylase 1 2.74077
PLA2G10 phospholipase A2, group X 2.74077
SFTA2 surfactant associated 2 2.74077
MYO15A myosin XVA 2.71464
CHKA choline kinase alpha 2.71464
ADRM1 adhesion regulating molecule 1 2.69443
AURKC aurora kinase C 2.65619
ARHGAP9 Rho GTPase activating protein 9 2.65619
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 2.64728
RFX8 RFX family member 8, lacking RFX DNA binding domain 2.6073
PGGHG protein-glucosylgalactosylhydroxylysine glucosidase 2.51981
RPH3A rabphilin 3A 2.40013
EVI5 ecotropic viral integration site 5 2.38477
ACTMAP actin maturation protease 2.37473
SHISA8 shisa family member 8 2.36191
ARMC7 armadillo repeat containing 7 2.35867
OLFML1 olfactomedin-like 1 2.35513
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.35513
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10 2.3116
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 2.3116
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.30148
ERH enhancer of rudimentary homolog (Drosophila) 2.29685
XDH xanthine dehydrogenase 2.29026
SF3B6 splicing factor 3b, subunit 6, 14kDa 2.255
OPA1 optic atrophy 1 (autosomal dominant) 2.255
E2F1 E2F transcription factor 1 2.25055
NAT9 N-acetyltransferase 9 (GCN5-related, putative) 2.25034
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha 2.22433
OR52A1 olfactory receptor, family 52, subfamily A, member 1 2.21991
MEN1 multiple endocrine neoplasia I 2.21933
FER1L5 fer-1-like family member 5 2.21551
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit 2.21551
NAV1 neuron navigator 1 2.20256
ZNF766 zinc finger protein 766 2.1919
UBB ubiquitin B 2.17326
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 2.17326
GMNN geminin, DNA replication inhibitor 2.16118
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 2.16118
ASNSD1 asparagine synthetase domain containing 1 2.16118
RADIL Ras association and DIL domains 2.15219
GGNBP2 gametogenetin binding protein 2 2.14837
TANK TRAF family member-associated NFKB activator 2.13998
C6ORF118 chromosome 6 open reading frame 118 2.13603
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.12881
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 2.12881
APOC1 apolipoprotein C-I 2.11959
MNT MAX network transcriptional repressor 2.11444
THAP7 THAP domain containing 7 2.11026
TRIM33 tripartite motif containing 33 2.09073
RSRC2 arginine/serine-rich coiled-coil 2 2.08402
FOXJ3 forkhead box J3 2.08088
ZNF595 zinc finger protein 595 2.07998
H2AZ1 H2A.Z variant histone 1 2.07998
ZSCAN1 zinc finger and SCAN domain containing 1 2.04929
SH3BGR SH3 domain binding glutamate-rich protein 2.04167
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 2.04167
RPL41 ribosomal protein L41 2.04167
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.03163
LINC02762 long intergenic non-protein coding RNA 2762 2.01659

decreased expression

Symbol Name Standardized Value
FBLN7 fibulin 7 -2.7551
SLC26A7 solute carrier family 26 (anion exchanger), member 7 -2.7551
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled -2.7551
CIDEB cell death-inducing DFFA-like effector b -2.74077
FADS2 fatty acid desaturase 2 -2.74077
PRKD3 protein kinase D3 -2.74077
MMP21 matrix metallopeptidase 21 -2.74077
SUSD5 sushi domain containing 5 -2.74077
CPM carboxypeptidase M -2.74077
APOH apolipoprotein H (beta-2-glycoprotein I) -2.74077
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) -2.74077
ULBP3 UL16 binding protein 3 -2.74077
OCA2 oculocutaneous albinism II -2.74077
USP42 ubiquitin specific peptidase 42 -2.74077
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) -2.74077
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -2.74077
CNGA4 cyclic nucleotide gated channel alpha 4 -2.74077
MSRB2 methionine sulfoxide reductase B2 -2.70076
PKNOX1 PBX/knotted 1 homeobox 1 -2.67386
CORO6 coronin 6 -2.64728
MYO1C myosin IC -2.64728
TMC8 transmembrane channel-like 8 -2.64728
ELMOD3 ELMO/CED-12 domain containing 3 -2.64728
NLRP3 NLR family, pyrin domain containing 3 -2.64728
PCGF6 polycomb group ring finger 6 -2.64728
GMFG glia maturation factor, gamma -2.64728
RAB7B RAB7B, member RAS oncogene family -2.64728
LRRC56 leucine rich repeat containing 56 -2.64728
TMEM100 transmembrane protein 100 -2.64728
RHCG Rh family, C glycoprotein -2.64728
PLCZ1 phospholipase C, zeta 1 -2.64728
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G -2.64728
KLRF1 killer cell lectin-like receptor subfamily F, member 1 -2.64728
DERPC DERPC proline and glycine rich nuclear protein -2.64728
LGALS7B lectin, galactoside-binding, soluble, 7B -2.64728
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 -2.64728
CD5 CD5 molecule -2.64728
RASL10A RAS-like, family 10, member A -2.64728
EGFLAM EGF-like, fibronectin type III and laminin G domains -2.64728
HMGXB4 HMG box domain containing 4 -2.64728
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) -2.64728
PTX3 pentraxin 3, long -2.64728
GFRA3 GDNF family receptor alpha 3 -2.64728
BTLA B and T lymphocyte associated -2.64728
GPR35 G protein-coupled receptor 35 -2.64728
SIGLEC15 sialic acid binding Ig-like lectin 15 -2.64728
KIF1C-AS1 KIF1C antisense RNA 1 -2.64728
NOX4 NADPH oxidase 4 -2.64728
ZCCHC12 zinc finger, CCHC domain containing 12 -2.64728
AOC2 amine oxidase, copper containing 2 (retina-specific) -2.64728
CD8A CD8a molecule -2.64728
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -2.64728
PRPH2 peripherin 2 (retinal degeneration, slow) -2.64728
CD53 CD53 molecule -2.64728
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 -2.64728
BMX BMX non-receptor tyrosine kinase -2.64728
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) -2.64728
ADAM17 ADAM metallopeptidase domain 17 -2.64017
PARP4 poly (ADP-ribose) polymerase family, member 4 -2.59579
SCUBE2 signal peptide, CUB domain, EGF-like 2 -2.58635
NACAD NAC alpha domain containing -2.58635
ACVR2B activin A receptor, type IIB -2.53113
GLRX2 glutaredoxin 2 -2.50523
EQTN equatorin, sperm acrosome associated -2.49643
PARVA parvin, alpha -2.48104
NPIPA6 nuclear pore complex interacting protein family, member A6 -2.48104
ZNF160 zinc finger protein 160 -2.44449
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 -2.43468
PEX2 peroxisomal biogenesis factor 2 -2.42269
PLAC9 placenta-specific 9 -2.39389
DPYSL4 dihydropyrimidinase-like 4 -2.38413
PCDH7 protocadherin 7 -2.35867
LMO3 LIM domain only 3 (rhombotin-like 2) -2.3307
ACE angiotensin I converting enzyme -2.3307
TRIM39 tripartite motif containing 39 -2.31841
ULK3 unc-51 like kinase 3 -2.31465
KPNA5 karyopherin alpha 5 (importin alpha 6) -2.31144
PURG purine-rich element binding protein G -2.30148
ARPC5L actin related protein 2/3 complex, subunit 5-like -2.29685
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 -2.29612
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -2.255
XKR7 XK, Kell blood group complex subunit-related family, member 7 -2.24277
PARP14 poly (ADP-ribose) polymerase family, member 14 -2.21991
RAB13 RAB13, member RAS oncogene family -2.21983
DCP2 decapping mRNA 2 -2.20133
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa -2.18277
TMX3 thioredoxin-related transmembrane protein 3 -2.16118
CEP131 centrosomal protein 131kDa -2.16118
FAM47E family with sequence similarity 47, member E -2.15827
TTLL10 tubulin tyrosine ligase-like family member 10 -2.1417
CFAP53 cilia and flagella associated protein 53 -2.1417
ARFIP1 ADP-ribosylation factor interacting protein 1 -2.13931
ANKS3 ankyrin repeat and sterile alpha motif domain containing 3 -2.13804
ZFP1 ZFP1 zinc finger protein -2.13759
ZDBF2 zinc finger, DBF-type containing 2 -2.13603
TFEB transcription factor EB -2.1314
C2CD2L C2CD2-like -2.12881
SLC22A17 solute carrier family 22, member 17 -2.12799
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma -2.12524
ROGDI rogdi homolog (Drosophila) -2.11939
BCAT1 branched chain amino-acid transaminase 1, cytosolic -2.11473
CMKLR1 chemerin chemokine-like receptor 1 -2.11026
SOX30 SRY (sex determining region Y)-box 30 -2.11026
ZNF774 zinc finger protein 774 -2.10362
IFI30 interferon, gamma-inducible protein 30 -2.07998
PRKCE protein kinase C, epsilon -2.0649
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 -2.05142
MIEF2 mitochondrial elongation factor 2 -2.0429
NDNF neuron-derived neurotrophic factor -2.04167
MRPS18B mitochondrial ribosomal protein S18B -2.03663
KCNK6 potassium channel, two pore domain subfamily K, member 6 -2.03163
GPATCH4 G patch domain containing 4 -2.01128
NOTCH4 notch 4 -2.00909