CBS Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description cystathionine-beta-synthase|The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2010] (NCBI Entrez Gene Database, 875)
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Genes

353 genes differentially expressed following the CBS gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CAGE1 cancer antigen 1 2.47392
LCAT lecithin-cholesterol acyltransferase 2.47392
DAW1 dynein assembly factor with WDR repeat domains 1 2.47392
ZNF285 zinc finger protein 285 2.47392
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.47392
COL20A1 collagen, type XX, alpha 1 2.47392
C17ORF99 chromosome 17 open reading frame 99 2.47392
GJB1 gap junction protein, beta 1, 32kDa 2.47392
EMILIN1 elastin microfibril interfacer 1 2.47392
AKAP3 A kinase (PRKA) anchor protein 3 2.47392
APOA1 apolipoprotein A-I 2.47392
MYT1L myelin transcription factor 1-like 2.47392
PRCD progressive rod-cone degeneration 2.47392
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 2.47392
C2CD4B C2 calcium-dependent domain containing 4B 2.47392
MPPED1 metallophosphoesterase domain containing 1 2.47392
ARSL arylsulfatase L 2.47392
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 2.47392
ETV2 ets variant 2 2.47392
SSUH2 ssu-2 homolog (C. elegans) 2.47392
DES desmin 2.47392
HLA-DMB major histocompatibility complex, class II, DM beta 2.47392
UBA7 ubiquitin-like modifier activating enzyme 7 2.47392
FGF4 fibroblast growth factor 4 2.47392
PTPRQ protein tyrosine phosphatase, receptor type, Q 2.47392
SPNS2 spinster homolog 2 (Drosophila) 2.47392
LOX lysyl oxidase 2.45109
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.45109
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.45109
SCG2 secretogranin II 2.45109
SLC26A8 solute carrier family 26 (anion exchanger), member 8 2.45109
SBK3 SH3 domain binding kinase family, member 3 2.45109
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 2.45109
GPR75 G protein-coupled receptor 75 2.45109
FER1L6 fer-1-like family member 6 2.45109
BCAR1 breast cancer anti-estrogen resistance 1 2.45109
CFHR3 complement factor H-related 3 2.45109
SBSN suprabasin 2.45109
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 2.45109
TMPRSS11D transmembrane protease, serine 11D 2.45109
FBXL8 F-box and leucine-rich repeat protein 8 2.45109
CUTC cutC copper transporter 2.45109
LMAN2 lectin, mannose-binding 2 2.45109
LYNX1 Ly6/neurotoxin 1 2.45109
POSTN periostin, osteoblast specific factor 2.45109
TRPV3 transient receptor potential cation channel, subfamily V, member 3 2.45109
RAPSN receptor-associated protein of the synapse 2.45109
RLN3 relaxin 3 2.45109
CAAP1 caspase activity and apoptosis inhibitor 1 2.45109
COPZ1 coatomer protein complex, subunit zeta 1 2.45109
GNRH2 gonadotropin-releasing hormone 2 2.45109
OXT oxytocin/neurophysin I prepropeptide 2.45109
DIO3 deiodinase, iodothyronine, type III 2.45109
TAL2 T-cell acute lymphocytic leukemia 2 2.45109
GYPB glycophorin B (MNS blood group) 2.45109
CIITA class II, major histocompatibility complex, transactivator 2.45109
CABP4 calcium binding protein 4 2.45109
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 2.45109
HCRTR1 hypocretin (orexin) receptor 1 2.45109
ZNF467 zinc finger protein 467 2.45109
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) 2.45109
PKD1L1 polycystic kidney disease 1 like 1 2.45109
DDO D-aspartate oxidase 2.45109
ATG13 autophagy related 13 2.45109
DRAM1 DNA-damage regulated autophagy modulator 1 2.45109
TUBB8 tubulin, beta 8 class VIII 2.45109
CIART circadian associated repressor of transcription 2.45109
CIMIP2B ciliary microtubule inner protein 2B 2.45109
CCDC198 coiled-coil domain containing 198 2.45109
TCIM transcriptional and immune response regulator 2.45109
SMIM38 small integral membrane protein 38 2.45109
CFAP65 cilia and flagella associated protein 65 2.45109
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 2.45109
FKBP6 FK506 binding protein 6, 36kDa 2.45109
CAPN2 calpain 2, (m/II) large subunit 2.45109
PNLIPRP2 pancreatic lipase-related protein 2 2.45109
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 2.45109
SPRR2F small proline-rich protein 2F 2.45109
SMLR1 small leucine-rich protein 1 2.45109
PLAAT2 phospholipase A and acyltransferase 2 2.45109
CARMIL3 capping protein regulator and myosin 1 linker 3 2.45109
CIMAP2 ciliary microtubule associated protein 2 2.45109
LOC114841035 uncharacterized LOC114841035 2.45109
CIMAP1D CIMAP1 family member D 2.45109
H4C15 H4 clustered histone 15 2.45109
LHFPL7 LHFPL tetraspan subfamily member 7 2.45109
MUCL3 mucin like 3 2.45109
LRMDA leucine rich melanocyte differentiation associated 2.45109
TERB1 telomere repeat binding bouquet formation protein 1 2.45109
VXN vexin 2.45109
TAFA3 TAFA chemokine like family member 3 2.45109
SPATA46 spermatogenesis associated 46 2.45109
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 2.45109
XKR3 XK, Kell blood group complex subunit-related family, member 3 2.45109
ACTA1 actin, alpha 1, skeletal muscle 2.45109
ZSWIM2 zinc finger, SWIM-type containing 2 2.45109
CLDN9 claudin 9 2.45109
LTBP2 latent transforming growth factor beta binding protein 2 2.45109
ARL5C ADP-ribosylation factor-like 5C 2.45109
RHOXF2 Rhox homeobox family, member 2 2.45109
PRB4 proline-rich protein BstNI subfamily 4 2.45109
KLHL33 kelch-like family member 33 2.45109
ACOT1 acyl-CoA thioesterase 1 2.45109
AAK1 AP2 associated kinase 1 2.45109
TBX22 T-box 22 2.45109
TMEM235 transmembrane protein 235 2.45109
TLR4 toll-like receptor 4 2.45109
IMPG1 interphotoreceptor matrix proteoglycan 1 2.45109
LEKR1 leucine, glutamate and lysine rich 1 2.45109
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) 2.45109
FAM107A family with sequence similarity 107, member A 2.45109
DLK2 delta-like 2 homolog (Drosophila) 2.45109
NPIPB8 nuclear pore complex interacting protein family, member B8 2.45109
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 2.45109
PLEK2 pleckstrin 2 2.45109
FMR1NB fragile X mental retardation 1 neighbor 2.45109
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) 2.45109
TIFA TRAF-interacting protein with forkhead-associated domain 2.45109
SYCP2 synaptonemal complex protein 2 2.45109
TECRL trans-2,3-enoyl-CoA reductase-like 2.45109
HCRT hypocretin (orexin) neuropeptide precursor 2.45109
AQP5 aquaporin 5 2.45109
OR10R2 olfactory receptor, family 10, subfamily R, member 2 2.45109
KLF4 Kruppel-like factor 4 (gut) 2.45109
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 2.45109
OAZ3 ornithine decarboxylase antizyme 3 2.45109
HPX hemopexin 2.45109
TRADD TNFRSF1A-associated via death domain 2.45109
CD53 CD53 molecule 2.45109
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.45109
APOC4 apolipoprotein C-IV 2.45109
CST4 cystatin S 2.45109
DNAH12 dynein, axonemal, heavy chain 12 2.45109
PRRX1 paired related homeobox 1 2.45109
LPAR5 lysophosphatidic acid receptor 5 2.45109
TMIGD3 transmembrane and immunoglobulin domain containing 3 2.45109
ECM1 extracellular matrix protein 1 2.45109
AGR2 anterior gradient 2 2.45109
PRSS57 protease, serine, 57 2.45109
ZNF671 zinc finger protein 671 2.45109
CPZ carboxypeptidase Z 2.45109
KCNK3 potassium channel, two pore domain subfamily K, member 3 2.45109
MYADML2 myeloid-associated differentiation marker-like 2 2.45109
SHOX2 short stature homeobox 2 2.45109
PSKH2 protein serine kinase H2 2.45109
MAB21L1 mab-21-like 1 (C. elegans) 2.45109
SLC25A34 solute carrier family 25, member 34 2.45109
CAPSL calcyphosine-like 2.45109
MSMP microseminoprotein, prostate associated 2.45109
GPR142 G protein-coupled receptor 142 2.45109
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 2.45109
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 2.45109
GAS2L2 growth arrest-specific 2 like 2 2.45109
WNT10B wingless-type MMTV integration site family, member 10B 2.45109
LRRN4 leucine rich repeat neuronal 4 2.45109
FBXO10 F-box protein 10 2.45109
ADRA2A adrenoceptor alpha 2A 2.45109
TMPPE transmembrane protein with metallophosphoesterase domain 2.45109
HIGD2B HIG1 hypoxia inducible domain family, member 2B 2.45109
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 2.45109
MCCD1 mitochondrial coiled-coil domain 1 2.45109
VWA3A von Willebrand factor A domain containing 3A 2.45109
TEX19 testis expressed 19 2.45109
C10ORF53 chromosome 10 open reading frame 53 2.45109
THBD thrombomodulin 2.45109
ZCCHC12 zinc finger, CCHC domain containing 12 2.45109
ZEB1 zinc finger E-box binding homeobox 1 2.45109
C20ORF144 chromosome 20 open reading frame 144 2.45109
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.45109
DND1 DND microRNA-mediated repression inhibitor 1 2.45109
SLC22A24 solute carrier family 22, member 24 2.45109
LGALS2 lectin, galactoside-binding, soluble, 2 2.45109
PCDHGA12 protocadherin gamma subfamily A, 12 2.45109
PRSS21 protease, serine, 21 (testisin) 2.45109
SNAI2 snail family zinc finger 2 2.45109
SOST sclerostin 2.45109
FAM9B family with sequence similarity 9, member B 2.45109
PITX1 paired-like homeodomain 1 2.45109
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 2.45109
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 2.45109
LCK LCK proto-oncogene, Src family tyrosine kinase 2.45109
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 2.45109
ZNF648 zinc finger protein 648 2.45109
CPLX4 complexin 4 2.45109
CPLX3 complexin 3 2.45109
OVCH2 ovochymase 2 (gene/pseudogene) 2.45109
HMX3 H6 family homeobox 3 2.45109
SLC10A5 solute carrier family 10, member 5 2.45109
LEP leptin 2.45109
CAMK1G calcium/calmodulin-dependent protein kinase IG 2.45109
OTOL1 otolin 1 2.45109
TMEM215 transmembrane protein 215 2.45109
NUTM2D NUT family member 2D 2.45109
CD80 CD80 molecule 2.45109
ROM1 retinal outer segment membrane protein 1 2.45109
RCC2 regulator of chromosome condensation 2 2.45109
PLGLB2 plasminogen-like B2 2.45109
POTEI POTE ankyrin domain family, member I 2.45109
TRPM2 transient receptor potential cation channel, subfamily M, member 2 2.45109
LAMP3 lysosomal-associated membrane protein 3 2.45109
ZNF534 zinc finger protein 534 2.45109
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 2.45109
PTPN7 protein tyrosine phosphatase, non-receptor type 7 2.45109
WBP2NL WBP2 N-terminal like 2.45109
EPS8 epidermal growth factor receptor pathway substrate 8 2.44865
CNOT6L CCR4-NOT transcription complex, subunit 6-like 2.44865
NVL nuclear VCP-like 2.44689
MOSPD3 motile sperm domain containing 3 2.43069
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1 2.41858
GPR149 G protein-coupled receptor 149 2.41649
DMGDH dimethylglycine dehydrogenase 2.41555
TPI1 triosephosphate isomerase 1 2.39455
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 2.37308
IGSF22 immunoglobulin superfamily, member 22 2.36666
ABI3BP ABI family, member 3 (NESH) binding protein 2.36666
NLRP2 NLR family, pyrin domain containing 2 2.36666
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 2.35797
LRATD1 LRAT domain containing 1 2.35762
MRPL48 mitochondrial ribosomal protein L48 2.34917
TAGLN transgelin 2.3417
TSPAN7 tetraspanin 7 2.31329
YPEL4 yippee-like 4 (Drosophila) 2.24003
MCM8 minichromosome maintenance complex component 8 2.2241
SPDYA speedy/RINGO cell cycle regulator family member A 2.2241
TWSG1 twisted gastrulation BMP signaling modulator 1 2.22049
CHMP1B charged multivesicular body protein 1B 2.20875
PPARA peroxisome proliferator-activated receptor alpha 2.20681
TRIQK triple QxxK/R motif containing 2.20197
ZKSCAN4 zinc finger with KRAB and SCAN domains 4 2.18543
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 2.17703
CAMTA2 calmodulin binding transcription activator 2 2.17054
PKP2 plakophilin 2 2.17054
RPL22 ribosomal protein L22 2.14898
GLI4 GLI family zinc finger 4 2.14654
BBS4 Bardet-Biedl syndrome 4 2.14031
RFC1 replication factor C (activator 1) 1, 145kDa 2.12527
FUNDC2 FUN14 domain containing 2 2.12527
POLQ polymerase (DNA directed), theta 2.1176
TTC28 tetratricopeptide repeat domain 28 2.1176
PPP1R18 protein phosphatase 1, regulatory subunit 18 2.11685
COL2A1 collagen, type II, alpha 1 2.10711
DHRS3 dehydrogenase/reductase (SDR family) member 3 2.10182
HYOU1 hypoxia up-regulated 1 2.10045
LMO3 LIM domain only 3 (rhombotin-like 2) 2.0818
CNPPD1 cyclin Pas1/PHO80 domain containing 1 2.07796
TMA16 translation machinery associated 16 homolog (S. cerevisiae) 2.06905
STRN4 striatin, calmodulin binding protein 4 2.06263
NSUN7 NOP2/Sun domain family, member 7 2.05839
CCDC74A coiled-coil domain containing 74A 2.05789
CENPE centromere protein E, 312kDa 2.05288
DYSF dysferlin 2.03354
LYAR Ly1 antibody reactive 2.01912

decreased expression

Symbol Name Standardized Value
CCL28 chemokine (C-C motif) ligand 28 -2.47392
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B -2.47392
SLA2 Src-like-adaptor 2 -2.47392
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 -2.47392
RWDD2A RWD domain containing 2A -2.47392
MTLN mitoregulin -2.47392
MAN2A2 mannosidase, alpha, class 2A, member 2 -2.47392
FOXI3 forkhead box I3 -2.47392
DENR density-regulated protein -2.45109
NLRP1 NLR family, pyrin domain containing 1 -2.45109
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit -2.45109
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -2.45109
AGBL1 ATP/GTP binding protein-like 1 -2.45109
CLCNKB chloride channel, voltage-sensitive Kb -2.45109
PCDHB13 protocadherin beta 13 -2.45109
GEMIN7 gem (nuclear organelle) associated protein 7 -2.45109
DEGS2 delta(4)-desaturase, sphingolipid 2 -2.45109
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -2.45109
HAUS1 HAUS augmin-like complex, subunit 1 -2.45109
SIRT7 sirtuin 7 -2.45109
EFNA1 ephrin-A1 -2.45109
DIO1 deiodinase, iodothyronine, type I -2.45109
SBF2 SET binding factor 2 -2.45109
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 -2.45109
PCDHB4 protocadherin beta 4 -2.45109
JOSD1 Josephin domain containing 1 -2.45109
PLA2G15 phospholipase A2, group XV -2.45109
CAPN11 calpain 11 -2.45109
PCDHA3 protocadherin alpha 3 -2.45109
PCDHB11 protocadherin beta 11 -2.45109
BBS5 Bardet-Biedl syndrome 5 -2.45109
ZC3H11C zinc finger CCCH-type containing 11C -2.45109
YIPF4 Yip1 domain family, member 4 -2.45109
DYNLT3 dynein, light chain, Tctex-type 3 -2.45109
KLHDC8A kelch domain containing 8A -2.45109
ESS2 ess-2 splicing factor homolog -2.45109
PLPPR4 phospholipid phosphatase related 4 -2.45109
CCDC71 coiled-coil domain containing 71 -2.45109
H4C12 H4 clustered histone 12 -2.45109
EVI2A ecotropic viral integration site 2A -2.45109
ARFRP1 ADP-ribosylation factor related protein 1 -2.45109
PCDH17 protocadherin 17 -2.45109
SPEF2 sperm flagellar 2 -2.45109
SPDYE16 speedy/RINGO cell cycle regulator family member E16 -2.45109
FAM78B family with sequence similarity 78, member B -2.45109
NGFR nerve growth factor receptor -2.45109
THOC7 THO complex 7 -2.45109
RSAD2 radical S-adenosyl methionine domain containing 2 -2.45109
RAB40A RAB40A, member RAS oncogene family -2.45109
CNTN3 contactin 3 (plasmacytoma associated) -2.45109
CBS cystathionine-beta-synthase -2.45109
ARG1 arginase 1 -2.45109
SF3B6 splicing factor 3b, subunit 6, 14kDa -2.44729
SUSD5 sushi domain containing 5 -2.44204
SFN stratifin -2.44204
IDNK idnK, gluconokinase homolog (E. coli) -2.44204
LHX8 LIM homeobox 8 -2.44204
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -2.42756
KLHL13 kelch-like family member 13 -2.42223
ZC3H4 zinc finger CCCH-type containing 4 -2.38398
ZNF22 zinc finger protein 22 -2.37854
LIPE lipase, hormone-sensitive -2.36708
LUC7L2 LUC7-like 2 (S. cerevisiae) -2.36516
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -2.36516
VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae) -2.36516
WDR86 WD repeat domain 86 -2.35639
ESYT3 extended synaptotagmin-like protein 3 -2.34917
SMIM10L2B small integral membrane protein 10 like 2B -2.34225
RPS12 ribosomal protein S12 -2.33009
TOR4A torsin family 4, member A -2.33009
EXOSC3 exosome component 3 -2.32608
AEBP2 AE binding protein 2 -2.26869
RBM3 RNA binding motif (RNP1, RRM) protein 3 -2.26137
TRIOBP TRIO and F-actin binding protein -2.25459
A2M alpha-2-macroglobulin -2.24757
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 -2.24003
IGSF9 immunoglobulin superfamily, member 9 -2.2241
SMTN smoothelin -2.22298
SNTG2 syntrophin, gamma 2 -2.20681
NDRG2 NDRG family member 2 -2.20681
FMNL3 formin-like 3 -2.19852
ADIPOR1 adiponectin receptor 1 -2.19336
ATRAID all-trans retinoic acid-induced differentiation factor -2.19275
TMEM154 transmembrane protein 154 -2.18503
ATP9A ATPase, class II, type 9A -2.17703
NAV2 neuron navigator 2 -2.14898
H2BC21 H2B clustered histone 21 -2.12527
ZSCAN25 zinc finger and SCAN domain containing 25 -2.12527
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 -2.08769
GALNT17 polypeptide N-acetylgalactosaminyltransferase 17 -2.07655
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -2.07563
IFI6 interferon, alpha-inducible protein 6 -2.0693
SLC66A1 solute carrier family 66 member 1 -2.0693
LXN latexin -2.0693
MARCHF2 membrane associated ring-CH-type finger 2 -2.06905
ZBTB10 zinc finger and BTB domain containing 10 -2.05288
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -2.04804
RAI1 retinoic acid induced 1 -2.01239
COTL1 coactosin-like F-actin binding protein 1 -2.01239
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3 -2.01239
CACNG6 calcium channel, voltage-dependent, gamma subunit 6 -2.00768