CCNB1 Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description cyclin B1|The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 891)
External Link https://ncbi.nlm.nih.gov/gene/891
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Genes

498 genes differentially expressed following the CCNB1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0131206
LTF lactotransferrin 0.0125489
AZGP1 alpha-2-glycoprotein 1, zinc-binding 0.0116639
LCN2 lipocalin 2 0.0111465
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0102228
S100A8 S100 calcium binding protein A8 0.0101506
S100A9 S100 calcium binding protein A9 0.00955419
MGLL monoglyceride lipase 0.00920167
SFRP1 secreted frizzled-related protein 1 0.0091788
CRISP3 cysteine-rich secretory protein 3 0.00917375
PDZK1IP1 PDZK1 interacting protein 1 0.00909748
NT5E 5'-nucleotidase, ecto (CD73) 0.00886559
CA12 carbonic anhydrase XII 0.00883402
TACSTD2 tumor-associated calcium signal transducer 2 0.00859541
PDGFC platelet derived growth factor C 0.00857405
IPO13 importin 13 0.0082705
G0S2 G0/G1 switch 2 0.00824206
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.00817198
FLRT3 fibronectin leucine rich transmembrane protein 3 0.00811712
MT1G metallothionein 1G 0.00810066
COCH cochlin 0.00804385
CCL20 chemokine (C-C motif) ligand 20 0.00801706
CCN2 cellular communication network factor 2 0.00783068
SMS spermine synthase 0.00776216
MT1HL1 metallothionein 1H-like 1 0.00762632
PLBD1 phospholipase B domain containing 1 0.00761524
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.00741234
TGFA transforming growth factor, alpha 0.00728075
CD9 CD9 molecule 0.00727941
TM4SF1 transmembrane 4 L six family member 1 0.0072534
KRT15 keratin 15, type I 0.00724334
PHLDA2 pleckstrin homology-like domain, family A, member 2 0.00720954
HIST1H2BD histone cluster 1, H2bd 0.00713073
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.00700624
PEG10 paternally expressed 10 0.00700354
ANPEP alanyl (membrane) aminopeptidase 0.00698187
AHNAK2 AHNAK nucleoprotein 2 0.00689906
IL1B interleukin 1, beta 0.0067504
INAVA innate immunity activator 0.00666973
S100A11 S100 calcium binding protein A11 0.00660255
CPM carboxypeptidase M 0.00656606
QPRT quinolinate phosphoribosyltransferase 0.00656309
LPIN1 lipin 1 0.00648892
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 0.00647015
NPC2 Niemann-Pick disease, type C2 0.00635469
PYCARD PYD and CARD domain containing 0.00634353
HSPB1 heat shock 27kDa protein 1 0.00633697
PIEZO1 piezo-type mechanosensitive ion channel component 1 0.00631139
TPSAB1 tryptase alpha/beta 1 0.00629902
MT1X metallothionein 1X 0.00629842
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.00625772
BTG2 BTG family, member 2 0.00624954
MAGEA3 melanoma antigen family A3 0.00624457
PYGB phosphorylase, glycogen; brain 0.00621505
MMP7 matrix metallopeptidase 7 0.00617366
ECM1 extracellular matrix protein 1 0.00615532
UFM1 ubiquitin-fold modifier 1 0.00609826
MT1H metallothionein 1H 0.00609601
MVP major vault protein 0.00607932
TMEM45A transmembrane protein 45A 0.00605351
DEFB1 defensin, beta 1 0.00602709
ZNF185 zinc finger protein 185 (LIM domain) 0.00598507
KLK3 kallikrein-related peptidase 3 0.00597859
KLK2 kallikrein-related peptidase 2 0.00594028
RFTN1 raftlin, lipid raft linker 1 0.00593785
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.00592482
KRT7 keratin 7, type II 0.00591506
TRIB2 tribbles pseudokinase 2 0.00591414
ACSL1 acyl-CoA synthetase long-chain family member 1 0.00590764
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.00590499
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 0.00589859
PLAAT3 phospholipase A and acyltransferase 3 0.00587482
RND3 Rho family GTPase 3 0.00584238
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 0.00582258
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.00579407
CHPT1 choline phosphotransferase 1 0.00578192
ZFP36L1 ZFP36 ring finger protein-like 1 0.00577852
LAMP1 lysosomal-associated membrane protein 1 0.00575085
MT1E metallothionein 1E 0.00572512
DRAM1 DNA-damage regulated autophagy modulator 1 0.00568778
SOX9 SRY (sex determining region Y)-box 9 0.00566296
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 0.00564957
BCL2L1 BCL2-like 1 0.00563899
GSTP1 glutathione S-transferase pi 1 0.00561087
SEC62 SEC62 homolog (S. cerevisiae) 0.005579
IGLL1 immunoglobulin lambda-like polypeptide 1 0.00557496
APOD apolipoprotein D 0.00556296
CRYAB crystallin, alpha B 0.00555396
LYPD1 LY6/PLAUR domain containing 1 0.00553865
HIST1H2BK histone cluster 1, H2bk 0.00550487
PSAP prosaposin 0.00549524
S100A12 S100 calcium binding protein A12 0.00549291
KRT14 keratin 14, type I 0.00548644
SYNE3 spectrin repeat containing, nuclear envelope family member 3 0.00544964
NEU1 sialidase 1 (lysosomal sialidase) 0.00543577
BTG1 B-cell translocation gene 1, anti-proliferative 0.00542597
PITX3 paired-like homeodomain 3 0.0054229
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.0053778
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 0.00536753
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0053554
MDK midkine (neurite growth-promoting factor 2) 0.00534427
PPP1R3C protein phosphatase 1, regulatory subunit 3C 0.00532899
SLPI secretory leukocyte peptidase inhibitor 0.00532161
ADCY9 adenylate cyclase 9 0.00531099
POLR2D polymerase (RNA) II (DNA directed) polypeptide D 0.00528532
GSDME gasdermin E 0.00523928
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) 0.0052117
PRKCI protein kinase C, iota 0.00520341
HMOX1 heme oxygenase 1 0.00520096
MSMB microseminoprotein, beta- 0.00519174
RARRES3 retinoic acid receptor responder (tazarotene induced) 3 0.00518833
CTSD cathepsin D 0.00518457
OPN3 opsin 3 0.00515207
TSPO translocator protein (18kDa) 0.00514587
DLK1 delta-like 1 homolog (Drosophila) 0.00513299
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.00512678
IL7R interleukin 7 receptor 0.0051255
KLK11 kallikrein-related peptidase 11 0.00512342
NUPR1 nuclear protein, transcriptional regulator, 1 0.00512268
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.00511969
PTK2B protein tyrosine kinase 2 beta 0.00509967
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.00507265
GATA2 GATA binding protein 2 0.00506544
TBX3 T-box 3 0.00506328
GPX1 glutathione peroxidase 1 0.00505787
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 0.00505499
PMEPA1 prostate transmembrane protein, androgen induced 1 0.00503811
WWTR1 WW domain containing transcription regulator 1 0.0050369
VNN1 vanin 1 0.00502057
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 0.00502018
MET MET proto-oncogene, receptor tyrosine kinase 0.00501987
EIF5B eukaryotic translation initiation factor 5B 0.00500962
DPP4 dipeptidyl-peptidase 4 0.00500643
PRSS8 protease, serine, 8 0.00500637
ELOVL1 ELOVL fatty acid elongase 1 0.00500468
PPP1R7 protein phosphatase 1, regulatory subunit 7 0.00499887
NPY neuropeptide Y 0.00499711
RAP2B RAP2B, member of RAS oncogene family 0.00499647
ASS1 argininosuccinate synthase 1 0.0049958
CD37 CD37 molecule 0.00498661
HDLBP high density lipoprotein binding protein 0.00498302
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.00497342
EMP3 epithelial membrane protein 3 0.00496983
MYO5A myosin VA (heavy chain 12, myoxin) 0.0049679
FN1 fibronectin 1 0.00496756
MMP9 matrix metallopeptidase 9 0.00490715
ALOX15B arachidonate 15-lipoxygenase, type B 0.00490574
SIRPA signal-regulatory protein alpha 0.00490156
UXS1 UDP-glucuronate decarboxylase 1 0.00489852
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.00488563
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.00488538
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.00486319
SCPEP1 serine carboxypeptidase 1 0.00486234
STK38 serine/threonine kinase 38 0.00485178
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 0.00484054
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.00483808
CD19 CD19 molecule 0.00481049
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 0.00480219
ALOX5 arachidonate 5-lipoxygenase 0.00480111
MLPH melanophilin 0.00478984
NAV3 neuron navigator 3 0.00478949
TUBB6 tubulin, beta 6 class V 0.00478933
ACSL3 acyl-CoA synthetase long-chain family member 3 0.00478183
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.0047809
STK26 serine/threonine protein kinase 26 0.00476805
ACP3 acid phosphatase 3 0.00476639
JUP junction plakoglobin 0.00476234
LEF1 lymphoid enhancer-binding factor 1 0.00473747
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 0.00471924
TP53I3 tumor protein p53 inducible protein 3 0.00470482
VPREB1 pre-B lymphocyte 1 0.00470302
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.00469748
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 0.0046965
MYO6 myosin VI 0.004695
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 0.00466198
MRC2 mannose receptor, C type 2 0.00463389
NSDHL NAD(P) dependent steroid dehydrogenase-like 0.00462158
IGF2R insulin-like growth factor 2 receptor 0.00460575
NPC1 Niemann-Pick disease, type C1 0.00459803
CFB complement factor B 0.00459534
PDLIM4 PDZ and LIM domain 4 0.00458828
CCNB2 cyclin B2 0.00458394
STK24 serine/threonine kinase 24 0.00457873
MT2A metallothionein 2A 0.00457202
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 0.00456736
CSRP1 cysteine and glycine-rich protein 1 0.00456282
LIMS1 LIM and senescent cell antigen-like domains 1 0.00456103
SIRT7 sirtuin 7 0.00455854
ELF5 E74-like factor 5 (ets domain transcription factor) 0.00455835
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.0045522
MARK4 MAP/microtubule affinity-regulating kinase 4 0.00455209
CEMIP2 cell migration inducing hyaluronidase 2 0.00454916
FSCN1 fascin actin-bundling protein 1 0.00454195
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 0.00454079
TMBIM1 transmembrane BAX inhibitor motif containing 1 0.00453459
SMAD3 SMAD family member 3 0.00452919
HSPB8 heat shock 22kDa protein 8 0.00452627
HOXB2 homeobox B2 0.00452584
MZB1 marginal zone B and B1 cell-specific protein 0.00452287
MT1F metallothionein 1F 0.00451997
FHL2 four and a half LIM domains 2 0.0044967
BLVRB biliverdin reductase B 0.00449442
COL9A2 collagen, type IX, alpha 2 0.00449112
WNT5B wingless-type MMTV integration site family, member 5B 0.00446238
MATN2 matrilin 2 0.0044607
KDM5D lysine (K)-specific demethylase 5D 0.00445232
TRPS1 trichorhinophalangeal syndrome I 0.00444751
EHD2 EH-domain containing 2 0.00444745
COTL1 coactosin-like F-actin binding protein 1 0.00444136
ADAM9 ADAM metallopeptidase domain 9 0.00442918
VGLL4 vestigial-like family member 4 0.00442246
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 0.00441912
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.00440989
PRDX1 peroxiredoxin 1 0.00440373
C9ORF16 chromosome 9 open reading frame 16 0.00439933
IFRD1 interferon-related developmental regulator 1 0.00437964
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 0.00437961
SPART spartin 0.00437755
KANK1 KN motif and ankyrin repeat domains 1 0.00437012
SSBP2 single-stranded DNA binding protein 2 0.00436442
VPREB3 pre-B lymphocyte 3 0.00435887
TUBA4A tubulin, alpha 4a 0.00435436
CD44 CD44 molecule (Indian blood group) 0.00435096
MAOB monoamine oxidase B 0.00434191
PERP PERP, TP53 apoptosis effector 0.00434117
ITGB4 integrin, beta 4 0.00433581
ZMYND8 zinc finger, MYND-type containing 8 0.00432858
NCF1C neutrophil cytosolic factor 1C pseudogene 0.00432122
CRYBG1 crystallin beta-gamma domain containing 1 0.00432118
ARHGAP6 Rho GTPase activating protein 6 0.00430676
VEGFC vascular endothelial growth factor C 0.0043032
WBP2 WW domain binding protein 2 0.00429364
SCAND1 SCAN domain containing 1 0.00429228
MINK1 misshapen-like kinase 1 0.00428234
KRT23 keratin 23, type I 0.00428021
SSR4 signal sequence receptor, delta 0.00427542
MFSD12 major facilitator superfamily domain containing 12 0.0042565
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.00424696
OSBPL3 oxysterol binding protein-like 3 0.00424047
GEM GTP binding protein overexpressed in skeletal muscle 0.00423746
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 0.00423637
VLDLR very low density lipoprotein receptor 0.00423436
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.00423018
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.00422305
RNF111 ring finger protein 111 0.00421872
PLA1A phospholipase A1 member A 0.0042067
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 0.0042025
TIMP1 TIMP metallopeptidase inhibitor 1 0.00419797

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -0.0275597
XIC X chromosome inactivation center -0.0113228
ASPN asporin -0.00895181
GRIA2 glutamate receptor, ionotropic, AMPA 2 -0.00871781
DHFR dihydrofolate reductase -0.00845389
NRN1 neuritin 1 -0.0082883
PTTG1 pituitary tumor-transforming 1 -0.00722728
CDKN3 cyclin-dependent kinase inhibitor 3 -0.00708715
SRSF1 serine/arginine-rich splicing factor 1 -0.00706606
GOLGA8A golgin A8 family, member A -0.00698212
PRIM1 primase, DNA, polypeptide 1 (49kDa) -0.00689752
GPM6A glycoprotein M6A -0.00687398
CCNA2 cyclin A2 -0.00682457
MAP7 microtubule-associated protein 7 -0.00681049
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A -0.0067928
TMPO thymopoietin -0.0067925
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) -0.00678956
PBK PDZ binding kinase -0.0067479
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) -0.00674284
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.0067294
GINS1 GINS complex subunit 1 (Psf1 homolog) -0.00669723
MRPS27 mitochondrial ribosomal protein S27 -0.00668735
TMSB15A thymosin beta 15a -0.00667
GUSBP3 glucuronidase, beta pseudogene 3 -0.00665953
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.00664877
SRSF6 serine/arginine-rich splicing factor 6 -0.00653272
LMNB1 lamin B1 -0.00651028
STMN2 stathmin 2 -0.00643718
DUT deoxyuridine triphosphatase -0.00641161
SNAP25 synaptosomal-associated protein, 25kDa -0.00633937
SCAMP1 secretory carrier membrane protein 1 -0.00620335
CA2 carbonic anhydrase II -0.00619188
SLC30A5 solute carrier family 30 (zinc transporter), member 5 -0.00612174
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -0.00600602
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -0.00600528
PURA purine-rich element binding protein A -0.00594781
RUFY3 RUN and FYVE domain containing 3 -0.00591122
GNAS GNAS complex locus -0.00588266
PTPRD protein tyrosine phosphatase, receptor type, D -0.00585654
COMMD10 COMM domain containing 10 -0.00585597
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 -0.00585281
FAM172A family with sequence similarity 172, member A -0.0058316
OLFM1 olfactomedin 1 -0.0058226
RFC4 replication factor C (activator 1) 4, 37kDa -0.00580371
PDLIM3 PDZ and LIM domain 3 -0.00577937
ACKR3 atypical chemokine receptor 3 -0.00577186
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa -0.00576551
CDC45 cell division cycle 45 -0.00565773
NUSAP1 nucleolar and spindle associated protein 1 -0.00565194
CPVL carboxypeptidase, vitellogenic-like -0.00563944
ANOS1 anosmin 1 -0.0056257
SLC26A2 solute carrier family 26 (anion exchanger), member 2 -0.00562523
REEP1 receptor accessory protein 1 -0.00561903
WDR41 WD repeat domain 41 -0.0055665
NCAM1 neural cell adhesion molecule 1 -0.00553896
MAP2K6 mitogen-activated protein kinase kinase 6 -0.00553295
FMO3 flavin containing monooxygenase 3 -0.00553182
HOMER1 homer scaffolding protein 1 -0.00552952
COL10A1 collagen, type X, alpha 1 -0.00550682
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.00543078
PBX1 pre-B-cell leukemia homeobox 1 -0.00543017
CHGB chromogranin B -0.00542182
COL3A1 collagen, type III, alpha 1 -0.00540629
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) -0.00539839
OIP5 Opa interacting protein 5 -0.00537563
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit -0.00533111
BTF3 basic transcription factor 3 -0.00530609
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) -0.00528747
C1QTNF3 C1q and tumor necrosis factor related protein 3 -0.00527968
MPPED2 metallophosphoesterase domain containing 2 -0.00526051
CASP2 caspase 2, apoptosis-related cysteine peptidase -0.00525208
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.00524112
NUP107 nucleoporin 107kDa -0.00523836
APOLD1 apolipoprotein L domain containing 1 -0.005228
MSX1 msh homeobox 1 -0.00521859
TRIP13 thyroid hormone receptor interactor 13 -0.00518633
AGGF1 angiogenic factor with G patch and FHA domains 1 -0.00517816
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) -0.00516397
CDCA4 cell division cycle associated 4 -0.00515874
THAP12 THAP domain containing 12 -0.00515366
MCM6 minichromosome maintenance complex component 6 -0.00515297
PPA2 pyrophosphatase (inorganic) 2 -0.00514622
HNRNPL heterogeneous nuclear ribonucleoprotein L -0.00513894
ZFPM2 zinc finger protein, FOG family member 2 -0.00513602
SOX11 SRY (sex determining region Y)-box 11 -0.00512054
CPS1 carbamoyl-phosphate synthase 1, mitochondrial -0.00511328
IFNGR1 interferon gamma receptor 1 -0.00510741
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 -0.00510157
TSPAN6 tetraspanin 6 -0.00509064
ELN elastin -0.00507997
HMMR hyaluronan-mediated motility receptor (RHAMM) -0.00507879
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide -0.00504004
RPA3 replication protein A3, 14kDa -0.00503914
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) -0.00498207
TRMT5 tRNA methyltransferase 5 -0.00498077
ACD adrenocortical dysplasia homolog (mouse) -0.00497205
SRSF7 serine/arginine-rich splicing factor 7 -0.00496508
HACD3 3-hydroxyacyl-CoA dehydratase 3 -0.00496261
HMGB2 high mobility group box 2 -0.0049581
AKAP7 A kinase (PRKA) anchor protein 7 -0.00495703
ERBIN erbb2 interacting protein -0.00495041
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant -0.00493856
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 -0.00492362
CCNE2 cyclin E2 -0.00492115
TMEM70 transmembrane protein 70 -0.0049174
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) -0.00491605
HSPA14 heat shock 70kDa protein 14 -0.00490708
LUM lumican -0.00489998
MTREX Mtr4 exosome RNA helicase -0.00488743
SPARCL1 SPARC-like 1 (hevin) -0.00488572
BMP7 bone morphogenetic protein 7 -0.00488267
NAP1L3 nucleosome assembly protein 1-like 3 -0.00486947
RCN2 reticulocalbin 2, EF-hand calcium binding domain -0.00486174
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1 -0.00484719
ABHD6 abhydrolase domain containing 6 -0.00483706
KIF20A kinesin family member 20A -0.00483359
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 -0.00480603
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa -0.00479392
CD36 CD36 molecule (thrombospondin receptor) -0.00479345
AREG amphiregulin -0.00478067
C2CD5 C2 calcium-dependent domain containing 5 -0.00477488
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.00476599
GINS2 GINS complex subunit 2 (Psf2 homolog) -0.00476555
HPF1 histone PARylation factor 1 -0.00474985
SMC2 structural maintenance of chromosomes 2 -0.00474546
CHN2 chimerin 2 -0.0047445
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 -0.00473116
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -0.00472336
BTBD3 BTB (POZ) domain containing 3 -0.00470673
INA internexin neuronal intermediate filament protein, alpha -0.00469628
RAD17 RAD17 homolog (S. pombe) -0.00469599
EIF5A eukaryotic translation initiation factor 5A -0.0046714
SH3GL3 SH3-domain GRB2-like 3 -0.00467104
TBCA tubulin folding cofactor A -0.00467072
PCSK6 proprotein convertase subtilisin/kexin type 6 -0.00466827
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 -0.00465661
FBXO11 F-box protein 11 -0.00465372
RMI1 RecQ mediated genome instability 1 -0.00464041
F2RL1 coagulation factor II (thrombin) receptor-like 1 -0.00462193
PCSK1 proprotein convertase subtilisin/kexin type 1 -0.00461663
NQO2 NAD(P)H dehydrogenase, quinone 2 -0.00461393
FEN1 flap structure-specific endonuclease 1 -0.00460174
F3 coagulation factor III (thromboplastin, tissue factor) -0.00459925
ENO2 enolase 2 (gamma, neuronal) -0.0045987
MYT1L myelin transcription factor 1-like -0.00459859
H2AZ1 H2A.Z variant histone 1 -0.00459484
PRC1 protein regulator of cytokinesis 1 -0.00458454
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -0.00458353
SLC25A46 solute carrier family 25, member 46 -0.00458269
MDM1 Mdm1 nuclear protein homolog (mouse) -0.00454867
NUP37 nucleoporin 37kDa -0.00454606
CDC42 cell division cycle 42 -0.0045398
PARPBP PARP1 binding protein -0.00453811
CD302 CD302 molecule -0.00450709
TCF4 transcription factor 4 -0.00450421
COX7C cytochrome c oxidase subunit VIIc -0.00449465
FABP4 fatty acid binding protein 4, adipocyte -0.00449137
COPS4 COP9 signalosome subunit 4 -0.00448017
RGS1 regulator of G-protein signaling 1 -0.00447793
TOX thymocyte selection-associated high mobility group box -0.00447324
NAIP NLR family, apoptosis inhibitory protein -0.00447133
ZWINT ZW10 interacting kinetochore protein -0.00447066
ZSCAN31 zinc finger and SCAN domain containing 31 -0.0044703
FAM169A family with sequence similarity 169, member A -0.00447028
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 -0.00446736
SEPHS1 selenophosphate synthetase 1 -0.00446506
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 -0.00446487
FBXO5 F-box protein 5 -0.0044629
TRAPPC13 trafficking protein particle complex 13 -0.0044509
BEX1 brain expressed, X-linked 1 -0.00445086
MARCKS myristoylated alanine-rich protein kinase C substrate -0.004439
SEPP1 selenoprotein P, plasma, 1 -0.00442675
ERAP1 endoplasmic reticulum aminopeptidase 1 -0.00441041
TMEM14A transmembrane protein 14A -0.00440741
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase) -0.00440442
SH3GL2 SH3-domain GRB2-like 2 -0.00438756
PGAM1 phosphoglycerate mutase 1 (brain) -0.00437762
PPID peptidylprolyl isomerase D -0.00437672
TPD52 tumor protein D52 -0.00437372
CAMTA1 calmodulin binding transcription activator 1 -0.00435982
TSPAN7 tetraspanin 7 -0.00435813
USP1 ubiquitin specific peptidase 1 -0.00435543
TMEM50B transmembrane protein 50B -0.00435504
TSPAN13 tetraspanin 13 -0.0043517
SLC38A1 solute carrier family 38, member 1 -0.00433328
ATP5F1C ATP synthase F1 subunit gamma -0.00431553
CHEK2 checkpoint kinase 2 -0.00430704
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.00430063
NSL1 NSL1, MIS12 kinetochore complex component -0.00429524
CDC42SE1 CDC42 small effector 1 -0.00429139
ITM2A integral membrane protein 2A -0.00429081
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -0.00428928
MRPS28 mitochondrial ribosomal protein S28 -0.00427598
MCM3 minichromosome maintenance complex component 3 -0.00426842
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.00425695
PON3 paraoxonase 3 -0.00425674
FYB1 FYN binding protein 1 -0.00424553
DEK DEK proto-oncogene -0.00424515
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 -0.00423001
ANO1 anoctamin 1, calcium activated chloride channel -0.00422834
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene) -0.0042272
TBC1D30 TBC1 domain family, member 30 -0.0042251
FRZB frizzled-related protein -0.00422364
FXYD6 FXYD domain containing ion transport regulator 6 -0.00422257
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 -0.00422158
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 -0.00421848
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.00421816
TCEAL2 transcription elongation factor A (SII)-like 2 -0.00421767
MAT2B methionine adenosyltransferase II, beta -0.00420849
ZFYVE16 zinc finger, FYVE domain containing 16 -0.00419608
NTS neurotensin -0.00419472
F12 coagulation factor XII (Hageman factor) -0.00419354
ST18 suppression of tumorigenicity 18, zinc finger -0.0041888
KRT13 keratin 13, type I -0.00417561
NMU neuromedin U -0.00417369
GARS1 glycyl-tRNA synthetase 1 -0.00415243
TTK TTK protein kinase -0.00413276
SELL selectin L -0.00413068
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase -0.0041304
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) -0.0041259
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide -0.0041251
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.00412269
CEP43 centrosomal protein 43 -0.00410495
SUCLG1 succinate-CoA ligase, alpha subunit -0.00407986
CKS1B CDC28 protein kinase regulatory subunit 1B -0.00406917
DKFZP586I1420 uncharacterized protein DKFZp586I1420 -0.00406443
RUSC1 RUN and SH3 domain containing 1 -0.00405777
RTN1 reticulon 1 -0.00405586
PLP1 proteolipid protein 1 -0.00405573
CDK1 cyclin-dependent kinase 1 -0.0040468
ATG3 autophagy related 3 -0.00402916
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.00402872
DNM3 dynamin 3 -0.00401872
GAS1 growth arrest-specific 1 -0.00401514
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 -0.00401219
EXOSC9 exosome component 9 -0.00400679
KLF9 Kruppel-like factor 9 -0.00400671
KIF2A kinesin heavy chain member 2A -0.00400561
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.00399856
SET SET nuclear proto-oncogene -0.00399836
FGL2 fibrinogen-like 2 -0.00396959
RRM1 ribonucleotide reductase M1 -0.00396654
FKBP5 FK506 binding protein 5 -0.0039663
CDC23 cell division cycle 23 -0.00396033
CYB5R4 cytochrome b5 reductase 4 -0.00395961
MCM5 minichromosome maintenance complex component 5 -0.00395504
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial -0.00395355
SUB1 SUB1 homolog (S. cerevisiae) -0.00394785
PCLO piccolo presynaptic cytomatrix protein -0.00393865
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -0.00393835