CCL3 Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description chemokine (C-C motif) ligand 3|This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010] (NCBI Entrez Gene Database, 6348)
External Link https://ncbi.nlm.nih.gov/gene/6348
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Genes

499 genes differentially expressed following the CCL3 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
KRT7 keratin 7, type II 0.0140056
S100A8 S100 calcium binding protein A8 0.0127137
MAP7 microtubule-associated protein 7 0.0100723
PERP PERP, TP53 apoptosis effector 0.00933441
LTF lactotransferrin 0.00827611
PCNA proliferating cell nuclear antigen 0.00798979
AMIGO2 adhesion molecule with Ig-like domain 2 0.00797848
INHBA inhibin, beta A 0.00764223
CXCL5 chemokine (C-X-C motif) ligand 5 0.00762822
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.00741176
MVP major vault protein 0.0073438
IL32 interleukin 32 0.00734124
KYNU kynureninase 0.00731076
DSP desmoplakin 0.00707835
S100A9 S100 calcium binding protein A9 0.00704509
HSPA1A heat shock 70kDa protein 1A 0.00704204
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.0070263
VAMP8 vesicle-associated membrane protein 8 0.00691258
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.00690421
RNF128 ring finger protein 128, E3 ubiquitin protein ligase 0.00685032
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 0.00683722
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.00681341
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.00680578
S100A7 S100 calcium binding protein A7 0.00671513
MMP1 matrix metallopeptidase 1 0.0066016
CST1 cystatin SN 0.00656799
FOSL1 FOS-like antigen 1 0.00644275
MIR22HG MIR22 host gene 0.00631901
FN1 fibronectin 1 0.0063062
UPK1B uroplakin 1B 0.00629262
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.00619624
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.00618923
SIK1 salt-inducible kinase 1 0.00618805
ACKR3 atypical chemokine receptor 3 0.00618307
BAMBI BMP and activin membrane-bound inhibitor 0.0061224
PLCB4 phospholipase C, beta 4 0.0060717
SCD5 stearoyl-CoA desaturase 5 0.00601325
F5 coagulation factor V (proaccelerin, labile factor) 0.00599685
TFF1 trefoil factor 1 0.00593551
CXCL9 chemokine (C-X-C motif) ligand 9 0.00589937
VEGFC vascular endothelial growth factor C 0.00589925
CCN2 cellular communication network factor 2 0.00588319
S100A12 S100 calcium binding protein A12 0.00583878
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0058366
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.00582098
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.00577147
BTG2 BTG family, member 2 0.00574627
S100A11 S100 calcium binding protein A11 0.00568063
CCR2 chemokine (C-C motif) receptor 2 0.00562177
IL1RN interleukin 1 receptor antagonist 0.00557969
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 0.00557683
COL11A1 collagen, type XI, alpha 1 0.00553553
VIM vimentin 0.00552785
THBS2 thrombospondin 2 0.0055068
LYZ lysozyme 0.00546716
JAG1 jagged 1 0.00541527
PIP prolactin-induced protein 0.00539972
SCGB2A2 secretoglobin, family 2A, member 2 0.00534682
MFAP5 microfibrillar associated protein 5 0.00534272
YPEL5 yippee-like 5 (Drosophila) 0.00525556
TPD52L1 tumor protein D52-like 1 0.00523559
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.00523035
FNDC3B fibronectin type III domain containing 3B 0.00522598
SLC31A2 solute carrier family 31 (copper transporter), member 2 0.00522065
CSTA cystatin A (stefin A) 0.0052081
PFKP phosphofructokinase, platelet 0.00520605
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.00520116
CXCL10 chemokine (C-X-C motif) ligand 10 0.00519873
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 0.00519615
CCNA2 cyclin A2 0.00519542
SIRPA signal-regulatory protein alpha 0.00517301
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.00516024
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.00514715
FABP4 fatty acid binding protein 4, adipocyte 0.00513293
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.00512465
CTSS cathepsin S 0.00510231
LYPD3 LY6/PLAUR domain containing 3 0.00508796
HSPB8 heat shock 22kDa protein 8 0.00508759
KRT17 keratin 17, type I 0.00503405
FERMT1 fermitin family member 1 0.00503174
ANXA3 annexin A3 0.00500858
HK2 hexokinase 2 0.00498186
NEBL nebulette 0.0049761
RAB29 RAB29, member RAS oncogene family 0.00497292
TUFT1 tuftelin 1 0.00496909
VLDLR very low density lipoprotein receptor 0.00496379
HECA headcase homolog (Drosophila) 0.00494886
ZMAT3 zinc finger, matrin-type 3 0.004909
CCR1 chemokine (C-C motif) receptor 1 0.00488441
PON3 paraoxonase 3 0.00485274
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.00484597
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.00484265
BASP1 brain abundant, membrane attached signal protein 1 0.00483483
GLRX glutaredoxin (thioltransferase) 0.00481817
CST4 cystatin S 0.00481693
SPRR1B small proline-rich protein 1B 0.00481197
ADO 2-aminoethanethiol (cysteamine) dioxygenase 0.00479985
S100P S100 calcium binding protein P 0.00476656
KLF4 Kruppel-like factor 4 (gut) 0.00474669
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 0.0047349
PLEK2 pleckstrin 2 0.00470554
PXDC1 PX domain containing 1 0.00470176
SHTN1 shootin 1 0.00469789
ELL2 elongation factor, RNA polymerase II, 2 0.00468641
PSCA prostate stem cell antigen 0.00467693
KLF9 Kruppel-like factor 9 0.00465226
LMCD1 LIM and cysteine-rich domains 1 0.00464774
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 0.00462711
ZNF365 zinc finger protein 365 0.00462215
BCL2A1 BCL2-related protein A1 0.00462173
FBP1 fructose-1,6-bisphosphatase 1 0.00461043
ZBTB38 zinc finger and BTB domain containing 38 0.00460451
POSTN periostin, osteoblast specific factor 0.00460067
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.00460018
IL6 interleukin 6 0.00459068
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 0.00458067
NAGK N-acetylglucosamine kinase 0.00454411
GPX2 glutathione peroxidase 2 0.00452317
HLA-C major histocompatibility complex, class I, C 0.00452287
TP63 tumor protein p63 0.00450547
STXBP2 syntaxin binding protein 2 0.00450368
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.00450133
ADGRE5 adhesion G protein-coupled receptor E5 0.00450005
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.004493
SGK1 serum/glucocorticoid regulated kinase 1 0.00448639
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.00448575
OSBPL10 oxysterol binding protein-like 10 0.0044778
EZR ezrin 0.00447436
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.00446611
CLTB clathrin, light chain B 0.00445139
CLIC3 chloride intracellular channel 3 0.00443188
KRT18 keratin 18, type I 0.00442967
MAN1C1 mannosidase, alpha, class 1C, member 1 0.0044231
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 0.00441187
OPHN1 oligophrenin 1 0.00437929
CDK14 cyclin-dependent kinase 14 0.00437745
SOX9 SRY (sex determining region Y)-box 9 0.00437574
DHDDS dehydrodolichyl diphosphate synthase 0.00437332
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.00435352
ACTA2 actin, alpha 2, smooth muscle, aorta 0.00434244
SNX7 sorting nexin 7 0.00433544
COL4A1 collagen, type IV, alpha 1 0.00432563
ACAA1 acetyl-CoA acyltransferase 1 0.00430525
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 0.00430162
DUSP5 dual specificity phosphatase 5 0.00429825
PYGL phosphorylase, glycogen, liver 0.0042979
CX3CR1 chemokine (C-X3-C motif) receptor 1 0.00428854
SOX10 SRY (sex determining region Y)-box 10 0.00428689
NQO2 NAD(P)H dehydrogenase, quinone 2 0.00428231
MYOF myoferlin 0.00424981
CTSZ cathepsin Z 0.00424738
TUBB2A tubulin, beta 2A class IIa 0.00424227
GRN granulin 0.00423
LCK LCK proto-oncogene, Src family tyrosine kinase 0.00422905
HLA-F major histocompatibility complex, class I, F 0.00422267
ELF5 E74-like factor 5 (ets domain transcription factor) 0.00417939
COBL cordon-bleu WH2 repeat protein 0.00416023
HOPX HOP homeobox 0.00415886
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.00415059
STAT1 signal transducer and activator of transcription 1, 91kDa 0.00413665
ELF4 E74-like factor 4 (ets domain transcription factor) 0.00413542
APOD apolipoprotein D 0.00412233
XPO7 exportin 7 0.00411009
SPHK1 sphingosine kinase 1 0.00409245
ZC3H12A zinc finger CCCH-type containing 12A 0.00409097
STX1A syntaxin 1A (brain) 0.00408825
RBMS1 RNA binding motif, single stranded interacting protein 1 0.00408527
CSRP1 cysteine and glycine-rich protein 1 0.0040841
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 0.00407849
CDA cytidine deaminase 0.00407761
TRIB1 tribbles pseudokinase 1 0.00405907
PHACTR2 phosphatase and actin regulator 2 0.00405268
AGR2 anterior gradient 2 0.00404425
PLIN1 perilipin 1 0.00404367
NCALD neurocalcin delta 0.00403062
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 0.0040263
MYO1E myosin IE 0.00401212
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.00399955
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) 0.00399801
SLC38A1 solute carrier family 38, member 1 0.0039931
STX7 syntaxin 7 0.00396983
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0039656
FHL2 four and a half LIM domains 2 0.00396485
IGF2R insulin-like growth factor 2 receptor 0.00395824
MFAP3L microfibrillar-associated protein 3-like 0.00395412
FYB1 FYN binding protein 1 0.00394323
KRT81 keratin 81, type II 0.00394157
BBX bobby sox homolog (Drosophila) 0.00393931
BAG3 BCL2-associated athanogene 3 0.00392587
TOX3 TOX high mobility group box family member 3 0.003924
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.00391076
CAPG capping protein (actin filament), gelsolin-like 0.00390308
CLDN1 claudin 1 0.00389663
MTCL1 microtubule crosslinking factor 1 0.00389137
CRISP3 cysteine-rich secretory protein 3 0.00387637
CLDN4 claudin 4 0.0038722
NT5DC2 5'-nucleotidase domain containing 2 0.00387031
AOX1 aldehyde oxidase 1 0.00387012
HLA-E major histocompatibility complex, class I, E 0.00385837
GREM1 gremlin 1, DAN family BMP antagonist 0.00385772
TACSTD2 tumor-associated calcium signal transducer 2 0.00385466
TFF2 trefoil factor 2 0.00384047
PLAU plasminogen activator, urokinase 0.00382709
CXCL2 chemokine (C-X-C motif) ligand 2 0.00382186
FHL1 four and a half LIM domains 1 0.0038196
WWC2 WW and C2 domain containing 2 0.00381265
DUSP14 dual specificity phosphatase 14 0.00380653
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 0.00380067
PALLD palladin, cytoskeletal associated protein 0.00379917
MAGEA4 melanoma antigen family A4 0.0037945
ACSL1 acyl-CoA synthetase long-chain family member 1 0.00377089
GCH1 GTP cyclohydrolase 1 0.00376181
OPTN optineurin 0.00375916
DIPK1A divergent protein kinase domain 1A 0.00375885
ADRB2 adrenoceptor beta 2, surface 0.0037574
SLC46A3 solute carrier family 46, member 3 0.00375548
AIM2 absent in melanoma 2 0.00374358
TULP4 tubby like protein 4 0.00373621
ISG20 interferon stimulated exonuclease gene 20kDa 0.00373601
TNIP1 TNFAIP3 interacting protein 1 0.00371436
MYO6 myosin VI 0.00370154
RHOB ras homolog family member B 0.00369941
CCR7 chemokine (C-C motif) receptor 7 0.00369119
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 0.00368624
GMDS GDP-mannose 4,6-dehydratase 0.00368591
PRF1 perforin 1 (pore forming protein) 0.00368532
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.00368129
NUAK1 NUAK family, SNF1-like kinase, 1 0.00366798
COL9A2 collagen, type IX, alpha 2 0.00366739
NOX4 NADPH oxidase 4 0.00365591
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.00365523
COMMD3 COMM domain containing 3 0.00365382
BCL3 B-cell CLL/lymphoma 3 0.00363134
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.00363128
ASPN asporin 0.0036179
BLNK B-cell linker 0.00361175
NSFL1C NSFL1 (p97) cofactor (p47) 0.00360938
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 0.0036061
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 0.00360542
MBL2 mannose-binding lectin (protein C) 2, soluble 0.00359859
INAVA innate immunity activator 0.00359711
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.00358973
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 0.00358957
LIPG lipase, endothelial 0.00358239
DRAM1 DNA-damage regulated autophagy modulator 1 0.00357646
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.00356688
RFTN1 raftlin, lipid raft linker 1 0.00356379
STK38L serine/threonine kinase 38 like 0.003562
CES3 carboxylesterase 3 0.00356105
ENC1 ectodermal-neural cortex 1 (with BTB domain) 0.00355966

decreased expression

Symbol Name Standardized Value
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.0141941
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.0117434
SST somatostatin -0.00856302
SIRT3 sirtuin 3 -0.00849122
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.00730402
RNF167 ring finger protein 167 -0.00721096
SPINK1 serine peptidase inhibitor, Kazal type 1 -0.00677666
SPON1 spondin 1, extracellular matrix protein -0.00669685
MDK midkine (neurite growth-promoting factor 2) -0.00662663
MUC16 mucin 16, cell surface associated -0.00660634
TSPAN7 tetraspanin 7 -0.00642773
CCNF cyclin F -0.00638843
PLAT plasminogen activator, tissue -0.00627862
FGG fibrinogen gamma chain -0.00624744
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.00623269
SSBP2 single-stranded DNA binding protein 2 -0.00606942
NBL1 neuroblastoma 1, DAN family BMP antagonist -0.00601095
DLK1 delta-like 1 homolog (Drosophila) -0.0059539
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0058446
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.00580783
FRZB frizzled-related protein -0.00580371
LMO2 LIM domain only 2 (rhombotin-like 1) -0.00580158
NID1 nidogen 1 -0.00576499
PITX3 paired-like homeodomain 3 -0.00576114
LYPD1 LY6/PLAUR domain containing 1 -0.00566339
HMGB3 high mobility group box 3 -0.00558192
CHKB choline kinase beta -0.00557666
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 -0.00556574
PENK proenkephalin -0.00555427
ANPEP alanyl (membrane) aminopeptidase -0.00549836
FKBP5 FK506 binding protein 5 -0.00544058
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) -0.00534246
MSLN mesothelin -0.00534202
CFI complement factor I -0.00530997
LRRC17 leucine rich repeat containing 17 -0.0053046
MEIS2 Meis homeobox 2 -0.00525457
TNNT1 troponin T type 1 (skeletal, slow) -0.00525164
PEG10 paternally expressed 10 -0.00524127
RAMP1 receptor (G protein-coupled) activity modifying protein 1 -0.0052312
ADIRF adipogenesis regulatory factor -0.00520666
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 -0.00517383
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -0.00516529
SFTPC surfactant protein C -0.00507668
FXYD1 FXYD domain containing ion transport regulator 1 -0.00506535
CLCA1 chloride channel accessory 1 -0.00505411
WFDC2 WAP four-disulfide core domain 2 -0.00504833
MUC4 mucin 4, cell surface associated -0.00504692
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.00504111
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -0.00501283
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 -0.00492648
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.00490651
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 -0.00490325
NES nestin -0.00489172
METRN meteorin, glial cell differentiation regulator -0.00487706
WT1 Wilms tumor 1 -0.00487682
CHODL chondrolectin -0.00486744
ARID4A AT rich interactive domain 4A (RBP1-like) -0.00482968
IGFBP5 insulin-like growth factor binding protein 5 -0.00482764
CRABP2 cellular retinoic acid binding protein 2 -0.00481822
MYO5C myosin VC -0.00481516
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -0.00481243
REG3A regenerating islet-derived 3 alpha -0.00476726
REG1B regenerating islet-derived 1 beta -0.00475938
NPTX2 neuronal pentraxin II -0.00475818
PAEP progestagen-associated endometrial protein -0.00469798
AP2A2 adaptor-related protein complex 2, alpha 2 subunit -0.00468302
SEPP1 selenoprotein P, plasma, 1 -0.00467527
KANK2 KN motif and ankyrin repeat domains 2 -0.00465845
IFITM1 interferon induced transmembrane protein 1 -0.00463959
FASN fatty acid synthase -0.00461045
REG1A regenerating islet-derived 1 alpha -0.00460442
RTN2 reticulon 2 -0.00457651
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.00456237
DMBT1 deleted in malignant brain tumors 1 -0.00451102
VBP1 von Hippel-Lindau binding protein 1 -0.00450617
NDN necdin, melanoma antigen (MAGE) family member -0.00448022
CDC20 cell division cycle 20 -0.00445897
COL6A2 collagen, type VI, alpha 2 -0.0044338
MRPL12 mitochondrial ribosomal protein L12 -0.00442498
VWA1 von Willebrand factor A domain containing 1 -0.00441842
CYBRD1 cytochrome b reductase 1 -0.00441045
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -0.00440325
PCP4 Purkinje cell protein 4 -0.00438184
RBBP8 retinoblastoma binding protein 8 -0.0043654
SPAG16 sperm associated antigen 16 -0.00436508
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -0.00435909
CTSG cathepsin G -0.00435585
ESD esterase D -0.00433974
DNASE1L3 deoxyribonuclease I-like 3 -0.00433819
NMU neuromedin U -0.00432766
NPY neuropeptide Y -0.00431065
PDGFD platelet derived growth factor D -0.00430082
MED28 mediator complex subunit 28 -0.00429975
GARS1 glycyl-tRNA synthetase 1 -0.00429897
SLIT2 slit homolog 2 (Drosophila) -0.00420283
GREB1 growth regulation by estrogen in breast cancer 1 -0.00419292
METTL7A methyltransferase like 7A -0.00418944
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.00418756
SLBP stem-loop binding protein -0.00417234
GANAB glucosidase, alpha; neutral AB -0.00417095
CD81 CD81 molecule -0.00416852
WBP5 WW domain binding protein 5 -0.00416212
RAI2 retinoic acid induced 2 -0.00415893
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 -0.00415646
FABP1 fatty acid binding protein 1, liver -0.00414801
CP ceruloplasmin (ferroxidase) -0.00414138
PTP4A3 protein tyrosine phosphatase type IVA, member 3 -0.0041396
CCL20 chemokine (C-C motif) ligand 20 -0.00413714
IFITM2 interferon induced transmembrane protein 2 -0.00413511
UGDH UDP-glucose 6-dehydrogenase -0.00412588
CCNB2 cyclin B2 -0.00412458
STAB1 stabilin 1 -0.00410723
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.00409521
SMAD6 SMAD family member 6 -0.00408504
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -0.00408334
EPHB2 EPH receptor B2 -0.00406395
CBS cystathionine-beta-synthase -0.00406346
DACH1 dachshund family transcription factor 1 -0.00404546
AURKA aurora kinase A -0.00404039
DEFA5 defensin, alpha 5, Paneth cell-specific -0.00403616
TMOD1 tropomodulin 1 -0.00403612
PLK1 polo-like kinase 1 -0.00403334
FGB fibrinogen beta chain -0.00402847
OIP5 Opa interacting protein 5 -0.00402658
LDB2 LIM domain binding 2 -0.0040208
DMAC2L distal membrane arm assembly component 2 like -0.00400435
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa -0.00399749
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -0.00398954
DHCR24 24-dehydrocholesterol reductase -0.0039858
CNN3 calponin 3, acidic -0.00397205
C4BPA complement component 4 binding protein, alpha -0.00396015
DEFB1 defensin, beta 1 -0.00395467
GET1 guided entry of tail-anchored proteins factor 1 -0.00394437
OLFML3 olfactomedin-like 3 -0.00392169
GRAMD1C GRAM domain containing 1C -0.00391185
KLK8 kallikrein-related peptidase 8 -0.00391006
GUCY1B3 guanylate cyclase 1, soluble, beta 3 -0.00390295
MECOM MDS1 and EVI1 complex locus -0.00390104
AHCY adenosylhomocysteinase -0.00389926
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.00389179
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -0.00388181
OLFM1 olfactomedin 1 -0.00387808
SCNN1A sodium channel, non voltage gated 1 alpha subunit -0.00385378
SCG5 secretogranin V -0.00385374
CLEC11A C-type lectin domain family 11, member A -0.00384203
EMX2 empty spiracles homeobox 2 -0.00382838
UBE2S ubiquitin-conjugating enzyme E2S -0.00381437
LMNB1 lamin B1 -0.00381387
DPYD dihydropyrimidine dehydrogenase -0.00380698
BCAT2 branched chain amino-acid transaminase 2, mitochondrial -0.00380424
EVA1B eva-1 homolog B (C. elegans) -0.00379792
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase -0.00376656
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.00376083
RGS5 regulator of G-protein signaling 5 -0.00376055
NCAM1 neural cell adhesion molecule 1 -0.00375348
HP haptoglobin -0.00374708
ATP5ME ATP synthase membrane subunit e -0.00374351
DEPDC1B DEP domain containing 1B -0.00372285
HDAC2 histone deacetylase 2 -0.00372232
PITX2 paired-like homeodomain 2 -0.00371183
CETN2 centrin, EF-hand protein, 2 -0.00370053
PDE2A phosphodiesterase 2A, cGMP-stimulated -0.0036954
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit -0.00368828
DEFA6 defensin, alpha 6, Paneth cell-specific -0.00368607
TSPAN12 tetraspanin 12 -0.00368115
FZD6 frizzled class receptor 6 -0.00368107
GLUL glutamate-ammonia ligase -0.00367684
ZBTB16 zinc finger and BTB domain containing 16 -0.00367408
SLC2A4RG SLC2A4 regulator -0.00367142
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) -0.00366761
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 -0.00365166
NUP160 nucleoporin 160kDa -0.00364616
YPEL1 yippee-like 1 (Drosophila) -0.00363998
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -0.00362972
TUBGCP3 tubulin, gamma complex associated protein 3 -0.00362503
CTR9 CTR9, Paf1/RNA polymerase II complex component -0.0036226
RGS4 regulator of G-protein signaling 4 -0.00362244
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -0.00361916
EFNB2 ephrin-B2 -0.00361677
DCK deoxycytidine kinase -0.00361308
SYBU syntabulin (syntaxin-interacting) -0.00360303
TXNDC9 thioredoxin domain containing 9 -0.00359121
APOB apolipoprotein B -0.00359043
U2AF1 U2 small nuclear RNA auxiliary factor 1 -0.00357444
QPRT quinolinate phosphoribosyltransferase -0.00356593
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) -0.00356323
GSTM3 glutathione S-transferase mu 3 (brain) -0.0035536
FGFR3 fibroblast growth factor receptor 3 -0.0035498
PID1 phosphotyrosine interaction domain containing 1 -0.00354614
USP1 ubiquitin specific peptidase 1 -0.00354499
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.00353621
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.00353091
CHN1 chimerin 1 -0.00353036
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) -0.00352654
MXRA7 matrix-remodelling associated 7 -0.00352267
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.00351412
C14ORF132 chromosome 14 open reading frame 132 -0.00351106
NFIC nuclear factor I/C (CCAAT-binding transcription factor) -0.00350304
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G -0.00350293
METTL5 methyltransferase like 5 -0.00350166
CLIC5 chloride intracellular channel 5 -0.00347893
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -0.00347392
EXOSC8 exosome component 8 -0.00346511
LEPR leptin receptor -0.00346441
RUVBL1 RuvB-like AAA ATPase 1 -0.00346184
CCDC47 coiled-coil domain containing 47 -0.00345482
NCK1 NCK adaptor protein 1 -0.00345151
MSX1 msh homeobox 1 -0.00345103
MBOAT7 membrane bound O-acyltransferase domain containing 7 -0.00345083
GLOD4 glyoxalase domain containing 4 -0.00343216
DBP D site of albumin promoter (albumin D-box) binding protein -0.00342787
PDIA3 protein disulfide isomerase family A, member 3 -0.0034273
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -0.00342425
TBX2 T-box 2 -0.00341901
TMEM97 transmembrane protein 97 -0.00341542
IFITM3 interferon induced transmembrane protein 3 -0.00341454
CFB complement factor B -0.0034114
HIRA histone cell cycle regulator -0.00340534
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -0.00339747
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta -0.00339602
GPC3 glypican 3 -0.0033907
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.00338955
ALOX5 arachidonate 5-lipoxygenase -0.00338938
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) -0.00338387
LIG1 ligase I, DNA, ATP-dependent -0.00338221
COCH cochlin -0.00337846
GPM6A glycoprotein M6A -0.00337553
SPON2 spondin 2, extracellular matrix protein -0.00337335
PCOLCE procollagen C-endopeptidase enhancer -0.00336867
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.00336104
CDKN3 cyclin-dependent kinase inhibitor 3 -0.00335758
EMC9 ER membrane protein complex subunit 9 -0.00334269
RAD51C RAD51 paralog C -0.00334102
LPAR6 lysophosphatidic acid receptor 6 -0.00333915
ZNF22 zinc finger protein 22 -0.00333898
ISYNA1 inositol-3-phosphate synthase 1 -0.00333765
SPC25 SPC25, NDC80 kinetochore complex component -0.00333747
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 -0.00333168
NCAPD3 non-SMC condensin II complex, subunit D3 -0.00332968
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.00332718
BST2 bone marrow stromal cell antigen 2 -0.00332264
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H') -0.00332071
CALML4 calmodulin-like 4 -0.00331477
SPOP speckle-type POZ protein -0.00331452
RPS5 ribosomal protein S5 -0.00331169
ASRGL1 asparaginase like 1 -0.00330914
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -0.00330772
LBR lamin B receptor -0.00329997
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.00329853