CCND2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description cyclin D2|The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014] (NCBI Entrez Gene Database, 894)
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Genes

295 genes differentially expressed following the CCND2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
RANBP3L RAN binding protein 3-like 2.48172
MAPK11 mitogen-activated protein kinase 11 2.48172
CLDN14 claudin 14 2.48172
MYH4 myosin, heavy chain 4, skeletal muscle 2.48172
SRGN serglycin 2.48172
CLDN34 claudin 34 2.48172
SUN3 Sad1 and UNC84 domain containing 3 2.48172
SLA2 Src-like-adaptor 2 2.48172
PRSS51 protease, serine, 51 2.48172
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.48172
FXYD3 FXYD domain containing ion transport regulator 3 2.48172
ARHGAP30 Rho GTPase activating protein 30 2.48172
RORC RAR-related orphan receptor C 2.48172
SMIM45 small integral membrane protein 45 2.48172
ERFE erythroferrone 2.48172
FOXA2 forkhead box A2 2.48172
GSTM5 glutathione S-transferase mu 5 2.4374
IL5RA interleukin 5 receptor, alpha 2.4374
FFAR4 free fatty acid receptor 4 2.4374
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 2.4374
CABP4 calcium binding protein 4 2.4374
NCF1 neutrophil cytosolic factor 1 2.4374
CNTNAP4 contactin associated protein-like 4 2.4374
TRIM17 tripartite motif containing 17 2.4374
MGAM2 maltase-glucoamylase 2 (putative) 2.4374
PCDHA2 protocadherin alpha 2 2.4374
SCGB2B2 secretoglobin, family 2B, member 2 2.4374
SOX18 SRY (sex determining region Y)-box 18 2.4374
GFAP glial fibrillary acidic protein 2.4374
KIAA2012 KIAA2012 2.4374
CD69 CD69 molecule 2.4374
OCSTAMP osteoclast stimulatory transmembrane protein 2.4374
TCP11 t-complex 11, testis-specific 2.4374
AVP arginine vasopressin 2.4374
CLEC14A C-type lectin domain family 14, member A 2.4374
CPLX4 complexin 4 2.4374
GRP gastrin-releasing peptide 2.4374
LRRC10B leucine rich repeat containing 10B 2.4374
ACP3 acid phosphatase 3 2.4374
SIGLEC5 sialic acid binding Ig-like lectin 5 2.4374
OPRL1 opiate receptor-like 1 2.4374
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.4374
SLC23A3 solute carrier family 23, member 3 2.4374
FAM221B family with sequence similarity 221, member B 2.4374
BIRC3 baculoviral IAP repeat containing 3 2.4374
CXCL2 chemokine (C-X-C motif) ligand 2 2.4374
TLK2 tousled-like kinase 2 2.4374
OVCH1 ovochymase 1 2.4374
CD1C CD1c molecule 2.4374
METTL4 methyltransferase like 4 2.4374
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 2.4374
CLEC6A C-type lectin domain family 6, member A 2.4374
DYNLRB2 dynein, light chain, roadblock-type 2 2.4374
GPR37L1 G protein-coupled receptor 37 like 1 2.4374
XKRX XK, Kell blood group complex subunit-related, X-linked 2.4374
MUSTN1 musculoskeletal, embryonic nuclear protein 1 2.4374
PLG plasminogen 2.4374
ETFRF1 electron transfer flavoprotein regulatory factor 1 2.4374
ESS2 ess-2 splicing factor homolog 2.4374
ANGPTL8 angiopoietin like 8 2.4374
PLAAT4 phospholipase A and acyltransferase 4 2.4374
DUSP29 dual specificity phosphatase 29 2.4374
CIMIP3 ciliary microtubule inner protein 3 2.4374
IGBP1C IGBP1 family member C 2.4374
SPATA31H1 SPATA31 subfamily H member 1 2.4374
OR2D3 olfactory receptor, family 2, subfamily D, member 3 2.4374
FAM131C family with sequence similarity 131, member C 2.4374
PGA5 pepsinogen 5, group I (pepsinogen A) 2.4374
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.4374
DUXB double homeobox B 2.4374
COLEC11 collectin sub-family member 11 2.4374
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.4374
LAX1 lymphocyte transmembrane adaptor 1 2.4374
USH1G Usher syndrome 1G (autosomal recessive) 2.4374
FAM153A family with sequence similarity 153, member A 2.4374
ISM2 isthmin 2 2.4374
E2F3 E2F transcription factor 3 2.4374
LIPF lipase, gastric 2.4374
RAB41 RAB41, member RAS oncogene family 2.4374
PCDHA3 protocadherin alpha 3 2.4374
RRAGA Ras-related GTP binding A 2.4374
PCDHB10 protocadherin beta 10 2.4374
VIT vitrin 2.4374
RNMT RNA (guanine-7-) methyltransferase 2.4374
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 2.4374
ZNF623 zinc finger protein 623 2.4374
ALAS2 5'-aminolevulinate synthase 2 2.4374
DHH desert hedgehog 2.4374
DYTN dystrotelin 2.4374
KLK11 kallikrein-related peptidase 11 2.4374
ZFP92 ZFP92 zinc finger protein 2.4374
OR8H1 olfactory receptor, family 8, subfamily H, member 1 2.4374
MAGEB17 melanoma antigen family B17 2.4374
DMTN dematin actin binding protein 2.4374
DMBT1 deleted in malignant brain tumors 1 2.4374
ZNF843 zinc finger protein 843 2.4374
POU3F2 POU class 3 homeobox 2 2.4374
PAQR3 progestin and adipoQ receptor family member III 2.4374
DMRTA2 DMRT-like family A2 2.4374
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 2.4374
VWA3B von Willebrand factor A domain containing 3B 2.4374
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 2.4374
BPIFB1 BPI fold containing family B, member 1 2.4374
KLHL41 kelch-like family member 41 2.4374
TAS2R50 taste receptor, type 2, member 50 2.4374
CDHR5 cadherin-related family member 5 2.4374
MAPKBP1 mitogen-activated protein kinase binding protein 1 2.4374
ARR3 arrestin 3, retinal (X-arrestin) 2.4374
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 2.4374
C11ORF91 chromosome 11 open reading frame 91 2.4374
C11ORF16 chromosome 11 open reading frame 16 2.4374
OPRK1 opioid receptor, kappa 1 2.4374
MAB21L1 mab-21-like 1 (C. elegans) 2.4374
GAGE10 G antigen 10 2.4374
TRIM55 tripartite motif containing 55 2.4374
MST1 macrophage stimulating 1 2.4374
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.4374
WFDC10A WAP four-disulfide core domain 10A 2.4374
SLC38A3 solute carrier family 38, member 3 2.4374
CD38 CD38 molecule 2.4374
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 2.4374
TMEM184A transmembrane protein 184A 2.4374
DRC1 dynein regulatory complex subunit 1 2.4374
SMCO3 single-pass membrane protein with coiled-coil domains 3 2.4374
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 2.4374
CCDC87 coiled-coil domain containing 87 2.4374
TECTA tectorin alpha 2.4374
MB myoglobin 2.4374
CLCF1 cardiotrophin-like cytokine factor 1 2.4374
TMEM132C transmembrane protein 132C 2.4374
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 2.4374
WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2.4374
CTSS cathepsin S 2.4374
PNMA5 paraneoplastic Ma antigen family member 5 2.4374
SPNS3 spinster homolog 3 (Drosophila) 2.4374
TGM6 transglutaminase 6 2.4374
PDCD1LG2 programmed cell death 1 ligand 2 2.4374
PADI3 peptidyl arginine deiminase, type III 2.4374
TAS2R42 taste receptor, type 2, member 42 2.4374
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 2.4374
GCM2 glial cells missing homolog 2 (Drosophila) 2.4374
GPR17 G protein-coupled receptor 17 2.4374
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 2.4374
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 2.4374
IL10RA interleukin 10 receptor, alpha 2.4374
RSPO2 R-spondin 2 2.42815
PRPH2 peripherin 2 (retinal degeneration, slow) 2.42573
FERRY3 FERRY endosomal RAB5 effector complex subunit 3 2.42573
CARM1 coactivator-associated arginine methyltransferase 1 2.42573
CNTFR ciliary neurotrophic factor receptor 2.42573
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 2.42573
TMEM217 transmembrane protein 217 2.42573
CNFN cornifelin 2.42573
RLBP1 retinaldehyde binding protein 1 2.42573
UBQLN1 ubiquilin 1 2.42573
RAD9A RAD9 homolog A (S. pombe) 2.42573
BMP2K BMP2 inducible kinase 2.4224
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) 2.36372
PDE5A phosphodiesterase 5A, cGMP-specific 2.35139
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 2.30953
ZNF816 zinc finger protein 816 2.29918
ART5 ADP-ribosyltransferase 5 2.2929
VWDE von Willebrand factor D and EGF domains 2.29064
MRAP2 melanocortin 2 receptor accessory protein 2 2.26366
RAD54L RAD54-like (S. cerevisiae) 2.25333
EXOC5 exocyst complex component 5 2.24005
NOLC1 nucleolar and coiled-body phosphoprotein 1 2.22838
DRC2 dynein regulatory complex subunit 2 2.20465
PES1 pescadillo ribosomal biogenesis factor 1 2.18627
ATG13 autophagy related 13 2.15643
MYO5A myosin VA (heavy chain 12, myoxin) 2.15618
ADGRL2 adhesion G protein-coupled receptor L2 2.13691
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 2.11478
SERP1 stress-associated endoplasmic reticulum protein 1 2.11478
FADD Fas (TNFRSF6)-associated via death domain 2.11478
HAS2 hyaluronan synthase 2 2.10992
ZDHHC3 zinc finger, DHHC-type containing 3 2.10247
SERTAD2 SERTA domain containing 2 2.10247
CARS1 cysteinyl-tRNA synthetase 1 2.09715
KIAA0753 KIAA0753 2.09391
H2AC11 H2A clustered histone 11 2.09312
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 2.07636
PWWP2B PWWP domain containing 2B 2.0733
FBXL5 F-box and leucine-rich repeat protein 5 2.0663
ANKRD28 ankyrin repeat domain 28 2.06617
NSF N-ethylmaleimide-sensitive factor 2.05904
IWS1 IWS1 homolog (S. cerevisiae) 2.05409
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 2.02798
IQCH IQ motif containing H 2.02798
VILL villin-like 2.02282

decreased expression

Symbol Name Standardized Value
SCUBE3 signal peptide, CUB domain, EGF-like 3 -2.48172
MSR1 macrophage scavenger receptor 1 -2.48172
NBEAL1 neurobeachin-like 1 -2.48172
RXRB retinoid X receptor, beta -2.48172
NFIC nuclear factor I/C (CCAAT-binding transcription factor) -2.48172
TESK1 testis-specific kinase 1 -2.4374
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 -2.4374
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 -2.4374
CD7 CD7 molecule -2.4374
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like -2.4374
CRYM crystallin, mu -2.4374
FAM86B1 family with sequence similarity 86, member B1 -2.4374
CCND2 cyclin D2 -2.4374
CCDC125 coiled-coil domain containing 125 -2.4374
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains -2.4374
MYLK3 myosin light chain kinase 3 -2.4374
FANK1 fibronectin type III and ankyrin repeat domains 1 -2.4374
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.42815
TMIE transmembrane inner ear -2.42573
RNF39 ring finger protein 39 -2.42573
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) -2.42573
MID2 midline 2 -2.42573
PLCZ1 phospholipase C, zeta 1 -2.42573
TMOD4 tropomodulin 4 (muscle) -2.42573
NPPC natriuretic peptide C -2.42573
PANO1 proapoptotic nucleolar protein 1 -2.42573
LEP leptin -2.42573
CYSRT1 cysteine-rich tail protein 1 -2.42573
NOXRED1 NADP-dependent oxidoreductase domain containing 1 -2.42573
BFSP2 beaded filament structural protein 2, phakinin -2.42573
GPR183 G protein-coupled receptor 183 -2.42573
TRPV3 transient receptor potential cation channel, subfamily V, member 3 -2.42573
TLE6 transducin-like enhancer of split 6 -2.42573
SCRG1 stimulator of chondrogenesis 1 -2.42573
ZNF98 zinc finger protein 98 -2.42573
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma -2.42573
TMEM196 transmembrane protein 196 -2.42573
HRH1 histamine receptor H1 -2.42573
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha -2.42573
TBX10 T-box 10 -2.42573
SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 -2.42573
CCNB3 cyclin B3 -2.42573
SHCBP1L SHC SH2-domain binding protein 1-like -2.42573
KCNRG potassium channel regulator -2.42573
RBP4 retinol binding protein 4, plasma -2.42573
TMEM52B transmembrane protein 52B -2.42573
RIPPLY2 ripply transcriptional repressor 2 -2.42573
SHOX short stature homeobox -2.42573
TRHR thyrotropin-releasing hormone receptor -2.42573
CDCA5 cell division cycle associated 5 -2.42573
CFAP47 cilia and flagella associated protein 47 -2.42573
COL11A2 collagen, type XI, alpha 2 -2.42573
DCDC2B doublecortin domain containing 2B -2.42573
EBF2 early B-cell factor 2 -2.42573
C2CD4D C2 calcium-dependent domain containing 4D -2.42573
CDH10 cadherin 10, type 2 (T2-cadherin) -2.42573
SYNM synemin, intermediate filament protein -2.42573
ETNPPL ethanolamine-phosphate phospho-lyase -2.42573
PLGLB1 plasminogen-like B1 -2.42573
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.42573
ADGRL4 adhesion G protein-coupled receptor L4 -2.42573
LRRN4 leucine rich repeat neuronal 4 -2.42573
NLRP3 NLR family, pyrin domain containing 3 -2.42573
CDC26 cell division cycle 26 -2.42573
ANKRD7 ankyrin repeat domain 7 -2.42573
ZBED5 zinc finger, BED-type containing 5 -2.42573
FAM177B family with sequence similarity 177, member B -2.42573
FAIM2 Fas apoptotic inhibitory molecule 2 -2.42573
CSDC2 cold shock domain containing C2, RNA binding -2.42573
OR4D1 olfactory receptor, family 4, subfamily D, member 1 -2.42573
ACSBG2 acyl-CoA synthetase bubblegum family member 2 -2.42573
SP100 SP100 nuclear antigen -2.42573
DSC2 desmocollin 2 -2.4224
NBPF12 neuroblastoma breakpoint family, member 12 -2.41397
GCFC2 GC-rich sequence DNA-binding factor 2 -2.41283
CFAP20 cilia and flagella associated protein 20 -2.38154
BCL7C B-cell CLL/lymphoma 7C -2.36723
SLC16A4 solute carrier family 16, member 4 -2.35932
ZNF225 zinc finger protein 225 -2.3389
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.33325
KIF18B kinesin family member 18B -2.27245
ZW10 zw10 kinetochore protein -2.26887
ANXA5 annexin A5 -2.26274
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 -2.18894
ZNF250 zinc finger protein 250 -2.18627
TBL2 transducin (beta)-like 2 -2.17868
CCDC32 coiled-coil domain containing 32 -2.08287
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 -2.07636
SMTNL2 smoothelin-like 2 -2.07636
DHRS7B dehydrogenase/reductase (SDR family) member 7B -2.0733
CR1 complement component (3b/4b) receptor 1 (Knops blood group) -2.0733
PCDH9 protocadherin 9 -2.04303
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -2.03372
TEDC1 tubulin epsilon and delta complex 1 -2.02647
KCTD11 potassium channel tetramerization domain containing 11 -2.02647
FITM2 fat storage-inducing transmembrane protein 2 -2.02647
SYNDIG1 synapse differentiation inducing 1 -2.02647
TMEM102 transmembrane protein 102 -2.02647
LZTS2 leucine zipper, putative tumor suppressor 2 -2.02647
HACL2 2-hydroxyacyl-CoA lyase 2 -2.02282
NPHP1 nephronophthisis 1 (juvenile) -2.02282
ADARB1 adenosine deaminase, RNA-specific, B1 -2.02178
PXDNL peroxidasin-like -2.017
UBE2M ubiquitin-conjugating enzyme E2M -2.00913
PDE4DIP phosphodiesterase 4D interacting protein -2.00657