CC-401 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/10430360
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Genes

200 proteins with high or low expression in CC-401 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
CLK1 CDC-like kinase 1 2.46
FBXO41 F-box protein 41 1.89
CLK4 CDC-like kinase 4 1.75
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.43
CCND1 cyclin D1 1.26
MAN2C1 mannosidase, alpha, class 2C, member 1 1.26
DHRS2 dehydrogenase/reductase (SDR family) member 2 1.22
CCND3 cyclin D3 1.16
CD63 CD63 molecule 1.16
TSPAN3 tetraspanin 3 1.08
DDB2 damage-specific DNA binding protein 2, 48kDa 1.04
PIP prolactin-induced protein 1.0
FAM199X family with sequence similarity 199, X-linked 1.0
SMC1B structural maintenance of chromosomes 1B 1.0
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.97
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.95
ARID5B AT rich interactive domain 5B (MRF1-like) 0.91
ANKRD10 ankyrin repeat domain 10 0.84
EPN3 epsin 3 0.8
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 0.77
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.75
CLK3 CDC-like kinase 3 0.75
ERBB3 erb-b2 receptor tyrosine kinase 3 0.74
TGFB1I1 transforming growth factor beta 1 induced transcript 1 0.73
NCOA4 nuclear receptor coactivator 4 0.7
PLIN2 perilipin 2 0.69
TTC38 tetratricopeptide repeat domain 38 0.68
CTSV cathepsin V 0.68
CSNK1D casein kinase 1, delta 0.66
TRIM2 tripartite motif containing 2 0.66
JPT1 Jupiter microtubule associated homolog 1 0.64
RETREG2 reticulophagy regulator family member 2 0.64
TACSTD2 tumor-associated calcium signal transducer 2 0.64
FTH1 ferritin, heavy polypeptide 1 0.63
H1FX H1 histone family, member X 0.63
MIB2 mindbomb E3 ubiquitin protein ligase 2 0.63
ORC1 origin recognition complex, subunit 1 0.62
CSNK1E casein kinase 1, epsilon 0.62
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 0.62
PHLDA3 pleckstrin homology-like domain, family A, member 3 0.62
METTL7A methyltransferase like 7A 0.61
TP53I3 tumor protein p53 inducible protein 3 0.61
MYH4 myosin, heavy chain 4, skeletal muscle 0.61
LPIN1 lipin 1 0.61
INAVA innate immunity activator 0.61
TP53 tumor protein p53 0.61
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 0.6
APOB apolipoprotein B 0.6
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.6
TP73 tumor protein p73 0.6
SULF2 sulfatase 2 0.59
CIT citron rho-interacting serine/threonine kinase 0.58
ZNF385A zinc finger protein 385A 0.58
PTPRD protein tyrosine phosphatase, receptor type, D 0.57
IDI1 isopentenyl-diphosphate delta isomerase 1 0.57
FDXR ferredoxin reductase 0.57
CLK2 CDC-like kinase 2 0.57
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.57
AXIN2 axin 2 0.57
HFE hemochromatosis 0.56
EHD2 EH-domain containing 2 0.56
MEX3C mex-3 RNA binding family member C 0.56
LAMB2 laminin, beta 2 (laminin S) 0.55
TCF19 transcription factor 19 0.55
PDLIM3 PDZ and LIM domain 3 0.54
ZDHHC23 zinc finger, DHHC-type containing 23 0.54
MAN1A1 mannosidase, alpha, class 1A, member 1 0.53
GRHL1 grainyhead-like 1 (Drosophila) 0.53
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 0.53
FGFBP1 fibroblast growth factor binding protein 1 0.53
SLC49A4 solute carrier family 49 member 4 0.53
CRAT carnitine O-acetyltransferase 0.53
CDK4 cyclin-dependent kinase 4 0.52
TCTEX1D2 Tctex1 domain containing 2 0.52
PPL periplakin 0.52
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.51
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.51
TPP1 tripeptidyl peptidase I 0.51
FBXL8 F-box and leucine-rich repeat protein 8 0.5
NAA80 N-alpha-acetyltransferase 80, NatH catalytic subunit 0.5
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.5
SLC35A5 solute carrier family 35, member A5 0.5
SENP7 SUMO1/sentrin specific peptidase 7 0.5
MVK mevalonate kinase 0.49
TMEM175 transmembrane protein 175 0.49
H1-2 H1.2 linker histone, cluster member 0.48
PTPRF protein tyrosine phosphatase, receptor type, F 0.48
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.47
GRTP1 growth hormone regulated TBC protein 1 0.47
RFX5 regulatory factor X, 5 (influences HLA class II expression) 0.47
NGFR nerve growth factor receptor 0.47
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 0.47
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.47
SUN2 Sad1 and UNC84 domain containing 2 0.46
MSL3P1 male-specific lethal 3 homolog (Drosophila) pseudogene 1 0.46
RTN4R reticulon 4 receptor 0.46
FAM114A1 family with sequence similarity 114, member A1 0.45
DHRS1 dehydrogenase/reductase (SDR family) member 1 0.45
FTL ferritin, light polypeptide 0.45
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.45

low expression

Symbol Name Standardized Value
ALPK3 alpha-kinase 3 -2.09
NALCN sodium leak channel, non selective -2.08
JUN jun proto-oncogene -1.81
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -1.41
SEPTIN4 septin 4 -1.37
F3 coagulation factor III (thromboplastin, tissue factor) -1.19
CPA4 carboxypeptidase A4 -1.17
MLPH melanophilin -1.1
TRIM9 tripartite motif containing 9 -1.04
HAS3 hyaluronan synthase 3 -1.03
IVNS1ABP influenza virus NS1A binding protein -1.03
FOSL1 FOS-like antigen 1 -0.95
PDE9A phosphodiesterase 9A -0.91
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.88
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.87
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.87
AKAP12 A kinase (PRKA) anchor protein 12 -0.85
GLCCI1 glucocorticoid induced 1 -0.85
PLD6 phospholipase D family, member 6 -0.83
ERRFI1 ERBB receptor feedback inhibitor 1 -0.83
WNT16 wingless-type MMTV integration site family, member 16 -0.8
TRIB1 tribbles pseudokinase 1 -0.78
TGFB1 transforming growth factor, beta 1 -0.77
TNS4 tensin 4 -0.76
PLAUR plasminogen activator, urokinase receptor -0.75
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.74
STC2 stanniocalcin 2 -0.74
PHLDA2 pleckstrin homology-like domain, family A, member 2 -0.73
BCAR3 breast cancer anti-estrogen resistance 3 -0.73
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.71
ZFP36L1 ZFP36 ring finger protein-like 1 -0.7
KPTN kaptin (actin binding protein) -0.7
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 -0.7
SPRY4 sprouty homolog 4 (Drosophila) -0.69
FAM117B family with sequence similarity 117, member B -0.69
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 -0.69
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) -0.69
FOSL2 FOS-like antigen 2 -0.69
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A -0.68
GK5 glycerol kinase 5 (putative) -0.66
NRP1 neuropilin 1 -0.66
CKM creatine kinase, muscle -0.65
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.65
CORO2B coronin, actin binding protein, 2B -0.65
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 -0.64
CAV2 caveolin 2 -0.63
EPHA4 EPH receptor A4 -0.63
THSD4 thrombospondin, type I, domain containing 4 -0.63
ACTBL2 actin, beta-like 2 -0.63
CASZ1 castor zinc finger 1 -0.63
KLK6 kallikrein-related peptidase 6 -0.62
SLC38A2 solute carrier family 38, member 2 -0.62
DUSP5 dual specificity phosphatase 5 -0.61
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -0.61
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.61
RHOBTB3 Rho-related BTB domain containing 3 -0.61
EREG epiregulin -0.6
ZBED8L ZBED8 like -0.6
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.6
REEP3 receptor accessory protein 3 -0.6
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.59
KPNA5 karyopherin alpha 5 (importin alpha 6) -0.58
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 -0.58
OBSL1 obscurin-like 1 -0.58
MINDY4 MINDY lysine 48 deubiquitinase 4 -0.57
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 -0.57
STMN3 stathmin-like 3 -0.56
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) -0.56
IFRD1 interferon-related developmental regulator 1 -0.56
ADAM19 ADAM metallopeptidase domain 19 -0.56
ZFAND2A zinc finger, AN1-type domain 2A -0.56
NR1D1 nuclear receptor subfamily 1, group D, member 1 -0.56
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 -0.56
GLRX glutaredoxin (thioltransferase) -0.56
TMEM200A transmembrane protein 200A -0.55
MYO10 myosin X -0.55
CABLES1 Cdk5 and Abl enzyme substrate 1 -0.55
SOX13 SRY (sex determining region Y)-box 13 -0.55
WSB2 WD repeat and SOCS box containing 2 -0.55
SH3RF2 SH3 domain containing ring finger 2 -0.55
FAM53B family with sequence similarity 53, member B -0.54
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) -0.54
SET SET nuclear proto-oncogene -0.53
KLK7 kallikrein-related peptidase 7 -0.53
ESYT2 extended synaptotagmin-like protein 2 -0.52
LRP5 low density lipoprotein receptor-related protein 5 -0.51
PRICKLE3 prickle homolog 3 (Drosophila) -0.51
NAV2 neuron navigator 2 -0.5
ZRANB1 zinc finger, RAN-binding domain containing 1 -0.5
SYTL3 synaptotagmin-like 3 -0.5
SATB2 SATB homeobox 2 -0.49
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 -0.49
NTSR1 neurotensin receptor 1 (high affinity) -0.49
OSGIN2 oxidative stress induced growth inhibitor family member 2 -0.48
KLHL21 kelch-like family member 21 -0.48
DNLZ DNL-type zinc finger -0.48
NR2F2 nuclear receptor subfamily 2, group F, member 2 -0.48
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.48
COQ10B coenzyme Q10 homolog B (S. cerevisiae) -0.47
EFNB2 ephrin-B2 -0.47