CCDC88C Gene Set

Dataset NURSA Protein-Protein Interactions
Category proteomics
Type interacting protein
Description coiled-coil domain containing 88C|This gene encodes a ubiquitously expressed coiled-coil domain-containing protein that interacts with the dishevelled protein and is a negative regulator of the Wnt signalling pathway. The protein encoded by this gene has a PDZ-domain binding motif in its C-terminus with which it interacts with the dishevelled protein. Dishevelled is a scaffold protein involved in the regulation of the Wnt signaling pathway. The Wnt signaling pathway plays an important role in embryonic development, tissue maintenance, and cancer progression. Mutations in this gene cause autosomal recessive, primary non-syndromic congenital hydrocephalus; a condition characterized by excessive accumulation of cerebrospinal fluid in the ventricles of the brain. [provided by RefSeq, Jan 2013] (NCBI Entrez Gene Database, 440193)
External Link http://www.ncbi.nlm.nih.gov/gene/440193
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4 interacting proteins for CCDC88C from the NURSA Protein-Protein Interactions dataset.

Symbol Name Standardized Value
PAPD4 PAP associated domain containing 4 0.705142
ANP32C acidic (leucine-rich) nuclear phosphoprotein 32 family, member C 0.683075
CCDC157 coiled-coil domain containing 157 0.683075
DNAH5 dynein, axonemal, heavy chain 5 0.683075