CCND1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description cyclin D1|The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 595)
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Genes

331 genes differentially expressed following the CCND1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 2.56081
MBD3L3 methyl-CpG binding domain protein 3-like 3 2.56081
SLC15A5 solute carrier family 15, member 5 2.56081
DMRTC1B DMRT-like family C1B 2.56081
ASB12 ankyrin repeat and SOCS box containing 12 2.56081
DIRAS3 DIRAS family, GTP-binding RAS-like 3 2.56081
MFAP5 microfibrillar associated protein 5 2.56081
ADAD2 adenosine deaminase domain containing 2 2.56081
CORO1B coronin, actin binding protein, 1B 2.56081
OR52E8 olfactory receptor, family 52, subfamily E, member 8 2.56081
FBLN7 fibulin 7 2.56081
DSG3 desmoglein 3 2.56081
TMEM191B transmembrane protein 191B 2.56081
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 2.56081
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 2.56081
SCG2 secretogranin II 2.56081
GNLY granulysin 2.56081
HEATR9 HEAT repeat containing 9 2.56081
ZFP57 ZFP57 zinc finger protein 2.56081
BTLA B and T lymphocyte associated 2.56081
HGD homogentisate 1,2-dioxygenase 2.56081
SOX18 SRY (sex determining region Y)-box 18 2.56081
KRT23 keratin 23, type I 2.56081
RIMBP2 RIMS binding protein 2 2.56081
TRIM73 tripartite motif containing 73 2.56081
REN renin 2.56081
GMNC geminin coiled-coil domain containing 2.56081
HEPHL1 hephaestin-like 1 2.56081
SETSIP SET-like protein 2.56081
BRICD5 BRICHOS domain containing 5 2.56081
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.56081
LGALS9 lectin, galactoside-binding, soluble, 9 2.56081
GALR2 galanin receptor 2 2.56081
ETV2 ets variant 2 2.56081
CRYAA crystallin, alpha A 2.56081
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 2.56081
DPPA3 developmental pluripotency associated 3 2.56081
TTLL9 tubulin tyrosine ligase-like family member 9 2.56081
UMODL1 uromodulin-like 1 2.56081
UNC45B unc-45 homolog B (C. elegans) 2.56081
ANKRD34A ankyrin repeat domain 34A 2.56081
GCKR glucokinase (hexokinase 4) regulator 2.56081
HAS1 hyaluronan synthase 1 2.56081
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 2.56081
TDRD6 tudor domain containing 6 2.56081
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 2.56081
LCN15 lipocalin 15 2.56081
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.56081
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.56081
MYL4 myosin, light chain 4, alkali; atrial, embryonic 2.56081
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 2.56081
PNMA6F PNMA family member 6F 2.56081
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) 2.56081
GIPC3 GIPC PDZ domain containing family, member 3 2.56081
SRGN serglycin 2.56081
FOXN4 forkhead box N4 2.56081
TBC1D3L TBC1 domain family, member 3L 2.56081
OR1C1 olfactory receptor, family 1, subfamily C, member 1 2.56081
WNT16 wingless-type MMTV integration site family, member 16 2.56081
GPR37L1 G protein-coupled receptor 37 like 1 2.56081
CIMIP7 ciliary microtubule inner protein 7 2.56081
STARD6 StAR-related lipid transfer (START) domain containing 6 2.56081
HTD2 hydroxyacyl-thioester dehydratase type 2 2.56081
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 2.56081
PLAAT2 phospholipase A and acyltransferase 2 2.56081
NOTCH2NLB notch 2 N-terminal like B 2.56081
TMA7B translation machinery associated 7 homolog B 2.56081
SRARP steroid receptor associated and regulated protein 2.56081
EZHIP EZH inhibitory protein 2.56081
ACP4 acid phosphatase 4 2.56081
MAJIN membrane anchored junction protein 2.56081
DUSP29 dual specificity phosphatase 29 2.56081
CFAP157 cilia and flagella associated protein 157 2.56081
CCDC190 coiled-coil domain containing 190 2.56081
CRACDL CRACD like 2.56081
RGS22 regulator of G-protein signaling 22 2.56081
CDKN2A cyclin-dependent kinase inhibitor 2A 2.56081
TRIM60 tripartite motif containing 60 2.56081
TLE6 transducin-like enhancer of split 6 2.56081
TLE2 transducin-like enhancer of split 2 2.56081
CD300E CD300e molecule 2.56081
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 2.56081
ACR acrosin 2.56081
GJA5 gap junction protein, alpha 5, 40kDa 2.56081
IL4I1 interleukin 4 induced 1 2.56081
TXLNB taxilin beta 2.56081
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.56081
LCAT lecithin-cholesterol acyltransferase 2.56081
RAB11FIP4 RAB11 family interacting protein 4 (class II) 2.56081
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 2.56081
SPDYC speedy/RINGO cell cycle regulator family member C 2.56081
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.56081
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.56081
SLC45A2 solute carrier family 45, member 2 2.56081
RSPH14 radial spoke head 14 homolog (Chlamydomonas) 2.56081
GZMM granzyme M (lymphocyte met-ase 1) 2.56081
GDF10 growth differentiation factor 10 2.56081
SCYL1 SCY1-like 1 (S. cerevisiae) 2.56081
TMCO2 transmembrane and coiled-coil domains 2 2.56081
MEOX1 mesenchyme homeobox 1 2.56081
NR1H4 nuclear receptor subfamily 1, group H, member 4 2.56081
LOC105378220 macrophage receptor MARCO-like 2.56081
NPFFR1 neuropeptide FF receptor 1 2.56081
BRDT bromodomain, testis-specific 2.56081
CTSO cathepsin O 2.56081
EGR2 early growth response 2 2.56081
TMEM132D transmembrane protein 132D 2.56081
GFI1B growth factor independent 1B transcription repressor 2.56081
DYTN dystrotelin 2.56081
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 2.56081
CPO carboxypeptidase O 2.56081
MAGEB17 melanoma antigen family B17 2.56081
TG thyroglobulin 2.56081
TF transferrin 2.56081
PRSS54 protease, serine, 54 2.56081
PDCD1LG2 programmed cell death 1 ligand 2 2.56081
PRSS50 protease, serine, 50 2.56081
CRYBB3 crystallin, beta B3 2.56081
IHH indian hedgehog 2.56081
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 2.56081
CDK20 cyclin-dependent kinase 20 2.56081
TEX19 testis expressed 19 2.56081
EDN2 endothelin 2 2.56081
JSRP1 junctional sarcoplasmic reticulum protein 1 2.56081
SMIM23 small integral membrane protein 23 2.56081
SERINC4 serine incorporator 4 2.56081
HSPA1L heat shock 70kDa protein 1-like 2.56081
CYSLTR1 cysteinyl leukotriene receptor 1 2.56081
CTAGE1 cutaneous T-cell lymphoma-associated antigen 1 2.56081
CD244 CD244 molecule, natural killer cell receptor 2B4 2.56081
BTNL3 butyrophilin-like 3 2.56081
THTPA thiamine triphosphatase 2.56081
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.56081
TRIM55 tripartite motif containing 55 2.56081
DQX1 DEAQ box RNA-dependent ATPase 1 2.56081
EMP1 epithelial membrane protein 1 2.56081
EFCAB9 EF-hand calcium binding domain 9 2.56081
RUMY3 RUMY family member 3 2.56081
TEKT1 tektin 1 2.56081
CALHM2 calcium homeostasis modulator 2 2.56081
AKAP11 A kinase (PRKA) anchor protein 11 2.56081
TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 2.56081
RNF148 ring finger protein 148 2.56081
PTPN7 protein tyrosine phosphatase, non-receptor type 7 2.56081
A1CF APOBEC1 complementation factor 2.56081
TTC36 tetratricopeptide repeat domain 36 2.56081
SPNS3 spinster homolog 3 (Drosophila) 2.56081
KCTD4 potassium channel tetramerization domain containing 4 2.56081
OXER1 oxoeicosanoid (OXE) receptor 1 2.56081
GGN gametogenetin 2.56081
CLEC18A C-type lectin domain family 18, member A 2.56081
NLRP3 NLR family, pyrin domain containing 3 2.56081
GJC2 gap junction protein, gamma 2, 47kDa 2.56081
PSD2 pleckstrin and Sec7 domain containing 2 2.56081
TPH1 tryptophan hydroxylase 1 2.56081
BHLHA15 basic helix-loop-helix family, member a15 2.56081
SNAI2 snail family zinc finger 2 2.56081
TECTB tectorin beta 2.56081
UPK1B uroplakin 1B 2.56081
TM4SF19 transmembrane 4 L six family member 19 2.56081
LMX1A LIM homeobox transcription factor 1, alpha 2.56081
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 2.56081
GPR150 G protein-coupled receptor 150 2.56081
EIF3G eukaryotic translation initiation factor 3, subunit G 2.56081
TRPM8 transient receptor potential cation channel, subfamily M, member 8 2.56081
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 2.56081
SMCO1 single-pass membrane protein with coiled-coil domains 1 2.56081
PTGDR prostaglandin D2 receptor (DP) 2.56081
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 2.56081
ADCY4 adenylate cyclase 4 2.56081
MAPK11 mitogen-activated protein kinase 11 2.56081
ENDOU endonuclease, polyU-specific 2.56081
APRT adenine phosphoribosyltransferase 2.54808
ZSCAN9 zinc finger and SCAN domain containing 9 2.52206
RITA1 RBPJ interacting and tubulin associated 1 2.51076
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 2.51076
PARP10 poly (ADP-ribose) polymerase family, member 10 2.51076
ASB16 ankyrin repeat and SOCS box containing 16 2.51076
LRRC34 leucine rich repeat containing 34 2.48751
SDF4 stromal cell derived factor 4 2.48751
TESMIN testis expressed metallothionein like protein 2.48751
RPS24 ribosomal protein S24 2.47207
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 2.46746
LDHAL6A lactate dehydrogenase A-like 6A 2.46353
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 2.46353
MLANA melan-A 2.46353
PWWP3B PWWP domain containing 3B 2.46353
LAMA5 laminin, alpha 5 2.46059
FBXW9 F-box and WD repeat domain containing 9 2.45341
SCRN3 secernin 3 2.43299
MYCT1 myc target 1 2.43299
SLITRK3 SLIT and NTRK-like family, member 3 2.43299
GOSR2 golgi SNAP receptor complex member 2 2.43299
CIZ1 CDKN1A interacting zinc finger protein 1 2.42753
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 2.42468
ZNF555 zinc finger protein 555 2.41607
BAG6 BCL2-associated athanogene 6 2.37455
GUSB glucuronidase, beta 2.36082
ZFAND2A zinc finger, AN1-type domain 2A 2.33294
YIPF6 Yip1 domain family, member 6 2.30427
TNS2 tensin 2 2.29678
PCDHB4 protocadherin beta 4 2.28511
SHISA7 shisa family member 7 2.28511
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25 2.28163
EPS15 epidermal growth factor receptor pathway substrate 15 2.27727
ZNF384 zinc finger protein 384 2.26673
TM7SF3 transmembrane 7 superfamily member 3 2.26351
WDTC1 WD and tetratricopeptide repeats 1 2.26279
CSMD1 CUB and Sushi multiple domains 1 2.25575
MRPS18B mitochondrial ribosomal protein S18B 2.21508
RHD Rh blood group, D antigen 2.21508
MOB2 MOB kinase activator 2 2.20787
TTC17 tetratricopeptide repeat domain 17 2.18468
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 2.17734
RAB25 RAB25, member RAS oncogene family 2.17695
MDK midkine (neurite growth-promoting factor 2) 2.17695
MZT2B mitotic spindle organizing protein 2B 2.17499
SV2A synaptic vesicle glycoprotein 2A 2.16836
C1ORF52 chromosome 1 open reading frame 52 2.16397
TRIOBP TRIO and F-actin binding protein 2.14599
DVL1 dishevelled segment polarity protein 1 2.13366
RPL30 ribosomal protein L30 2.1293
UNC5D unc-5 homolog D (C. elegans) 2.11186
ZFR2 zinc finger RNA binding protein 2 2.10901
BTBD7 BTB (POZ) domain containing 7 2.10831
ZNF678 zinc finger protein 678 2.10048
THAP11 THAP domain containing 11 2.08787
TEX22 testis expressed 22 2.08318
MYO1E myosin IE 2.06906
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 2.06718
SH2B2 SH2B adaptor protein 2 2.06524
ZNF461 zinc finger protein 461 2.06524
ZSCAN10 zinc finger and SCAN domain containing 10 2.06524
CXADR coxsackie virus and adenovirus receptor 2.05731
PRDM2 PR domain containing 2, with ZNF domain 2.05671
MFSD12 major facilitator superfamily domain containing 12 2.05274
RPS15 ribosomal protein S15 2.04125
ENAH enabled homolog (Drosophila) 2.04125
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 2.03711
RPS3 ribosomal protein S3 2.01881
B4GAT1 beta-1,4-glucuronyltransferase 1 2.01154

decreased expression

Symbol Name Standardized Value
CCND1 cyclin D1 -2.56081
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F -2.56081
MIEF2 mitochondrial elongation factor 2 -2.56081
EIF5A eukaryotic translation initiation factor 5A -2.56081
S100A13 S100 calcium binding protein A13 -2.56081
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein -2.56081
GMPR guanosine monophosphate reductase -2.56081
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 -2.56081
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 -2.56081
GRHL3 grainyhead-like 3 (Drosophila) -2.56081
ANKRD10 ankyrin repeat domain 10 -2.56081
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha -2.56081
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) -2.56081
ZNF572 zinc finger protein 572 -2.56081
HIPK4 homeodomain interacting protein kinase 4 -2.56081
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like -2.54669
CNTNAP4 contactin associated protein-like 4 -2.52206
NXPH4 neurexophilin 4 -2.52206
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 -2.52206
ELL3 elongation factor RNA polymerase II-like 3 -2.52206
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 -2.52206
TRPV3 transient receptor potential cation channel, subfamily V, member 3 -2.52206
ATP8B4 ATPase, class I, type 8B, member 4 -2.52206
GNG13 guanine nucleotide binding protein (G protein), gamma 13 -2.52206
TMEM100 transmembrane protein 100 -2.52206
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow -2.52206
ABI3BP ABI family, member 3 (NESH) binding protein -2.52206
ZNF329 zinc finger protein 329 -2.52206
RLBP1 retinaldehyde binding protein 1 -2.52206
TMEM238L transmembrane protein 238 like -2.52206
EVI2A ecotropic viral integration site 2A -2.52206
CNR1 cannabinoid receptor 1 (brain) -2.52206
DEPP1 DEPP autophagy regulator 1 -2.52206
ZFP92 ZFP92 zinc finger protein -2.52206
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) -2.52206
DUSP13B dual specificity phosphatase 13B -2.52206
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 -2.52206
TMEM179 transmembrane protein 179 -2.52206
AMIGO1 adhesion molecule with Ig-like domain 1 -2.52206
SPATA16 spermatogenesis associated 16 -2.52206
ZBTB16 zinc finger and BTB domain containing 16 -2.52206
ZNF436 zinc finger protein 436 -2.52206
SLCO1C1 solute carrier organic anion transporter family, member 1C1 -2.52206
DRC3 dynein regulatory complex subunit 3 -2.52206
GLS glutaminase -2.48751
CSAD cysteine sulfinic acid decarboxylase -2.48461
JAM3 junctional adhesion molecule 3 -2.45631
ZNF491 zinc finger protein 491 -2.39837
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B -2.39837
KATNIP katanin interacting protein -2.38568
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -2.36468
ITGA6 integrin, alpha 6 -2.30276
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) -2.30276
ZCCHC8 zinc finger, CCHC domain containing 8 -2.29678
TXNDC16 thioredoxin domain containing 16 -2.28163
ZNF141 zinc finger protein 141 -2.27253
TMEM213 transmembrane protein 213 -2.26805
COX11 COX11 cytochrome c oxidase copper chaperone -2.25004
CUL7 cullin 7 -2.23865
WDSUB1 WD repeat, sterile alpha motif and U-box domain containing 1 -2.23632
TCEA1 transcription elongation factor A (SII), 1 -2.21971
ZNF385C zinc finger protein 385C -2.21508
NPTN neuroplastin -2.20519
RTN4R reticulon 4 receptor -2.19736
GLIPR2 GLI pathogenesis-related 2 -2.14599
MROH8 maestro heat-like repeat family member 8 -2.14599
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 -2.1293
DENND10 DENN domain containing 10 -2.1175
INTS6 integrator complex subunit 6 -2.10048
TRIO trio Rho guanine nucleotide exchange factor -2.10048
PDE4B phosphodiesterase 4B, cAMP-specific -2.07767
BCCIP BRCA2 and CDKN1A interacting protein -2.06524
ANO2 anoctamin 2, calcium activated chloride channel -2.06524
TMX4 thioredoxin-related transmembrane protein 4 -2.05671
NCK1 NCK adaptor protein 1 -2.05274
CCDC175 coiled-coil domain containing 175 -2.05083
TBC1D2 TBC1 domain family, member 2 -2.04674
DGKE diacylglycerol kinase, epsilon 64kDa -2.04189
RARS2 arginyl-tRNA synthetase 2, mitochondrial -2.04125
ZNF37A zinc finger protein 37A -2.03711
ZNF827 zinc finger protein 827 -2.03711
AQP5 aquaporin 5 -2.03711
PDS5A PDS5 cohesin associated factor A -2.0361
ANAPC5 anaphase promoting complex subunit 5 -2.03555
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -2.03555
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -2.01881
USP43 ubiquitin specific peptidase 43 -2.01881
PKDCC protein kinase domain containing, cytoplasmic -2.01395
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 -2.01395
PRDM11 PR domain containing 11 -2.01001