CCND2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description cyclin D2|The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014] (NCBI Entrez Gene Database, 894)
External Link http://www.ncbi.nlm.nih.gov/gene/894
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71 interacting proteins for CCND2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AKAP8 A kinase (PRKA) anchor protein 8
AMY2A amylase, alpha 2A (pancreatic)
C2CD5 C2 calcium-dependent domain containing 5
CABLES1 Cdk5 and Abl enzyme substrate 1
CABLES2 Cdk5 and Abl enzyme substrate 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNA2 cyclin A2
CCNB1 cyclin B1
CCND3 cyclin D3
CCNH cyclin H
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CCT7 chaperonin containing TCP1, subunit 7 (eta)
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CDK18 cyclin-dependent kinase 18
CDK2 cyclin-dependent kinase 2
CDK3 cyclin-dependent kinase 3
CDK4 cyclin-dependent kinase 4
CDK5 cyclin-dependent kinase 5
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDK6 cyclin-dependent kinase 6
CDK7 cyclin-dependent kinase 7
CDKL3 cyclin-dependent kinase-like 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
DCLK3 doublecortin-like kinase 3
DMBT1 deleted in malignant brain tumors 1
DMTF1 cyclin D binding myb-like transcription factor 1
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
E2F3 E2F transcription factor 3
E2F4 E2F transcription factor 4, p107/p130-binding
E2F5 E2F transcription factor 5, p130-binding
FBXL2 F-box and leucine-rich repeat protein 2
FIBP fibroblast growth factor (acidic) intracellular binding protein
FOXM1 forkhead box M1
GLUD1 glutamate dehydrogenase 1
GSK3B glycogen synthase kinase 3 beta
HDAC1 histone deacetylase 1
HIST1H1A histone cluster 1, H1a
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
KIAA0195 KIAA0195
MAPK14 mitogen-activated protein kinase 14
MNAT1 MNAT CDK-activating kinase assembly factor 1
NPDC1 neural proliferation, differentiation and control, 1
PCGF2 polycomb group ring finger 2
PIGR polymeric immunoglobulin receptor
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RB1 retinoblastoma 1
RBL1 retinoblastoma-like 1
RBL2 retinoblastoma-like 2
RBX1 ring-box 1, E3 ubiquitin protein ligase
RUNX1 runt-related transcription factor 1
SERTAD1 SERTA domain containing 1
STIP1 stress-induced phosphoprotein 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCP1 t-complex 1
TFDP1 transcription factor Dp-1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TRAP1 TNF receptor-associated protein 1
TSC2 tuberous sclerosis 2
UBC ubiquitin C
WDR33 WD repeat domain 33